CN102895662B - 用于实体瘤的化学栓塞治疗的组合物 - Google Patents

用于实体瘤的化学栓塞治疗的组合物 Download PDF

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Publication number
CN102895662B
CN102895662B CN201210299592.2A CN201210299592A CN102895662B CN 102895662 B CN102895662 B CN 102895662B CN 201210299592 A CN201210299592 A CN 201210299592A CN 102895662 B CN102895662 B CN 102895662B
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China
Prior art keywords
water
composition according
microballoon
particle
composition
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Expired - Lifetime
Application number
CN201210299592.2A
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English (en)
Chinese (zh)
Other versions
CN102895662A (zh
Inventor
A·L·刘易斯
P·W·斯特拉福德
S·W·莱帕德
B·霍尔
福哈多 M·V·冈萨雷斯
P·加西亚
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Boston Scientific Medical Device Ltd
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Biocompatibles UK Ltd
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Priority claimed from GB0305322A external-priority patent/GB0305322D0/en
Application filed by Biocompatibles UK Ltd filed Critical Biocompatibles UK Ltd
Priority claimed from CNA2004800040624A external-priority patent/CN1747721A/zh
Publication of CN102895662A publication Critical patent/CN102895662A/zh
Application granted granted Critical
Publication of CN102895662B publication Critical patent/CN102895662B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0015Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00Processes of polymerisation
    • C08F2/12Polymerisation in non-solvents
    • C08F2/14Organic medium
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/12Polymers provided for in subclasses C08C or C08F
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/30Introducing nitrogen atoms or nitrogen-containing groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/48Isomerisation; Cyclisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23Carbohydrates
    • A61L2300/232Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00Chemical modification of a polymer
    • C08F2810/30Chemical modification of a polymer leading to the formation or introduction of aliphatic or alicyclic unsaturated groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
CN201210299592.2A 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物 Expired - Lifetime CN102895662B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP03250868 2003-02-12
EP03250868.1 2003-02-12
GB0305322.0 2003-03-07
GB0305322A GB0305322D0 (en) 2003-03-07 2003-03-07 Chemoembolisation
CNA2004800040624A CN1747721A (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800040624A Division CN1747721A (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物

Publications (2)

Publication Number Publication Date
CN102895662A CN102895662A (zh) 2013-01-30
CN102895662B true CN102895662B (zh) 2017-09-12

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Family Applications (4)

Application Number Title Priority Date Filing Date
CN201210299592.2A Expired - Lifetime CN102895662B (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物
CN201410044028.5A Expired - Lifetime CN103908704B (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物
CN201310320841.6A Expired - Lifetime CN103393605B (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物
CN201610844279.0A Expired - Lifetime CN106267325B (zh) 2003-02-12 2004-02-12 一种组合物的生产方法

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Application Number Title Priority Date Filing Date
CN201410044028.5A Expired - Lifetime CN103908704B (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物
CN201310320841.6A Expired - Lifetime CN103393605B (zh) 2003-02-12 2004-02-12 用于实体瘤的化学栓塞治疗的组合物
CN201610844279.0A Expired - Lifetime CN106267325B (zh) 2003-02-12 2004-02-12 一种组合物的生产方法

Country Status (9)

Country Link
EP (1) EP1592405B1 (https=)
JP (2) JP4895802B2 (https=)
KR (1) KR101157260B1 (https=)
CN (4) CN102895662B (https=)
AT (1) ATE396708T1 (https=)
DE (1) DE602004014101D1 (https=)
ES (1) ES2308149T3 (https=)
HK (1) HK1079980B (https=)
WO (1) WO2004071495A1 (https=)

