JP2006511912A5 - - Google Patents
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- JP2006511912A5 JP2006511912A5 JP2004563709A JP2004563709A JP2006511912A5 JP 2006511912 A5 JP2006511912 A5 JP 2006511912A5 JP 2004563709 A JP2004563709 A JP 2004563709A JP 2004563709 A JP2004563709 A JP 2004563709A JP 2006511912 A5 JP2006511912 A5 JP 2006511912A5
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- JP
- Japan
- Prior art keywords
- ions
- group
- ion
- tof mass
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002500 ions Chemical class 0.000 claims description 724
- 238000000034 method Methods 0.000 claims description 33
- 238000001819 mass spectrum Methods 0.000 claims description 23
- 230000001902 propagating effect Effects 0.000 claims description 18
- 230000003111 delayed effect Effects 0.000 claims description 7
- 238000003795 desorption Methods 0.000 claims description 6
- 238000004949 mass spectrometry Methods 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 4
- 239000007943 implant Substances 0.000 claims description 4
- 238000002513 implantation Methods 0.000 claims description 4
- 230000005284 excitation Effects 0.000 claims description 3
- 238000001228 spectrum Methods 0.000 description 45
- 239000012634 fragment Substances 0.000 description 40
- 238000004885 tandem mass spectrometry Methods 0.000 description 34
- 238000005259 measurement Methods 0.000 description 26
- 239000000523 sample Substances 0.000 description 23
- 239000002243 precursor Substances 0.000 description 19
- 102000004169 proteins and genes Human genes 0.000 description 17
- 108090000623 proteins and genes Proteins 0.000 description 17
- 238000010586 diagram Methods 0.000 description 12
- 238000000605 extraction Methods 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 230000005684 electric field Effects 0.000 description 7
- 102000004196 processed proteins & peptides Human genes 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- 238000010884 ion-beam technique Methods 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 238000013467 fragmentation Methods 0.000 description 4
- 238000006062 fragmentation reaction Methods 0.000 description 4
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 230000000644 propagated effect Effects 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 102100031680 Beta-catenin-interacting protein 1 Human genes 0.000 description 2
- 101000993469 Homo sapiens Beta-catenin-interacting protein 1 Proteins 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 150000001793 charged compounds Chemical class 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000000451 chemical ionisation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005686 electrostatic field Effects 0.000 description 1
- 230000006862 enzymatic digestion Effects 0.000 description 1
- 238000000105 evaporative light scattering detection Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/327,471 US6933497B2 (en) | 2002-12-20 | 2002-12-20 | Time-of-flight mass analyzer with multiple flight paths |
| PCT/US2003/040276 WO2004059693A2 (en) | 2002-12-20 | 2003-12-17 | Time-of-flight mass analyzer with multiple flight paths |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006511912A JP2006511912A (ja) | 2006-04-06 |
| JP2006511912A5 true JP2006511912A5 (enExample) | 2010-02-12 |
Family
