JP2007533686A5 - - Google Patents
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- Publication number
- JP2007533686A5 JP2007533686A5 JP2007508810A JP2007508810A JP2007533686A5 JP 2007533686 A5 JP2007533686 A5 JP 2007533686A5 JP 2007508810 A JP2007508810 A JP 2007508810A JP 2007508810 A JP2007508810 A JP 2007508810A JP 2007533686 A5 JP2007533686 A5 JP 2007533686A5
- Authority
- JP
- Japan
- Prior art keywords
- antagonist
- agonist
- active ingredient
- dopamine
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 31
- 239000004480 active ingredient Substances 0.000 claims 18
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 claims 16
- 229940083324 Selective androgen receptor modulator Drugs 0.000 claims 16
- 239000000556 agonist Substances 0.000 claims 16
- 239000005557 antagonist Substances 0.000 claims 16
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 16
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 16
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 16
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims 16
- 229940124597 therapeutic agent Drugs 0.000 claims 14
- 229940079593 drug Drugs 0.000 claims 13
- PPRRDFIXUUSXRA-UHFFFAOYSA-N flibanserin Chemical compound FC(F)(F)C1=CC=CC(N2CCN(CCN3C(NC4=CC=CC=C43)=O)CC2)=C1 PPRRDFIXUUSXRA-UHFFFAOYSA-N 0.000 claims 13
- 229960002053 flibanserin Drugs 0.000 claims 13
- 239000002253 acid Substances 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 claims 8
- 102100036321 5-hydroxytryptamine receptor 2A Human genes 0.000 claims 8
- 101710138091 5-hydroxytryptamine receptor 2A Proteins 0.000 claims 8
- 239000000674 adrenergic antagonist Substances 0.000 claims 8
- 229960000711 alprostadil Drugs 0.000 claims 8
- 239000003098 androgen Substances 0.000 claims 8
- ZOOGRGPOEVQQDX-UHFFFAOYSA-N cyclic GMP Natural products O1C2COP(O)(=O)OC2C(O)C1N1C=NC2=C1NC(N)=NC2=O ZOOGRGPOEVQQDX-UHFFFAOYSA-N 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 8
- 229960003638 dopamine Drugs 0.000 claims 8
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 8
- 239000000262 estrogen Substances 0.000 claims 8
- 229940011871 estrogen Drugs 0.000 claims 8
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 claims 8
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 8
- 102000004305 alpha Adrenergic Receptors Human genes 0.000 claims 7
- 108090000861 alpha Adrenergic Receptors Proteins 0.000 claims 7
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 claims 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 150000004677 hydrates Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 230000003287 optical effect Effects 0.000 claims 6
- 230000001568 sexual effect Effects 0.000 claims 6
- 108010008364 Melanocortins Proteins 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 239000002865 melanocortin Substances 0.000 claims 5
- 239000003723 serotonin 1A agonist Substances 0.000 claims 5
- 102000001307 androgen receptors Human genes 0.000 claims 4
- 108010080146 androgen receptors Proteins 0.000 claims 4
- 102000015694 estrogen receptors Human genes 0.000 claims 3
- 108010038795 estrogen receptors Proteins 0.000 claims 3
- 239000000336 melanocortin receptor agonist Substances 0.000 claims 3
- 208000021663 Female sexual arousal disease Diseases 0.000 claims 2
- 208000006262 Psychological Sexual Dysfunctions Diseases 0.000 claims 2
- 208000029899 Sexual aversion disease Diseases 0.000 claims 2
- 208000027520 Somatoform disease Diseases 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 208000024309 orgasm disease Diseases 0.000 claims 2
- 208000027753 pain disease Diseases 0.000 claims 2
- 230000035807 sensation Effects 0.000 claims 2
- 230000035946 sexual desire Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 claims 1
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 claims 1
- 229940030486 androgens Drugs 0.000 claims 1
- 229940052760 dopamine agonists Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56466204P | 2004-04-22 | 2004-04-22 | |
| US63180004P | 2004-11-30 | 2004-11-30 | |
| PCT/EP2005/004081 WO2005102342A1 (en) | 2004-04-22 | 2005-04-18 | New pharmaceutical compositions for the treatment of sexual disorders ii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007533686A JP2007533686A (ja) | 2007-11-22 |
| JP2007533686A5 true JP2007533686A5 (enExample) | 2008-06-05 |
Family
ID=34966041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007508810A Pending JP2007533686A (ja) | 2004-04-22 | 2005-04-18 | 性的障害ｉｉ治療用の新規医薬組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US20050245539A1 (enExample) |
| EP (1) | EP1740181A1 (enExample) |
| JP (1) | JP2007533686A (enExample) |
| KR (1) | KR20070014184A (enExample) |
| AR (1) | AR048705A1 (enExample) |
| AU (1) | AU2005235422B2 (enExample) |
| BR (1) | BRPI0510074A (enExample) |
| CA (1) | CA2563743A1 (enExample) |
| IL (1) | IL178730A0 (enExample) |
| MX (1) | MXPA06012059A (enExample) |
| NZ (1) | NZ551340A (enExample) |
| PE (1) | PE20060464A1 (enExample) |
| RU (1) | RU2445095C2 (enExample) |
| TW (1) | TW200538115A (enExample) |
| UY (1) | UY28862A1 (enExample) |
