JP2006515640A - 部分的に生分解可能な温度およびpH感受性ヒドロゲル - Google Patents
部分的に生分解可能な温度およびpH感受性ヒドロゲル Download PDFInfo
- Publication number
- JP2006515640A JP2006515640A JP2004566918A JP2004566918A JP2006515640A JP 2006515640 A JP2006515640 A JP 2006515640A JP 2004566918 A JP2004566918 A JP 2004566918A JP 2004566918 A JP2004566918 A JP 2004566918A JP 2006515640 A JP2006515640 A JP 2006515640A
- Authority
- JP
- Japan
- Prior art keywords
- hydrogel
- dextran
- maleic acid
- acid monoester
- isopropylacrylamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 81
- 239000011976 maleic acid Substances 0.000 claims abstract description 39
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 230000004044 response Effects 0.000 claims abstract description 8
- 229920002307 Dextran Polymers 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 10
- 238000006467 substitution reaction Methods 0.000 claims description 9
- 230000036760 body temperature Effects 0.000 claims description 6
- 239000011557 critical solution Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 27
- 239000002243 precursor Substances 0.000 description 26
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 21
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 17
- 229920003213 poly(N-isopropyl acrylamide) Polymers 0.000 description 12
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
- 239000012153 distilled water Substances 0.000 description 9
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 9
- 239000000499 gel Substances 0.000 description 8
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 230000008961 swelling Effects 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 5
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 5
- 230000014759 maintenance of location Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid group Chemical group C(\C=C/C(=O)O)(=O)O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- KWVGIHKZDCUPEU-UHFFFAOYSA-N 2,2-dimethoxy-2-phenylacetophenone Chemical compound C=1C=CC=CC=1C(OC)(OC)C(=O)C1=CC=CC=C1 KWVGIHKZDCUPEU-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 239000002879 Lewis base Substances 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical group [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 150000007527 lewis bases Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- -1 α-D-glucopyranosyl Chemical group 0.000 description 2
- 239000004971 Cross linker Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- 230000006903 response to temperature Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000002352 surface water Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002076 thermal analysis method Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/56—Acrylamide; Methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/10—Esters
- C08F222/12—Esters of phenols or saturated alcohols
- C08F222/16—Esters having free carboxylic acid groups, e.g. monoalkyl maleates or fumarates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L51/02—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to polysaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44035503P | 2003-01-16 | 2003-01-16 | |
| PCT/US2003/035985 WO2004064816A1 (en) | 2003-01-16 | 2003-12-03 | PARTIALLY BIODEGRADABLE TEMPERATURE AND pH SENSITIVE HYDROGEL |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006515640A true JP2006515640A (ja) | 2006-06-01 |
| JP2006515640A5 JP2006515640A5 (enExample) | 2007-01-25 |
Family
ID=32771810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004566918A Pending JP2006515640A (ja) | 2003-01-16 | 2003-12-03 | 部分的に生分解可能な温度およびpH感受性ヒドロゲル |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7420024B2 (enExample) |
| EP (1) | EP1583520A4 (enExample) |
| JP (1) | JP2006515640A (enExample) |
| CN (1) | CN100341484C (enExample) |
| AU (1) | AU2003294258B2 (enExample) |
| CA (1) | CA2513502C (enExample) |
| WO (1) | WO2004064816A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008534732A (ja) * | 2005-04-13 | 2008-08-28 | スンキュンクヮン・ユニバーシティ・ファウンデーション・フォー・コーポレート・コラボレーション | 新規な温度及びpH感受性のブロック共重合体及びこれを用いた高分子ヒドロゲル |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4500263B2 (ja) * | 2003-07-28 | 2010-07-14 | 帝人株式会社 | 温度応答性ハイドロゲル |
| ATE533791T1 (de) * | 2005-09-27 | 2011-12-15 | Univ Grenoble 1 | Mit einer polymerisierbaren gruppierung funktionalisiertes hydrogel und anwendungen davon als biosensoren oder bioreaktoren |
| US9987221B2 (en) * | 2007-08-23 | 2018-06-05 | Boston Scientific Scimed, Inc. | Injectable hydrogel compositions |
| US9150788B2 (en) * | 2007-09-18 | 2015-10-06 | Syracuse University | Non-amphiphile-based water-in-water emulsion and uses thereof |
| US20090183503A1 (en) * | 2008-01-18 | 2009-07-23 | Alberto Verdesi | Exhaust apparatus |
| CN102325814B (zh) * | 2009-01-14 | 2014-03-12 | 康奈尔大学 | 用于生物医学用途的生物可降解型水凝胶的制备 |
| US10669174B2 (en) | 2011-10-26 | 2020-06-02 | The University Of Kentucky Research Foundation | Water purification device and a method of decontaminating a water supply |
| US9615573B1 (en) | 2014-09-04 | 2017-04-11 | Rose M. Moore | Product and method for providing anti-microbial delivery |
| CN108017750A (zh) * | 2017-06-28 | 2018-05-11 | 南华大学 | 一种温敏水凝胶保水剂及其制备方法和应用 |
| CN107759725B (zh) | 2017-11-10 | 2020-02-18 | 中国石油大学(华东) | 一种适用于油井水泥浆的pH敏感性吸水树脂及其应用 |
| CN109620689B (zh) * | 2019-01-10 | 2020-06-05 | 浙江大学 | 一种基于软体复合膜的柔性器及人体表面持续按摩方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5272784A (en) * | 1975-12-12 | 1977-06-17 | Pharmacia Fine Chemicals Ab | Dextrane derivative gel for electrophoresis separation |
| JPH11322941A (ja) * | 1998-05-11 | 1999-11-26 | Japan Science & Technology Corp | 温度応答型生体内分解性高分子 |
| JP2002256075A (ja) * | 2001-02-28 | 2002-09-11 | Sentomedo:Kk | 温度応答性材料およびそれを含む組成物 |
| JP2002541308A (ja) * | 1999-04-12 | 2002-12-03 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 疎水性および親水性の成分を有する水性ゲル形成システム |
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| CH445129A (fr) * | 1964-04-29 | 1967-10-15 | Nestle Sa | Procédé pour la préparation de composés d'inclusion à poids moléculaire élevé |
| US3732206A (en) * | 1971-03-01 | 1973-05-08 | Anheuser Busch | Preparation of ether-ester starch derivative |
| GB1424862A (en) * | 1973-01-19 | 1976-02-11 | Research Corp | Resin compositions |
| US3884909A (en) * | 1973-09-24 | 1975-05-20 | Standard Brands Inc | Gelatinizable crosslinked cationic starch and method for its manufacture |
| US4032488A (en) * | 1975-10-03 | 1977-06-28 | Meito Sangyo Kabushiki Kaisha | Dextran ester-olefin compound copolymer and process for preparing same |
| DE3613309A1 (de) * | 1986-04-19 | 1987-10-22 | Huels Chemische Werke Ag | Verfahren zur herstellung von wasserabsorbierenden und wasserquellfaehigen polysaccharidpfropfpolymeren |
| JPS63118308A (ja) * | 1986-11-06 | 1988-05-23 | Nippon Synthetic Chem Ind Co Ltd:The | 高吸水性樹脂の製造法 |
| DE3714732C3 (de) * | 1987-05-02 | 1994-07-14 | Grillo Werke Ag | Copolymerisate auf der Basis von ungesättigten Carbonsäuren und zur Enolatbildung befähigten Monosacchariden, Verfahren zur Herstellung derselben und ihre Verwendung |
| DE3801633A1 (de) * | 1988-01-21 | 1989-07-27 | Starchem Gmbh | Verfahren zur herstellung von wasserabsorbierenden und wasserquellbaren polysaccharid-pfropfpolymeren |
| US4958015A (en) * | 1988-09-30 | 1990-09-18 | Uop | Preparation of crosslinked cyclodextrin resins with enhanced porosity |
| US5003022A (en) * | 1989-02-10 | 1991-03-26 | Penford Products Company | Starch graft polymers |
| DE3920621A1 (de) * | 1989-06-23 | 1991-01-03 | Battelle Institut E V | Formmasse auf der basis von staerkeether zur ausformung biologisch abbaubarer formteile |
| US5055541A (en) * | 1989-06-27 | 1991-10-08 | Sequa Chemicals, Inc. | Starch polymer graft composition and method of preparation |
| FR2663940B1 (fr) * | 1990-07-02 | 1994-04-08 | Rhone Poulenc Chimie | Polysaccharides greffes, leur procede de preparation et leur application comme agents de sequestration. |
| US5529914A (en) * | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| US5403898A (en) * | 1992-05-04 | 1995-04-04 | Brigham Young University | Single arm attached cyclodextrin polysiloxanes and use thereof as chiral stationary phases in chromatographic separation of enantiomers |
| EP0748342B1 (en) * | 1994-03-04 | 2001-10-04 | University of Washington | Block and graft copolymers and methods relating thereto |
| FI98818C (fi) * | 1994-03-21 | 1997-08-25 | Valtion Teknillinen | Alifaattisilla polyestereillä oksastetut tärkkelysjohdannaiset ja menetelmä niiden valmistamiseksi sekä käyttö |
| US5603955A (en) * | 1994-07-18 | 1997-02-18 | University Of Cincinnati | Enhanced loading of solutes into polymer gels |
| JP3008071B2 (ja) * | 1995-03-03 | 2000-02-14 | 日本コーンスターチ株式会社 | エステル化ビニルエステルグラフト重合澱粉 |
| US5540929A (en) * | 1995-03-08 | 1996-07-30 | Board Of Trustees Operating Michigan State University | Polysaccharides grafted with aliphatic polyesters derived from cyclic esters |
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| TW354451B (en) * | 1995-09-18 | 1999-03-11 | Ibm | Method of fabricating cross-linked biobased materials and structures fabricated therewith a method comprising the step of: forming the mixture of polymer and cross-linked agent |
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-
2003
- 2003-12-03 WO PCT/US2003/035985 patent/WO2004064816A1/en not_active Ceased
- 2003-12-03 AU AU2003294258A patent/AU2003294258B2/en not_active Ceased
- 2003-12-03 JP JP2004566918A patent/JP2006515640A/ja active Pending
- 2003-12-03 CN CNB2003801084269A patent/CN100341484C/zh not_active Expired - Fee Related
- 2003-12-03 US US10/537,354 patent/US7420024B2/en not_active Expired - Fee Related
- 2003-12-03 EP EP03789739A patent/EP1583520A4/en not_active Withdrawn
- 2003-12-03 CA CA2513502A patent/CA2513502C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5272784A (en) * | 1975-12-12 | 1977-06-17 | Pharmacia Fine Chemicals Ab | Dextrane derivative gel for electrophoresis separation |
| JPH11322941A (ja) * | 1998-05-11 | 1999-11-26 | Japan Science & Technology Corp | 温度応答型生体内分解性高分子 |
| JP2002541308A (ja) * | 1999-04-12 | 2002-12-03 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 疎水性および親水性の成分を有する水性ゲル形成システム |
| JP2002256075A (ja) * | 2001-02-28 | 2002-09-11 | Sentomedo:Kk | 温度応答性材料およびそれを含む組成物 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008534732A (ja) * | 2005-04-13 | 2008-08-28 | スンキュンクヮン・ユニバーシティ・ファウンデーション・フォー・コーポレート・コラボレーション | 新規な温度及びpH感受性のブロック共重合体及びこれを用いた高分子ヒドロゲル |
| JP4753992B2 (ja) * | 2005-04-13 | 2011-08-24 | スンキュンクヮン・ユニバーシティ・ファウンデーション・フォー・コーポレート・コラボレーション | 新規な温度及びpH感受性のブロック共重合体及びこれを用いた高分子ヒドロゲル |
| US8835492B2 (en) | 2005-04-13 | 2014-09-16 | Sungyunkwan University Foundation For Corporate Collaboration | Temperature and pH sensitive block copolymer and polymeric hydrogels using the same |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2513502A1 (en) | 2004-08-05 |
| CN1735406A (zh) | 2006-02-15 |
| AU2003294258B2 (en) | 2009-05-28 |
| EP1583520A1 (en) | 2005-10-12 |
| US7420024B2 (en) | 2008-09-02 |
| CN100341484C (zh) | 2007-10-10 |
| EP1583520A4 (en) | 2007-05-23 |
| WO2004064816A1 (en) | 2004-08-05 |
| AU2003294258A1 (en) | 2004-08-13 |
| US20060128918A1 (en) | 2006-06-15 |
| CA2513502C (en) | 2012-02-07 |
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