ID=32594262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004563709A Pending JP2006511912A (ja) | 2002-12-20 | 2003-12-17 | 複数の飛行経路を有する飛行時間型質量分析器 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6933497B2 (enExample) |
| EP (1) | EP1584099A2 (enExample) |
| JP (1) | JP2006511912A (enExample) |
| WO (1) | WO2004059693A2 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1721150A4 (en) * | 2004-03-04 | 2008-07-02 | Mds Inc Dbt Mds Sciex Division | METHOD AND SYSTEM FOR SAMPLE MASS ANALYSIS |
| US7504621B2 (en) * | 2004-03-04 | 2009-03-17 | Mds Inc. | Method and system for mass analysis of samples |
| FR2895834B1 (fr) * | 2006-01-03 | 2012-11-02 | Physikron | Procede et systeme de spectrometrie de masse en tandem sans selection de masse primaire et a temps de vol,pour des ions multicharges |
| WO2007138679A1 (ja) * | 2006-05-30 | 2007-12-06 | Shimadzu Corporation | 質量分析装置 |
| CA2656481C (en) * | 2006-07-03 | 2016-04-05 | Physikron | Method and system of tandem mass spectrometry without primary mass selection for multicharged ions |
| GB0620963D0 (en) | 2006-10-20 | 2006-11-29 | Thermo Finnigan Llc | Multi-channel detection |
| GB0624993D0 (en) * | 2006-12-14 | 2007-01-24 | Micromass Ltd | Mass spectrometer |
| US7663100B2 (en) * | 2007-05-01 | 2010-02-16 | Virgin Instruments Corporation | Reversed geometry MALDI TOF |
| US7564026B2 (en) * | 2007-05-01 | 2009-07-21 | Virgin Instruments Corporation | Linear TOF geometry for high sensitivity at high mass |
| US7838824B2 (en) * | 2007-05-01 | 2010-11-23 | Virgin Instruments Corporation | TOF-TOF with high resolution precursor selection and multiplexed MS-MS |
| US7589319B2 (en) | 2007-05-01 | 2009-09-15 | Virgin Instruments Corporation | Reflector TOF with high resolution and mass accuracy for peptides and small molecules |
| US7667195B2 (en) * | 2007-05-01 | 2010-02-23 | Virgin Instruments Corporation | High performance low cost MALDI MS-MS |
| US7564028B2 (en) * | 2007-05-01 | 2009-07-21 | Virgin Instruments Corporation | Vacuum housing system for MALDI-TOF mass spectrometry |
| JP2008282571A (ja) * | 2007-05-08 | 2008-11-20 | Shimadzu Corp | 飛行時間型質量分析計 |
| DE102007049640B3 (de) * | 2007-10-17 | 2009-04-02 | Bruker Daltonik Gmbh | Messung von Tochterionenspektren aus einer MALDI-Ionisierung |
| JP4894929B2 (ja) * | 2007-12-20 | 2012-03-14 | 株式会社島津製作所 | 質量分析装置 |
| JP5072682B2 (ja) * | 2008-03-28 | 2012-11-14 | 富士フイルム株式会社 | 質量分析用デバイス、これを用いる質量分析装置および質量分析方法 |
| GB2467548B (en) * | 2009-02-04 | 2013-02-27 | Nu Instr Ltd | Detection arrangements in mass spectrometers |
| US8847155B2 (en) | 2009-08-27 | 2014-09-30 | Virgin Instruments Corporation | Tandem time-of-flight mass spectrometry with simultaneous space and velocity focusing |
| WO2011127091A1 (en) | 2010-04-05 | 2011-10-13 | Indiana University Research And Technology Corporation | Method for enhancement of mass resolution over a limited mass range for time-of-flight spectrometry |
| WO2011140040A1 (en) * | 2010-05-04 | 2011-11-10 | Indiana University Research And Technology Corporation | Combined distance-of-flight and time-of-flight mass spectrometer |
| DE102010032823B4 (de) | 2010-07-30 | 2013-02-07 | Ion-Tof Technologies Gmbh | Verfahren sowie ein Massenspektrometer zum Nachweis von Ionen oder nachionisierten Neutralteilchen aus Proben |
| DE102011004725A1 (de) * | 2011-02-25 | 2012-08-30 | Helmholtz-Zentrum Potsdam Deutsches GeoForschungsZentrum - GFZ Stiftung des Öffentlichen Rechts des Landes Brandenburg | Verfahren und Vorrichtung zur Erhöhung des Durchsatzes bei Flugzeitmassenspektrometern |