| WO (1) | WO2005102342A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11513390A (ja) * | 1995-10-06 | 1999-11-16 | アーチ デベロップメント コーポレイション | 細胞殺傷のウイルス増強のための方法および組成物 |
| US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
| US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
| UA78974C2 (en) * | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
| US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
| US20040048877A1 (en) * | 2002-05-22 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions containing flibanserin |
| US20050239798A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
| EP1750766B1 (en) | 2004-05-11 | 2013-07-03 | Emotional Brain B.V. | Pharmaceutical formulations and uses thereof in the treatment of female sexual dysfunction |
| US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
| EP1789048A1 (en) * | 2004-09-03 | 2007-05-30 | Boehringer Ingelheim International GmbH | Method for the treatment of attention deficit hyperactivity disorder |
| US20060211685A1 (en) * | 2005-03-04 | 2006-09-21 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of depression |
| WO2006096439A2 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
| CA2599937A1 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders |
| WO2006097344A1 (en) * | 2005-03-17 | 2006-09-21 | Synthon B.V. | Pharmaceutical tablets of crystalline type ii aripiprazole |
| EP1904182A2 (en) * | 2005-05-06 | 2008-04-02 | Boehringer Ingelheim International GmbH | Method for the treatment of drug abuse with flibanserin |
| EP1888071A1 (en) * | 2005-05-19 | 2008-02-20 | Boehringer Ingelheim International GmbH | Method for the treatment of drug-induced sexual dysfunction |
| JP2008540672A (ja) * | 2005-05-19 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 病状に起因する性的機能不全の治療方法 |
| EP1912650B8 (en) | 2005-08-03 | 2017-10-18 | Sprout Pharmaceuticals, Inc. | Use of flibanserin in the treatment of obesity |
| ES2397275T3 (es) * | 2005-08-04 | 2013-03-05 | Sirtris Pharmaceuticals, Inc. | Derivados de imidazopiridina como agentes moduladores de la sirtuína |
| US20070123540A1 (en) * | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
| JP2009513604A (ja) | 2005-10-29 | 2009-04-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 月経前障害及び他の女性の性的障害治療用のベンゾイミダゾロン誘導体 |
| US20070105869A1 (en) * | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
| EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| US20070142395A1 (en) * | 2005-12-16 | 2007-06-21 | Vela Pharmaceuticals, Inc. | Treatment of sexual dysfunction with 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2(1H)-quinolone or salt thereof |
| CA2641917A1 (en) * | 2006-02-18 | 2007-08-23 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment of attention deficit hyperactivity disorder comprising flibanserin |
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| DK2021006T3 (en) * | 2006-05-09 | 2015-11-23 | Sprout Pharmaceuticals Inc | USE OF flibanserin in postmenopausal SEXLYSTFORSTYRRELSER |
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| WO2009123626A1 (en) * | 2008-04-01 | 2009-10-08 | Ocean 1 806, Llc | Orodispersable formulations of phosphodiesterase-5 (pde-5) inhibitors |
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| EA200900264A1 (ru) * | 2006-08-14 | 2009-08-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Композиции флибансерина и способ их приготовления |
| JP5220746B2 (ja) * | 2006-08-25 | 2013-06-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 制御放出システム及びその製造方法 |
-
2005
- 2005-04-18 RU RU2006140962/15A patent/RU2445095C2/ru not_active IP Right Cessation
- 2005-04-18 MX MXPA06012059A patent/MXPA06012059A/es not_active Application Discontinuation
- 2005-04-18 BR BRPI0510074-7A patent/BRPI0510074A/pt not_active IP Right Cessation
- 2005-04-18 EP EP05736586A patent/EP1740181A1/en not_active Ceased
- 2005-04-18 CA CA002563743A patent/CA2563743A1/en not_active Abandoned
- 2005-04-18 AU AU2005235422A patent/AU2005235422B2/en not_active Ceased
- 2005-04-18 WO PCT/EP2005/004081 patent/WO2005102342A1/en not_active Ceased
- 2005-04-18 KR KR1020067024443A patent/KR20070014184A/ko not_active Ceased
- 2005-04-18 JP JP2007508810A patent/JP2007533686A/ja active Pending
- 2005-04-18 NZ NZ551340A patent/NZ551340A/en not_active IP Right Cessation
- 2005-04-19 UY UY28862A patent/UY28862A1/es not_active Application Discontinuation
- 2005-04-20 PE PE2005000435A patent/PE20060464A1/es not_active Application Discontinuation
- 2005-04-20 US US11/110,449 patent/US20050245539A1/en not_active Abandoned
- 2005-04-21 TW TW094112651A patent/TW200538115A/zh unknown
- 2005-04-22 AR ARP050101598A patent/AR048705A1/es not_active Application Discontinuation
-
2006
- 2006-10-19 IL IL178730A patent/IL178730A0/en unknown
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2007
- 2007-12-20 US US11/960,957 patent/US20080103155A1/en not_active Abandoned
-
2011
- 2011-01-10 US US12/987,388 patent/US20110105519A1/en not_active Abandoned
-
2012
- 2012-10-18 US US13/654,674 patent/US20130203766A1/en not_active Abandoned
-
2015
- 2015-03-13 US US14/656,877 patent/US20150320739A1/en not_active Abandoned
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