|
SE0102299D0
(sv)
|
2001-06-26 |
2001-06-26 |
Astrazeneca Ab |
Compounds
|
|
SE0102764D0
(sv)
|
2001-08-17 |
2001-08-17 |
Astrazeneca Ab |
Compounds
|
|
BR0314864A
(pt)
|
2002-10-03 |
2005-08-02 |
Novartis Ag |
Compostos orgânicos
|
|
GB0226931D0
(en)
|
2002-11-19 |
2002-12-24 |
Astrazeneca Ab |
Chemical compounds
|
|
GB0226930D0
(en)
|
2002-11-19 |
2002-12-24 |
Astrazeneca Ab |
Chemical compounds
|
|
US7262196B2
(en)
*
|
2003-02-11 |
2007-08-28 |
Prosidion Limited |
Tri(cyclo) substituted amide glucokinase activator compounds
|
|
BRPI0509573A
(pt)
|
2004-04-02 |
2007-09-25 |
Novartis Ag |
derivados de sulfonamida-tiazolpiridina como ativadores de glicocinase úteis para o tratamento de diabetes do tipo 2
|
|
US7781451B2
(en)
|
2004-04-02 |
2010-08-24 |
Novartis Ag |
Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions
|
|
EP1824835A1
(en)
*
|
2004-12-03 |
2007-08-29 |
Novo Nordisk A/S |
Heteroaromatic glucokinase activators
|
|
KR101346902B1
(ko)
|
2005-07-09 |
2014-01-02 |
아스트라제네카 아베 |
당뇨병 치료에 있어 glk 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체
|
|
WO2007026761A1
(ja)
*
|
2005-08-31 |
2007-03-08 |
Astellas Pharma Inc. |
チアゾール誘導体
|
|
JP2007063225A
(ja)
*
|
2005-09-01 |
2007-03-15 |
Takeda Chem Ind Ltd |
イミダゾピリジン化合物
|
|
CA2624102A1
(en)
|
2005-09-29 |
2007-04-12 |
Sanofi-Aventis |
Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals
|
|
GT200600429A
(es)
*
|
2005-09-30 |
2007-04-30 |
|
Compuestos organicos
|
|
GT200600428A
(es)
*
|
2005-09-30 |
2007-05-21 |
|
Compuestos organicos
|
|
EP1948614A2
(en)
*
|
2005-11-18 |
2008-07-30 |
Takeda San Diego, Inc. |
Glucokinase activators
|
|
EP2001875A2
(en)
|
2006-03-08 |
2008-12-17 |
Takeda San Diego, Inc. |
Glucokinase activators
|
|
WO2007125105A2
(en)
*
|
2006-04-28 |
2007-11-08 |
Transtech Pharma, Inc. |
Benzamide glucokinase activators
|
|
PE20080251A1
(es)
|
2006-05-04 |
2008-04-25 |
Boehringer Ingelheim Int |
Usos de inhibidores de dpp iv
|
|
EP2049518B1
(en)
*
|
2006-05-31 |
2011-08-31 |
Takeda San Diego, Inc. |
Indazole and isoindole derivatives as glucokinase activating agents.
|
|
KR20090025358A
(ko)
|
2006-07-24 |
2009-03-10 |
에프. 호프만-라 로슈 아게 |
글루코키나제 활성화제로서의 피라졸
|
|
FR2903985B1
(fr)
|
2006-07-24 |
2008-09-05 |
Sanofi Aventis Sa |
Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
|
|
FR2904316B1
(fr)
|
2006-07-31 |
2008-09-05 |
Sanofi Aventis Sa |
Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique.
|
|
US20080107725A1
(en)
*
|
2006-10-13 |
2008-05-08 |
Albano Antonio A |
Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers
|
|
US7902248B2
(en)
*
|
2006-12-14 |
2011-03-08 |
Hoffmann-La Roche Inc. |
Oxime glucokinase activators
|
|
WO2008074694A1
(en)
*
|
2006-12-20 |
2008-06-26 |
F. Hoffmann-La Roche Ag |
Crystallization of glucokinase activators
|
|
US8163779B2
(en)
|
2006-12-20 |
2012-04-24 |
Takeda San Diego, Inc. |
Glucokinase activators
|
|
TW200831081A
(en)
*
|
2006-12-25 |
2008-08-01 |
Kyorin Seiyaku Kk |
Glucokinase activator
|
|
FR2910473B1
(fr)
|
2006-12-26 |
2009-02-13 |
Sanofi Aventis Sa |
Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique.
|
|
EP2105435A4
(en)
|
2007-01-10 |
2011-06-15 |
Mitsubishi Tanabe Pharma Corp |
Hydrazone derivative
|
|
KR20200123866A
(ko)
|
2007-02-09 |
2020-10-30 |
메타베이시스 테라퓨틱스, 인크. |
글루카곤 수용체의 길항제
|
|
JP5248477B2
(ja)
*
|
2007-03-07 |
2013-07-31 |
杏林製薬株式会社 |
グルコキナーゼ活性化物質
|
|
US8173645B2
(en)
*
|
2007-03-21 |
2012-05-08 |
Takeda San Diego, Inc. |
Glucokinase activators
|
|
CA2682304A1
(en)
|
2007-04-04 |
2008-10-16 |
F. Hoffmann-La Roche Ag |
Microbial reduction of an acetoxyketone
|
|
WO2008128335A1
(en)
*
|
2007-04-20 |
2008-10-30 |
Merck Frosst Canada Ltd. |
Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
|
|
WO2009022179A2
(en)
*
|
2007-08-14 |
2009-02-19 |
Astrazeneca Ab |
Glucokinase activators in the treatment of osteoarthritis
|
|
JP5580201B2
(ja)
*
|
2007-10-08 |
2014-08-27 |
アドビヌス・セラピューティクス・プライベート・リミテッド |
グルコキナーゼアクチベータとしてのアセトアミド誘導体、その製法及び医薬応用
|
|
JP5287730B2
(ja)
|
2008-01-18 |
2013-09-11 |
アステラス製薬株式会社 |
フェニルアセトアミド誘導体
|
|
US8258134B2
(en)
*
|
2008-04-16 |
2012-09-04 |
Hoffmann-La Roche Inc. |
Pyridazinone glucokinase activators
|
|
US7741327B2
(en)
|
2008-04-16 |
2010-06-22 |
Hoffmann-La Roche Inc. |
Pyrrolidinone glucokinase activators
|
|
KR101608259B1
(ko)
|
2008-04-28 |
2016-04-01 |
교린 세이야꾸 가부시키 가이샤 |
시클로펜틸아크릴산아미드 유도체
|
|
PT2799428T
(pt)
|
2008-08-13 |
2017-02-17 |
Metabasis Therapeutics Inc |
Antagonistas de glicagina
|
|
UA104742C2
(uk)
*
|
2008-12-19 |
2014-03-11 |
Эли Лилли Энд Компани |
Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази
|
|
US20110021570A1
(en)
*
|
2009-07-23 |
2011-01-27 |
Nancy-Ellen Haynes |
Pyridone glucokinase activators
|
|
US20110040091A1
(en)
|
2009-08-13 |
2011-02-17 |
Stephan Bachmann |
Process for the preparation of (r)-2-phenyl propionic acid derivatives
|
|
US20110054174A1
(en)
|
2009-08-28 |
2011-03-03 |
Stephan Bachmann |
Process for the preparation of a glucokinase activator compound
|
|
EP2493871B1
(en)
|
2009-10-30 |
2014-09-03 |
Domain Therapeutics |
Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
|
|
US8222416B2
(en)
|
2009-12-14 |
2012-07-17 |
Hoffmann-La Roche Inc. |
Azaindole glucokinase activators
|
|
CN102959076B
(zh)
|
2010-03-31 |
2015-09-16 |
斯克里普斯研究所 |
重编程细胞
|
|
CN102971313A
(zh)
|
2010-04-14 |
2013-03-13 |
百时美施贵宝公司 |
新颖的葡糖激酶激活剂及其使用方法
|
|
US8178689B2
(en)
|
2010-06-17 |
2012-05-15 |
Hoffman-La Roche Inc. |
Tricyclic compounds
|
|
AR082590A1
(es)
|
2010-08-12 |
2012-12-19 |
Hoffmann La Roche |
Inhibidores de la tirosina-quinasa de bruton
|
|
NZ610225A
(en)
*
|
2010-11-16 |
2015-08-28 |
Acetylon Pharmaceuticals Inc |
Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
|
|
US8470866B2
(en)
|
2011-05-03 |
2013-06-25 |
Hoffmann-La Roche Inc. |
Isoindolinone derivatives
|
|
US9630929B2
(en)
|
2011-10-31 |
2017-04-25 |
Xenon Pharmaceuticals Inc. |
Benzenesulfonamide compounds and their use as therapeutic agents
|
|
JP6014155B2
(ja)
|
2011-10-31 |
2016-10-25 |
ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. |
ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
|
|
SG11201408284VA
(en)
|
2012-05-22 |
2015-02-27 |
Xenon Pharmaceuticals Inc |
N-substituted benzamides and their use in the treatment of pain
|
|
US10071957B2
(en)
|
2012-07-06 |
2018-09-11 |
Genentech, Inc. |
N-substituted benzamides and methods of use thereof
|
|
US9550775B2
(en)
|
2013-03-14 |
2017-01-24 |
Genentech, Inc. |
Substituted triazolopyridines and methods of use thereof
|
|
MX2015010775A
(es)
|
2013-03-15 |
2016-04-25 |
Genentech Inc |
Benzoxazoles sustituidos y metodos para usarlos.
