JP2006513209A - 免疫調節因子および抗癌剤としてのトリプトライド誘導体 - Google Patents
免疫調節因子および抗癌剤としてのトリプトライド誘導体 Download PDFInfo
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- JP2006513209A JP2006513209A JP2004563632A JP2004563632A JP2006513209A JP 2006513209 A JP2006513209 A JP 2006513209A JP 2004563632 A JP2004563632 A JP 2004563632A JP 2004563632 A JP2004563632 A JP 2004563632A JP 2006513209 A JP2006513209 A JP 2006513209A
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- triptolide
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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| US43420302P | 2002-12-17 | 2002-12-17 | |
| PCT/US2003/040104 WO2004058246A1 (en) | 2002-12-17 | 2003-12-16 | Triptolide derivatives as immunomodulator and anticancer agents |
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| JP2006513209A true JP2006513209A (ja) | 2006-04-20 |
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| US7820834B2 (en) * | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
| US8048914B2 (en) * | 2004-02-09 | 2011-11-01 | Pharmagenesis, Inc. | Methods for isolation of triptolide compounds from Tripterygium wilfordii |
| ES2385716T3 (es) * | 2004-03-02 | 2012-07-30 | Pharmagenesis, Inc. | Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer |
| EP1781267A4 (en) * | 2004-05-17 | 2009-03-11 | Combinatorx Inc | METHOD AND REAGENTS FOR THE TREATMENT OF INFAMOUS DISEASES |
| US20070244080A1 (en) * | 2004-06-25 | 2007-10-18 | Pharmagenesis, Inc. | Method for Treatment of Inflammatory Disorders Using Triptolide Compounds |
| WO2006044496A2 (en) | 2004-10-13 | 2006-04-27 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| CN101352434B (zh) * | 2007-07-25 | 2010-10-06 | 中山大学 | 雷公藤内酯醇在制备治疗与c-KIT酪氨酸激酶相关肿瘤的药物的用途 |
| CN104387406A (zh) * | 2009-02-05 | 2015-03-04 | 药物起源公司 | 作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物 |
| EP2427467B1 (en) | 2009-05-07 | 2015-08-05 | Regents of the University of Minnesota | Triptolide prodrugs |
| US9150600B2 (en) | 2009-05-07 | 2015-10-06 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| CN102258525A (zh) * | 2010-05-28 | 2011-11-30 | 上海汇伦生命科技有限公司 | Hq-091212的药物应用 |
| CN103709227B (zh) * | 2012-10-09 | 2017-07-04 | 上海汇伦生命科技有限公司 | 双键取代雷公藤内酯衍生物及其制备方法和应用 |
| US20160038454A1 (en) * | 2013-03-15 | 2016-02-11 | Pharmagenesis, Inc. | Intravenous formulations of triptolide compounds as immunomodulators and anticancer agents |
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| JPH03178977A (ja) * | 1989-09-08 | 1991-08-02 | Chugoku Igaku Kagakuin Hifubyo Kenkyusho | ジテルペンラクトン化合物及びその製造方法 |
| JP2001081030A (ja) * | 1999-07-13 | 2001-03-27 | Mitsuhiro Hatta | 免疫抑制剤の副作用防御剤 |
| JP2001504437A (ja) * | 1996-03-01 | 2001-04-03 | ファーマジェネシス，インコーポレイテッド | 免疫抑制性化合物および方法 |
| JP2001525851A (ja) * | 1997-05-23 | 2001-12-11 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | 自己免疫疾患の治療に有用な新規なトリプトリド誘導体 |
| WO2002056835A2 (en) * | 2001-01-19 | 2002-07-25 | Pharmagenesis, Inc. | Anticancer treatment using triptolide prodrugs |
| JP2002523495A (ja) * | 1998-09-02 | 2002-07-30 | ファーマジェネシス， インコーポレイテッド | 高い水溶性を有するトリプトリドプロドラッグ |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5430054A (en) * | 1989-12-22 | 1995-07-04 | Jiangsu Family Planning Institute | Preparation methods of diterpene lactone compounds and application of the same to antifertility |
| US6004999A (en) * | 1997-05-23 | 1999-12-21 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
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2003
- 2003-12-16 WO PCT/US2003/040104 patent/WO2004058246A1/en not_active Ceased
- 2003-12-16 AU AU2003297211A patent/AU2003297211A1/en not_active Abandoned
- 2003-12-16 CN CNA2003801061290A patent/CN1726025A/zh active Pending
- 2003-12-16 CA CA002508217A patent/CA2508217A1/en not_active Abandoned
- 2003-12-16 US US10/738,753 patent/US7019151B2/en not_active Expired - Fee Related
- 2003-12-16 EP EP03814060A patent/EP1581208A1/en not_active Withdrawn
- 2003-12-16 JP JP2004563632A patent/JP2006513209A/ja active Pending
-
2006
- 2006-01-27 US US11/340,928 patent/US7098348B2/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03178977A (ja) * | 1989-09-08 | 1991-08-02 | Chugoku Igaku Kagakuin Hifubyo Kenkyusho | ジテルペンラクトン化合物及びその製造方法 |
| JP2001504437A (ja) * | 1996-03-01 | 2001-04-03 | ファーマジェネシス，インコーポレイテッド | 免疫抑制性化合物および方法 |
| JP2001525851A (ja) * | 1997-05-23 | 2001-12-11 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | 自己免疫疾患の治療に有用な新規なトリプトリド誘導体 |
| JP2002523495A (ja) * | 1998-09-02 | 2002-07-30 | ファーマジェネシス， インコーポレイテッド | 高い水溶性を有するトリプトリドプロドラッグ |
| JP2001081030A (ja) * | 1999-07-13 | 2001-03-27 | Mitsuhiro Hatta | 免疫抑制剤の副作用防御剤 |
| WO2002056835A2 (en) * | 2001-01-19 | 2002-07-25 | Pharmagenesis, Inc. | Anticancer treatment using triptolide prodrugs |
Also Published As
| Publication number | Publication date |
|---|---|
| US7098348B2 (en) | 2006-08-29 |
| WO2004058246A1 (en) | 2004-07-15 |
| US7019151B2 (en) | 2006-03-28 |
| AU2003297211A1 (en) | 2004-07-22 |
| US20060128975A1 (en) | 2006-06-15 |
| CA2508217A1 (en) | 2004-07-15 |
| CN1726025A (zh) | 2006-01-25 |
| US20040152767A1 (en) | 2004-08-05 |
| EP1581208A1 (en) | 2005-10-05 |
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