MA27646A1 - Derives d'avermectine b1 et d'avermectine b1 monosaccharidique ayant un substituant alcoxymethyle en position 4" ou 4' - Google Patents

Derives d'avermectine b1 et d'avermectine b1 monosaccharidique ayant un substituant alcoxymethyle en position 4" ou 4'

Info

Publication number
MA27646A1
MA27646A1 MA28349A MA28349A MA27646A1 MA 27646 A1 MA27646 A1 MA 27646A1 MA 28349 A MA28349 A MA 28349A MA 28349 A MA28349 A MA 28349A MA 27646 A1 MA27646 A1 MA 27646A1
Authority
MA
Morocco
Prior art keywords
alkyl
compounds
tautomer
alkoxy
relates
Prior art date
Application number
MA28349A
Other languages
English (en)
Inventor
Peter Maienfisch
Kessabi Fiona Murphy
Jerome Cassayre
Laura Quaranta
Thomas Pitterna
Ottmar Franz Hueter
Pierre Jung
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of MA27646A1 publication Critical patent/MA27646A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'invention concerne un composé représenté par la formule (I). Dans cette formule, n prend la valeur de 0 ou 1; A-B représente -CH=CH- ou -CH2-CH2-; R1 représente un alkyle en C1-C12, un cycloalkyle en C3-C8 ou un alcényle en C2-C12; R2 représente par exemple un alkyle en C1-C12, un alcényle en C2-C12 ou un alcynyle en C2-C12; lesquels sont éventuellement substitués par un à cinq substituants choisis dans le groupe constitué de OH, halogène, CN, -N3, -NO2, cycloalkyle en C3-C8, norbornylène-yle-, cycloalcényle en C3-C8; halocycloalkyle en C3-C8, alcoxy en C1-C12, alcoxy en C1-C6-alcoxy en C1-C6, cycloalcoxy en C3-C8, haloalcoxy en C1-C12, alkylthio en C1-C12, cycloalkylthio en C3-C8, haloalkylthio en C1-C12, alkylsulfinyle en C1-C12, cycloalkylsulfinyle en C3-C8, haloalkylsulfinyle en C1-C12, halocycloalkylsulfinyle en C3-C8, alkylsulfonyle en C1-C12, cycloalkylsulfonyle en C3-C8, haloalkylsulfonyle en C1-C12, halocycloalkylsulfonyle en C3-C8, -NR4R6, -X-C(=Y)-R4, -X-C(=Y)-Z-R4, -P(=O)(alkyle en OC1-C6)2, aryle, hétérocyclyle, aryloxy, arylthio et hétérocyclyloxy; R3 représente par exemple H, alkyle en C1-C12 ou alkyle en C1-C12 qui peut être éventuellement substitué. L'invention concerne également des isomères possibles E/Z de ces composés, leur mélange isomérique E/Z et/ou leur tautomère qui se présente dans chaque cas sous forme libre ou sous forme de sel. L'invention concerne enfin un procédé de préparation et d'utilisation de ces composés et de leur tautomère, des pesticides dont le principe actif est choisi parmi ces composés et leur tautomère, et un procédé de préparation de ces composés et de ces compositions, et leur utilisation.
MA28349A 2002-12-20 2005-06-17 Derives d'avermectine b1 et d'avermectine b1 monosaccharidique ayant un substituant alcoxymethyle en position 4" ou 4' MA27646A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0229804.0A GB0229804D0 (en) 2002-12-20 2002-12-20 Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position

Publications (1)

Publication Number Publication Date
MA27646A1 true MA27646A1 (fr) 2005-12-01

Family

ID=9950151

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28349A MA27646A1 (fr) 2002-12-20 2005-06-17 Derives d'avermectine b1 et d'avermectine b1 monosaccharidique ayant un substituant alcoxymethyle en position 4" ou 4'

Country Status (22)

Country Link
US (3) US7737261B2 (fr)
EP (1) EP1581546B1 (fr)
JP (2) JP4851094B2 (fr)
KR (1) KR101109500B1 (fr)
CN (1) CN1738828B (fr)
AR (1) AR042533A1 (fr)
AU (1) AU2003302284B2 (fr)
BR (1) BR0317601A (fr)
CA (1) CA2507774C (fr)
CO (1) CO5690647A1 (fr)
ES (1) ES2742899T3 (fr)
GB (1) GB0229804D0 (fr)
IL (1) IL169092A (fr)
MA (1) MA27646A1 (fr)
MX (1) MXPA05006036A (fr)
PE (1) PE20040713A1 (fr)
PL (1) PL211483B1 (fr)
RU (1) RU2330857C2 (fr)
TW (1) TW200512214A (fr)
UA (1) UA81281C2 (fr)
WO (1) WO2004056844A1 (fr)
ZA (1) ZA200504353B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0229804D0 (en) * 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
JP2010006703A (ja) * 2006-11-07 2010-01-14 Hokko Chem Ind Co Ltd アベルメクチンモノ配糖体誘導体
RU2472801C1 (ru) * 2011-05-11 2013-01-20 Игорь Викторович Заварзин 5-о-производные авермектина, способ их получения и антипаразитарные средства на их основе
RU2453553C1 (ru) * 2011-05-11 2012-06-20 Игорь Викторович Заварзин 5-о-сукциноилавермектин, способ его получения и антипаразитарное средство на его основе
CN103613625B (zh) * 2013-12-02 2016-03-02 兰州大学 一种阿维菌素类化合物及其制备方法和在农药中的用途
CN104402953B (zh) * 2014-11-28 2017-07-28 大庆志飞生物化工有限公司 阿维菌素单糖化合物及其制备方法和用途
CN104402954A (zh) * 2014-11-28 2015-03-11 大庆志飞生物化工有限公司 甲胺基阿维菌素单糖化合物及其制备方法和用途
JP6577184B2 (ja) 2014-12-24 2019-09-18 Ntn株式会社 転がり軸受
CN107501368B (zh) * 2017-09-30 2020-02-21 中国科学院成都生物研究所 一种多拉菌素衍生物的合成及其杀虫应用
CN113150053A (zh) * 2020-01-22 2021-07-23 华东理工大学 偶氮苯类阿维菌素衍生物及其制备方法和应用
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US18993A (en) * 1857-12-29 Cider-mill
US148520A (en) * 1874-03-10 Improvement in faucets
US87519A (en) * 1869-03-02 Improvement in furnace-stoves and registers
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
GB8811037D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
EP0353959A2 (fr) 1988-08-02 1990-02-07 Beecham Group Plc Antibiotiques du type macrolide à activité anthelminthique
SE465605B (sv) * 1990-02-26 1991-10-07 Harry Nilsson Skivfilter
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
US5169839A (en) * 1990-05-11 1992-12-08 Merck & Co., Inc. Derivatives of 3'- and 3"-o-desmethyl avermectin compounds, compositions and methods of treating melmintic and parasitic infections
US5262400A (en) 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
US5411737A (en) * 1991-10-15 1995-05-02 Merck & Co., Inc. Slow release syneresing polymeric drug delivery device
PL174488B1 (pl) * 1993-05-10 1998-08-31 Merck & Co Inc Preparat do zwalczania pasożytów zwierząt oraz sposób wytwarzania preparatu do zwalczania pasożytów zwierząt
US5602107A (en) * 1993-05-10 1997-02-11 Merck & Co., Inc. Pour-on formulations consisting of gylcols, glycerides and avermectin compounds
US5436355A (en) * 1994-02-03 1995-07-25 Merck & Co., Inc. Process for making avermectin/zein compositions
TW327125B (en) * 1994-02-07 1998-02-21 Merck & Co Inc Composition and method for protecting against pine exhausted
US7144866B2 (en) 2000-08-09 2006-12-05 The Kitasato Institute Avermectin derivatives
US20040087519A1 (en) 2000-08-09 2004-05-06 Satoshi Omura Avermectin derivatives
CA2477614A1 (fr) * 2002-03-05 2003-09-18 Merck & Co., Inc. Marqueur biologique indiquant l'efficacite des medicaments coupe-faim
GB0229804D0 (en) * 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position

Also Published As

Publication number Publication date
US8263566B2 (en) 2012-09-11
IL169092A (en) 2010-12-30
PL211483B1 (pl) 2012-05-31
KR20050088133A (ko) 2005-09-01
JP5302297B2 (ja) 2013-10-02
MXPA05006036A (es) 2005-08-18
JP4851094B2 (ja) 2012-01-11
US7737261B2 (en) 2010-06-15
US8017589B2 (en) 2011-09-13
CN1738828B (zh) 2012-09-05
JP2011102303A (ja) 2011-05-26
CN1738828A (zh) 2006-02-22
CA2507774C (fr) 2011-06-14
IL169092A0 (en) 2007-07-04
RU2330857C2 (ru) 2008-08-10
AU2003302284B2 (en) 2009-07-23
CA2507774A1 (fr) 2004-07-08
EP1581546A1 (fr) 2005-10-05
JP2006515849A (ja) 2006-06-08
UA81281C2 (en) 2007-12-25
BR0317601A (pt) 2005-11-29
AR042533A1 (es) 2005-06-22
EP1581546B1 (fr) 2019-03-20
US20060148729A1 (en) 2006-07-06
US20100210574A1 (en) 2010-08-19
TW200512214A (en) 2005-04-01
AU2003302284A1 (en) 2004-07-14
US20110230429A1 (en) 2011-09-22
CO5690647A1 (es) 2006-10-31
ES2742899T3 (es) 2020-02-17
ZA200504353B (en) 2006-03-29
GB0229804D0 (en) 2003-01-29
PL377497A1 (pl) 2006-02-06
PE20040713A1 (es) 2004-12-02
WO2004056844A1 (fr) 2004-07-08
KR101109500B1 (ko) 2012-01-31
RU2005122943A (ru) 2006-01-20

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