|
|
SG11201601291QA
(en)
|
2013-08-23 |
2016-03-30 |
Parion Sciences Inc |
Dithiol mucolytic agents
|
|
WO2015054099A1
(en)
|
2013-10-08 |
2015-04-16 |
Acetylon Pharmaceuticals, Inc. |
Combinations of histone deacetylase inhibitors and either her2 inhibitors or pi3k inhibitors
|
|
US9278963B2
(en)
|
2013-10-10 |
2016-03-08 |
Acetylon Pharmaceuticals, Inc. |
Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
|
|
US10660890B2
(en)
|
2013-10-24 |
2020-05-26 |
National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Nih Division Of Extramural Inventions And Technology Resources (Deitr) |
Treatment of polycystic diseases with an HDAC6 inhibitor
|
|
CR20160296A
(es)
|
2013-11-27 |
2016-09-20 |
Genentech Inc |
Benzamidas sustituidas y métodos para usarlas
|
|
EP2878339A1
(en)
|
2013-12-02 |
2015-06-03 |
Siena Biotech S.p.A. |
SIP3 antagonists
|
|
WO2015084905A1
(en)
|
2013-12-03 |
2015-06-11 |
Acetylon Pharmaceuticals, Inc. |
Combinations of histone deacetylase inhibitors and immunomodulatory drugs
|
|
US9464073B2
(en)
|
2014-02-26 |
2016-10-11 |
Acetylon Pharmaceuticals, Inc. |
Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
|
|
WO2015191900A1
(en)
|
2014-06-12 |
2015-12-17 |
Ligand Pharmaceuticals, Inc. |
Glucagon antagonists
|
|
CN106715418A
(zh)
|
2014-07-07 |
2017-05-24 |
基因泰克公司 |
治疗化合物及其使用方法
|
|
JP6952602B2
(ja)
|
2014-07-07 |
2021-10-20 |
アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. |
ヒストンデアセチラーゼ阻害剤による白血病の治療
|
|
EP3186257B1
(en)
|
2014-08-27 |
2019-02-06 |
Prexton Therapeutics SA |
Novel chromone oxime derivative and its use as allosteric modulator of metabotropic glutamate receptors
|
|
US9937174B2
(en)
|
2014-12-05 |
2018-04-10 |
University of Modena and Reggio Emilia |
Combinations of histone deacetylase inhibitors and bendamustine
|
|
KR20170108088A
(ko)
|
2015-01-30 |
2017-09-26 |
패리온 사이언스 인코퍼레이티드 |
신규 모노티올 점액용해제
|
|
JP2018520986A
(ja)
|
2015-04-30 |
2018-08-02 |
パリオン・サイエンシィズ・インコーポレーテッド |
ジチオール粘液溶解剤の新規なプロドラッグ
|
|
JP2018520107A
(ja)
|
2015-05-22 |
2018-07-26 |
ジェネンテック, インコーポレイテッド |
置換ベンズアミド及びその使用方法
|
|
US10272084B2
(en)
|
2015-06-01 |
2019-04-30 |
Regenacy Pharmaceuticals, Llc |
Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy
|
|
PT3341380T
(pt)
|
2015-08-27 |
2019-12-19 |
Prexton Therapeutics Sa |
Derivado de oxima de cromona penetrante no cérebro para a terapêutica da discinesia induzida por levodopa
|
|
EP3341353A1
(en)
|
2015-08-27 |
2018-07-04 |
Genentech, Inc. |
Therapeutic compounds and methods of use thereof
|
|
CN108290881B
(zh)
|
2015-09-28 |
2021-12-07 |
健泰科生物技术公司 |
治疗性化合物和其使用方法
|
|
US10899732B2
(en)
|
2015-11-25 |
2021-01-26 |
Genentech, Inc. |
Substituted benzamides useful as sodium channel blockers
|
|
EP3854782A1
(en)
|
2016-03-30 |
2021-07-28 |
Genentech, Inc. |
Substituted benzamides and methods of use thereof
|
|
US11813261B2
(en)
|
2016-04-19 |
2023-11-14 |
Acetylon Pharmaceuticals, Inc. |
HDAC inhibitors, alone or in combination with BTK inhibitors, for treating chronic lymphocytic leukemia
|
|
JP7072557B2
(ja)
|
2016-07-22 |
2022-05-20 |
ブリストル-マイヤーズ スクイブ カンパニー |
グルコキナーゼ活性化剤およびその使用方法
|
|
AU2017347549A1
(en)
|
2016-10-17 |
2019-05-02 |
Genentech, Inc. |
Therapeutic compounds and methods of use thereof
|
|
JP2020511511A
(ja)
|
2017-03-24 |
2020-04-16 |
ジェネンテック, インコーポレイテッド |
ナトリウムチャネル阻害剤としての4−ピペリジン−n−(ピリミジン−4−イル)クロマン−7−スルホンアミド誘導体
|
|
WO2019160940A1
(en)
|
2018-02-13 |
2019-08-22 |
Ligand Pharmaceuticals Incorporated |
Glucagon receptor antagonists
|
|
AR114263A1
(es)
|
2018-02-26 |
2020-08-12 |
Genentech Inc |
Compuestos terapéuticos y métodos para utilizarlos
|
|
WO2019191702A1
(en)
|
2018-03-30 |
2019-10-03 |
F. Hoffmann-La Roche Ag |
Substituted hydro-pyrido-azines as sodium channel inhibitors
|
|
TW202003490A
(zh)
|
2018-05-22 |
2020-01-16 |
瑞士商赫孚孟拉羅股份公司 |
治療性化合物及其使用方法
|