CN1726025A - 作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物 - Google Patents

作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物 Download PDF

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Publication number
CN1726025A
CN1726025A CNA2003801061290A CN200380106129A CN1726025A CN 1726025 A CN1726025 A CN 1726025A CN A2003801061290 A CNA2003801061290 A CN A2003801061290A CN 200380106129 A CN200380106129 A CN 200380106129A CN 1726025 A CN1726025 A CN 1726025A
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CN
China
Prior art keywords
triptolide
cells
compound
oxo
croh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2003801061290A
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English (en)
Chinese (zh)
Inventor
D·戴
J·H·马瑟
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Pharmagenesis Inc
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Pharmagenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmagenesis Inc filed Critical Pharmagenesis Inc
Publication of CN1726025A publication Critical patent/CN1726025A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNA2003801061290A 2002-12-17 2003-12-16 作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物 Pending CN1726025A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43420302P 2002-12-17 2002-12-17
US60/434,203 2002-12-17

Publications (1)

Publication Number Publication Date
CN1726025A true CN1726025A (zh) 2006-01-25

Family

ID=32682009

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2003801061290A Pending CN1726025A (zh) 2002-12-17 2003-12-16 作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物

Country Status (7)

Country Link
US (2) US7019151B2 (https=)
EP (1) EP1581208A1 (https=)
JP (1) JP2006513209A (https=)
CN (1) CN1726025A (https=)
AU (1) AU2003297211A1 (https=)
CA (1) CA2508217A1 (https=)
WO (1) WO2004058246A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101352434B (zh) * 2007-07-25 2010-10-06 中山大学 雷公藤内酯醇在制备治疗与c-KIT酪氨酸激酶相关肿瘤的药物的用途
CN102258525A (zh) * 2010-05-28 2011-11-30 上海汇伦生命科技有限公司 Hq-091212的药物应用
CN102307881A (zh) * 2009-02-05 2012-01-04 药物起源公司 作为抗癌药和免疫调制剂的雷公藤内酯c-环衍生物
CN103709227A (zh) * 2012-10-09 2014-04-09 上海汇伦生命科技有限公司 双键取代雷公藤内酯衍生物及其制备方法和应用
CN105263475A (zh) * 2013-03-15 2016-01-20 制药创源有限公司 雷公藤甲素静脉注射乳剂用作免疫调制剂和抗癌药

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2468277A1 (en) * 2002-05-31 2012-06-27 Pharmagenesis, Inc. Triptolide derivatives for modulation of apoptosis and immunosuppression
US7820834B2 (en) * 2003-12-24 2010-10-26 Pharmagenesis, Inc. Triptolide 5,6-derivatives as immunomodulators and anticancer agents
US8048914B2 (en) * 2004-02-09 2011-11-01 Pharmagenesis, Inc. Methods for isolation of triptolide compounds from Tripterygium wilfordii
ES2385716T3 (es) * 2004-03-02 2012-07-30 Pharmagenesis, Inc. Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer
EP1781267A4 (en) * 2004-05-17 2009-03-11 Combinatorx Inc METHOD AND REAGENTS FOR THE TREATMENT OF INFAMOUS DISEASES
US20070244080A1 (en) * 2004-06-25 2007-10-18 Pharmagenesis, Inc. Method for Treatment of Inflammatory Disorders Using Triptolide Compounds
WO2006044496A2 (en) 2004-10-13 2006-04-27 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
EP2427467B1 (en) 2009-05-07 2015-08-05 Regents of the University of Minnesota Triptolide prodrugs
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1027371C (zh) * 1989-09-08 1995-01-11 中国医学科学院皮肤病研究所 二萜内酯化合物的合成方法
US5430054A (en) * 1989-12-22 1995-07-04 Jiangsu Family Planning Institute Preparation methods of diterpene lactone compounds and application of the same to antifertility
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods
ATE222910T1 (de) * 1997-05-23 2002-09-15 Aventis Pharma Inc Triptolid-derivate nützlich zur behandlung von autoimmunkrankheiten
US6004999A (en) * 1997-05-23 1999-12-21 Hoechst Marion Roussel, Inc. Triptolide derivatives useful in the treatment of autoimmune diseases
CN1316997A (zh) * 1998-09-02 2001-10-10 法玛吉尼西斯公司 具有高水溶性的雷公藤内酯前药
JP2001081030A (ja) * 1999-07-13 2001-03-27 Mitsuhiro Hatta 免疫抑制剤の副作用防御剤
US6620843B2 (en) * 2001-01-19 2003-09-16 Pharmagenesis Anticancer treatment using triptolide prodrugs

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101352434B (zh) * 2007-07-25 2010-10-06 中山大学 雷公藤内酯醇在制备治疗与c-KIT酪氨酸激酶相关肿瘤的药物的用途
CN102307881A (zh) * 2009-02-05 2012-01-04 药物起源公司 作为抗癌药和免疫调制剂的雷公藤内酯c-环衍生物
CN102307881B (zh) * 2009-02-05 2014-12-24 药物起源公司 作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物
CN102258525A (zh) * 2010-05-28 2011-11-30 上海汇伦生命科技有限公司 Hq-091212的药物应用
CN103709227A (zh) * 2012-10-09 2014-04-09 上海汇伦生命科技有限公司 双键取代雷公藤内酯衍生物及其制备方法和应用
WO2014056401A1 (zh) * 2012-10-09 2014-04-17 上海汇伦生命科技有限公司 双键取代雷公藤内酯衍生物及其制备方法和应用
CN103709227B (zh) * 2012-10-09 2017-07-04 上海汇伦生命科技有限公司 双键取代雷公藤内酯衍生物及其制备方法和应用
CN105263475A (zh) * 2013-03-15 2016-01-20 制药创源有限公司 雷公藤甲素静脉注射乳剂用作免疫调制剂和抗癌药

Also Published As

Publication number Publication date
US7098348B2 (en) 2006-08-29
WO2004058246A1 (en) 2004-07-15
US7019151B2 (en) 2006-03-28
AU2003297211A1 (en) 2004-07-22
US20060128975A1 (en) 2006-06-15
CA2508217A1 (en) 2004-07-15
JP2006513209A (ja) 2006-04-20
US20040152767A1 (en) 2004-08-05
EP1581208A1 (en) 2005-10-05

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CN1726025A (zh) 作为免疫调节剂和抗癌剂的雷公藤内酯醇衍生物
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Open date: 20060125