JP2012512684A5 - - Google Patents
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- Publication number
- JP2012512684A5 JP2012512684A5 JP2011541629A JP2011541629A JP2012512684A5 JP 2012512684 A5 JP2012512684 A5 JP 2012512684A5 JP 2011541629 A JP2011541629 A JP 2011541629A JP 2011541629 A JP2011541629 A JP 2011541629A JP 2012512684 A5 JP2012512684 A5 JP 2012512684A5
- Authority
- JP
- Japan
- Prior art keywords
- bone
- poly
- cell
- substrate
- bone implant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 18
- 230000003014 reinforcing effect Effects 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 12
- 210000002805 bone matrix Anatomy 0.000 claims description 11
- 210000001519 tissue Anatomy 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 241000283690 Bos taurus Species 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 230000012010 growth Effects 0.000 claims description 3
- 230000035755 proliferation Effects 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims 31
- 210000000988 bone and bone Anatomy 0.000 claims 30
- 239000007943 implant Substances 0.000 claims 20
- 229920001577 copolymer Polymers 0.000 claims 15
- 229920002988 biodegradable polymer Polymers 0.000 claims 12
- 239000004621 biodegradable polymer Substances 0.000 claims 12
- 239000000126 substance Substances 0.000 claims 11
- 230000010261 cell growth Effects 0.000 claims 8
- 108010010803 Gelatin Proteins 0.000 claims 6
- 229920000229 biodegradable polyester Polymers 0.000 claims 6
- 239000004622 biodegradable polyester Substances 0.000 claims 6
- 229920000159 gelatin Polymers 0.000 claims 6
- 239000008273 gelatin Substances 0.000 claims 6
- 235000019322 gelatine Nutrition 0.000 claims 6
- 235000011852 gelatine desserts Nutrition 0.000 claims 6
- 230000001737 promoting effect Effects 0.000 claims 6
- 230000003229 cytophilic effect Effects 0.000 claims 4
- -1 poly (amide ester Chemical class 0.000 claims 4
- 238000001356 surgical procedure Methods 0.000 claims 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- 229920000954 Polyglycolide Polymers 0.000 claims 3
- 239000002318 adhesion promoter Substances 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 230000021164 cell adhesion Effects 0.000 claims 3
- 230000004663 cell proliferation Effects 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 239000007952 growth promoter Substances 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims 3
- 229920001610 polycaprolactone Polymers 0.000 claims 3
- 229920000515 polycarbonate Polymers 0.000 claims 3
- 239000004417 polycarbonate Substances 0.000 claims 3
- 239000004626 polylactic acid Substances 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 229930003231 vitamin Natural products 0.000 claims 3
- 235000013343 vitamin Nutrition 0.000 claims 3
- 239000011782 vitamin Substances 0.000 claims 3
- 229940088594 vitamin Drugs 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- 229920000936 Agarose Polymers 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 229920002307 Dextran Polymers 0.000 claims 2
- 102000009123 Fibrin Human genes 0.000 claims 2
- 108010073385 Fibrin Proteins 0.000 claims 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000003462 bioceramic Substances 0.000 claims 2
- 239000005312 bioglass Substances 0.000 claims 2
- 239000000919 ceramic Substances 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229950003499 fibrin Drugs 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- 235000006539 genistein Nutrition 0.000 claims 2
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 claims 2
- 229940045109 genistein Drugs 0.000 claims 2
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 229930014626 natural product Natural products 0.000 claims 2
- 230000002138 osteoinductive effect Effects 0.000 claims 2
- 229920001245 poly(D,L-lactide-co-caprolactone) Polymers 0.000 claims 2
- 229920000058 polyacrylate Polymers 0.000 claims 2
- 229920001230 polyarylate Polymers 0.000 claims 2
- 239000004632 polycaprolactone Substances 0.000 claims 2
- 239000004633 polyglycolic acid Substances 0.000 claims 2
- 229920002635 polyurethane Polymers 0.000 claims 2
- 239000004814 polyurethane Substances 0.000 claims 2
- 235000003687 soy isoflavones Nutrition 0.000 claims 2
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 claims 2
- 229940079488 strontium ranelate Drugs 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229930182556 Polyacetal Natural products 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 229920002396 Polyurea Polymers 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229930003316 Vitamin D Natural products 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 1
- 150000001261 hydroxy acids Chemical class 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 229920005615 natural polymer Polymers 0.000 claims 1
- 230000000399 orthopedic effect Effects 0.000 claims 1
- 229920001432 poly(L-lactide) Polymers 0.000 claims 1
- 229920006209 poly(L-lactide-co-D,L-lactide) Polymers 0.000 claims 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 1
- 229920000117 poly(dioxanone) Polymers 0.000 claims 1
- 229920003055 poly(ester-imide) Polymers 0.000 claims 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 1
- 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920000767 polyaniline Polymers 0.000 claims 1
- 229920002721 polycyanoacrylate Polymers 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000193 polymethacrylate Polymers 0.000 claims 1
- 229920006324 polyoxymethylene Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920000128 polypyrrole Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229920000123 polythiophene Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000013557 residual solvent Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 235000019166 vitamin D Nutrition 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
- 229940046008 vitamin d Drugs 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01997/08 | 2008-12-19 | ||
| CH01997/08A CH700138B1 (it) | 2008-12-19 | 2008-12-19 | Matrice per impianto osseo e procedimento di preparazione della stessa. |
| PCT/IB2009/007759 WO2010070416A1 (en) | 2008-12-19 | 2009-12-15 | Bone implant matrix and method of preparing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512684A JP2012512684A (ja) | 2012-06-07 |
| JP2012512684A5 true JP2012512684A5 (enExample) | 2014-08-21 |
| JP5801719B2 JP5801719B2 (ja) | 2015-10-28 |
Family
ID=40566331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541629A Active JP5801719B2 (ja) | 2008-12-19 | 2009-12-15 | 骨インプラント基材及びその調製方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9770532B2 (enExample) |
| EP (1) | EP2358407B1 (enExample) |
| JP (1) | JP5801719B2 (enExample) |
| CN (2) | CN106890361A (enExample) |
| BR (1) | BRPI0923017B1 (enExample) |
| CH (1) | CH700138B1 (enExample) |
| ES (1) | ES2557105T3 (enExample) |
| RU (1) | RU2532385C2 (enExample) |
| WO (1) | WO2010070416A1 (enExample) |
| ZA (1) | ZA201103322B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9452001B2 (en) * | 2005-02-22 | 2016-09-27 | Tecres S.P.A. | Disposable device for treatment of infections of human limbs |
| US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| US11207109B2 (en) * | 2010-10-20 | 2021-12-28 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| CA2863967C (en) | 2012-02-07 | 2021-02-09 | Lifenet Health | Liquefaction of bone matrix |
| EP3307287A4 (en) * | 2015-06-09 | 2018-12-19 | Orthocyte Corporation | Osteogenic graft forming unit |
| KR101671150B1 (ko) * | 2016-07-15 | 2016-10-31 | 가톨릭관동대학교산학협력단 | 안와벽용 임플란트 |
| RU2630464C1 (ru) * | 2016-07-29 | 2017-09-08 | Федеральное государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт лекарственных и ароматических растений (ФГБНУ ВИЛАР) | Комбинированный способ стерилизации костных имплантатов |
| CN106581747A (zh) * | 2016-12-08 | 2017-04-26 | 山东明德生物医学工程有限公司 | 一种含锶骨水泥及制备方法 |
| IT201800002658A1 (it) * | 2018-02-13 | 2019-08-13 | Surgical Clinicare S R L | Dispositivo per impianto nello spazio intervertebrale e uso di matrice per impianti ossei in chirurgia vertebrale |
| CN108939150A (zh) * | 2018-09-05 | 2018-12-07 | 华东理工大学 | 基于POFC/β-TCP和雷尼酸锶的骨质疏松缺损修复用支架 |
| EP3714909A1 (en) * | 2019-03-28 | 2020-09-30 | Industrie Biomediche Insubri S.A. | Improved bone implant matrix comprising proline-rich peptide and method of preparing the same |
| EP3818994A1 (en) * | 2019-11-08 | 2021-05-12 | Septodont ou Septodont SAS ou Specialites Septodont | Non-breaking filament for shaping bone and dental substitutes |
| RU2758551C1 (ru) * | 2021-01-13 | 2021-10-29 | Общество с ограниченной ответственностью "Медлайн Компани" | Способ определения адсорбционной ёмкости гранулированного остеокондуктивного костнопластического материала |
| RU2758570C1 (ru) * | 2021-01-13 | 2021-10-29 | Общество с ограниченной ответственностью "Медлайн Компани" | Способ дегазации гранулированного остеокондуктивного костнопластического материала |
| IT202100005438A1 (it) | 2021-03-09 | 2022-09-09 | Pharmaexceed S R L | Scaffold per la rigenerazione ossea e relativo metodo di fabbricazione |
| EP4643893A1 (en) | 2024-04-30 | 2025-11-05 | Industrie Biomediche Insubri S.A. | A cold-cleaning process for deriving a decellularized graft tissue to be used as a medical device, or as a raw material |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6376573B1 (en) * | 1994-12-21 | 2002-04-23 | Interpore International | Porous biomaterials and methods for their manufacture |
| US20020076429A1 (en) * | 1998-01-28 | 2002-06-20 | John F. Wironen | Bone paste subjected to irradiative and thermal treatment |
| US6293970B1 (en) * | 1998-06-30 | 2001-09-25 | Lifenet | Plasticized bone and soft tissue grafts and methods of making and using same |
| WO2000015273A1 (de) * | 1998-09-11 | 2000-03-23 | Gerhard Schmidmaier | Biologisch aktive implantate |
| AU1593001A (en) | 1999-11-12 | 2001-06-06 | Fibrogen, Inc. | Recombinant gelatin in vaccines |
| US20040265385A1 (en) * | 2001-04-12 | 2004-12-30 | Therics, Inc. | Porous biostructure partially occupied by interpenetrant and method for making same |
| US20020183858A1 (en) * | 2001-06-05 | 2002-12-05 | Contiliano Joseph H. | Attachment of absorbable tissue scaffolds to scaffold fixation devices |
| JP5165823B2 (ja) | 2001-09-20 | 2013-03-21 | 株式会社ニッピ | ゼラチン加水分解物の成形方法 |
| EP3254710B1 (en) * | 2003-04-11 | 2019-05-22 | Etex Corporation | Osteoinductive bone material |
| WO2004098456A2 (en) * | 2003-05-01 | 2004-11-18 | Therics, Inc. | Porous biostructure partially occupied by interpenetrant and method for making same |
| US20050020506A1 (en) | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
| JP2007526085A (ja) | 2004-03-02 | 2007-09-13 | ナノセラピューティクス・インコーポレイテッド | 骨を修復するための組成物ならびにそのような組成物を調製および使用するための方法 |
| US20070224245A1 (en) * | 2006-02-08 | 2007-09-27 | Northwestern University | Poly (diol co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices |
| RU2322955C2 (ru) * | 2006-02-13 | 2008-04-27 | ГОУ ВПО Военно-медицинская академия им. С.М. Кирова | Способ изготовления имплантата для пластики дефектов хрящевой ткани |
| KR100846836B1 (ko) * | 2007-01-15 | 2008-07-17 | 한스바이오메드 주식회사 | 골재생촉진 조성물 |
| CA2710207C (en) * | 2007-12-21 | 2017-06-06 | Rti Biologics, Inc. | Osteoinductive putties and methods of making and using such putties |
-
2008
- 2008-12-19 CH CH01997/08A patent/CH700138B1/it unknown
-
2009
- 2009-12-15 CN CN201710105757.0A patent/CN106890361A/zh active Pending
- 2009-12-15 EP EP09796449.8A patent/EP2358407B1/en active Active
- 2009-12-15 WO PCT/IB2009/007759 patent/WO2010070416A1/en not_active Ceased
- 2009-12-15 RU RU2011126095/15A patent/RU2532385C2/ru active
- 2009-12-15 ES ES09796449.8T patent/ES2557105T3/es active Active
- 2009-12-15 JP JP2011541629A patent/JP5801719B2/ja active Active
- 2009-12-15 CN CN2009801507256A patent/CN102256633A/zh active Pending
- 2009-12-15 US US13/128,062 patent/US9770532B2/en active Active
- 2009-12-15 BR BRPI0923017-3A patent/BRPI0923017B1/pt active IP Right Grant
-
2011
- 2011-05-06 ZA ZA2011/03322A patent/ZA201103322B/en unknown
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