CA2502064A1 - Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer - Google Patents

Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer Download PDF

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Publication number
CA2502064A1
CA2502064A1 CA002502064A CA2502064A CA2502064A1 CA 2502064 A1 CA2502064 A1 CA 2502064A1 CA 002502064 A CA002502064 A CA 002502064A CA 2502064 A CA2502064 A CA 2502064A CA 2502064 A1 CA2502064 A1 CA 2502064A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
cancer
tumor
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002502064A
Other languages
English (en)
French (fr)
Inventor
Glenn Friedman
Jeffrey Mckie
Jonathan Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Signal Pharmaceuticals LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2502064A1 publication Critical patent/CA2502064A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
CA002502064A 2002-10-15 2003-10-15 Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer Abandoned CA2502064A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41846902P 2002-10-15 2002-10-15
US60/418,469 2002-10-15
US10/685,722 2003-10-14
US10/685,722 US7091235B2 (en) 2002-10-15 2003-10-14 Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer
PCT/US2003/032932 WO2004035002A2 (en) 2002-10-15 2003-10-15 Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer

Publications (1)

Publication Number Publication Date
CA2502064A1 true CA2502064A1 (en) 2004-04-29

Family

ID=32110155

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002502064A Abandoned CA2502064A1 (en) 2002-10-15 2003-10-15 Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer

Country Status (13)

Country Link
US (3) US7091235B2 (enExample)
EP (1) EP1556374A4 (enExample)
JP (1) JP2006515275A (enExample)
KR (1) KR20050072764A (enExample)
CN (1) CN100457751C (enExample)
AU (1) AU2003286441A1 (enExample)
BR (1) BR0315400A (enExample)
CA (1) CA2502064A1 (enExample)
IL (1) IL168059A0 (enExample)
MX (1) MXPA05003909A (enExample)
NZ (1) NZ539675A (enExample)
WO (1) WO2004035002A2 (enExample)
ZA (1) ZA200503026B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091235B2 (en) * 2002-10-15 2006-08-15 Signal Pharmaceuticals, Llc Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer
AU2004266233A1 (en) * 2003-08-13 2005-03-03 Amgen, Inc. Melanin concentrating hormone receptor antagonist
CA2534428A1 (en) * 2003-08-13 2005-03-03 Paul A. Tempest Melanin concentrating hormone receptor antagonists
WO2005028472A1 (en) * 2003-09-15 2005-03-31 Signal Pharmaceuticals, Llc Benzopyranone compounds, compositions thereof, and methods of treatment therewith
JP2008528495A (ja) * 2005-01-21 2008-07-31 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ イオンチャンネル開口薬としての新規なクマリン誘導体
AU2006262190A1 (en) * 2005-06-24 2007-01-04 Signal Pharmaceuticals, Llc. Benzopyranone compounds for treating cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US633155A (en) 1898-02-23 1899-09-19 William W Ramsay Fence-repairing tool.
US5633155A (en) * 1992-08-19 1997-05-27 Jinro Limited Expression vector for phytolacca antiviral protein and process for preparing transgenic plant transformed therewith
US6444688B1 (en) * 1995-06-07 2002-09-03 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side chains
US6291456B1 (en) * 1998-12-30 2001-09-18 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
US6331562B1 (en) * 1998-12-30 2001-12-18 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
JP2002533456A (ja) * 1998-12-30 2002-10-08 シグナル ファーマシューティカルズ, インコーポレイテッド エストロゲン受容体のモジュレートを行うための化合物および方法
KR20020075388A (ko) 1999-12-30 2002-10-04 시그널 파머슈티컬스 인크 에스트로겐 수용체의 조절 화합물 및 조절 방법
US7148252B2 (en) * 2001-10-03 2006-12-12 Signal Pharmaceuticals, Llc Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis
CN100436440C (zh) * 2002-04-19 2008-11-26 信号药品公司 苯并吡喃酮化合物、其组合物以及其治疗方法
US6620838B1 (en) * 2002-04-19 2003-09-16 Signal Pharmaceuticals, Inc. Benzopyrazone compounds, compositions thereof, and methods of treatment therewith
US7091235B2 (en) * 2002-10-15 2006-08-15 Signal Pharmaceuticals, Llc Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer

Also Published As

Publication number Publication date
US7091235B2 (en) 2006-08-15
KR20050072764A (ko) 2005-07-12
US20060194866A1 (en) 2006-08-31
CN100457751C (zh) 2009-02-04
WO2004035002A2 (en) 2004-04-29
NZ539675A (en) 2006-10-27
ZA200503026B (en) 2006-11-29
JP2006515275A (ja) 2006-05-25
US20040225005A1 (en) 2004-11-11
IL168059A0 (en) 2009-02-11
US7589119B2 (en) 2009-09-15
EP1556374A2 (en) 2005-07-27
AU2003286441A1 (en) 2004-05-04
BR0315400A (pt) 2005-08-16
MXPA05003909A (es) 2005-09-30
US7358274B2 (en) 2008-04-15
CN1717405A (zh) 2006-01-04
WO2004035002A3 (en) 2004-08-26
US20080146648A1 (en) 2008-06-19
EP1556374A4 (en) 2007-12-19

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20091015