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DE01918975T1 (de) 2000-03-24 2006-04-13 Biosphere Medical, Inc., Rockland Mikrokügelchen zur aktiven Embolisierung
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
EP3085361A1 (en) * 2004-09-07 2016-10-26 Biocompatibles UK Limited Compositions comprising camptothecins in microspheres
KR20140090270A (ko) * 2005-05-09 2014-07-16 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및 방법
US20080305176A1 (en) * 2006-01-24 2008-12-11 Biocompatibles Uk Limited Process For Loading Polymer Particles With Drug
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
EP2034951B2 (en) 2006-06-22 2020-03-25 Biocompatibles UK Limited Rehydratable pharmaceutical product
EP1985286A1 (en) 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
JP5302300B2 (ja) * 2007-05-11 2013-10-02 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ アンスラサイクリンの医薬組成物
WO2009022190A1 (en) * 2007-08-16 2009-02-19 Biocompatibles Uk Limited Delivery of drug combinations
EP3181123A1 (en) 2008-12-02 2017-06-21 Biocompatibles Uk Ltd. Pancreatic tumour treatment
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
US20150224221A1 (en) 2012-08-31 2015-08-13 Chung-Ang University Industry-Academic Cooperation Foundation Method for preparing microspheres for emboli, and method for preparing microspheres to which drug-containing carrier is bound
JP6420817B2 (ja) * 2013-03-15 2018-11-07 バイオコンパティブルズ ユーケー リミテッド 結像可能な塞栓性微小球
GB2519738A (en) 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
PL3264997T3 (pl) 2015-03-02 2019-07-31 Accurate Medical Therapeutics Ltd. Cewniki z otworami bocznymi do modyfikowania i podawania zawiesin pacjentowi
GB201515602D0 (en) 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
CN115137870B (zh) 2016-03-14 2024-05-10 生物相容性英国公司 包含颗粒的乳液
JP6921116B2 (ja) 2016-05-04 2021-08-18 アキュレイト メディカル セラピューティクス リミテッド スリットパターンを有する塞栓マイクロカテーテルヘッド
US11382990B2 (en) 2016-11-16 2022-07-12 The Usa, As Represented By The Secretary, Dhhs Imageable polymers, methods of making and methods of use thereof
CN116173284B (zh) * 2017-07-13 2025-09-19 瓦里安医疗系统公司 栓塞微球
JP7364193B2 (ja) 2017-11-02 2023-10-18 アキュレイト メディカル セラピューティクス リミテッド 内蔵フィルタを有する塞栓術用カテーテル
TW202000189A (zh) 2018-06-29 2020-01-01 英商白康帝英國有限公司 不透射線聚合物
CN113727699A (zh) 2019-03-22 2021-11-30 生物相容英国有限公司 栓塞微球和方法
WO2020234889A1 (en) 2019-05-23 2020-11-26 Accurate Medical Therapeutics Ltd. Embolization catheter for reflux free delivery of microspheres
GB201910286D0 (en) 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
AU2021227230A1 (en) * 2020-02-25 2022-09-08 Hepion Pharmaceuticals, Inc. Use of cyclosporine analogues for treating cancer
CN114099442B (zh) * 2020-08-25 2024-01-30 复旦大学 用于肿瘤放化疗栓塞治疗和影像的多功能微球制剂及其制备方法
CN113797383A (zh) * 2021-09-28 2021-12-17 迪格瑞医疗科技(苏州)有限公司 一种高弹性、高载药量的栓塞微球及其制备方法
CN118434411A (zh) 2021-12-23 2024-08-02 波士顿科学医疗设备有限公司 化学栓塞组合物及其治疗方法

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Also Published As

Publication number Publication date
CN103908704B (zh) 2017-09-01
JP5616251B2 (ja) 2014-10-29
CN103393605B (zh) 2018-05-29
CN103908704A (zh) 2014-07-09
CN102895662A (zh) 2013-01-30
KR101157260B1 (ko) 2012-06-15
CN106267325A (zh) 2017-01-04
CN103393605A (zh) 2013-11-20
JP2006515358A (ja) 2006-05-25
JP4895802B2 (ja) 2012-03-14
ES2308149T3 (es) 2008-12-01
WO2004071495A1 (en) 2004-08-26
ATE396708T1 (de) 2008-06-15
KR20050103224A (ko) 2005-10-27
DE602004014101D1 (de) 2008-07-10
JP2011178784A (ja) 2011-09-15
HK1079980A1 (en) 2006-04-21
CN106267325B (zh) 2019-09-24
EP1592405B1 (en) 2008-05-28
EP1592405A1 (en) 2005-11-09
HK1079980B (en) 2008-11-14

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