JP2006518589A5 - - Google Patents
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- Publication number
- JP2006518589A5 JP2006518589A5 JP2005501293A JP2005501293A JP2006518589A5 JP 2006518589 A5 JP2006518589 A5 JP 2006518589A5 JP 2005501293 A JP2005501293 A JP 2005501293A JP 2005501293 A JP2005501293 A JP 2005501293A JP 2006518589 A5 JP2006518589 A5 JP 2006518589A5
- Authority
- JP
- Japan
- Prior art keywords
- adenovirus
- protein
- promoter
- nucleic acid
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000701161 unidentified adenovirus Species 0.000 claims 102
- 108090000623 proteins and genes Proteins 0.000 claims 68
- 102000004169 proteins and genes Human genes 0.000 claims 65
- 150000007523 nucleic acids Chemical class 0.000 claims 41
- 108020004707 nucleic acids Proteins 0.000 claims 35
- 102000039446 nucleic acids Human genes 0.000 claims 35
- 210000004027 cell Anatomy 0.000 claims 26
- 206010028980 Neoplasm Diseases 0.000 claims 20
- 230000010076 replication Effects 0.000 claims 19
- 101710199711 Early E1A protein Proteins 0.000 claims 13
- 239000013598 vector Substances 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 8
- 230000001613 neoplastic effect Effects 0.000 claims 7
- 210000000056 organ Anatomy 0.000 claims 7
- 210000001519 tissue Anatomy 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 4
- 239000013543 active substance Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000022131 cell cycle Effects 0.000 claims 3
- 230000006037 cell lysis Effects 0.000 claims 3
- 239000000824 cytostatic agent Substances 0.000 claims 3
- 230000002074 deregulated effect Effects 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 230000003362 replicative effect Effects 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 2
- 241000282472 Canis lupus familiaris Species 0.000 claims 2
- 241000283707 Capra Species 0.000 claims 2
- 241000700198 Cavia Species 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 241000283086 Equidae Species 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- 241000282887 Suidae Species 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000001276 controlling effect Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 108700026220 vif Genes Proteins 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- 108010057856 Adenovirus E2 Proteins Proteins 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 229940123587 Cell cycle inhibitor Drugs 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 206010061968 Gastric neoplasm Diseases 0.000 claims 1
- 206010019695 Hepatic neoplasm Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 206010020843 Hyperthermia Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010029098 Neoplasm skin Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 206010062129 Tongue neoplasm Diseases 0.000 claims 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 claims 1
- 108700025716 Tumor Suppressor Genes Proteins 0.000 claims 1
- 108010067390 Viral Proteins Proteins 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000001085 cytostatic effect Effects 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000005616 epidermal appendage tumor Diseases 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000036031 hyperthermia Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 claims 1
- 208000025402 neoplasm of esophagus Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000023974 pharynx neoplasm Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 208000023958 prostate neoplasm Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 201000008753 synovium neoplasm Diseases 0.000 claims 1
- 208000025421 tumor of uterus Diseases 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10248039 | 2002-10-15 | ||
| DE10248039.7 | 2002-10-15 | ||
| DE10322530.7 | 2003-05-19 | ||
| DE10322530 | 2003-05-19 | ||
| PCT/EP2003/005583 WO2003099859A2 (de) | 2002-05-27 | 2003-05-27 | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
| DE10324085.3 | 2003-05-27 | ||
| DE10324085 | 2003-05-27 | ||
| EPPCT/EP03/05583 | 2003-05-27 | ||
