JP2006508161A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006508161A5 JP2006508161A5 JP2004556337A JP2004556337A JP2006508161A5 JP 2006508161 A5 JP2006508161 A5 JP 2006508161A5 JP 2004556337 A JP2004556337 A JP 2004556337A JP 2004556337 A JP2004556337 A JP 2004556337A JP 2006508161 A5 JP2006508161 A5 JP 2006508161A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- group
- aryl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003446 ligand Substances 0.000 claims description 16
- 239000000758 substrate Substances 0.000 claims description 7
- 239000003054 catalyst Substances 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 19
- 125000005842 heteroatom Chemical group 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 229910052698 phosphorus Inorganic materials 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- -1 dicycloalkylamino Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000005366 cycloalkylthio group Chemical group 0.000 claims 3
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 3
- 150000002576 ketones Chemical class 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004437 phosphorous atom Chemical group 0.000 claims 3
- 229910052710 silicon Inorganic materials 0.000 claims 3
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
- 125000005248 alkyl aryloxy group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 238000005984 hydrogenation reaction Methods 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- UQRONKZLYKUEMO-UHFFFAOYSA-N 4-methyl-1-(2,4,6-trimethylphenyl)pent-4-en-2-one Chemical group CC(=C)CC(=O)Cc1c(C)cc(C)cc1C UQRONKZLYKUEMO-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 150000001491 aromatic compounds Chemical class 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000004986 diarylamino group Chemical group 0.000 claims 1
- 239000003574 free electron Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000002466 imines Chemical class 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 229910052762 osmium Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052707 ruthenium Inorganic materials 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH20332002 | 2002-12-02 | ||
| PCT/EP2003/050902 WO2004050585A1 (en) | 2002-12-02 | 2003-11-27 | Catalytic hydrogeneration of carbon-heteroatom double bonds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006508161A JP2006508161A (ja) | 2006-03-09 |
| JP2006508161A5 true JP2006508161A5 (cg-RX-API-DMAC7.html) | 2006-11-02 |
Family
ID=32399972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004556337A Pending JP2006508161A (ja) | 2002-12-02 | 2003-11-27 | 炭素−ヘテロ原子二重結合の接触水素化 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7446236B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1567464B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2006508161A (cg-RX-API-DMAC7.html) |
| CN (1) | CN100384791C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE359986T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003298328A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2507908A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60313357T2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2283867T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004050585A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7326784B2 (en) | 2003-12-19 | 2008-02-05 | Altana Pharma Ag | Intermediates for the preparation of tricyclic dihydropyrano-imidazo-pyridines derivatives |
| JP5038912B2 (ja) | 2005-02-16 | 2012-10-03 | アナコール ファーマシューティカルズ，インコーポレイテッド | ホウ素含有小分子 |
| CN106008571A (zh) | 2005-12-30 | 2016-10-12 | 安纳考尔医药公司 | 含硼的小分子 |
| DK1988779T5 (en) | 2006-02-16 | 2016-10-10 | Anacor Pharmaceuticals Inc | SMALL boron MOLECULES AS ANTI-INFLAMMATORY AGENTS |
| US20090105481A1 (en) * | 2006-03-10 | 2009-04-23 | Felix Spindler | Asymmetric Catalytic Hydrogenation of Prochiral Ketones and Aldehydes |
| EP2564857B1 (en) | 2008-03-06 | 2017-05-03 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
| WO2010028005A1 (en) * | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2010027975A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2010106364A2 (en) * | 2009-03-17 | 2010-09-23 | Johnson Matthey Public Limited Company | Process |
| AP4039A (en) * | 2009-08-14 | 2017-02-28 | Daitao Chen | Boron-containing small molecules as antiprotozoal agents |
