JP2006515849A5 - - Google Patents
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- Publication number
- JP2006515849A5 JP2006515849A5 JP2004561378A JP2004561378A JP2006515849A5 JP 2006515849 A5 JP2006515849 A5 JP 2006515849A5 JP 2004561378 A JP2004561378 A JP 2004561378A JP 2004561378 A JP2004561378 A JP 2004561378A JP 2006515849 A5 JP2006515849 A5 JP 2006515849A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heterocyclyl
- aryl
- alkoxy
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003118 aryl group Chemical group 0.000 claims 22
- 125000000623 heterocyclic group Chemical group 0.000 claims 21
- 229910052736 halogen Inorganic materials 0.000 claims 14
- 125000001424 substituent group Chemical group 0.000 claims 14
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000004104 aryloxy group Chemical group 0.000 claims 8
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 7
- 125000005110 aryl thio group Chemical group 0.000 claims 6
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 5
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000004643 (C1-C12) haloalkoxy group Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 2
- 125000004641 (C1-C12) haloalkyl group Chemical group 0.000 claims 2
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 2
- 229910005965 SO 2 Inorganic materials 0.000 claims 2
- 241000607479 Yersinia pestis Species 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
- 239000003905 agrochemical Substances 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims 1
- RRZXIRBKKLTSOM-UHFFFAOYSA-N avermectin B1a Natural products C1=CC(C)C(C(C)CC)OC11OC(CC=C(C)C(OC2OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C2)C(C)C=CC=C2C3(C(C(=O)O4)C=C(C)C(O)C3OC2)O)CC4C1 RRZXIRBKKLTSOM-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- -1 methylenedioxy Chemical group 0.000 claims 1
- 150000003839 salts Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0229804.0A GB0229804D0 (en) | 2002-12-20 | 2002-12-20 | Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position |
| GB0229804.0 | 2002-12-20 | ||
| PCT/EP2003/014613 WO2004056844A1 (en) | 2002-12-20 | 2003-12-19 | Avermectin b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4”- or 4’-position |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010286151A Division JP5302297B2 (ja) | 2002-12-20 | 2010-12-22 | ４”位又は４’−位にアルコキシメチル置換基を有するアベルメクチンｂ１及びアベルメクチンｂ１単糖誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006515849A JP2006515849A (ja) | 2006-06-08 |
| JP2006515849A5 true JP2006515849A5 (enExample) | 2007-02-01 |
| JP4851094B2 JP4851094B2 (ja) | 2012-01-11 |
Family
ID=9950151
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004561378A Expired - Fee Related JP4851094B2 (ja) | 2002-12-20 | 2003-12-19 | アベルメクチンｂ１及び４”位又は４’−位にアルコキシメチル置換基を有するアベルメクチンｂ１モノサッカライド誘導体 |
| JP2010286151A Expired - Fee Related JP5302297B2 (ja) | 2002-12-20 | 2010-12-22 | ４”位又は４’−位にアルコキシメチル置換基を有するアベルメクチンｂ１及びアベルメクチンｂ１単糖誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010286151A Expired - Fee Related JP5302297B2 (ja) | 2002-12-20 | 2010-12-22 | ４”位又は４’−位にアルコキシメチル置換基を有するアベルメクチンｂ１及びアベルメクチンｂ１単糖誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US7737261B2 (enExample) |
