JP2006516252A5 - - Google Patents
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- JP2006516252A5 JP2006516252A5 JP2004565732A JP2004565732A JP2006516252A5 JP 2006516252 A5 JP2006516252 A5 JP 2006516252A5 JP 2004565732 A JP2004565732 A JP 2004565732A JP 2004565732 A JP2004565732 A JP 2004565732A JP 2006516252 A5 JP2006516252 A5 JP 2006516252A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- composition
- copolymer
- composition according
- caprolactone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 24
- 229920001577 copolymer Polymers 0.000 claims 13
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 8
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims 6
- 239000004098 Tetracycline Substances 0.000 claims 5
- 235000014655 lactic acid Nutrition 0.000 claims 5
- 239000004310 lactic acid Substances 0.000 claims 5
- 229960002180 tetracycline Drugs 0.000 claims 5
- 229930101283 tetracycline Natural products 0.000 claims 5
- 235000019364 tetracycline Nutrition 0.000 claims 5
- 150000003522 tetracyclines Chemical class 0.000 claims 5
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- OZJPLYNZGCXSJM-UHFFFAOYSA-N 5-valerolactone Chemical compound O=C1CCCCO1 OZJPLYNZGCXSJM-UHFFFAOYSA-N 0.000 claims 2
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 2
- 229920002988 biodegradable polymer Polymers 0.000 claims 2
- 239000004621 biodegradable polymer Substances 0.000 claims 2
- 239000004053 dental implant Substances 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 230000000921 morphogenic effect Effects 0.000 claims 2
- 230000000399 orthopedic effect Effects 0.000 claims 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims 1
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical group C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims 1
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 229940122361 Bisphosphonate Drugs 0.000 claims 1
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- 102100022545 Bone morphogenetic protein 8B Human genes 0.000 claims 1
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 102000000503 Collagen Type II Human genes 0.000 claims 1
- 108010041390 Collagen Type II Proteins 0.000 claims 1
- 102000001187 Collagen Type III Human genes 0.000 claims 1
- 108010069502 Collagen Type III Proteins 0.000 claims 1
- 102000004266 Collagen Type IV Human genes 0.000 claims 1
- 108010042086 Collagen Type IV Proteins 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 101000899368 Homo sapiens Bone morphogenetic protein 8B Proteins 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 claims 1
- 125000005910 alkyl carbonate group Chemical group 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 230000003190 augmentative effect Effects 0.000 claims 1
- 150000004663 bisphosphonates Chemical class 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 229960003722 doxycycline Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229940012952 fibrinogen Drugs 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229960004023 minocycline Drugs 0.000 claims 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 229920001432 poly(L-lactide) Polymers 0.000 claims 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920000193 polymethacrylate Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002379 silicone rubber Polymers 0.000 claims 1
- 239000004945 silicone rubber Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43680602P | 2002-12-27 | 2002-12-27 | |
