JP2006516267A5 - - Google Patents
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- Publication number
- JP2006516267A5 JP2006516267A5 JP2005516402A JP2005516402A JP2006516267A5 JP 2006516267 A5 JP2006516267 A5 JP 2006516267A5 JP 2005516402 A JP2005516402 A JP 2005516402A JP 2005516402 A JP2005516402 A JP 2005516402A JP 2006516267 A5 JP2006516267 A5 JP 2006516267A5
- Authority
- JP
- Japan
- Prior art keywords
- active ingredient
- formula
- group
- medicament
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000004480 active ingredient Substances 0.000 claims 24
- 239000003814 drug Substances 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 231100000572 poisoning Toxicity 0.000 claims 5
- 230000000607 poisoning effect Effects 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 229930004668 tropane alkaloid Natural products 0.000 claims 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-M L-tartrate(1-) Chemical compound OC(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-M 0.000 claims 2
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 239000000812 cholinergic antagonist Substances 0.000 claims 2
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- GBHRVZIGDIUCJB-UHFFFAOYSA-N hydrogenphosphite Chemical class OP([O-])[O-] GBHRVZIGDIUCJB-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 claims 2
- 229960002646 scopolamine Drugs 0.000 claims 2
- 150000003813 tropane derivatives Chemical class 0.000 claims 2
- 229940122041 Cholinesterase inhibitor Drugs 0.000 claims 1
- STECJAGHUSJQJN-USLFZFAMSA-N LSM-4015 Chemical compound C1([C@@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-USLFZFAMSA-N 0.000 claims 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003958 nerve gas Substances 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 150000002903 organophosphorus compounds Chemical class 0.000 claims 1
- 210000005037 parasympathetic nerve Anatomy 0.000 claims 1
- 239000000734 parasympathomimetic agent Substances 0.000 claims 1
- 229940127242 parasympathomimetic drug Drugs 0.000 claims 1
- 230000001499 parasympathomimetic effect Effects 0.000 claims 1
- 239000011814 protection agent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10301851A DE10301851A1 (de) | 2003-01-17 | 2003-01-17 | Verfahren zur medikamentösen Prophylaxe gegen Vergiftungen durch Cholinesterase-Hemmer, sowie hierfür geeignete Wirkstoffe und Arzneimittel |
| PCT/EP2004/000289 WO2004064829A1 (de) | 2003-01-17 | 2004-01-16 | Verfahren zur medikamentösen prophylaxe gegen vergiftungen durch cholinesterase-hemmer, sowie hierfür geeignete wirkstoffe und arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006516267A JP2006516267A (ja) | 2006-06-29 |
| JP2006516267A5 true JP2006516267A5 (enExample) | 2006-08-10 |
Family
ID=32602728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005516402A Pending JP2006516267A (ja) | 2003-01-17 | 2004-01-16 | コリンエステラーゼ阻害剤中毒の医薬的予防方法並びにこれに適する活性物質および医薬 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060183796A1 (enExample) |
| EP (1) | EP1585514A1 (enExample) |
| JP (1) | JP2006516267A (enExample) |
| KR (1) | KR20050104347A (enExample) |
| CN (1) | CN1741800A (enExample) |
| BR (1) | BRPI0406580A (enExample) |
| DE (1) | DE10301851A1 (enExample) |
| IL (1) | IL169687A0 (enExample) |
| WO (1) | WO2004064829A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2936150B1 (fr) * | 2008-09-19 | 2013-09-06 | Dermathologiques D Uriage Lab | Nouvelles compositions dermatologiques protectrices de la peau et des muqueuses |
| GB0809905D0 (en) * | 2008-06-02 | 2008-07-09 | Secr Defence | A Transdermal drug delivery device |
| CA3193154A1 (en) * | 2020-08-31 | 2022-03-03 | Nobelpharma Co., Ltd. | Patch for alleviating or treating symptoms of neurodegenerative disease |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL74497A (en) * | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
| DK0606366T3 (da) * | 1991-09-26 | 2003-10-06 | Us Gov Health & Human Serv | Substituerede phenseriner og phenylcarbamater af (-)-eserolin, (-)-N1-noreserolin og (-)-N1-benzylnoreserolin som specifikke inhibitorer af acetylcholinesterase |
| DE4342174C1 (de) * | 1993-12-10 | 1995-05-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System sowie ein Verfahren zur Herstellung eines transdermalen therapeutischen Systems zur kombinierten transdermalen Anwendung von Physostigmin und Scopolamin für die Prophylaxe und zur Vorbehandlung einer Vergiftung durch hochtoxische phosphororganische Nervengifte, insbesondere Soman und seine Verwendung |
| DE4342173A1 (de) * | 1993-12-10 | 1995-06-14 | Lohmann Therapie Syst Lts | Pharmazeutische Formulierung zur Prophylaxe bzw. Vorbehandlung einer Vergiftung durch phosphororganische Cholinesterasehemmer |
| US5807671A (en) * | 1995-01-09 | 1998-09-15 | Yissum Research Development Company Of Hebrew University Of Jerusalem | Method of screening for genetic predisposition to anticholinesterase therapy |
| US6955819B2 (en) * | 1998-09-29 | 2005-10-18 | Zars, Inc. | Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances |
| JP4422342B2 (ja) * | 1998-11-27 | 2010-02-24 | ザノヒェミア・ファルマツォイティカ・アー・ゲー | せん妄の治療へのコリン作動性中枢神経系エフェクターの使用 |
| US6756385B2 (en) * | 2000-07-31 | 2004-06-29 | Pfizer Inc. | Imidazole derivatives |
-
2003
- 2003-01-17 DE DE10301851A patent/DE10301851A1/de not_active Withdrawn
-
2004
- 2004-01-16 BR BR0406580-8A patent/BRPI0406580A/pt not_active IP Right Cessation
- 2004-01-16 EP EP04702672A patent/EP1585514A1/de not_active Withdrawn
- 2004-01-16 JP JP2005516402A patent/JP2006516267A/ja active Pending
- 2004-01-16 CN CNA2004800024123A patent/CN1741800A/zh active Pending
- 2004-01-16 WO PCT/EP2004/000289 patent/WO2004064829A1/de not_active Ceased
- 2004-01-16 US US10/542,515 patent/US20060183796A1/en not_active Abandoned
- 2004-01-16 KR KR1020057012992A patent/KR20050104347A/ko not_active Ceased
-
2005
- 2005-07-14 IL IL169687A patent/IL169687A0/en unknown
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