KR101157260B1 - 고형 종양의 화학색전술용 조성물 - Google Patents

고형 종양의 화학색전술용 조성물 Download PDF

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Publication number
KR101157260B1
KR101157260B1 KR1020057014847A KR20057014847A KR101157260B1 KR 101157260 B1 KR101157260 B1 KR 101157260B1 KR 1020057014847 A KR1020057014847 A KR 1020057014847A KR 20057014847 A KR20057014847 A KR 20057014847A KR 101157260 B1 KR101157260 B1 KR 101157260B1
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South Korea
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composition
microspheres
water
polymer
doxorubicin
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Expired - Fee Related
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KR1020057014847A
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English (en)
Korean (ko)
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KR20050103224A (ko
Inventor
앤드류 루이스
피터 윌리엄 스트라포드
사이먼 윌리엄 레파드
브렌다 할
파자르도 마리아 빅토리아 곤잘레스
페드로 가르시아
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바이오컴페터블즈 유케이 리미티드
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Publication of KR20050103224A publication Critical patent/KR20050103224A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/12—Polymerisation in non-solvents
    • C08F2/14—Organic medium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/12—Polymers provided for in subclasses C08C or C08F
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/48—Isomerisation; Cyclisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/30—Chemical modification of a polymer leading to the formation or introduction of aliphatic or alicyclic unsaturated groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
KR1020057014847A 2003-02-12 2004-02-12 고형 종양의 화학색전술용 조성물 Expired - Fee Related KR101157260B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP03250868.1 2003-02-12
EP03250868 2003-02-12
GB0305322A GB0305322D0 (en) 2003-03-07 2003-03-07 Chemoembolisation
GB0305322.0 2003-03-07
PCT/GB2004/000548 WO2004071495A1 (en) 2003-02-12 2004-02-12 Composition for chemoembolotherapy of solid tumors

Publications (2)

Publication Number Publication Date
KR20050103224A KR20050103224A (ko) 2005-10-27
KR101157260B1 true KR101157260B1 (ko) 2012-06-15

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KR1020057014847A Expired - Fee Related KR101157260B1 (ko) 2003-02-12 2004-02-12 고형 종양의 화학색전술용 조성물

Country Status (9)

Country Link
EP (1) EP1592405B1 (https=)
JP (2) JP4895802B2 (https=)
KR (1) KR101157260B1 (https=)
CN (4) CN103393605B (https=)
AT (1) ATE396708T1 (https=)
DE (1) DE602004014101D1 (https=)
ES (1) ES2308149T3 (https=)
HK (1) HK1079980B (https=)
WO (1) WO2004071495A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014035206A2 (ko) 2012-08-31 2014-03-06 중앙대학교 산학협력단 색전용 마이크로스피어의 제조방법 및 약물 함유 나노수송체가 결합된 마이크로스피어의 제조방법

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100872884B1 (ko) 2000-03-24 2008-12-10 바이오스피어 메디칼 인코포레이티드 능동 색전화용 미소구
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
US20070275991A1 (en) * 2004-09-07 2007-11-29 Biocompatibles Uk Limited Drug Delivery From Embolic Agents
KR101429774B1 (ko) * 2005-05-09 2014-10-02 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및방법
US20080305176A1 (en) * 2006-01-24 2008-12-11 Biocompatibles Uk Limited Process For Loading Polymer Particles With Drug
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US9107833B2 (en) 2006-06-22 2015-08-18 Biocompatibles Uk Limited Rehydratable pharmaceutical product
EP1985286A1 (en) 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
WO2008138758A1 (en) 2007-05-11 2008-11-20 Nerviano Medical Sciences S.R.L. Pharmaceutical composition of an anthracycline
JP2010536738A (ja) * 2007-08-16 2010-12-02 バイオコンパティブルズ ユーケー リミテッド 薬剤の組み合わせの送達
CA2745238A1 (en) * 2008-12-02 2010-06-10 Biocompatibles Uk Limited Pancreatic tumour treatment
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
HK1220119A1 (zh) * 2013-03-15 2017-04-28 Matthew R. Dreher 可成像栓塞微球
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) * 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
WO2016139590A1 (en) * 2015-03-02 2016-09-09 Accurate Medical Therapeutics Ltd. Embolization particulates for occluding a blood vessel
GB201515602D0 (en) 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
US20190070332A1 (en) 2016-03-14 2019-03-07 Biocompatibles Uk Limited Oily compositions
ES2865433T3 (es) 2016-05-04 2021-10-15 Accurate Medical Therapeutics Ltd Cabezal de microcatéter de embolización que tiene un patrón ranurado
EP3541368B1 (en) 2016-11-16 2023-07-12 The United States of America, as represented by the Secretary, Department of Health and Human Services Imageable particles, methods of making and methods of use thereof
WO2019014408A1 (en) * 2017-07-13 2019-01-17 Boston Scientific Scimed, Inc. EMBOLIC MICROSPHERES
WO2019087191A1 (en) 2017-11-02 2019-05-09 Accurate Medical Therapeutics Ltd. Embolization catheter with integral filter
JP7322073B2 (ja) 2018-06-29 2023-08-07 バイオコンパティブルズ ユーケー リミテッド 放射線不透過性ポリマー
AU2020244771B2 (en) 2019-03-22 2022-10-27 Biocompatibles Uk Limited Embolic microspheres and methods
EP3972500B1 (en) 2019-05-23 2025-04-30 Accurate Medical Therapeutics Ltd. Embolization catheter for reflux free delivery of microspheres
GB201910286D0 (en) 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
IL295498A (en) * 2020-02-25 2022-10-01 Hepion Pharmaceuticals Inc Use of cyclosporine analogues for treating cancer
CN114099442B (zh) * 2020-08-25 2024-01-30 复旦大学 用于肿瘤放化疗栓塞治疗和影像的多功能微球制剂及其制备方法
CN113797383A (zh) * 2021-09-28 2021-12-17 迪格瑞医疗科技(苏州)有限公司 一种高弹性、高载药量的栓塞微球及其制备方法
US20230201122A1 (en) 2021-12-23 2023-06-29 Boston Scientific Medical Device Limited Chemoembolic compositions and methods of treatment using them

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978713A (en) * 1987-12-16 1990-12-18 Ciba-Geigy Corporation Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bound through ether groups and hydrogel contact lenses made therefrom

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3041627B2 (ja) * 1989-04-13 2000-05-15 武田薬品工業株式会社 アントラサイクリン系抗生物質の安定組成物
JPH06329542A (ja) * 1993-05-21 1994-11-29 Kibun Food Chemifa Co Ltd 不溶性アルギン酸塩粒子を含む局所血管止血用組成物および動脈化学塞栓用組成物
US5932248A (en) * 1993-11-18 1999-08-03 Paragon Medical Limited Controlled release preparations for cytotoxic or cytostatic drugs
AU8877098A (en) * 1997-09-05 1999-03-29 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising contrast agent for chemoembolization
AU4566001A (en) * 2000-03-13 2001-09-24 Biocure Inc Embolic compositions
US6852816B2 (en) * 2000-10-06 2005-02-08 Biocompatibles Uk Limited Zwitterionic polymers
US20060165804A1 (en) * 2002-09-25 2006-07-27 Lewis Andrew L Polymer compositions for administration to animals

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978713A (en) * 1987-12-16 1990-12-18 Ciba-Geigy Corporation Polyvinyl alcohol derivatives containing pendant vinylic monomer reaction product units bound through ether groups and hydrogel contact lenses made therefrom

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014035206A2 (ko) 2012-08-31 2014-03-06 중앙대학교 산학협력단 색전용 마이크로스피어의 제조방법 및 약물 함유 나노수송체가 결합된 마이크로스피어의 제조방법

Also Published As

Publication number Publication date
KR20050103224A (ko) 2005-10-27
CN103908704B (zh) 2017-09-01
HK1079980A1 (en) 2006-04-21
CN103393605B (zh) 2018-05-29
JP2011178784A (ja) 2011-09-15
EP1592405A1 (en) 2005-11-09
CN103908704A (zh) 2014-07-09
HK1079980B (en) 2008-11-14
ATE396708T1 (de) 2008-06-15
JP4895802B2 (ja) 2012-03-14
ES2308149T3 (es) 2008-12-01
JP5616251B2 (ja) 2014-10-29
CN106267325A (zh) 2017-01-04
DE602004014101D1 (de) 2008-07-10
CN106267325B (zh) 2019-09-24
CN103393605A (zh) 2013-11-20
CN102895662B (zh) 2017-09-12
JP2006515358A (ja) 2006-05-25
CN102895662A (zh) 2013-01-30
EP1592405B1 (en) 2008-05-28
WO2004071495A1 (en) 2004-08-26

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