AU2003297211A1 - Triptolide derivatives as immunomodulator and anticancer agents - Google Patents
Triptolide derivatives as immunomodulator and anticancer agents Download PDFInfo
- Publication number
- AU2003297211A1 AU2003297211A1 AU2003297211A AU2003297211A AU2003297211A1 AU 2003297211 A1 AU2003297211 A1 AU 2003297211A1 AU 2003297211 A AU2003297211 A AU 2003297211A AU 2003297211 A AU2003297211 A AU 2003297211A AU 2003297211 A1 AU2003297211 A1 AU 2003297211A1
- Authority
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- Australia
- Prior art keywords
- compound
- triptolide
- cells
- compounds
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43420302P | 2002-12-17 | 2002-12-17 | |
| US60/434,203 | 2002-12-17 | ||
| PCT/US2003/040104 WO2004058246A1 (en) | 2002-12-17 | 2003-12-16 | Triptolide derivatives as immunomodulator and anticancer agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2003297211A1 true AU2003297211A1 (en) | 2004-07-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003297211A Abandoned AU2003297211A1 (en) | 2002-12-17 | 2003-12-16 | Triptolide derivatives as immunomodulator and anticancer agents |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7019151B2 (https=) |
| EP (1) | EP1581208A1 (https=) |
| JP (1) | JP2006513209A (https=) |
| CN (1) | CN1726025A (https=) |
| AU (1) | AU2003297211A1 (https=) |
| CA (1) | CA2508217A1 (https=) |
| WO (1) | WO2004058246A1 (https=) |
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| EP2468277A1 (en) * | 2002-05-31 | 2012-06-27 | Pharmagenesis, Inc. | Triptolide derivatives for modulation of apoptosis and immunosuppression |
| WO2005062913A2 (en) * | 2003-12-24 | 2005-07-14 | Pharmagenesis, Inc. | Triplide 5,6-derivatives as immunomodulators and anticancer agents |
| EP1722806A4 (en) * | 2004-02-09 | 2009-09-16 | Pharmagenesis Inc | METHOD OF ISOLATING TRIPTOLIDE COMPOUNDS FROM TRIPTERYGIUM WILFORDII |
| WO2005084365A2 (en) * | 2004-03-02 | 2005-09-15 | Pharmagenesis, Inc. | Triptolide lactone ring derivatives as immunomodulators and anticancer agents |
| BRPI0511272A (pt) * | 2004-05-17 | 2007-12-04 | Combinatorx Inc | métodos e reagentes para o tratamento de distúrbios imunoinflamatórios |
| WO2006012204A2 (en) * | 2004-06-25 | 2006-02-02 | Pharmagenesis, Inc. | Method for treatment of inflammatory disorders using triptolide compounds |
| WO2006044496A2 (en) * | 2004-10-13 | 2006-04-27 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| CN101352434B (zh) * | 2007-07-25 | 2010-10-06 | 中山大学 | 雷公藤内酯醇在制备治疗与c-KIT酪氨酸激酶相关肿瘤的药物的用途 |
| CN104387406A (zh) | 2009-02-05 | 2015-03-04 | 药物起源公司 | 作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物 |
| DK2427467T3 (en) | 2009-05-07 | 2015-11-09 | Univ Minnesota | Triptolid prodrugs |
| US9150600B2 (en) | 2009-05-07 | 2015-10-06 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| CN102258525A (zh) * | 2010-05-28 | 2011-11-30 | 上海汇伦生命科技有限公司 | Hq-091212的药物应用 |
| CN103709227B (zh) * | 2012-10-09 | 2017-07-04 | 上海汇伦生命科技有限公司 | 双键取代雷公藤内酯衍生物及其制备方法和应用 |
| EP2968140A4 (en) * | 2013-03-15 | 2016-11-16 | Pharmagenesis Inc | INTRAVENOUS EMULSIONS OF TRIPTOLIDE AS IMMUNOMODULATORS AND ANTICROBIAL I |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1027371C (zh) * | 1989-09-08 | 1995-01-11 | 中国医学科学院皮肤病研究所 | 二萜内酯化合物的合成方法 |
| US5430054A (en) * | 1989-12-22 | 1995-07-04 | Jiangsu Family Planning Institute | Preparation methods of diterpene lactone compounds and application of the same to antifertility |
| US5663335A (en) | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
| DK0983275T3 (da) * | 1997-05-23 | 2002-12-23 | Aventis Pharma Inc | Nye triptolidderivater, der er nyttige til behandling af autoimmune sygdomme |
| US6004999A (en) * | 1997-05-23 | 1999-12-21 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
| CA2342901A1 (en) | 1998-09-02 | 2000-03-09 | Pharmagenesis, Inc. | Triptolide prodrugs having high aqueous solubility |
| JP2001081030A (ja) * | 1999-07-13 | 2001-03-27 | Mitsuhiro Hatta | 免疫抑制剤の副作用防御剤 |
| US6620843B2 (en) | 2001-01-19 | 2003-09-16 | Pharmagenesis | Anticancer treatment using triptolide prodrugs |
-
2003
- 2003-12-16 WO PCT/US2003/040104 patent/WO2004058246A1/en not_active Ceased
- 2003-12-16 AU AU2003297211A patent/AU2003297211A1/en not_active Abandoned
- 2003-12-16 CA CA002508217A patent/CA2508217A1/en not_active Abandoned
- 2003-12-16 CN CNA2003801061290A patent/CN1726025A/zh active Pending
- 2003-12-16 US US10/738,753 patent/US7019151B2/en not_active Expired - Fee Related
- 2003-12-16 JP JP2004563632A patent/JP2006513209A/ja active Pending
- 2003-12-16 EP EP03814060A patent/EP1581208A1/en not_active Withdrawn
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2006
- 2006-01-27 US US11/340,928 patent/US7098348B2/en not_active Expired - Fee Related
Also Published As
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|---|---|
| US7019151B2 (en) | 2006-03-28 |
| CN1726025A (zh) | 2006-01-25 |
| CA2508217A1 (en) | 2004-07-15 |
| US20040152767A1 (en) | 2004-08-05 |
| JP2006513209A (ja) | 2006-04-20 |
| WO2004058246A1 (en) | 2004-07-15 |
| US20060128975A1 (en) | 2006-06-15 |
| EP1581208A1 (en) | 2005-10-05 |
| US7098348B2 (en) | 2006-08-29 |
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| Date | Code | Title | Description |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |