AU2003302284B2 - Avermectin B1 and avermectin B1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position - Google Patents

Avermectin B1 and avermectin B1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position Download PDF

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Publication number
AU2003302284B2
AU2003302284B2 AU2003302284A AU2003302284A AU2003302284B2 AU 2003302284 B2 AU2003302284 B2 AU 2003302284B2 AU 2003302284 A AU2003302284 A AU 2003302284A AU 2003302284 A AU2003302284 A AU 2003302284A AU 2003302284 B2 AU2003302284 B2 AU 2003302284B2
Authority
AU
Australia
Prior art keywords
spp
alkyl
heterocyclyl
aryl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003302284A
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English (en)
Other versions
AU2003302284A1 (en
Inventor
Jerome Cassayre
Ottmar Franz Hueter
Pierre Jung
Peter Maienfisch
Fiona Murphy Kessabi
Thomas Pitterna
Laura Quaranta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Animal Health USA Inc
Original Assignee
Boehringer Ingelheim Animal Health USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Animal Health USA Inc filed Critical Boehringer Ingelheim Animal Health USA Inc
Publication of AU2003302284A1 publication Critical patent/AU2003302284A1/en
Assigned to MERIAL LIMITED reassignment MERIAL LIMITED Request for Assignment Assignors: SYNGENTA PARTICIPATIONS AG
Application granted granted Critical
Publication of AU2003302284B2 publication Critical patent/AU2003302284B2/en
Assigned to MERIAL, INC. reassignment MERIAL, INC. Request for Assignment Assignors: MERIAL LIMITED
Assigned to Boehringer Ingelheim Animal Health USA Inc. reassignment Boehringer Ingelheim Animal Health USA Inc. Request for Assignment Assignors: MERIAL, INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2003302284A 2002-12-20 2003-12-19 Avermectin B1 and avermectin B1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position Ceased AU2003302284B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0229804.0 2002-12-20
GBGB0229804.0A GB0229804D0 (en) 2002-12-20 2002-12-20 Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
PCT/EP2003/014613 WO2004056844A1 (en) 2002-12-20 2003-12-19 Avermectin b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4”- or 4’-position

Publications (2)

Publication Number Publication Date
AU2003302284A1 AU2003302284A1 (en) 2004-07-14
AU2003302284B2 true AU2003302284B2 (en) 2009-07-23

Family

ID=9950151

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003302284A Ceased AU2003302284B2 (en) 2002-12-20 2003-12-19 Avermectin B1 and avermectin B1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position

Country Status (22)

Country Link
US (3) US7737261B2 (enExample)
EP (1) EP1581546B1 (enExample)
JP (2) JP4851094B2 (enExample)
KR (1) KR101109500B1 (enExample)
CN (1) CN1738828B (enExample)
AR (1) AR042533A1 (enExample)
AU (1) AU2003302284B2 (enExample)
BR (1) BR0317601A (enExample)
CA (1) CA2507774C (enExample)
CO (1) CO5690647A1 (enExample)
ES (1) ES2742899T3 (enExample)
GB (1) GB0229804D0 (enExample)
IL (1) IL169092A (enExample)
MA (1) MA27646A1 (enExample)
MX (1) MXPA05006036A (enExample)
PE (1) PE20040713A1 (enExample)
PL (1) PL211483B1 (enExample)
RU (1) RU2330857C2 (enExample)
TW (1) TW200512214A (enExample)
UA (1) UA81281C2 (enExample)
WO (1) WO2004056844A1 (enExample)
ZA (1) ZA200504353B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0229804D0 (en) * 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
JP2010006703A (ja) * 2006-11-07 2010-01-14 Hokko Chem Ind Co Ltd アベルメクチンモノ配糖体誘導体
RU2453553C1 (ru) * 2011-05-11 2012-06-20 Игорь Викторович Заварзин 5-о-сукциноилавермектин, способ его получения и антипаразитарное средство на его основе
RU2472801C1 (ru) * 2011-05-11 2013-01-20 Игорь Викторович Заварзин 5-о-производные авермектина, способ их получения и антипаразитарные средства на их основе
CN103613625B (zh) * 2013-12-02 2016-03-02 兰州大学 一种阿维菌素类化合物及其制备方法和在农药中的用途
CN104402953B (zh) * 2014-11-28 2017-07-28 大庆志飞生物化工有限公司 阿维菌素单糖化合物及其制备方法和用途
CN104402954A (zh) * 2014-11-28 2015-03-11 大庆志飞生物化工有限公司 甲胺基阿维菌素单糖化合物及其制备方法和用途
JP6577184B2 (ja) 2014-12-24 2019-09-18 Ntn株式会社 転がり軸受
CN107501368B (zh) * 2017-09-30 2020-02-21 中国科学院成都生物研究所 一种多拉菌素衍生物的合成及其杀虫应用
CN113150053B (zh) * 2020-01-22 2024-10-01 华东理工大学 偶氮苯类阿维菌素衍生物及其制备方法和应用
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0456509A1 (en) * 1990-05-11 1991-11-13 Merck & Co. Inc. Derivatives of 3' - and 3"-0-desmethyl avermectin compounds
EP0516731A1 (en) * 1990-02-26 1992-12-09 Harry Nilsson DISC FILTER.