| EP (1) | EP1581546B1 (enExample) |
| JP (2) | JP4851094B2 (enExample) |
| KR (1) | KR101109500B1 (enExample) |
| CN (1) | CN1738828B (enExample) |
| AR (1) | AR042533A1 (enExample) |
| AU (1) | AU2003302284B2 (enExample) |
| BR (1) | BR0317601A (enExample) |
| CA (1) | CA2507774C (enExample) |
| CO (1) | CO5690647A1 (enExample) |
| ES (1) | ES2742899T3 (enExample) |
| GB (1) | GB0229804D0 (enExample) |
| IL (1) | IL169092A (enExample) |
| MA (1) | MA27646A1 (enExample) |
| MX (1) | MXPA05006036A (enExample) |
| PE (1) | PE20040713A1 (enExample) |
| PL (1) | PL211483B1 (enExample) |
| RU (1) | RU2330857C2 (enExample) |
| TW (1) | TW200512214A (enExample) |
| UA (1) | UA81281C2 (enExample) |
| WO (1) | WO2004056844A1 (enExample) |
| ZA (1) | ZA200504353B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0229804D0 (en) * | 2002-12-20 | 2003-01-29 | Syngenta Participations Ag | Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position |
| JP2010006703A (ja) * | 2006-11-07 | 2010-01-14 | Hokko Chem Ind Co Ltd | アベルメクチンモノ配糖体誘導体 |
| RU2472801C1 (ru) * | 2011-05-11 | 2013-01-20 | Игорь Викторович Заварзин | 5-о-производные авермектина, способ их получения и антипаразитарные средства на их основе |
| RU2453553C1 (ru) * | 2011-05-11 | 2012-06-20 | Игорь Викторович Заварзин | 5-о-сукциноилавермектин, способ его получения и антипаразитарное средство на его основе |
| CN103613625B (zh) * | 2013-12-02 | 2016-03-02 | 兰州大学 | 一种阿维菌素类化合物及其制备方法和在农药中的用途 |
| CN104402954A (zh) * | 2014-11-28 | 2015-03-11 | 大庆志飞生物化工有限公司 | 甲胺基阿维菌素单糖化合物及其制备方法和用途 |
| CN104402953B (zh) * | 2014-11-28 | 2017-07-28 | 大庆志飞生物化工有限公司 | 阿维菌素单糖化合物及其制备方法和用途 |
| JP6577184B2 (ja) | 2014-12-24 | 2019-09-18 | Ntn株式会社 | 転がり軸受 |
| CN107501368B (zh) * | 2017-09-30 | 2020-02-21 | 中国科学院成都生物研究所 | 一种多拉菌素衍生物的合成及其杀虫应用 |
| CN113150053B (zh) * | 2020-01-22 | 2024-10-01 | 华东理工大学 | 偶氮苯类阿维菌素衍生物及其制备方法和应用 |
| CN113817008B (zh) * | 2021-07-15 | 2023-05-23 | 湖州师范学院 | 新型琥珀酰基十六元大环内酯的制备方法及用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US87519A (en) * | 1869-03-02 | Improvement in furnace-stoves and registers | ||
| US148520A (en) * | 1874-03-10 | Improvement in faucets | ||
| US18993A (en) * | 1857-12-29 | Cider-mill | ||
| SE434277B (sv) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4874749A (en) * | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| GB8811037D0 (en) | 1988-05-10 | 1988-06-15 | Glaxo Group Ltd | Chemical compounds |
| EP0353959A2 (en) | 1988-08-02 | 1990-02-07 | Beecham Group Plc | Antihelmintic macrolide antibiotics |
| SE465605B (sv) * | 1990-02-26 | 1991-10-07 | Harry Nilsson | Skivfilter |
| JP2622197B2 (ja) | 1990-03-01 | 1997-06-18 | 三共株式会社 | １３−エーテル置換ミルベマイシン誘導体 |
| US5169839A (en) * | 1990-05-11 | 1992-12-08 | Merck & Co., Inc. | Derivatives of 3'- and 3"-o-desmethyl avermectin compounds, compositions and methods of treating melmintic and parasitic infections |
| US5262400A (en) * | 1991-06-20 | 1993-11-16 | Merck & Co., Inc. | 4α-substituted avermectin derivatives |
| US5411737A (en) | 1991-10-15 | 1995-05-02 | Merck & Co., Inc. | Slow release syneresing polymeric drug delivery device |
