JP2006519216A5 - - Google Patents
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- Publication number
- JP2006519216A5 JP2006519216A5 JP2006502261A JP2006502261A JP2006519216A5 JP 2006519216 A5 JP2006519216 A5 JP 2006519216A5 JP 2006502261 A JP2006502261 A JP 2006502261A JP 2006502261 A JP2006502261 A JP 2006502261A JP 2006519216 A5 JP2006519216 A5 JP 2006519216A5
- Authority
- JP
- Japan
- Prior art keywords
- imaging agent
- diagnostic imaging
- formula
- agent according
- matrix metalloproteinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002059 diagnostic imaging Methods 0.000 claims 12
- 239000012216 imaging agent Substances 0.000 claims 12
- 239000003446 ligand Substances 0.000 claims 7
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 claims 6
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 150000004696 coordination complex Chemical class 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 239000002184 metal Substances 0.000 claims 4
- 229910052751 metal Inorganic materials 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 239000011630 iodine Substances 0.000 claims 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0302891A GB0302891D0 (en) | 2003-02-10 | 2003-02-10 | Diagnostic imaging agents for cardiovascular disease |
| GB0307524A GB0307524D0 (en) | 2003-04-01 | 2003-04-01 | Diagnostic imaging agents with MMP inhibitory activity |
| PCT/GB2004/000524 WO2004069365A1 (en) | 2003-02-10 | 2004-02-10 | Diagnostic imaging agents with mmp inhibitory activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006519216A JP2006519216A (ja) | 2006-08-24 |
| JP2006519216A5 true JP2006519216A5 (enExample) | 2007-03-29 |
Family
ID=32852413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006502261A Pending JP2006519216A (ja) | 2003-02-10 | 2004-02-10 | Ｍｍｐ阻害活性を有する画像診断剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8231858B2 (enExample) |
| EP (1) | EP1592458A1 (enExample) |
| JP (1) | JP2006519216A (enExample) |
| AU (1) | AU2004210208B2 (enExample) |
| CA (1) | CA2514885A1 (enExample) |
| NO (1) | NO20053776L (enExample) |
| RU (1) | RU2005123801A (enExample) |
| WO (1) | WO2004069365A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0326546D0 (en) * | 2003-11-14 | 2003-12-17 | Amersham Plc | Inhibitor imaging agents |
| GB0421308D0 (en) * | 2004-09-24 | 2004-10-27 | Amersham Plc | Enzyme inhibitor imaging agents |
| JP5368099B2 (ja) | 2005-10-07 | 2013-12-18 | ゲルベ | ガリウムと錯体形成することが可能なシグナル部分にカップリングされた、生物学的標的の認識のための部分を含んでなる化合物 |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| WO2008045298A2 (en) | 2006-10-06 | 2008-04-17 | Mallinckrodt Inc. | Self-aligning radioisotope elution system |
| EP2149568A1 (en) | 2008-07-22 | 2010-02-03 | Bracco Imaging S.p.A | Aryl-sulphonamidic dimers as metalloproteases inhibitors |
| EP2147684A1 (en) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| US9153350B2 (en) | 2011-01-19 | 2015-10-06 | Mallinckrodt Llc | Protective shroud for nuclear pharmacy generators |
| US8809804B2 (en) * | 2011-01-19 | 2014-08-19 | Mallinckrodt Llc | Holder and tool for radioisotope elution system |
| US8866104B2 (en) | 2011-01-19 | 2014-10-21 | Mallinckrodt Llc | Radioisotope elution system |
| WO2013010573A1 (en) * | 2011-07-18 | 2013-01-24 | Universitaet Muenster | Compounds with matrix-metalloproteinase inhibitory activity |
| US9023318B2 (en) | 2011-06-08 | 2015-05-05 | Siemens Medical Solutions Usa, Inc. | Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof |
| EP2775906B1 (en) * | 2011-11-11 | 2019-07-03 | Yale University | Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging |
| EP2644601A1 (en) * | 2012-03-28 | 2013-10-02 | Westfälische Wilhelms-Universität Münster | Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof |
| GB202012671D0 (en) * | 2020-08-13 | 2020-09-30 | Nrf Ithemba Labs | Theranostic Compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
| US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| TW453995B (en) | 1995-12-15 | 2001-09-11 | Novartis Ag | Certain alpha-substituted arylsulfonamido acetohydroxamic acids |
| WO1998050348A1 (en) * | 1997-05-09 | 1998-11-12 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| US6656448B1 (en) * | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| US6989139B2 (en) * | 2000-02-15 | 2006-01-24 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| DE60114022T2 (de) * | 2000-05-30 | 2006-07-13 | Board Of Governors Of Wayne State University, Detroit | Matrix metalloproteinase-inhibitoren |
-
2004
- 2004-02-10 EP EP04709657A patent/EP1592458A1/en not_active Withdrawn
- 2004-02-10 JP JP2006502261A patent/JP2006519216A/ja active Pending
- 2004-02-10 WO PCT/GB2004/000524 patent/WO2004069365A1/en not_active Ceased
- 2004-02-10 US US10/544,945 patent/US8231858B2/en not_active Expired - Fee Related
- 2004-02-10 CA CA002514885A patent/CA2514885A1/en not_active Abandoned
- 2004-02-10 AU AU2004210208A patent/AU2004210208B2/en not_active Ceased
- 2004-02-10 RU RU2005123801/15A patent/RU2005123801A/ru not_active Application Discontinuation
-
2005
- 2005-08-09 NO NO20053776A patent/NO20053776L/no not_active Application Discontinuation
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