| WO2013134165A1 (en) * | 2012-03-08 | 2013-09-12 | Virgin Instruments Corporation | Tandem time-of-flight mass spectrometry with simultaneous space and velocity focusing |
| EP2850648B8 (en) * | 2012-05-18 | 2020-10-28 | Micromass UK Limited | Orthogonal acceleration coaxial cylinder time of flight mass analyser |
| WO2014107043A1 (ko) * | 2013-01-03 | 2014-07-10 | 서울대학교 산학협력단 | 전체 이온 개수를 측정하여 일정한 온도에서 생성된 이온들의 질량 스펙트럼을 구하는 방법 및 말디 질량분석법을 이용한 정량 분석을 위한 매트릭스의 용도 |
| US8735810B1 (en) | 2013-03-15 | 2014-05-27 | Virgin Instruments Corporation | Time-of-flight mass spectrometer with ion source and ion detector electrically connected |
| WO2015026727A1 (en) | 2013-08-19 | 2015-02-26 | Virgin Instruments Corporation | Ion optical system for maldi-tof mass spectrometer |
| US9870911B2 (en) * | 2013-12-23 | 2018-01-16 | Dh Technologies Development Pte. Ltd. | Method and apparatus for processing ions |
| WO2015097507A1 (en) * | 2013-12-24 | 2015-07-02 | Dh Technologies Development Pte. Ltd. | High speed polarity switch time-of-flight spectrometer |
| DE102014104451B4 (de) * | 2014-03-28 | 2018-11-15 | Krohne Messtechnik Gmbh | Massenspektrometer |
| US9997345B2 (en) | 2014-04-01 | 2018-06-12 | Micromass Uk Limited | Orthogonal acceleration coaxial cylinder mass analyser |
| GB2535754A (en) * | 2015-02-26 | 2016-08-31 | Nu Instr Ltd | Mass spectrometers |
| US10424470B2 (en) * | 2015-03-25 | 2019-09-24 | Tofwerk Ag | Apparatus and method for mass spectrometry |
| GB201507363D0 (en) | 2015-04-30 | 2015-06-17 | Micromass Uk Ltd And Leco Corp | Multi-reflecting TOF mass spectrometer |
| GB2541383B (en) * | 2015-08-14 | 2018-12-12 | Thermo Fisher Scient Bremen Gmbh | Mirror lens for directing an ion beam |
| GB201520130D0 (en) | 2015-11-16 | 2015-12-30 | Micromass Uk Ltd And Leco Corp | Imaging mass spectrometer |
| GB201520134D0 (en) | 2015-11-16 | 2015-12-30 | Micromass Uk Ltd And Leco Corp | Imaging mass spectrometer |
| GB201520540D0 (en) | 2015-11-23 | 2016-01-06 | Micromass Uk Ltd And Leco Corp | Improved ion mirror and ion-optical lens for imaging |
| GB201613988D0 (en) | 2016-08-16 | 2016-09-28 | Micromass Uk Ltd And Leco Corp | Mass analyser having extended flight path |
| US10319574B2 (en) | 2016-08-22 | 2019-06-11 | Highland Innovations Inc. | Categorization data manipulation using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer |
| WO2018039135A1 (en) * | 2016-08-22 | 2018-03-01 | Eung Joon Jo | Shot-to-shot sampling using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer |
| US10192727B2 (en) * | 2017-03-28 | 2019-01-29 | Varian Semiconductor Equipment Associates, Inc. | Electrodynamic mass analysis |
| GB2567794B (en) | 2017-05-05 | 2023-03-08 | Micromass Ltd | Multi-reflecting time-of-flight mass spectrometers |
| GB2563571B (en) | 2017-05-26 | 2023-05-24 | Micromass Ltd | Time of flight mass analyser with spatial focussing |
| US11049712B2 (en) | 2017-08-06 | 2021-06-29 | Micromass Uk Limited | Fields for multi-reflecting TOF MS |
| EP3662502A1 (en) | 2017-08-06 | 2020-06-10 | Micromass UK Limited | Printed circuit ion mirror with compensation |
| US11211238B2 (en) | 2017-08-06 | 2021-12-28 | Micromass Uk Limited | Multi-pass mass spectrometer |
| WO2019030476A1 (en) | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | INJECTION OF IONS IN MULTI-PASSAGE MASS SPECTROMETERS |