| US5602107A (en) | 1993-05-10 | 1997-02-11 | Merck & Co., Inc. | Pour-on formulations consisting of gylcols, glycerides and avermectin compounds |
| PL174488B1 (pl) | 1993-05-10 | 1998-08-31 | Merck & Co Inc | Preparat do zwalczania pasożytów zwierząt oraz sposób wytwarzania preparatu do zwalczania pasożytów zwierząt |
| AU684828B2 (en) * | 1993-08-19 | 1998-01-08 | Merck Sharp & Dohme Corp. | Thermodynamically stable crystal form of 4"-deoxy-4"-(epi)-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation |
| US5436355A (en) | 1994-02-03 | 1995-07-25 | Merck & Co., Inc. | Process for making avermectin/zein compositions |
| TW327125B (en) | 1994-02-07 | 1998-02-21 | Merck & Co Inc | Composition and method for protecting against pine exhausted |
| WO2002012248A1 (en) | 2000-08-09 | 2002-02-14 | The Kitasato Institute | Avermectin derivatives |
| WO2002012261A1 (fr) | 2000-08-09 | 2002-02-14 | The Kitasato Institute | Dérivés d'avermectine |
| CA2477614A1 (en) * | 2002-03-05 | 2003-09-18 | Merck & Co., Inc. | Biomarker for efficacy of appetite suppressant drugs |
| GB0229804D0 (en) * | 2002-12-20 | 2003-01-29 | Syngenta Participations Ag | Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position |
-
2002
- 2002-12-20 GB GBGB0229804.0A patent/GB0229804D0/en not_active Ceased
-
2003
- 2003-12-12 PE PE2003001284A patent/PE20040713A1/es active IP Right Grant
- 2003-12-18 TW TW092135927A patent/TW200512214A/zh unknown
- 2003-12-18 AR ARP030104712A patent/AR042533A1/es active IP Right Grant
- 2003-12-19 MX MXPA05006036A patent/MXPA05006036A/es active IP Right Grant
- 2003-12-19 CN CN2003801088575A patent/CN1738828B/zh not_active Expired - Lifetime
- 2003-12-19 PL PL377497A patent/PL211483B1/pl unknown
- 2003-12-19 KR KR1020057011622A patent/KR101109500B1/ko not_active Expired - Fee Related
- 2003-12-19 JP JP2004561378A patent/JP4851094B2/ja not_active Expired - Fee Related
- 2003-12-19 WO PCT/EP2003/014613 patent/WO2004056844A1/en not_active Ceased
- 2003-12-19 EP EP03810843.7A patent/EP1581546B1/en not_active Expired - Lifetime
- 2003-12-19 AU AU2003302284A patent/AU2003302284B2/en not_active Ceased
- 2003-12-19 US US10/539,274 patent/US7737261B2/en active Active
- 2003-12-19 BR BR0317601-0A patent/BR0317601A/pt not_active Application Discontinuation
- 2003-12-19 ES ES03810843T patent/ES2742899T3/es not_active Expired - Lifetime
- 2003-12-19 UA UAA200507209A patent/UA81281C2/uk unknown
- 2003-12-19 CA CA2507774A patent/CA2507774C/en not_active Expired - Fee Related
- 2003-12-19 RU RU2005122943/04A patent/RU2330857C2/ru active
-
2005
- 2005-06-09 IL IL169092A patent/IL169092A/en active IP Right Grant
- 2005-06-17 CO CO05059203A patent/CO5690647A1/es not_active Application Discontinuation
- 2005-06-17 MA MA28349A patent/MA27646A1/fr unknown
-
2006
- 2006-01-06 ZA ZA200504353A patent/ZA200504353B/en unknown
-
2010
- 2010-04-27 US US12/768,280 patent/US8017589B2/en not_active Expired - Fee Related
- 2010-12-22 JP JP2010286151A patent/JP5302297B2/ja not_active Expired - Fee Related
-
2011
- 2011-05-27 US US13/117,292 patent/US8263566B2/en not_active Expired - Fee Related
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