| PCT/EP2003/011427 WO2004035616A2 (de) | 2002-10-15 | 2003-10-15 | Adenovirus mit umgekehrter reihenfolge der expression von genen und verwendung davon |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006518589A JP2006518589A (ja) | 2006-08-17 |
| JP2006518589A5 true JP2006518589A5 (https=) | 2006-11-24 |
| JP4988199B2 JP4988199B2 (ja) | 2012-08-01 |
Family
ID=32314683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501293A Expired - Lifetime JP4988199B2 (ja) | 2002-10-15 | 2003-10-15 | 新規アデノウイルス、それをコードする核酸及びその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8951772B2 (https=) |
| EP (1) | EP1554375B1 (https=) |
| JP (1) | JP4988199B2 (https=) |
| KR (1) | KR101123510B1 (https=) |
| AU (1) | AU2010257327C1 (https=) |
| CA (1) | CA2515650C (https=) |
| DK (1) | DK1554375T3 (https=) |
| MX (1) | MXPA05004074A (https=) |
| PL (1) | PL219321B1 (https=) |
| SG (1) | SG165168A1 (https=) |
| WO (1) | WO2004035616A2 (https=) |
| ZA (1) | ZA200502680B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
| US8071740B2 (en) | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| CN100506284C (zh) | 2001-10-19 | 2009-07-01 | 脉管生物生长有限公司 | 多核苷酸构建体、药物组合物以及靶向的下调血管生成和抗癌的治疗方法 |
| JP5213298B2 (ja) | 2002-05-27 | 2013-06-19 | ホルム，ペル・ゾンネ | アデノウイルスおよびそれをコードしている核酸の新たな使用 |
| CA2546178A1 (en) | 2003-11-14 | 2005-06-09 | Per Sonne Holm | New use of adenovirus and nucleic acids coding therefor |
| EP1689446B1 (de) * | 2003-11-14 | 2015-01-07 | Per Sonne Holm | Neue adenoviren, dafür codierende nukleinsäuren und deren verwendung |
| US20090232800A1 (en) * | 2004-12-31 | 2009-09-17 | Per Sonne Holm | E1-minus adenoviruses and use thereof |
| SG158133A1 (en) * | 2004-12-31 | 2010-01-29 | Sonne Holm | Method for reversing multiple resistance in animal cells |
| KR100747646B1 (ko) | 2005-02-25 | 2007-08-08 | 연세대학교 산학협력단 | 데코린 유전자를 포함하는 유전자 전달 시스템 및 이를 포함하는 약제학적 항종양 조성물 |
| WO2012022496A2 (en) | 2010-08-19 | 2012-02-23 | Per Sonne Holm | Method for killing tumor stem cells |
| KR20210031852A (ko) * | 2018-03-05 | 2021-03-23 | 클리니쿰 레히츠 데어 이자르 데어 테크니쉔 우니베르지테트 뮌헨 | 종양 세포 붕괴성 아데노바이러스와 cdk4/6 억제제의 조합물에 의한 종양의 치료 |
| AU2019294294A1 (en) | 2018-06-25 | 2021-02-11 | Fondazione Telethon Ets | Gene therapy |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE178490T1 (de) * | 1993-02-16 | 1999-04-15 | Onyx Pharmaceuticals | Cytopathische viren zur therapie und prophylaxe der neoplasie |
| US5998205A (en) * | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
| US6254862B1 (en) * | 1997-03-03 | 2001-07-03 | Calydon, Inc. | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
| US6100086A (en) * | 1997-04-14 | 2000-08-08 | Genzyme Corporation | Transgene expression systems |
| DE10015413A1 (de) * | 2000-03-23 | 2001-09-27 | Max Delbrueck Centrum | Mittel zur Diagnose und Therapie viraler Erkrankungen |
| AU2002235141A1 (en) * | 2000-11-27 | 2002-06-03 | Geron Corporation | Glycosyltransferase vectors for treating cancer |
| US20030095989A1 (en) * | 2000-12-18 | 2003-05-22 | Irving John M. | Chimeric cytolytic viruses for cancer treatment |
| EP1346058B1 (de) * | 2000-12-28 | 2007-05-02 | Per Sonne Holm | Adenovirale systeme und deren anwendungen |
| US20030138405A1 (en) * | 2001-04-17 | 2003-07-24 | Juan Fueyo | Conditionally replicative adenovirus to target the Rb and Rb-related pathways |
-
2003
- 2003-10-15 MX MXPA05004074A patent/MXPA05004074A/es active IP Right Grant
- 2003-10-15 KR KR1020057006313A patent/KR101123510B1/ko not_active Expired - Fee Related
- 2003-10-15 CA CA2515650A patent/CA2515650C/en not_active Expired - Fee Related
- 2003-10-15 US US10/531,366 patent/US8951772B2/en not_active Expired - Lifetime
- 2003-10-15 PL PL376573A patent/PL219321B1/pl unknown
- 2003-10-15 WO PCT/EP2003/011427 patent/WO2004035616A2/de not_active Ceased
- 2003-10-15 EP EP03753560.6A patent/EP1554375B1/de not_active Expired - Lifetime
- 2003-10-15 JP JP2005501293A patent/JP4988199B2/ja not_active Expired - Lifetime
- 2003-10-15 DK DK03753560.6T patent/DK1554375T3/en active
- 2003-10-15 SG SG200703426-7A patent/SG165168A1/en unknown
-
2005
- 2005-04-01 ZA ZA2005/02680A patent/ZA200502680B/en unknown
-
2010
- 2010-12-20 AU AU2010257327A patent/AU2010257327C1/en not_active Ceased
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