JP2006515358A5 - - Google Patents
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- Publication number
- JP2006515358A5 JP2006515358A5 JP2006500252A JP2006500252A JP2006515358A5 JP 2006515358 A5 JP2006515358 A5 JP 2006515358A5 JP 2006500252 A JP2006500252 A JP 2006500252A JP 2006500252 A JP2006500252 A JP 2006500252A JP 2006515358 A5 JP2006515358 A5 JP 2006515358A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- group
- sulfonic
- pka
- phosphonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03250868.1 | 2003-02-12 | ||
| EP03250868 | 2003-02-12 | ||
| GB0305322A GB0305322D0 (en) | 2003-03-07 | 2003-03-07 | Chemoembolisation |
| GB0305322.0 | 2003-03-07 | ||
| PCT/GB2004/000548 WO2004071495A1 (en) | 2003-02-12 | 2004-02-12 | Composition for chemoembolotherapy of solid tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011034961A Division JP5616251B2 (ja) | 2003-02-12 | 2011-02-21 | 固形腫瘍の化学的塞栓療法用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006515358A JP2006515358A (ja) | 2006-05-25 |
| JP2006515358A5 true JP2006515358A5 (https=) | 2011-04-14 |
| JP4895802B2 JP4895802B2 (ja) | 2012-03-14 |
Family
ID=32870779
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500252A Expired - Lifetime JP4895802B2 (ja) | 2003-02-12 | 2004-02-12 | 固形腫瘍の化学的塞栓療法用組成物 |
| JP2011034961A Expired - Lifetime JP5616251B2 (ja) | 2003-02-12 | 2011-02-21 | 固形腫瘍の化学的塞栓療法用組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011034961A Expired - Lifetime JP5616251B2 (ja) | 2003-02-12 | 2011-02-21 | 固形腫瘍の化学的塞栓療法用組成物 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1592405B1 (https=) |
| JP (2) | JP4895802B2 (https=) |
| KR (1) | KR101157260B1 (https=) |
| CN (4) | CN103393605B (https=) |
| AT (1) | ATE396708T1 (https=) |
| DE (1) | DE602004014101D1 (https=) |
| ES (1) | ES2308149T3 (https=) |
| HK (1) | HK1079980B (https=) |
| WO (1) | WO2004071495A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100872884B1 (ko) | 2000-03-24 | 2008-12-10 | 바이오스피어 메디칼 인코포레이티드 | 능동 색전화용 미소구 |
| WO2005087193A2 (en) * | 2004-03-11 | 2005-09-22 | Biocompatibles Uk Limited | Chemoembolisation involving an anthracycline compound |
| US20070275991A1 (en) * | 2004-09-07 | 2007-11-29 | Biocompatibles Uk Limited | Drug Delivery From Embolic Agents |
| KR101429774B1 (ko) * | 2005-05-09 | 2014-10-02 | 바이오스피어 메디칼 에스.에이. | 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및방법 |
| US20080305176A1 (en) * | 2006-01-24 | 2008-12-11 | Biocompatibles Uk Limited | Process For Loading Polymer Particles With Drug |
| WO2007090127A2 (en) | 2006-01-30 | 2007-08-09 | Surgica Corporation | Compressible intravascular embolization particles and related methods and delivery systems |
| US9107833B2 (en) | 2006-06-22 | 2015-08-18 | Biocompatibles Uk Limited | Rehydratable pharmaceutical product |
| EP1985286A1 (en) | 2007-04-24 | 2008-10-29 | Biocompatibles UK Limited | Microspheres for treatment of brain tumours |
| WO2008138758A1 (en) | 2007-05-11 | 2008-11-20 | Nerviano Medical Sciences S.R.L. | Pharmaceutical composition of an anthracycline |
| JP2010536738A (ja) * | 2007-08-16 | 2010-12-02 | バイオコンパティブルズ ユーケー リミテッド | 薬剤の組み合わせの送達 |
| CA2745238A1 (en) * | 2008-12-02 | 2010-06-10 | Biocompatibles Uk Limited | Pancreatic tumour treatment |
| GB201101429D0 (en) * | 2011-01-27 | 2011-03-16 | Biocompatibles Uk Ltd | Drug delivery system |
| JP5957610B2 (ja) | 2012-08-31 | 2016-07-27 | チュンアン ユニバーシティー インダストリー アカデミック コアポレイション ファウンデイション | 塞栓用のミクロスフェアの製造方法及び薬物含有ナノ輸送体が結合されたミクロスフェアの製造方法 |
| HK1220119A1 (zh) * | 2013-03-15 | 2017-04-28 | Matthew R. Dreher | 可成像栓塞微球 |
| GB2519738A (en) * | 2013-09-06 | 2015-05-06 | Biocompatibles Uk Ltd | Radiopaque polymers |
| GB2521997A (en) * | 2013-09-06 | 2015-07-15 | Biocompatibles Uk Ltd | Radiopaque polymers |
| WO2016139590A1 (en) * | 2015-03-02 | 2016-09-09 | Accurate Medical Therapeutics Ltd. | Embolization particulates for occluding a blood vessel |
