JP2006519813A5 - - Google Patents
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- Publication number
- JP2006519813A5 JP2006519813A5 JP2006504812A JP2006504812A JP2006519813A5 JP 2006519813 A5 JP2006519813 A5 JP 2006519813A5 JP 2006504812 A JP2006504812 A JP 2006504812A JP 2006504812 A JP2006504812 A JP 2006504812A JP 2006519813 A5 JP2006519813 A5 JP 2006519813A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- disease
- therapeutic treatment
- cancer
- prophylactic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000004736 B-Cell Leukemia Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 1
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000000389 T-cell leukemia Diseases 0.000 claims 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20030290571 EP1454908B1 (en) | 2003-03-07 | 2003-03-07 | Substituted pyridinyl-2-(diaza-bicyclo-alkyl)-pyrimidinone derivatives |
| EP03290571.3 | 2003-03-07 | ||
| EP03290570.5 | 2003-03-07 | ||
| EP03290570A EP1454910A1 (en) | 2003-03-07 | 2003-03-07 | Substituted pyrimidinyl-2-(diaza-bicyclo-alkyl)-pyrimidone derivatives |
| PCT/EP2004/003050 WO2004078759A1 (en) | 2003-03-07 | 2004-03-05 | Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006519813A JP2006519813A (ja) | 2006-08-31 |
| JP2006519813A5 true JP2006519813A5 (enExample) | 2007-04-19 |
| JP4778890B2 JP4778890B2 (ja) | 2011-09-21 |
Family
ID=32963795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006504812A Expired - Fee Related JP4778890B2 (ja) | 2003-03-07 | 2004-03-05 | 置換された２−（ジアザ−ビシクロ−アルキル）−ピリミドン誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7211581B2 (enExample) |
| EP (1) | EP1603910B1 (enExample) |
| JP (1) | JP4778890B2 (enExample) |
| KR (1) | KR101072159B1 (enExample) |
| AR (1) | AR043486A1 (enExample) |
| AT (1) | ATE440844T1 (enExample) |
| AU (1) | AU2004218249B2 (enExample) |
| BR (1) | BRPI0408186A (enExample) |
| CA (1) | CA2516934C (enExample) |
| CY (1) | CY1111132T1 (enExample) |
| DE (1) | DE602004022784D1 (enExample) |
| DK (1) | DK1603910T3 (enExample) |
| EA (1) | EA008595B1 (enExample) |
| ES (1) | ES2332132T3 (enExample) |
| IL (1) | IL170468A (enExample) |
| MX (1) | MXPA05009575A (enExample) |
| NO (1) | NO20054141L (enExample) |
| NZ (1) | NZ542136A (enExample) |
| PL (1) | PL1603910T3 (enExample) |
| PT (1) | PT1603910E (enExample) |
| SI (1) | SI1603910T1 (enExample) |
| WO (1) | WO2004078759A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200813015A (en) | 2006-03-15 | 2008-03-16 | Mitsubishi Pharma Corp | 2-(cyclic amino)-pyrimidone derivatives |
| EP1992620A1 (en) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Arylamide pyrimidone derivatives for the treatment of neurodegenerative diseases |
| EP1992625A1 (en) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Arylamide pyrimidone compounds |
| EP1992624A1 (en) | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Heteroarylamide pyrimidone compounds |
| EP1992621A1 (en) * | 2007-05-16 | 2008-11-19 | Sanofi-Aventis | Heteroarylamide-substituted pyrimidone derivatives for the treatment of neurodegenerative diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4994460A (en) * | 1989-06-01 | 1991-02-19 | Bristol-Myers Squibb Co. | Agents for treatment of brain ischemia |
| US5883254A (en) * | 1996-11-08 | 1999-03-16 | Hoffmann-La Roche Inc. | Process for making pyrimidine derivatives |
| EP1136483A1 (en) * | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | 2-[Piperazinyl]pyrimidone derivatives |
| AU2001262150A1 (en) * | 2000-03-23 | 2001-10-03 | Mitsubishi Pharma Corporation | 2-(nitrogen-heterocyclic)pyrimidone derivatives |
| ES2250883T3 (es) * | 2002-02-28 | 2006-04-16 | Sanofi-Aventis | Derivados de 2-piridinil y 2-pirimidinil-6,7,8,9-tetrahidropirimido(1,2-a)pirimidin-4-ona sustituidos con heteroarilo. |
-
2004
- 2004-03-05 AR ARP040100695A patent/AR043486A1/es not_active Application Discontinuation
- 2004-03-05 DK DK04717644T patent/DK1603910T3/da active
- 2004-03-05 ES ES04717644T patent/ES2332132T3/es not_active Expired - Lifetime
- 2004-03-05 DE DE602004022784T patent/DE602004022784D1/de not_active Expired - Lifetime
- 2004-03-05 WO PCT/EP2004/003050 patent/WO2004078759A1/en not_active Ceased
- 2004-03-05 PT PT04717644T patent/PT1603910E/pt unknown
- 2004-03-05 MX MXPA05009575A patent/MXPA05009575A/es active IP Right Grant
- 2004-03-05 NZ NZ542136A patent/NZ542136A/en not_active IP Right Cessation
- 2004-03-05 CA CA2516934A patent/CA2516934C/en not_active Expired - Fee Related
- 2004-03-05 EA EA200501243A patent/EA008595B1/ru not_active IP Right Cessation
- 2004-03-05 JP JP2006504812A patent/JP4778890B2/ja not_active Expired - Fee Related
- 2004-03-05 AU AU2004218249A patent/AU2004218249B2/en not_active Ceased
- 2004-03-05 EP EP04717644A patent/EP1603910B1/en not_active Expired - Lifetime
- 2004-03-05 SI SI200431263T patent/SI1603910T1/sl unknown
- 2004-03-05 AT AT04717644T patent/ATE440844T1/de active
- 2004-03-05 BR BRPI0408186-2A patent/BRPI0408186A/pt not_active IP Right Cessation
- 2004-03-05 PL PL04717644T patent/PL1603910T3/pl unknown
-
2005
- 2005-08-23 IL IL170468A patent/IL170468A/en not_active IP Right Cessation
- 2005-09-06 US US11/219,923 patent/US7211581B2/en not_active Expired - Fee Related
- 2005-09-06 NO NO20054141A patent/NO20054141L/no not_active Application Discontinuation
- 2005-09-06 KR KR1020057016636A patent/KR101072159B1/ko not_active Expired - Fee Related
-
2007
- 2007-03-29 US US11/693,345 patent/US7452897B2/en not_active Expired - Fee Related
-
2009
- 2009-10-26 CY CY20091101113T patent/CY1111132T1/el unknown
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