JP2006513236A5 - - Google Patents

Info

Publication number

JP2006513236A5

JP2006513236A5 JP2004564917A JP2004564917A JP2006513236A5 JP 2006513236 A5 JP2006513236 A5 JP 2006513236A5 JP 2004564917 A JP2004564917 A JP 2004564917A JP 2004564917 A JP2004564917 A JP 2004564917A JP 2006513236 A5 JP2006513236 A5 JP 2006513236A5

Authority

JP

Japan

Prior art keywords

pharmaceutical formulation

microparticles

less

particles

pharmaceutical

Prior art date

2003-12-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 34
• 239000011859 microparticle Substances 0.000 claims 22
• 239000002245 particle Substances 0.000 claims 14
• 239000000825 pharmaceutical preparation Substances 0.000 claims 12
• 239000013543 active substance Substances 0.000 claims 10
• 239000010419 fine particle Substances 0.000 claims 8
• 229920006395 saturated elastomer Polymers 0.000 claims 8
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 6
• 238000012387 aerosolization Methods 0.000 claims 6
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 6
• 229960003942 amphotericin b Drugs 0.000 claims 6
• 150000002632 lipids Chemical class 0.000 claims 6
• 239000011159 matrix material Substances 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• 230000002209 hydrophobic effect Effects 0.000 claims 4
• 239000007788 liquid Substances 0.000 claims 4
• 239000000463 material Substances 0.000 claims 4
• 230000002685 pulmonary effect Effects 0.000 claims 4
• KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
• YKIOPDIXYAUOFN-UHFFFAOYSA-N 2,3-di(icosanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCCCC YKIOPDIXYAUOFN-UHFFFAOYSA-N 0.000 claims 2
• 150000001768 cations Chemical class 0.000 claims 2
• FRKBLBQTSTUKOV-UHFFFAOYSA-N diphosphatidyl glycerol Natural products OP(O)(=O)OCC(OP(O)(O)=O)COP(O)(O)=O FRKBLBQTSTUKOV-UHFFFAOYSA-N 0.000 claims 2
• 229940112141 dry powder inhaler Drugs 0.000 claims 2
• 229940071648 metered dose inhaler Drugs 0.000 claims 2
• 239000006199 nebulizer Substances 0.000 claims 2
• 150000008105 phosphatidylcholines Chemical class 0.000 claims 2
• 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
• 229940067605 phosphatidylethanolamines Drugs 0.000 claims 2
• 229940067626 phosphatidylinositols Drugs 0.000 claims 2
• 150000003905 phosphatidylinositols Chemical class 0.000 claims 2
• 150000008106 phosphatidylserines Chemical class 0.000 claims 2
• 239000000843 powder Substances 0.000 claims 2
• 239000003380 propellant Substances 0.000 claims 2
• 238000001694 spray drying Methods 0.000 claims 2
• 238000005507 spraying Methods 0.000 claims 2
• 239000000725 suspension Substances 0.000 claims 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
• 229940121375 antifungal agent Drugs 0.000 claims 1
• 239000003429 antifungal agent Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 150000003904 phospholipids Chemical class 0.000 claims 1