| GB201515602D0 (en) | 2015-09-03 | 2015-10-21 | Biocompatibles Uk Ltd | Polymers and microspheres |
| US20190070332A1 (en) | 2016-03-14 | 2019-03-07 | Biocompatibles Uk Limited | Oily compositions |
| ES2865433T3 (es) | 2016-05-04 | 2021-10-15 | Accurate Medical Therapeutics Ltd | Cabezal de microcatéter de embolización que tiene un patrón ranurado |
| EP3541368B1 (en) | 2016-11-16 | 2023-07-12 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Imageable particles, methods of making and methods of use thereof |
| WO2019014408A1 (en) * | 2017-07-13 | 2019-01-17 | Boston Scientific Scimed, Inc. | EMBOLIC MICROSPHERES |
| WO2019087191A1 (en) | 2017-11-02 | 2019-05-09 | Accurate Medical Therapeutics Ltd. | Embolization catheter with integral filter |
| JP7322073B2 (ja) | 2018-06-29 | 2023-08-07 | バイオコンパティブルズ ユーケー リミテッド | 放射線不透過性ポリマー |
| AU2020244771B2 (en) | 2019-03-22 | 2022-10-27 | Biocompatibles Uk Limited | Embolic microspheres and methods |
| EP3972500B1 (en) | 2019-05-23 | 2025-04-30 | Accurate Medical Therapeutics Ltd. | Embolization catheter for reflux free delivery of microspheres |
| GB201910286D0 (en) | 2019-07-18 | 2019-09-04 | Biocompatibles Uk Ltd | Radiopaque polymers |
| IL295498A (en) * | 2020-02-25 | 2022-10-01 | Hepion Pharmaceuticals Inc | Use of cyclosporine analogues for treating cancer |
| CN114099442B (zh) * | 2020-08-25 | 2024-01-30 | 复旦大学 | 用于肿瘤放化疗栓塞治疗和影像的多功能微球制剂及其制备方法 |
| CN113797383A (zh) * | 2021-09-28 | 2021-12-17 | 迪格瑞医疗科技(苏州)有限公司 | 一种高弹性、高载药量的栓塞微球及其制备方法 |
| US20230201122A1 (en) | 2021-12-23 | 2023-06-29 | Boston Scientific Medical Device Limited | Chemoembolic compositions and methods of treatment using them |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4978713A (en) * | 1987-12-16 | 1990-12-18 | Ciba-Geigy Corporation | Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bound through ether groups and hydrogel contact lenses made therefrom |
| JP3041627B2 (ja) * | 1989-04-13 | 2000-05-15 | 武田薬品工業株式会社 | アントラサイクリン系抗生物質の安定組成物 |
| JPH06329542A (ja) * | 1993-05-21 | 1994-11-29 | Kibun Food Chemifa Co Ltd | 不溶性アルギン酸塩粒子を含む局所血管止血用組成物および動脈化学塞栓用組成物 |
| US5932248A (en) * | 1993-11-18 | 1999-08-03 | Paragon Medical Limited | Controlled release preparations for cytotoxic or cytostatic drugs |
| AU8877098A (en) * | 1997-09-05 | 1999-03-29 | Nycomed Imaging As | Polymer particles made of polyvinyl alcohol and comprising contrast agent for chemoembolization |
| AU4566001A (en) * | 2000-03-13 | 2001-09-24 | Biocure Inc | Embolic compositions |
| US6852816B2 (en) * | 2000-10-06 | 2005-02-08 | Biocompatibles Uk Limited | Zwitterionic polymers |
| US20060165804A1 (en) * | 2002-09-25 | 2006-07-27 | Lewis Andrew L | Polymer compositions for administration to animals |
-
2004
- 2004-02-12 CN CN201310320841.6A patent/CN103393605B/zh not_active Expired - Lifetime
- 2004-02-12 CN CN201210299592.2A patent/CN102895662B/zh not_active Expired - Lifetime
- 2004-02-12 CN CN201610844279.0A patent/CN106267325B/zh not_active Expired - Lifetime
- 2004-02-12 HK HK05112166.8A patent/HK1079980B/en not_active IP Right Cessation
- 2004-02-12 DE DE602004014101T patent/DE602004014101D1/de not_active Expired - Lifetime
- 2004-02-12 WO PCT/GB2004/000548 patent/WO2004071495A1/en not_active Ceased
- 2004-02-12 CN CN201410044028.5A patent/CN103908704B/zh not_active Expired - Lifetime
- 2004-02-12 JP JP2006500252A patent/JP4895802B2/ja not_active Expired - Lifetime
- 2004-02-12 EP EP04710431A patent/EP1592405B1/en not_active Expired - Lifetime
- 2004-02-12 AT AT04710431T patent/ATE396708T1/de not_active IP Right Cessation
- 2004-02-12 KR KR1020057014847A patent/KR101157260B1/ko not_active Expired - Fee Related
- 2004-02-12 ES ES04710431T patent/ES2308149T3/es not_active Expired - Lifetime
-
2011
- 2011-02-21 JP JP2011034961A patent/JP5616251B2/ja not_active Expired - Lifetime
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