RU2393221C2 - Аденовирус с обращенной генной экспрессией и его применение - Google Patents

Аденовирус с обращенной генной экспрессией и его применение Download PDF

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Publication number
RU2393221C2
RU2393221C2 RU2005114516/13A RU2005114516A RU2393221C2 RU 2393221 C2 RU2393221 C2 RU 2393221C2 RU 2005114516/13 A RU2005114516/13 A RU 2005114516/13A RU 2005114516 A RU2005114516 A RU 2005114516A RU 2393221 C2 RU2393221 C2 RU 2393221C2
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Russia
Prior art keywords
protein
adenovirus
promoter
nucleic acid
cells
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RU2005114516/13A
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English (en)
Russian (ru)
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RU2005114516A (ru
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Пер Сонне ХОЛЬМ (DE)
Пер Сонне ХОЛЬМ
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Пер Сонне ХОЛЬМ
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Priority claimed from PCT/EP2003/005583 external-priority patent/WO2003099859A2/de
Application filed by Пер Сонне ХОЛЬМ filed Critical Пер Сонне ХОЛЬМ
Publication of RU2005114516A publication Critical patent/RU2005114516A/ru
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Publication of RU2393221C2 publication Critical patent/RU2393221C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2005114516/13A 2002-10-15 2003-10-15 Аденовирус с обращенной генной экспрессией и его применение RU2393221C2 (ru)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE10248039 2002-10-15
DE10248039.7 2002-10-15
DE10322530 2003-05-19
DE10322530.7 2003-05-19
PCT/EP2003/005583 WO2003099859A2 (de) 2002-05-27 2003-05-27 Neue verwendung von adenoviren und dafür codierenden nukleinsäuren
DE10324085.3 2003-05-27
DE10324085 2003-05-27
EPPCT/EP03/05583 2003-05-27

Publications (2)

Publication Number Publication Date
RU2005114516A RU2005114516A (ru) 2006-01-20
RU2393221C2 true RU2393221C2 (ru) 2010-06-27

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ID=34317534

Family Applications (1)

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RU2005114516/13A RU2393221C2 (ru) 2002-10-15 2003-10-15 Аденовирус с обращенной генной экспрессией и его применение

Country Status (5)

Country Link
JP (1) JP4988199B2 (https=)
KR (1) KR101123510B1 (https=)
AU (1) AU2003271730A1 (https=)
CA (1) CA2515650C (https=)
RU (1) RU2393221C2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2561050C2 (ru) * 2013-08-28 2015-08-20 Федеральное государственное бюджетное учреждение науки Институт биофизики клетки Российской академии наук (ИБК РАН) Применение белка yb-1 и его фрагментов для изготовления лекарственных средств при лечении болезни альцгеймера
RU2685876C2 (ru) * 2013-09-24 2019-04-23 Юниверсити Оф Вашингтон Сру Итс Сентер Фор Коммершиализэйшн Белки, связывающие десмоглеин 2 (dsg2), и их применение
RU2768287C1 (ru) * 2018-07-10 2022-03-23 Генемедицине Ко., Лтд. Противоопухолевая композиция

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2487811A1 (en) 2002-05-27 2003-12-04 Per Sonne Holm Use of adenoviruses replicating in a yb-1 dependent manner for the treatment of tumors
EP1689445B1 (de) 2003-11-14 2015-02-25 Per Sonne Holm Neue verwendung von adenoviren und dafür codierende nukleinsäuren
EP1689446B1 (de) * 2003-11-14 2015-01-07 Per Sonne Holm Neue adenoviren, dafür codierende nukleinsäuren und deren verwendung
EP1830864A2 (de) * 2004-12-31 2007-09-12 Per Sonne Holm E1 -minus adenoviren und deren verwendung
JP5584393B2 (ja) 2004-12-31 2014-09-03 ホルム，ペル・ゾンネ 動物細胞における多剤耐性を逆転させる方法
CA3092907A1 (en) * 2018-03-05 2019-09-12 Klinikum Rechts Der Isar Der Technischen Universitat Munchen Treatment of tumors by a combination of an oncolytic adenovirus and a cdk4/6 inhibitor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046779A1 (en) * 1997-04-14 1998-10-22 Genzyme Corporation Adenoviral vectors comprising a modified e4 region but retaining e4orf3
WO2001070951A2 (de) * 2000-03-23 2001-09-27 Max-Delbrück-Centrum für Molekulare Medizin Mittel zur diagnose und therapie viraler erkrankungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE199568T1 (de) * 1993-02-16 2001-03-15 Onyx Pharma Inc Cytopatische viren zur therapie und prophylaxe der neoplasie
US6254862B1 (en) * 1997-03-03 2001-07-03 Calydon, Inc. Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof
ES2287181T3 (es) * 2000-12-28 2007-12-16 Per Sonne Holm Sistemas adenovirales y sus aplicaciones.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046779A1 (en) * 1997-04-14 1998-10-22 Genzyme Corporation Adenoviral vectors comprising a modified e4 region but retaining e4orf3
WO2001070951A2 (de) * 2000-03-23 2001-09-27 Max-Delbrück-Centrum für Molekulare Medizin Mittel zur diagnose und therapie viraler erkrankungen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WONG H.K. et al. "Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters", J Virol. 1994 Aug; 68(8): 4910-4920. GANLY I. et al., "Replication and cytolysis of an E1B-attenuated adenovirus in drug-resistant ovarian tumour cells is associated with reduced apoptosis". Gene Ther. 2001 Mar; 8(5): 369-375. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2561050C2 (ru) * 2013-08-28 2015-08-20 Федеральное государственное бюджетное учреждение науки Институт биофизики клетки Российской академии наук (ИБК РАН) Применение белка yb-1 и его фрагментов для изготовления лекарственных средств при лечении болезни альцгеймера
RU2685876C2 (ru) * 2013-09-24 2019-04-23 Юниверсити Оф Вашингтон Сру Итс Сентер Фор Коммершиализэйшн Белки, связывающие десмоглеин 2 (dsg2), и их применение
RU2768287C1 (ru) * 2018-07-10 2022-03-23 Генемедицине Ко., Лтд. Противоопухолевая композиция

Also Published As

Publication number Publication date
JP2006518589A (ja) 2006-08-17
AU2003271730A2 (en) 2004-05-04
JP4988199B2 (ja) 2012-08-01
CA2515650C (en) 2019-10-01
CA2515650A1 (en) 2004-04-29
KR20050061530A (ko) 2005-06-22
KR101123510B1 (ko) 2012-04-12
RU2005114516A (ru) 2006-01-20
AU2003271730A1 (en) 2004-05-04

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