JP2006515275A5 - - Google Patents
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- Publication number
- JP2006515275A5 JP2006515275A5 JP2004545432A JP2004545432A JP2006515275A5 JP 2006515275 A5 JP2006515275 A5 JP 2006515275A5 JP 2004545432 A JP2004545432 A JP 2004545432A JP 2004545432 A JP2004545432 A JP 2004545432A JP 2006515275 A5 JP2006515275 A5 JP 2006515275A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutical composition
- tumor
- composition according
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- -1 n- propyl Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 206010014967 Ependymoma Diseases 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 2
- 208000025997 central nervous system neoplasm Diseases 0.000 claims 2
- 238000007917 intracranial administration Methods 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 206010027191 meningioma Diseases 0.000 claims 2
- 210000005170 neoplastic cell Anatomy 0.000 claims 2
- 208000014500 neuronal tumor Diseases 0.000 claims 2
- 206010062261 spinal cord neoplasm Diseases 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010007953 Central nervous system lymphoma Diseases 0.000 claims 1
- 201000009047 Chordoma Diseases 0.000 claims 1
- 208000009798 Craniopharyngioma Diseases 0.000 claims 1
- 208000021309 Germ cell tumor Diseases 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 102000006386 Myelin Proteins Human genes 0.000 claims 1
- 108010083674 Myelin Proteins Proteins 0.000 claims 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 1
- 208000009277 Neuroectodermal Tumors Diseases 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000010097 Unknown Primary Neoplasms Diseases 0.000 claims 1
- 206010002224 anaplastic astrocytoma Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000133 brain stem Anatomy 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 210000000038 chest Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000002429 large intestine Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 208000022080 low-grade astrocytoma Diseases 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 208000030883 malignant astrocytoma Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000008806 mesenchymal cell neoplasm Diseases 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000005012 myelin Anatomy 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 208000007538 neurilemmoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 208000010916 pituitary tumor Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000030266 primary brain neoplasm Diseases 0.000 claims 1
- 208000016800 primary central nervous system lymphoma Diseases 0.000 claims 1
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 210000004116 schwann cell Anatomy 0.000 claims 1
- 206010039667 schwannoma Diseases 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 206010055031 vascular neoplasm Diseases 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 0 *c1ccc(C(Cc(cc2)ccc2OCCN2CCCC2)=C(c(cc2)ccc2Cl)C(O2)=O)c2c1 Chemical compound *c1ccc(C(Cc(cc2)ccc2OCCN2CCCC2)=C(c(cc2)ccc2Cl)C(O2)=O)c2c1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41846902P | 2002-10-15 | 2002-10-15 | |
| US10/685,722 US7091235B2 (en) | 2002-10-15 | 2003-10-14 | Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer |
| PCT/US2003/032932 WO2004035002A2 (en) | 2002-10-15 | 2003-10-15 | Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006515275A JP2006515275A (ja) | 2006-05-25 |
| JP2006515275A5 true JP2006515275A5 (enExample) | 2006-11-24 |
Family
ID=32110155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004545432A Pending JP2006515275A (ja) | 2002-10-15 | 2003-10-15 | ベンゾピラノン化合物、その組成物および癌の治療または予防方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7091235B2 (enExample) |
| EP (1) | EP1556374A4 (enExample) |
| JP (1) | JP2006515275A (enExample) |
| KR (1) | KR20050072764A (enExample) |
| CN (1) | CN100457751C (enExample) |
| AU (1) | AU2003286441A1 (enExample) |
| BR (1) | BR0315400A (enExample) |
| CA (1) | CA2502064A1 (enExample) |
| IL (1) | IL168059A0 (enExample) |
| MX (1) | MXPA05003909A (enExample) |
| NZ (1) | NZ539675A (enExample) |
| WO (1) | WO2004035002A2 (enExample) |
| ZA (1) | ZA200503026B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091235B2 (en) * | 2002-10-15 | 2006-08-15 | Signal Pharmaceuticals, Llc | Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer |
| US7514438B2 (en) * | 2003-08-13 | 2009-04-07 | Amgen, Inc. | Melanin concentrating hormone receptor antagonist |
| CA2534428A1 (en) * | 2003-08-13 | 2005-03-03 | Paul A. Tempest | Melanin concentrating hormone receptor antagonists |
| AU2004274445A1 (en) * | 2003-09-15 | 2005-03-31 | Novartis Ag | Benzopyranone compounds, compositions thereof, and methods of treatment therewith |
| CA2595472A1 (en) | 2005-01-21 | 2006-07-27 | Janssen Pharmaceutica N.V. | Novel coumarin derivatives as ion channel openers |
| JP2008543944A (ja) * | 2005-06-24 | 2008-12-04 | シグナル ファーマシューティカルズ，エルエルシー | 癌を治療するためのベンゾピラノン化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US633155A (en) | 1898-02-23 | 1899-09-19 | William W Ramsay | Fence-repairing tool. |
| US5633155A (en) * | 1992-08-19 | 1997-05-27 | Jinro Limited | Expression vector for phytolacca antiviral protein and process for preparing transgenic plant transformed therewith |
| US6444688B1 (en) * | 1995-06-07 | 2002-09-03 | Eli Lilly And Company | Compounds and compositions with nitrogen-containing non-basic side chains |
| US6291456B1 (en) | 1998-12-30 | 2001-09-18 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| JP2002533456A (ja) | 1998-12-30 | 2002-10-08 | シグナル ファーマシューティカルズ， インコーポレイテッド | エストロゲン受容体のモジュレートを行うための化合物および方法 |
| US6331562B1 (en) | 1998-12-30 | 2001-12-18 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| EP1246814B1 (en) | 1999-12-30 | 2005-02-16 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
| US7148252B2 (en) | 2001-10-03 | 2006-12-12 | Signal Pharmaceuticals, Llc | Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis |
| AU2003239155B2 (en) * | 2002-04-19 | 2008-12-04 | Novartis Ag | Benzopyranone compounds, compositions thereof, and methods of treatment therewith |
| US6620838B1 (en) * | 2002-04-19 | 2003-09-16 | Signal Pharmaceuticals, Inc. | Benzopyrazone compounds, compositions thereof, and methods of treatment therewith |
| US7091235B2 (en) * | 2002-10-15 | 2006-08-15 | Signal Pharmaceuticals, Llc | Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer |
-
2003
- 2003-10-14 US US10/685,722 patent/US7091235B2/en not_active Expired - Fee Related
- 2003-10-15 BR BR0315400-9A patent/BR0315400A/pt not_active IP Right Cessation
- 2003-10-15 MX MXPA05003909A patent/MXPA05003909A/es active IP Right Grant
- 2003-10-15 KR KR1020057006631A patent/KR20050072764A/ko not_active Ceased
- 2003-10-15 JP JP2004545432A patent/JP2006515275A/ja active Pending
- 2003-10-15 CN CNB2003801043358A patent/CN100457751C/zh not_active Expired - Fee Related
- 2003-10-15 ZA ZA200503025A patent/ZA200503026B/xx unknown
- 2003-10-15 CA CA002502064A patent/CA2502064A1/en not_active Abandoned
- 2003-10-15 WO PCT/US2003/032932 patent/WO2004035002A2/en not_active Ceased
- 2003-10-15 EP EP03777639A patent/EP1556374A4/en not_active Withdrawn
- 2003-10-15 NZ NZ539675A patent/NZ539675A/en unknown
- 2003-10-15 AU AU2003286441A patent/AU2003286441A1/en not_active Abandoned
-
2005
- 2005-04-14 IL IL168059A patent/IL168059A0/en unknown
-
2006
- 2006-05-09 US US11/431,056 patent/US7358274B2/en not_active Expired - Fee Related
-
2008
- 2008-02-22 US US12/072,011 patent/US7589119B2/en not_active Expired - Fee Related
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