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US87519A (en) * 1869-03-02 Improvement in furnace-stoves and registers
US148520A (en) * 1874-03-10 Improvement in faucets
US18993A (en) * 1857-12-29 Cider-mill
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4874749A (en) * 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
GB8811037D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
EP0353959A2 (en) 1988-08-02 1990-02-07 Beecham Group Plc Antihelmintic macrolide antibiotics
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
US5411737A (en) * 1991-10-15 1995-05-02 Merck & Co., Inc. Slow release syneresing polymeric drug delivery device
US5602107A (en) * 1993-05-10 1997-02-11 Merck & Co., Inc. Pour-on formulations consisting of gylcols, glycerides and avermectin compounds
PL174488B1 (pl) * 1993-05-10 1998-08-31 Merck & Co Inc Preparat do zwalczania pasożytów zwierząt oraz sposób wytwarzania preparatu do zwalczania pasożytów zwierząt
SK281684B6 (sk) * 1993-08-19 2001-06-11 Merck & Co., Inc. Hemihydrát kryštalickej soli 4''-deoxy-4''-epimetylaminoavermektínu b1a/b1b s kyselinou benzoovou, spôsob jeho výroby a prostriedok s jeho obsahom
US5436355A (en) * 1994-02-03 1995-07-25 Merck & Co., Inc. Process for making avermectin/zein compositions
TW327125B (en) * 1994-02-07 1998-02-21 Merck & Co Inc Composition and method for protecting against pine exhausted
CA2418975C (en) 2000-08-09 2012-01-17 Satoshi Omura Avermectin derivatives
WO2002012261A1 (fr) 2000-08-09 2002-02-14 The Kitasato Institute Dérivés d'avermectine
US20050169839A1 (en) * 2002-03-05 2005-08-04 Fong Tung M. Biomarker for efficacy of appetite suppressant drugs
GB0229804D0 (en) 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0516731A1 (en) * 1990-02-26 1992-12-09 Harry Nilsson DISC FILTER.
EP0456509A1 (en) * 1990-05-11 1991-11-13 Merck & Co. Inc. Derivatives of 3' - and 3"-0-desmethyl avermectin compounds
US5169839A (en) * 1990-05-11 1992-12-08 Merck & Co., Inc. Derivatives of 3'- and 3"-o-desmethyl avermectin compounds, compositions and methods of treating melmintic and parasitic infections

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Jones et al. J. Agric. Food Chem. 1994, 42(8), 1786-90 *
Shoop et al. Int. J. Parasit. 1996, 26(11), 1227-1235 *
Tsukamoto et al. Bioorg. Med. Chem. 2000, 8(1), 19-26 *

Also Published As

Publication number Publication date
MA27646A1 (fr) 2005-12-01
US7737261B2 (en) 2010-06-15
US20060148729A1 (en) 2006-07-06
MXPA05006036A (es) 2005-08-18
CN1738828B (zh) 2012-09-05
PL211483B1 (pl) 2012-05-31
KR101109500B1 (ko) 2012-01-31
PE20040713A1 (es) 2004-12-02
JP2006515849A (ja) 2006-06-08
BR0317601A (pt) 2005-11-29
GB0229804D0 (en) 2003-01-29
CA2507774C (en) 2011-06-14
WO2004056844A1 (en) 2004-07-08
TW200512214A (en) 2005-04-01
US8263566B2 (en) 2012-09-11
UA81281C2 (en) 2007-12-25
JP2011102303A (ja) 2011-05-26
RU2005122943A (ru) 2006-01-20
JP5302297B2 (ja) 2013-10-02
KR20050088133A (ko) 2005-09-01
CO5690647A1 (es) 2006-10-31
ES2742899T3 (es) 2020-02-17
ZA200504353B (en) 2006-03-29
US20100210574A1 (en) 2010-08-19
JP4851094B2 (ja) 2012-01-11
CN1738828A (zh) 2006-02-22
EP1581546A1 (en) 2005-10-05
US20110230429A1 (en) 2011-09-22
IL169092A (en) 2010-12-30
IL169092A0 (en) 2007-07-04
PL377497A1 (pl) 2006-02-06
AR042533A1 (es) 2005-06-22
EP1581546B1 (en) 2019-03-20
AU2003302284A1 (en) 2004-07-14
RU2330857C2 (ru) 2008-08-10
CA2507774A1 (en) 2004-07-08
US8017589B2 (en) 2011-09-13

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PC1 Assignment before grant (sect. 113)

Owner name: MERIAL LIMITED

Free format text: FORMER APPLICANT(S): SYNGENTA PARTICIPATIONS AG

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: MERIAL, INC.

Free format text: FORMER OWNER(S): MERIAL LIMITED

PC Assignment registered

Owner name: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.

Free format text: FORMER OWNER(S): MERIAL, INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired