JP2006515620A5 - - Google Patents

Info

Publication number

JP2006515620A5

JP2006515620A5 JP2006500813A JP2006500813A JP2006515620A5 JP 2006515620 A5 JP2006515620 A5 JP 2006515620A5 JP 2006500813 A JP2006500813 A JP 2006500813A JP 2006500813 A JP2006500813 A JP 2006500813A JP 2006515620 A5 JP2006515620 A5 JP 2006515620A5

Authority

JP

Japan

Prior art keywords

insulin

use according

medicament

oral administration

hours

Prior art date

2004-01-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 86
• 102000004877 Insulin Human genes 0.000 claims 41
• 108090001061 Insulin Proteins 0.000 claims 41
• 229940125396 insulin Drugs 0.000 claims 41
• 239000003814 drug Substances 0.000 claims 17
• 241000124008 Mammalia Species 0.000 claims 15
• 206010012601 diabetes mellitus Diseases 0.000 claims 10
• 238000004519 manufacturing process Methods 0.000 claims 8
• VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims 6
• 108010075254 C-Peptide Proteins 0.000 claims 6
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 6
• 208000002705 Glucose Intolerance Diseases 0.000 claims 6
• 239000008103 glucose Substances 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• 201000009104 prediabetes syndrome Diseases 0.000 claims 6
• UQFYDAAKCZKDHS-UHFFFAOYSA-M sodium;4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate Chemical compound [Na+].OC1=CC(Cl)=CC=C1C(=O)NCCCC([O-])=O UQFYDAAKCZKDHS-UHFFFAOYSA-M 0.000 claims 6
• 241000282414 Homo sapiens Species 0.000 claims 5
• 210000004369 blood Anatomy 0.000 claims 5
• 239000008280 blood Substances 0.000 claims 5
• 239000000126 substance Substances 0.000 claims 5
• 238000010521 absorption reaction Methods 0.000 claims 4
• 230000007423 decrease Effects 0.000 claims 4
• 229940124447 delivery agent Drugs 0.000 claims 4
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 4
• 239000002552 dosage form Substances 0.000 claims 3
• 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 241000283690 Bos taurus Species 0.000 claims 1
• 241000283073 Equus caballus Species 0.000 claims 1
• 241000282326 Felis catus Species 0.000 claims 1
• 241001494479 Pecora Species 0.000 claims 1
• 241000009328 Perro Species 0.000 claims 1
• 241000283984 Rodentia Species 0.000 claims 1
• 241000282898 Sus scrofa Species 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 230000030833 cell death Effects 0.000 claims 1
• 230000003915 cell function Effects 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 230000004064 dysfunction Effects 0.000 claims 1
• 238000005259 measurement Methods 0.000 claims 1
• 210000004877 mucosa Anatomy 0.000 claims 1
• 229940125395 oral insulin Drugs 0.000 claims 1
• 210000005259 peripheral blood Anatomy 0.000 claims 1
• 239000011886 peripheral blood Substances 0.000 claims 1
• 210000003240 portal vein Anatomy 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000002035 prolonged effect Effects 0.000 claims 1
• 239000007909 solid dosage form Substances 0.000 claims 1