| WO2019030472A1 (en) | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | IONIC MIRROR FOR MULTI-REFLECTION MASS SPECTROMETERS |
| US11081332B2 (en) | 2017-08-06 | 2021-08-03 | Micromass Uk Limited | Ion guide within pulsed converters |
| US11817303B2 (en) | 2017-08-06 | 2023-11-14 | Micromass Uk Limited | Accelerator for multi-pass mass spectrometers |
| EP4163637A1 (en) * | 2018-02-28 | 2023-04-12 | Ionpath, Inc. | Source-detector synchronization in multiplexed secondary ion mass spectrometry |
| GB201806507D0 (en) | 2018-04-20 | 2018-06-06 | Verenchikov Anatoly | Gridless ion mirrors with smooth fields |
| GB201807626D0 (en) | 2018-05-10 | 2018-06-27 | Micromass Ltd | Multi-reflecting time of flight mass analyser |
| GB201807605D0 (en) | 2018-05-10 | 2018-06-27 | Micromass Ltd | Multi-reflecting time of flight mass analyser |
| GB201808530D0 (en) | 2018-05-24 | 2018-07-11 | Verenchikov Anatoly | TOF MS detection system with improved dynamic range |
| GB201810573D0 (en) | 2018-06-28 | 2018-08-15 | Verenchikov Anatoly | Multi-pass mass spectrometer with improved duty cycle |
| GB201901411D0 (en) | 2019-02-01 | 2019-03-20 | Micromass Ltd | Electrode assembly for mass spectrometer |
| GB201903779D0 (en) | 2019-03-20 | 2019-05-01 | Micromass Ltd | Multiplexed time of flight mass spectrometer |
| GB2595481B (en) * | 2020-05-27 | 2024-02-21 | Smiths Detection Watford Ltd | An ion shutter, a method of controlling ion shutter, and detection methods and apparatus |
| GB2619766B (en) * | 2022-06-17 | 2024-12-18 | Thermo Fisher Scient Bremen Gmbh | Time-of-flight mass spectrometric analysis of labelled analyte molecules |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3025764C2 (de) * | 1980-07-08 | 1984-04-19 | Hermann Prof. Dr. 6301 Fernwald Wollnik | Laufzeit-Massenspektrometer |
| JPS6182652A (ja) * | 1984-09-29 | 1986-04-26 | Shimadzu Corp | 飛行時間型衝突解離質量分析装置 |
| DE4305363A1 (de) * | 1993-02-23 | 1994-08-25 | Hans Bernhard Dr Linden | Massenspektrometer zur flugzeitabhängigen Massentrennung |
| JPH09326243A (ja) * | 1996-06-05 | 1997-12-16 | Shimadzu Corp | Ｍａｌｄｉ−ｔｏｆ質量分析装置 |
| DE19635645C2 (de) | 1996-09-03 | 2000-12-28 | Bruker Daltonik Gmbh | Verfahren für die hochauflösende Spektrenaufnahme von Analytionen in einem linearen Flugzeitmassenspektrometer |
| WO1999001889A1 (en) * | 1997-07-02 | 1999-01-14 | Merck & Co., Inc. | Novel mass spectrometer |
| JP3695111B2 (ja) * | 1997-12-18 | 2005-09-14 | 株式会社島津製作所 | 飛行時間型質量分析装置 |
| US6348688B1 (en) * | 1998-02-06 | 2002-02-19 | Perseptive Biosystems | Tandem time-of-flight mass spectrometer with delayed extraction and method for use |
| GB2339958B (en) * | 1998-07-17 | 2001-02-21 | Genomic Solutions Ltd | Time-of-flight mass spectrometer |
| JP4345199B2 (ja) * | 2000-06-09 | 2009-10-14 | 株式会社島津製作所 | 飛行時間型質量分析装置 |
| US6627883B2 (en) * | 2001-03-02 | 2003-09-30 | Bruker Daltonics Inc. | Apparatus and method for analyzing samples in a dual ion trap mass spectrometer |
| CA2448332C (en) * | 2001-05-25 | 2009-04-14 | Analytica Of Branford, Inc. | Multiple detection systems |
-
2002
- 2002-12-20 US US10/327,471 patent/US6933497B2/en not_active Expired - Lifetime
-
2003
- 2003-12-17 JP JP2004563709A patent/JP2006511912A/ja active Pending
- 2003-12-17 WO PCT/US2003/040276 patent/WO2004059693A2/en not_active Ceased
- 2003-12-17 EP EP03814128A patent/EP1584099A2/en not_active Withdrawn
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