| PCT/US2003/041330 WO2004060425A2 (en) | 2002-12-27 | 2003-12-24 | Compositions and methods of using collagen and mmpi |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006516252A JP2006516252A (ja) | 2006-06-29 |
| JP2006516252A5 true JP2006516252A5 (enExample) | 2007-02-15 |
Family
ID=32713092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004565732A Withdrawn JP2006516252A (ja) | 2002-12-27 | 2003-12-24 | コラーゲンおよびmmpiを用いる組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040192658A1 (enExample) |
| EP (1) | EP1585555A2 (enExample) |
| JP (1) | JP2006516252A (enExample) |
| KR (1) | KR20050086949A (enExample) |
| CN (1) | CN1732023A (enExample) |
| AU (1) | AU2003300379A1 (enExample) |
| BR (1) | BR0317715A (enExample) |
| CA (1) | CA2509060A1 (enExample) |
| WO (1) | WO2004060425A2 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7744651B2 (en) | 2002-09-18 | 2010-06-29 | Warsaw Orthopedic, Inc | Compositions and methods for treating intervertebral discs with collagen-based materials |
| US20040054414A1 (en) | 2002-09-18 | 2004-03-18 | Trieu Hai H. | Collagen-based materials and methods for augmenting intervertebral discs |
| CN100394989C (zh) | 2002-11-15 | 2008-06-18 | 华沙整形外科股份有限公司 | 包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节 |
| US20060002969A1 (en) * | 2004-01-27 | 2006-01-05 | University Of Washington | Methods for reducing the foreign body reaction |
| US20050186240A1 (en) * | 2004-02-23 | 2005-08-25 | Ringeisen Timothy A. | Gel suitable for implantation and delivery system |
| US7597687B2 (en) * | 2004-10-29 | 2009-10-06 | Spinal Restoration, Inc. | Injection of fibrin sealant including an anesthetic in spinal applications |
| US8419722B2 (en) * | 2004-10-29 | 2013-04-16 | Spinal Restoration, Inc. | Apparatus and method for injection of fibrin sealant in spinal applications |
| US8206448B2 (en) | 2004-10-29 | 2012-06-26 | Spinal Restoration, Inc. | Injection of fibrin sealant using reconstituted components in spinal applications |
| US20060073208A1 (en) * | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
| DE102005034420A1 (de) * | 2004-12-23 | 2006-07-06 | Ossacur Ag | Gelartiges Material zur Füllung von Knochen- und/oder Knorpeldefekten |
| US8071574B2 (en) * | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| EP1714642A1 (en) * | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery |
| EP1986657A4 (en) * | 2006-02-16 | 2011-07-20 | Discogen Llc | METHOD OF TREATING A SUBJECT SUFFERING FROM DEGENERATIVE DISCOPATHY BY A MATRIX METALLOPROTEASE INHIBITOR |
| DE102006026589A1 (de) * | 2006-06-01 | 2007-12-06 | Ossacur Ag | Verwendung eines Kollagens mit osteoinduktiven Wirkstoffen zur Behandlung von Sehnen- und/oder Bänderdefekten |
| US8399619B2 (en) | 2006-06-30 | 2013-03-19 | Warsaw Orthopedic, Inc. | Injectable collagen material |
| US8118779B2 (en) | 2006-06-30 | 2012-02-21 | Warsaw Orthopedic, Inc. | Collagen delivery device |
| US20080177330A1 (en) * | 2006-10-24 | 2008-07-24 | Ralph James D | Self-locking screws for medical implants |
| US20120195938A1 (en) * | 2007-05-30 | 2012-08-02 | James Louis Rutkowski | Formulations and methods for recovery from dental surgery |
| US20090054984A1 (en) | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
| US9393002B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
| US9034002B2 (en) | 2008-02-18 | 2015-05-19 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US8317808B2 (en) | 2008-02-18 | 2012-11-27 | Covidien Lp | Device and method for rolling and inserting a prosthetic patch into a body cavity |
| US8808314B2 (en) | 2008-02-18 | 2014-08-19 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
| US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US8758373B2 (en) | 2008-02-18 | 2014-06-24 | Covidien Lp | Means and method for reversibly connecting a patch to a patch deployment device |
| US9833240B2 (en) | 2008-02-18 | 2017-12-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9044235B2 (en) | 2008-02-18 | 2015-06-02 | Covidien Lp | Magnetic clip for implant deployment device |
| US9398944B2 (en) | 2008-02-18 | 2016-07-26 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9393093B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
| CA2721507C (en) | 2008-04-18 | 2017-10-03 | Collplant Ltd. | Methods of generating and using procollagen |
| US9492375B2 (en) * | 2008-07-23 | 2016-11-15 | Warsaw Orthopedic, Inc. | Foam carrier for bone grafting |
| US8039433B2 (en) * | 2008-08-19 | 2011-10-18 | Warsaw Orthopedic, Inc. | Osteogenic compositions containing a coloring agent |
| EP2323736A1 (en) * | 2008-09-09 | 2011-05-25 | University of East Anglia | Treatment of fibrotic eye disorders using an mmp2 inhibitor |
| US8252228B1 (en) * | 2008-10-13 | 2012-08-28 | Abbott Cardiovascular Systems Inc. | Methods for sterilizing carriers for treatment of a kidney |
| US20100094338A1 (en) * | 2008-10-15 | 2010-04-15 | Tyco Healthcare Group Lp | Hydroxamate-initiated polymers |
| WO2010046893A1 (en) | 2008-10-20 | 2010-04-29 | Polytouch Medical Ltd. | A device for attaching a patch to a biological tissue |
| CA2769707A1 (en) | 2009-08-17 | 2011-02-24 | Tyco Healthcare Group Lp | Articulating patch deployment device and method of use |
| CA2769666C (en) | 2009-08-17 | 2018-02-13 | Arie Levy | Means and method for reversibly connecting an implant to a deployment device |
| US20160208011A1 (en) | 2010-01-28 | 2016-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
| WO2017120461A1 (en) | 2016-01-08 | 2017-07-13 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
| US10487148B2 (en) | 2010-01-28 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating aging-associated impairments |
| WO2012094708A1 (en) * | 2011-01-12 | 2012-07-19 | The University Of Queensland | Bone graft biomaterial |
| US9161968B2 (en) | 2011-04-08 | 2015-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists |
| JP6289362B2 (ja) * | 2011-04-26 | 2018-03-07 | アールディーディー ファーマ リミテッド | 肛門直腸疾患の処置のためのオキシメタゾリン |
| US8998059B2 (en) | 2011-08-01 | 2015-04-07 | Ethicon Endo-Surgery, Inc. | Adjunct therapy device having driver with cavity for hemostatic agent |
| US9492170B2 (en) | 2011-08-10 | 2016-11-15 | Ethicon Endo-Surgery, Inc. | Device for applying adjunct in endoscopic procedure |
| US9101359B2 (en) | 2011-09-13 | 2015-08-11 | Ethicon Endo-Surgery, Inc. | Surgical staple cartridge with self-dispensing staple buttress |
| US8998060B2 (en) | 2011-09-13 | 2015-04-07 | Ethicon Endo-Surgery, Inc. | Resistive heated surgical staple cartridge with phase change sealant |
| US9999408B2 (en) | 2011-09-14 | 2018-06-19 | Ethicon Endo-Surgery, Inc. | Surgical instrument with fluid fillable buttress |
| US9254180B2 (en) | 2011-09-15 | 2016-02-09 | Ethicon Endo-Surgery, Inc. | Surgical instrument with staple reinforcement clip |
| US9125649B2 (en) | 2011-09-15 | 2015-09-08 | Ethicon Endo-Surgery, Inc. | Surgical instrument with filled staple |
| US9393018B2 (en) | 2011-09-22 | 2016-07-19 | Ethicon Endo-Surgery, Inc. | Surgical staple assembly with hemostatic feature |
| US9198644B2 (en) | 2011-09-22 | 2015-12-01 | Ethicon Endo-Surgery, Inc. | Anvil cartridge for surgical fastening device |
| US8985429B2 (en) | 2011-09-23 | 2015-03-24 | Ethicon Endo-Surgery, Inc. | Surgical stapling device with adjunct material application feature |
| US8899464B2 (en) | 2011-10-03 | 2014-12-02 | Ethicon Endo-Surgery, Inc. | Attachment of surgical staple buttress to cartridge |
| US9089326B2 (en) | 2011-10-07 | 2015-07-28 | Ethicon Endo-Surgery, Inc. | Dual staple cartridge for surgical stapler |
| ES2813524T3 (es) * | 2011-12-28 | 2021-03-24 | Amgen Inc | Método para tratar la pérdida de hueso alveolar mediante el uso de anticuerpos antiesclerostina |
| EP2814517A1 (en) * | 2012-02-15 | 2014-12-24 | Microarray Limited | Wound screen |
| TWI478943B (zh) * | 2012-12-27 | 2015-04-01 | Ind Tech Res Inst | 高分子組成物用於製備具有抑制基質金屬蛋白酶之活性的功效的醫療器材或抑制劑的用途 |
| JP6667438B2 (ja) | 2013-12-09 | 2020-03-18 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 老化に関連する状態を処置する方法及び組成物 |
| US10905779B2 (en) | 2013-12-09 | 2021-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening human blood products comprising plasma using immunocompromised rodent models |
| EP3148599B1 (en) | 2014-05-30 | 2019-12-18 | Sofradim Production | Method for preparing neutralized matrix of non-antigenic collagenous material |
| CN105012995B (zh) * | 2015-06-04 | 2018-03-09 | 武汉维斯第医用科技股份有限公司 | 一种含促骨愈合药物的胶原蛋白海绵及其制备方法 |
| CN113855804A (zh) | 2015-06-15 | 2021-12-31 | 小利兰·斯坦福大学托管委员会 | 用于治疗衰老相关病症的方法和组合物 |
| CN107811965A (zh) * | 2017-04-25 | 2018-03-20 | 中国药科大学 | 一种缓释巴马司他的聚酯-聚醚温敏凝胶制剂及制备方法 |
| TW201932124A (zh) * | 2018-01-18 | 2019-08-16 | 近鎰生技股份有限公司 | 止血材料、其製備方法及包含其的藥物組合物 |
| WO2025147459A1 (en) * | 2024-01-04 | 2025-07-10 | Nano Precision Medical, Inc. | Stabilization of peptides and proteins in implantable devices and formulations |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862225A (en) * | 1961-08-18 | 1975-01-21 | Pfizer | D-ring substituted tetracyclines |
| GB1068587A (en) * | 1963-12-06 | 1967-05-10 | Biorex Laboratories Ltd | Dental fillers and bone cements comprising collagen |
| US4066694A (en) * | 1971-02-09 | 1978-01-03 | Pfizer Inc. | 4-hydroxy-4-dedimethylamino-tetracyclines |
| BE792050A (fr) * | 1971-12-04 | 1973-03-16 | Amezua Fernandez Piedal | Procede d'obtention d'un nouveau derive antibiotique |
| US3951962A (en) * | 1973-11-14 | 1976-04-20 | Yamanouchi Pharmaceutical Co., Ltd. | Novel N-alkenyltetracycline derivatives |
| US3949073A (en) * | 1974-11-18 | 1976-04-06 | The Board Of Trustees Of Leland Stanford Junior University | Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution |
| CA1073360A (en) * | 1975-10-22 | 1980-03-11 | John R. Daniels | Non-antigenic collagen and articles of manufacture |
| US4018889A (en) * | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
| US4193813A (en) * | 1976-09-07 | 1980-03-18 | Medi-Coll, Inc. | Method for making collagen sponge |
| US4263293A (en) * | 1980-05-30 | 1981-04-21 | E. R. Squibb & Sons, Inc. | Heterocyclic containing amides as inhibitors of mammalian collagenase |
| US4367233A (en) * | 1981-10-02 | 1983-01-04 | American Home Products Corporation | Inhibitors of mammalian collagenase |
| US4371465A (en) * | 1981-10-07 | 1983-02-01 | American Home Products Corporation | Mammalian collagenase inhibitors |
| US4374765A (en) * | 1981-10-07 | 1983-02-22 | American Home Products Corporation | Mammalian collagenase inhibitors |
| US4371466A (en) * | 1981-10-07 | 1983-02-01 | American Home Products Corporation | Mammalian collagenase inhibitors |
| US4424208A (en) * | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
| US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
| US4642117A (en) * | 1985-03-22 | 1987-02-10 | Collagen Corporation | Mechanically sheared collagen implant material and method |
| CA1260391A (en) * | 1985-03-28 | 1989-09-26 | Karl A. Piez | Xenogeneic collagen/mineral preparations in bone repair |
| US4720486A (en) * | 1985-10-18 | 1988-01-19 | Monsanto Company | Method of inhibiting vertebrate collagenase activity using peptide hydroxamic acid derivatives |
| DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| FR2609289B1 (fr) * | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
| US5843445A (en) * | 1987-06-24 | 1998-12-01 | Autoimmune, Inc. | Method of treating rheumatoid arthritis with type II collagen |
| HU200917B (en) * | 1987-07-20 | 1990-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical compositions comprising quinoline or naphthyridinecarboxylic acid and tetracycline derivatives as active ingredient |
| US4918208A (en) * | 1987-07-28 | 1990-04-17 | Nippon Kayaku Kabushiki Kaisha | Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline |
| CA1339083C (en) * | 1987-11-13 | 1997-07-29 | Steven R. Jefferies | Bone repair material and delayed drug delivery system |
| US5073114A (en) * | 1988-02-23 | 1991-12-17 | Detsch Steven G | Bone growing method and composition |
| US5290552A (en) * | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
| US5936035A (en) * | 1988-11-21 | 1999-08-10 | Cohesion Technologies, Inc. | Biocompatible adhesive compositions |
| US5614587A (en) * | 1988-11-21 | 1997-03-25 | Collagen Corporation | Collagen-based bioadhesive compositions |
| US5304595A (en) * | 1988-11-21 | 1994-04-19 | Collagen Corporation | Collagen-polymer conjugates |
| GB8827308D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| DE69033982T2 (de) * | 1989-03-21 | 2002-10-24 | The United States Of America, Represented By The Secretary | Matrizenmetalloproteinase-inhibitor-peptide |
| US5106949A (en) * | 1989-09-15 | 1992-04-21 | Organogenesis, Inc. | Collagen compositions and methods for preparation thereof |
| US5104660A (en) * | 1989-11-21 | 1992-04-14 | Bruce A. Barber | Method of preparing an antimicrobial wound dressing |
| US5178604A (en) * | 1990-05-31 | 1993-01-12 | Iovision, Inc. | Glaucoma implant |
| US5081106A (en) * | 1990-07-16 | 1992-01-14 | The Oregon Health Sciences University | Wound dressing protocol utilizing collagen gelatin formed with iodine |
| US5892112A (en) * | 1990-11-21 | 1999-04-06 | Glycomed Incorporated | Process for preparing synthetic matrix metalloprotease inhibitors |
| US5183900A (en) * | 1990-11-21 | 1993-02-02 | Galardy Richard E | Matrix metalloprotease inhibitors |
| US5189178A (en) * | 1990-11-21 | 1993-02-23 | Galardy Richard E | Matrix metalloprotease inhibitors |
| US5889058A (en) * | 1990-12-03 | 1999-03-30 | Celltech Limited | Peptidyl derivatives |
| JPH05503720A (ja) * | 1990-12-03 | 1993-06-17 | セルテック リミテッド | ペプチジル誘導体 |
| GB9102635D0 (en) * | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
| AU654857B2 (en) * | 1991-03-29 | 1994-11-24 | Collagen Corporation | Device and method for treating facial lines |
| US5083522A (en) * | 1991-05-13 | 1992-01-28 | Ashrow David P | Swimming harness |
| US5281628A (en) * | 1991-10-04 | 1994-01-25 | American Cyanamid Company | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines |
| US5290217A (en) * | 1991-10-10 | 1994-03-01 | Earl K. Sipes | Method and apparatus for hernia repair |
| EP0639982A1 (en) * | 1992-05-01 | 1995-03-01 | British Biotech Pharmaceuticals Limited | Use of mmp inhibitors |
| WO1993023075A1 (en) * | 1992-05-14 | 1993-11-25 | Oncologix, Inc. | Treatment of vascular leakage syndrome and collagenase induced disease by administration of matrix metalloproteinase inhibitors |