| WO2011049971A1 (en) | 2009-10-20 | 2011-04-28 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| US20110212918A1 (en) * | 2009-11-11 | 2011-09-01 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2011094450A1 (en) | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
| US8623911B2 (en) | 2010-03-19 | 2014-01-07 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agent |
| MX352607B (es) * | 2010-04-07 | 2017-11-30 | Glaxosmithkline Llc Star | Proceso para la preparacion de benzoxaboroles. |
| BR112013005426B1 (pt) | 2010-09-07 | 2021-08-24 | Anacor Pharmaceuticals, Inc | Composto, composição, combinação, e, formulação farmacêutica |
| DK3030519T3 (da) | 2013-08-09 | 2022-01-31 | Glaxosmithkline Ip No 2 Ltd | Tricykliske benzoxaborol-forbindelser og anvendelser deraf |
| GB201401230D0 (en) * | 2014-01-24 | 2014-03-12 | Givaudan Sa | Improvements in or relating to organic compounds |
| MA41495A (fr) | 2015-02-12 | 2017-12-19 | Anacor Pharmaceuticals Inc | Composés benzoxaborole et leurs utilisations |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2693190B1 (fr) * | 1992-07-02 | 1994-09-23 | Elf Aquitaine | Procédé d'hydrogénation énantiosélectif de la double liaison C=O OXO. |
| US6476233B1 (en) * | 1998-11-12 | 2002-11-05 | The Penn State Research Foundation | Transition metal-catalyzed reactions based on chiral amine oxazolinyl ligands and related compounds |
| NL1015655C2 (nl) | 2000-07-07 | 2002-01-08 | Dsm Nv | Katalysator voor de asymmetrische hydrogenering. |
| WO2002022526A2 (en) * | 2000-09-13 | 2002-03-21 | Firmenich S.A. | Catalytic hydrogenation processes |
-
2003
- 2003-11-27 AU AU2003298328A patent/AU2003298328A1/en not_active Abandoned
- 2003-11-27 US US10/536,883 patent/US7446236B2/en not_active Expired - Lifetime
- 2003-11-27 AT AT03796062T patent/ATE359986T1/de not_active IP Right Cessation
- 2003-11-27 JP JP2004556337A patent/JP2006508161A/ja active Pending
- 2003-11-27 ES ES03796062T patent/ES2283867T3/es not_active Expired - Lifetime
- 2003-11-27 EP EP03796062A patent/EP1567464B1/en not_active Expired - Lifetime
- 2003-11-27 WO PCT/EP2003/050902 patent/WO2004050585A1/en not_active Ceased
- 2003-11-27 DE DE60313357T patent/DE60313357T2/de not_active Expired - Lifetime
- 2003-11-27 CA CA002507908A patent/CA2507908A1/en not_active Abandoned
- 2003-11-27 CN CNB2003801045565A patent/CN100384791C/zh not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006508161A5 (cg-RX-API-DMAC7.html) | ||
| US6909009B2 (en) | Alkane and alkane group dehydrogenation with organometallic catalysts | |
| JP6469863B2 (ja) | ゲルミレン系有機触媒を用いたヒドロシリル化方法 | |
| CN102458659B (zh) | 不对称氢化催化剂 | |
| US8558017B2 (en) | Ruthenium (II) catalysts for use in stereoselective cyclopropanations | |
| JP5545756B2 (ja) | ベンゾ［ｈ］キノリン種の新規配位子およびそれらを含む遷移金属錯体および触媒としての前記錯体の使用 | |
| US7446236B2 (en) | Catalytic hydrogenation of carbon-heteroatom double bonds | |
| US7378560B2 (en) | Ruthenium complex and process for producing tert-alkyl alcohol therewith | |
| Widhalm et al. | Chiral ferrocene derivatives containing a 2, 2′-bridged binaphthyl moiety | |
| US7291753B2 (en) | Transfer hydrogenation processes and catalysts | |
| TW200813079A (en) | Method for making optically active amino phosphinylbutanoic acids | |
| JP4597466B2 (ja) | ルテニウム化合物を製造する方法 | |
| JP2002187895A5 (cg-RX-API-DMAC7.html) | ||
| JP2010519272A (ja) | 不斉水素化反応で使用されるビス（フェロセニルホスフィノ）フェロセン配位子 | |
| Kuriyama | Development of efficient catalytic arylation of aldehydes with thioether-imidazolinium carbene ligands | |
| JPS63230694A (ja) | 少なくとも１個のシクロアルキル環を含有するシランまたはシロキサン化合物の製法 | |
| Korostylev et al. | Chiral pyrophosphites—synthesis and application as ligands in Rh (I)-catalyzed asymmetric hydrogenation | |
| EP1844061B1 (en) | Metallocene-based phosphorus chiral phosphines | |
| JP5685046B2 (ja) | 光学純度低下防止方法 | |
| JP6056036B2 (ja) | 光学活性２−アリールピペリジニウム塩の製造方法 | |
| Debnath et al. | Synthesis and coordination chemistry of new asymmetric donor/acceptor pincer ligands, 1, 3-C 6 H 4 (CH 2 P t Bu (R f)) 2 (R f= CF 3, C 2 F 5) | |
| WO2007034975A1 (ja) | ジホスフィン配位子およびそれを用いた遷移金属錯体 | |
| US9896402B2 (en) | Method for preventing decrease in optical purity | |
| JP2012031119A (ja) | 軸不斉イソキノリン誘導体及びその製造方法並びに不斉合成方法 | |
| JP5232374B2 (ja) | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |