JP2006516183A5 - - Google Patents
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- Publication number
- JP2006516183A5 JP2006516183A5 JP2004532151A JP2004532151A JP2006516183A5 JP 2006516183 A5 JP2006516183 A5 JP 2006516183A5 JP 2004532151 A JP2004532151 A JP 2004532151A JP 2004532151 A JP2004532151 A JP 2004532151A JP 2006516183 A5 JP2006516183 A5 JP 2006516183A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- frpb
- neisseria
- pharmaceutical composition
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004169 proteins and genes Human genes 0.000 claims 44
- 108090000623 proteins and genes Proteins 0.000 claims 44
- 150000001413 amino acids Chemical class 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 241000588653 Neisseria Species 0.000 claims 11
- 238000012217 deletion Methods 0.000 claims 11
- 230000037430 deletion Effects 0.000 claims 11
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 8
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims 5
- 108010031133 Transferrin-Binding Protein A Proteins 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 claims 4
- 206010018612 Gonorrhoea Diseases 0.000 claims 3
- 208000034762 Meningococcal Infections Diseases 0.000 claims 3
- 206010062212 Neisseria infection Diseases 0.000 claims 3
- 241000588650 Neisseria meningitidis Species 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000001786 gonorrhea Diseases 0.000 claims 3
- 210000003000 inclusion body Anatomy 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 108010031127 Transferrin-Binding Protein B Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 229920001542 oligosaccharide Polymers 0.000 claims 2
- 150000002482 oligosaccharides Chemical class 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- PKIFFNOAKKWUOS-UHFFFAOYSA-N 3-(2-methyltridecan-2-ylazaniumyl)propane-1-sulfonate Chemical compound CCCCCCCCCCCC(C)(C)[NH2+]CCCS([O-])(=O)=O PKIFFNOAKKWUOS-UHFFFAOYSA-N 0.000 claims 1
- 101000874355 Escherichia coli (strain K12) Outer membrane protein assembly factor BamA Proteins 0.000 claims 1
- 101710186862 Factor H binding protein Proteins 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 101001041393 Homo sapiens Serine protease HTRA1 Proteins 0.000 claims 1
- 101000873843 Homo sapiens Sorting and assembly machinery component 50 homolog Proteins 0.000 claims 1
- 108010002231 IgA-specific serine endopeptidase Proteins 0.000 claims 1
- 101150022636 MAFB gene Proteins 0.000 claims 1
- 101100212666 Neisseria meningitidis serogroup B (strain MC58) NMB0964 gene Proteins 0.000 claims 1
- 101710116435 Outer membrane protein Proteins 0.000 claims 1
- 101800001295 Putative ATP-dependent helicase Proteins 0.000 claims 1
- 101800001006 Putative helicase Proteins 0.000 claims 1
- 102100021119 Serine protease HTRA1 Human genes 0.000 claims 1
- 102100035853 Sorting and assembly machinery component 50 homolog Human genes 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241001505901 Streptococcus sp. 'group A' Species 0.000 claims 1
- 241000193990 Streptococcus sp. 'group B' Species 0.000 claims 1
- 108010073429 Type V Secretion Systems Proteins 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960000789 guanidine hydrochloride Drugs 0.000 claims 1
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- IZWSFJTYBVKZNK-UHFFFAOYSA-N lauryl sulfobetaine Chemical compound CCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O IZWSFJTYBVKZNK-UHFFFAOYSA-N 0.000 claims 1
- 238000002703 mutagenesis Methods 0.000 claims 1
- 231100000350 mutagenesis Toxicity 0.000 claims 1
- 101150101156 slc51a gene Proteins 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0220199.4A GB0220199D0 (en) | 2002-08-30 | 2002-08-30 | Mutant protein and refolding method |
| PCT/EP2003/009634 WO2004020463A2 (en) | 2002-08-30 | 2003-08-28 | Mutant protein and refolding method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006516183A JP2006516183A (ja) | 2006-06-29 |
| JP2006516183A5 true JP2006516183A5 (OSRAM) | 2006-11-30 |
Family
ID=9943242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004532151A Pending JP2006516183A (ja) | 2002-08-30 | 2003-08-28 | 突然変異型タンパク質およびリフォールディング方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060141563A1 (OSRAM) |
| EP (1) | EP1572729B1 (OSRAM) |
| JP (1) | JP2006516183A (OSRAM) |
| AT (1) | ATE481983T1 (OSRAM) |
| AU (1) | AU2003287945A1 (OSRAM) |
| CA (1) | CA2495086A1 (OSRAM) |
| DE (1) | DE60334316D1 (OSRAM) |
| ES (1) | ES2351598T3 (OSRAM) |
| GB (1) | GB0220199D0 (OSRAM) |
| WO (1) | WO2004020463A2 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2414667A (en) | 2004-06-03 | 2005-12-07 | Isis Innovation | Vaccine compositions of N. meningitidis PorA and FetA antigens |
| PL2878307T3 (pl) | 2005-06-27 | 2020-01-31 | Glaxosmithkline Biologicals S.A. | Kompozycja immunogenna |
| US20090246224A1 (en) * | 2006-06-12 | 2009-10-01 | Nathalie Devos | Vaccine |
| US8647634B2 (en) | 2008-12-25 | 2014-02-11 | The Chemo-Sero-Therapeutic Research Institute | Recombinant avian infectious coryza vaccine and process for preparing same |
| AU2011300418B2 (en) * | 2010-09-10 | 2016-05-12 | Glaxosmithkline Biologicals Sa | Meningococcus overexpressing NadA and/or NHBA and outer membrane vesicles derived therefrom |
| CN103228787B (zh) * | 2010-09-28 | 2017-06-23 | 阿贝拉生物科学公司 | 用于分泌性蛋白表达的融合蛋白 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265567B1 (en) * | 1995-04-07 | 2001-07-24 | University Of North Carolina At Chapel Hill | Isolated FrpB nucleic acid molecule |
| US6084076A (en) * | 1995-12-21 | 2000-07-04 | Ajinomoto Co., Inc. | Method of refolding human activin A |
| IL150822A0 (en) * | 2000-01-25 | 2003-02-12 | Univ Queensland | PROTEINS COMPRISING CONSERVED REGIONS OF NEISSERIA MENINGITIDIS SURFACE ANTIGEN NhhA |
-
2002
- 2002-08-30 GB GBGB0220199.4A patent/GB0220199D0/en not_active Ceased
-
2003
- 2003-08-28 JP JP2004532151A patent/JP2006516183A/ja active Pending
- 2003-08-28 WO PCT/EP2003/009634 patent/WO2004020463A2/en not_active Ceased
- 2003-08-28 AU AU2003287945A patent/AU2003287945A1/en not_active Abandoned
- 2003-08-28 DE DE60334316T patent/DE60334316D1/de not_active Expired - Lifetime
- 2003-08-28 ES ES03779785T patent/ES2351598T3/es not_active Expired - Lifetime
- 2003-08-28 US US10/526,062 patent/US20060141563A1/en not_active Abandoned
- 2003-08-28 CA CA002495086A patent/CA2495086A1/en not_active Abandoned
- 2003-08-28 EP EP03779785A patent/EP1572729B1/en not_active Expired - Lifetime
- 2003-08-28 AT AT03779785T patent/ATE481983T1/de not_active IP Right Cessation
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