| US5594006A (en) * | 1993-03-18 | 1997-01-14 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives as matrix metalloproteinases inhibitors |
| DE69426684T2 (de) * | 1993-03-25 | 2001-09-06 | Institute Of Pharmacology, Chengdu | Verbindung zur hemmung der knochenresorption und zur beschleunigung der knochenbildung |
| ATE182137T1 (de) * | 1993-04-27 | 1999-07-15 | Celltech Therapeutics Ltd | Peptidylderivate als inhibitoren von metalloproteinase |
| US6013792A (en) * | 1993-08-05 | 2000-01-11 | Syntex (U.S.A.), Inc. | Matrix metalloprotease inhibitors |
| US5523291A (en) * | 1993-09-07 | 1996-06-04 | Datascope Investment Corp. | Injectable compositions for soft tissue augmentation |
| US6037472A (en) * | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
| BR9506535A (pt) * | 1994-01-20 | 1997-09-16 | British Biotech Pharm | Inibidores de metaloproteinases |
| GB9401129D0 (en) * | 1994-01-21 | 1994-03-16 | British Bio Technology | Hydroxamic acid derivatives as metalloproteinase inhibitors |
| HUT74511A (en) * | 1994-01-22 | 1997-01-28 | British Biotech Pharm | Metalloproteinase inhibitors, pharmaceutical compns. contg. them and process to prepare the said compds. |
| US5514716A (en) * | 1994-02-25 | 1996-05-07 | Sterling Winthrop, Inc. | Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof |
| JPH10500986A (ja) * | 1994-05-28 | 1998-01-27 | ブリテッシュ バイオテック ファーマシューティカルズ リミテッド | 金属タンパク質分解酵素阻害剤 |
| PT766664E (pt) * | 1994-06-22 | 2000-08-31 | British Biotech Pharm | Inibidores de metaloproteinases |
| US5616689A (en) * | 1994-07-13 | 1997-04-01 | Collagen Corporation | Method of controlling structure stability of collagen fibers produced form solutions or dispersions treated with sodium hydroxide for infectious agent deactivation |
| FI971412A7 (fi) * | 1994-10-05 | 1997-04-04 | Darwin Discovery Ltd | Peptididyyliyhdisteet ja niiden terapeuttinen käyttö metalloproteaasie n estäjinä |
| US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
| GB9423914D0 (en) * | 1994-11-26 | 1995-01-11 | British Biotech Pharm | Polyether derivatives as metalloproteinase inhibitors |
| US5843925A (en) * | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| JP2902318B2 (ja) * | 1994-12-28 | 1999-06-07 | 呉羽化学工業株式会社 | エスクレチン誘導体、その製造方法及びマトリックスメタロプロテアーゼ阻害剤 |
| CA2218503C (en) * | 1995-04-20 | 2001-07-24 | Pfizer Inc. | Arylsulfonyl hydroxamic acid derivatives |
| US5886022A (en) * | 1995-06-05 | 1999-03-23 | Bayer Corporation | Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors |
| AU723740B2 (en) * | 1995-06-06 | 2000-09-07 | Howmedica Inc. | Biocompatible hydroxyapatite formulations and uses therefor |
| US5856446A (en) * | 1995-07-07 | 1999-01-05 | Autoimmune Inc. | Method of treating rheumatoid arthritis with low dose type II collagen |
| KR980009238A (ko) * | 1995-07-28 | 1998-04-30 | 우에노 도시오 | 설포닐아미노산 유도체 |
| WO1997010226A1 (en) * | 1995-09-11 | 1997-03-20 | Novartis Ag | Process for preparing a 2-chloro-5-chloromethyl-thiazole compound |
| EP1704878B1 (en) * | 1995-12-18 | 2013-04-10 | AngioDevice International GmbH | Crosslinked polymer compositions and methods for their use |
| GB9607120D0 (en) * | 1996-04-04 | 1996-06-12 | Chiroscience Ltd | Compounds |
| US5863915A (en) * | 1996-05-15 | 1999-01-26 | Bayer Corporation | Substituted 4-arylbutyric acid derivatives as matrix metalloprotease |
| RU2221781C2 (ru) * | 1996-07-22 | 2004-01-20 | Монсанто Компани | Тиолсульфоновые соединения в качестве ингибитора матриксной металлопротеазы и способы лечения |
| ES2231879T3 (es) * | 1996-08-16 | 2005-05-16 | Warner-Lambert Company Llc | Inhibidores de metaloproteinasas de la matriz de acido butirico. |
| US6022948A (en) * | 1996-09-17 | 2000-02-08 | Washington University | Method of cell surface activation and inhibition |
| US6228869B1 (en) * | 1996-10-16 | 2001-05-08 | American Cyanamid Company | Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
| US5962481A (en) * | 1996-10-16 | 1999-10-05 | American Cyanamid Company | Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| GB9621814D0 (en) * | 1996-10-19 | 1996-12-11 | British Biotech Pharm | Metalloproteinase inhibitors |
| AUPO366496A0 (en) * | 1996-11-15 | 1996-12-12 | Lions Eye Institute | Collagen preparations |
| AU720615B2 (en) * | 1997-01-17 | 2000-06-08 | Pharmacia & Upjohn Company | Bis-sulfonomides hydroxamic acids as MMP inhibitors |
| GB9702088D0 (en) * | 1997-01-31 | 1997-03-19 | Pharmacia & Upjohn Spa | Matrix metalloproteinase inhibitors |
| US6197791B1 (en) * | 1997-02-27 | 2001-03-06 | American Cyanamid Company | N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| US6172057B1 (en) * | 1997-02-27 | 2001-01-09 | American Cyanamid Company | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| US5893837A (en) * | 1997-02-28 | 1999-04-13 | Staar Surgical Company, Inc. | Glaucoma drain implanting device and method |
| US6169103B1 (en) * | 1998-03-03 | 2001-01-02 | Warner-Lambert | Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
| NL1008531C2 (nl) * | 1998-03-09 | 1999-09-10 | Stichting Tech Wetenschapp | Huidsubstituut en een topische samenstelling voor huidwonden. |
| US6037361A (en) * | 1998-03-09 | 2000-03-14 | Warner-Lambert Company | Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
| US6168807B1 (en) * | 1998-07-23 | 2001-01-02 | Les Laboratoires Aeterna Inc. | Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof |
| US6509337B1 (en) * | 1998-09-17 | 2003-01-21 | Pfizer Inc. | Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors |
| US6183496B1 (en) * | 1998-11-02 | 2001-02-06 | Datascope Investment Corp. | Collapsible hemostatic plug |
| US6511993B1 (en) * | 1999-06-03 | 2003-01-28 | Kevin Neil Dack | Metalloprotease inhibitors |
| US6294694B1 (en) * | 1999-06-04 | 2001-09-25 | Wisconsin Alumni Research Foundation | Matrix metalloproteinase inhibitors and method of using same |
| US6503892B2 (en) * | 2000-04-26 | 2003-01-07 | New England Medical Center Hospitals Inc. | Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve |
| RU2270835C2 (ru) * | 2000-07-18 | 2006-02-27 | Лео Фарма А/С | Производные 1,3,2-оксазафосфациклоалкана, фармацевтическая композиция на их основе и способ лечения |
| US20030181371A1 (en) * | 2001-12-28 | 2003-09-25 | Angiotech Pharmaceuticals, Inc. | Compositions and methods of using collajolie |
-
2003
- 2003-12-24 AU AU2003300379A patent/AU2003300379A1/en not_active Abandoned
- 2003-12-24 KR KR1020057012146A patent/KR20050086949A/ko not_active Withdrawn
- 2003-12-24 EP EP03814968A patent/EP1585555A2/en not_active Withdrawn
- 2003-12-24 JP JP2004565732A patent/JP2006516252A/ja not_active Withdrawn
- 2003-12-24 CA CA002509060A patent/CA2509060A1/en not_active Abandoned
- 2003-12-24 WO PCT/US2003/041330 patent/WO2004060425A2/en not_active Ceased
- 2003-12-24 BR BR0317715-7A patent/BR0317715A/pt not_active IP Right Cessation
- 2003-12-24 US US10/746,911 patent/US20040192658A1/en not_active Abandoned
- 2003-12-24 CN CNA200380107727XA patent/CN1732023A/zh active Pending
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