JP2006508107A5 - - Google Patents
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- JP2006508107A5 JP2006508107A5 JP2004550489A JP2004550489A JP2006508107A5 JP 2006508107 A5 JP2006508107 A5 JP 2006508107A5 JP 2004550489 A JP2004550489 A JP 2004550489A JP 2004550489 A JP2004550489 A JP 2004550489A JP 2006508107 A5 JP2006508107 A5 JP 2006508107A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- composition
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- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 **=*C(c1c(*)*n*(N*)*1)=*[*+] Chemical compound **=*C(c1c(*)*n*(N*)*1)=*[*+] 0.000 description 10
- QEITZRMTXOMJER-UHFFFAOYSA-N C1C2C(CC3)C3CCC12 Chemical compound C1C2C(CC3)C3CCC12 QEITZRMTXOMJER-UHFFFAOYSA-N 0.000 description 1
- LXNRLNDZSUGVIZ-UHFFFAOYSA-N CC1C(C)(CC2)C2CC1 Chemical compound CC1C(C)(CC2)C2CC1 LXNRLNDZSUGVIZ-UHFFFAOYSA-N 0.000 description 1
- XGOJEEATRXFBJN-UHFFFAOYSA-N CCC(C1)=CC=C(C(C=C2N)C=C=C2OC)N=C1Nc1cccc(OC2C=CC=CC2)c1 Chemical compound CCC(C1)=CC=C(C(C=C2N)C=C=C2OC)N=C1Nc1cccc(OC2C=CC=CC2)c1 XGOJEEATRXFBJN-UHFFFAOYSA-N 0.000 description 1
- FLLVWQWXWWJBLW-UHFFFAOYSA-N CCC(C1)=CC=C(c(cc2N)ccc2OC)N=C1Nc(cc1)ccc1S(=C)=O Chemical compound CCC(C1)=CC=C(c(cc2N)ccc2OC)N=C1Nc(cc1)ccc1S(=C)=O FLLVWQWXWWJBLW-UHFFFAOYSA-N 0.000 description 1
- CXUIMSIUZAGXBG-UHFFFAOYSA-O CCC(C1)=CCC(C(CC2N)=CC=C2OC)N=C1[NH2+]c1cc(C)cc(C)c1 Chemical compound CCC(C1)=CCC(C(CC2N)=CC=C2OC)N=C1[NH2+]c1cc(C)cc(C)c1 CXUIMSIUZAGXBG-UHFFFAOYSA-O 0.000 description 1
- CBEGTFNCNBGGFY-UHFFFAOYSA-O CCC(C1)=CCC(c(cc2N)ccc2OC)N=C1[NH2+]c1cccc(-c2ccccc2)c1 Chemical compound CCC(C1)=CCC(c(cc2N)ccc2OC)N=C1[NH2+]c1cccc(-c2ccccc2)c1 CBEGTFNCNBGGFY-UHFFFAOYSA-O 0.000 description 1
- SJYXRQQGBIFRBO-UHFFFAOYSA-O CCC(CC(C)[NH2+]C(C1)C=CC=C1C(OCC)=O)=CC=C(C(C=C1N)=CCC1OC)N Chemical compound CCC(CC(C)[NH2+]C(C1)C=CC=C1C(OCC)=O)=CC=C(C(C=C1N)=CCC1OC)N SJYXRQQGBIFRBO-UHFFFAOYSA-O 0.000 description 1
- QJTBHYFTQAEADC-UHFFFAOYSA-O COC(C(N)=C1)=CCC1C(N)=CC1C(CC([NH2+]c2ccccc2)=C)C1 Chemical compound COC(C(N)=C1)=CCC1C(N)=CC1C(CC([NH2+]c2ccccc2)=C)C1 QJTBHYFTQAEADC-UHFFFAOYSA-O 0.000 description 1
- WAGDBAZSJRNKMB-UHFFFAOYSA-O COc(c(N)c1)ccc1-c1cccc([NH2+]C(C2)C=CC=C2F)n1 Chemical compound COc(c(N)c1)ccc1-c1cccc([NH2+]C(C2)C=CC=C2F)n1 WAGDBAZSJRNKMB-UHFFFAOYSA-O 0.000 description 1
- WSXBWBYDNIVHHN-UHFFFAOYSA-O COc1cc([NH2+]c2nc(-c(cc3N)ccc3OC)ccn2)ccc1 Chemical compound COc1cc([NH2+]c2nc(-c(cc3N)ccc3OC)ccn2)ccc1 WSXBWBYDNIVHHN-UHFFFAOYSA-O 0.000 description 1
- VORBWXREWDZPFB-MKMHIBQSSA-N C[C@H](CC1)C2(C)C1C1C2CC1 Chemical compound C[C@H](CC1)C2(C)C1C1C2CC1 VORBWXREWDZPFB-MKMHIBQSSA-N 0.000 description 1
- IQZDIBKPVOENRY-UHFFFAOYSA-N C[OH+][NH+](c(cc(cc1)-c2ccnc(NC3(C4)C=CC=C4C3)n2)c1O)[O-] Chemical compound C[OH+][NH+](c(cc(cc1)-c2ccnc(NC3(C4)C=CC=C4C3)n2)c1O)[O-] IQZDIBKPVOENRY-UHFFFAOYSA-N 0.000 description 1
- NDJURPXFXIUTPX-UHFFFAOYSA-N Cc1cc(Nc2nc(-c(cc3N)ccc3OC)ccn2)ccc1 Chemical compound Cc1cc(Nc2nc(-c(cc3N)ccc3OC)ccn2)ccc1 NDJURPXFXIUTPX-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42404302P | 2002-11-05 | 2002-11-05 | |
| PCT/US2003/035188 WO2004041810A1 (en) | 2002-11-05 | 2003-11-05 | Compounds useful as inhibitors of jak and other protein kinases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010139840A Division JP2010195838A (ja) | 2002-11-05 | 2010-06-18 | Ｊａｋおよび他のプロテインキナーゼのインヒビターとして有用な化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006508107A JP2006508107A (ja) | 2006-03-09 |
| JP2006508107A5 true JP2006508107A5 (OSRAM) | 2006-08-31 |
Family
ID=32312743
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004550489A Pending JP2006508107A (ja) | 2002-11-05 | 2003-11-05 | Ｊａｋおよび他のプロテインキナーゼのインヒビターとして有用な化合物 |
| JP2010139840A Pending JP2010195838A (ja) | 2002-11-05 | 2010-06-18 | Ｊａｋおよび他のプロテインキナーゼのインヒビターとして有用な化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010139840A Pending JP2010195838A (ja) | 2002-11-05 | 2010-06-18 | Ｊａｋおよび他のプロテインキナーゼのインヒビターとして有用な化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7348335B2 (OSRAM) |
| EP (1) | EP1560824A1 (OSRAM) |
| JP (2) | JP2006508107A (OSRAM) |
| AU (2) | AU2003286895A1 (OSRAM) |
| CA (1) | CA2507406A1 (OSRAM) |
| WO (1) | WO2004041810A1 (OSRAM) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| RS51752B (sr) | 2002-07-29 | 2011-12-31 | Rigel Pharmaceuticals | Metode tretiranja i prevencije autoimunih oboljenja jedinjenjima 2,4-pirimidindiamina |
| US7304071B2 (en) * | 2002-08-14 | 2007-12-04 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
| WO2004041789A1 (en) * | 2002-11-01 | 2004-05-21 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of jak and other protein kinases |
| US20050014753A1 (en) * | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
| HRP20130602T1 (en) | 2003-07-30 | 2013-07-31 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| JP2007500179A (ja) | 2003-07-30 | 2007-01-11 | サイクラセル・リミテッド | キナーゼ阻害剤としての２−アミノフェニル−４−フェニルピリミジン |
| CN102127056B (zh) * | 2003-12-03 | 2013-08-21 | Ym生物科学澳大利亚私人有限公司 | 微管蛋白抑制剂 |
| US20080027034A1 (en) * | 2004-09-10 | 2008-01-31 | Shah Tushar P | Ciclesonide and Syk Inhibitor Combination and Method of Use Thereof |
| TW200626559A (en) * | 2004-10-13 | 2006-08-01 | Wyeth Corp | Anilino-pyrimidine analogs |
| DE602006010979D1 (de) | 2005-01-19 | 2010-01-21 | Rigel Pharmaceuticals Inc | Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
| CA2599544A1 (en) | 2005-02-28 | 2006-09-08 | Japan Tobacco Inc. | Novel aminopyridine compound with syk inhibitory activity |
| CA2608367C (en) | 2005-06-08 | 2014-08-19 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| EA200870217A1 (ru) | 2006-01-30 | 2009-02-27 | Экселиксис, Инк. | 4-арил-2-аминопиримидины или 4-арил-2-аминоалкилпиримидины в качестве модуляторов jak-2 и содержащие их фармацевтические композиции |
| ES2622493T3 (es) | 2006-02-24 | 2017-07-06 | Rigel Pharmaceuticals, Inc. | Composiciones y métodos para la inhibición de la ruta de JAK |
| EP2402318A1 (en) * | 2006-03-31 | 2012-01-04 | Novartis AG | DGAT inhibitors |
| WO2007120593A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | Anilino-pyrimidine phenyl and benzothiophene analogs |
| WO2008009458A1 (en) * | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors |
| CA2673125C (en) | 2006-10-19 | 2015-04-21 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| WO2008065155A1 (en) * | 2006-11-30 | 2008-06-05 | Ingenium Pharmaceuticals Gmbh | Cdk inhibitors for treating pain |
| EP2101783A2 (en) * | 2006-12-11 | 2009-09-23 | Novartis Ag | Method of preventing or treating myocardial ischemia |
| CN104030990B (zh) * | 2007-03-12 | 2017-01-04 | Ym生物科学澳大利亚私人有限公司 | 苯基氨基嘧啶化合物及其用途 |
| AU2013201306B2 (en) * | 2007-03-12 | 2015-11-12 | Glaxosmithkline Llc | Phenyl Amino Pyrimidine Compounds and Uses Thereof |
| AU2016200866B2 (en) * | 2007-03-12 | 2017-06-22 | Glaxosmithkline Llc | Phenyl amino pyrimidine compounds and uses thereof |
| CA2698511C (en) * | 2007-09-04 | 2016-10-11 | The Scripps Research Institute | Substituted pyrimidinyl-amines as protein kinase inhibitors |
| AU2009214440B2 (en) * | 2008-02-15 | 2014-09-25 | Rigel Pharmaceuticals, Inc. | Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases |
| US20110009421A1 (en) * | 2008-02-27 | 2011-01-13 | Takeda Pharmaceutical Company Limited | Compound having 6-membered aromatic ring |
| GB0805477D0 (en) * | 2008-03-26 | 2008-04-30 | Univ Nottingham | Pyrimidines triazines and their use as pharmaceutical agents |
| AU2009244897B2 (en) | 2008-04-16 | 2014-11-13 | Alexion Pharmaceuticals, Inc. | 2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| WO2009131687A2 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| ES2607851T3 (es) * | 2008-05-15 | 2017-04-04 | The University Of North Carolina At Chapel Hill | Objetivos novedosos para la regulación de la angiogénesis |
| MX2012004313A (es) * | 2009-10-12 | 2012-07-20 | Myrexis Inc | Compuestos de amino-pirimidina como inhibidores de cinasa 1 de union a tank (tbk1) y/o i-kappa-b-cinasa epsilon (ikk epsilon). |
| US8735417B2 (en) | 2009-12-17 | 2014-05-27 | Merck Sharp & Dohme Corp. | Aminopyrimidines as Syk inhibitors |
| SG181857A1 (en) | 2009-12-23 | 2012-07-30 | Takeda Pharmaceutical | Fused heteroaromatic pyrrolidinones as syk inhibitors |
| EP2635557A2 (en) | 2010-11-01 | 2013-09-11 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
| WO2012066065A1 (en) * | 2010-11-17 | 2012-05-24 | Novartis Ag | Phenyl-heteroaryl amine compounds and their uses |
| WO2012066070A1 (en) * | 2010-11-17 | 2012-05-24 | Novartis Ag | 3-(aminoaryl)-pyridine compounds |
| EP2668177B1 (en) * | 2011-01-28 | 2014-10-22 | Boehringer Ingelheim International GmbH | Substituted pyridinyl-pyrimidines and their use as medicaments |
| US9145391B2 (en) | 2011-05-10 | 2015-09-29 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as Syk inhibitors |
| EP2723739B1 (en) | 2011-06-22 | 2016-08-24 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| SG10201601352UA (en) | 2011-11-23 | 2016-03-30 | Portola Pharm Inc | Pyrazine kinase inhibitors |
| AR089776A1 (es) | 2012-01-23 | 2014-09-17 | Boehringer Ingelheim Int | 5,8-dihidro-6h-pirazolo[3,4-h]quinazolinas como inhibidores de igf-1r/ir |
| WO2013175415A1 (en) * | 2012-05-23 | 2013-11-28 | Piramal Enterprises Limited | Substituted pyrimidine compounds and uses thereof |
| US8809359B2 (en) | 2012-06-29 | 2014-08-19 | Ym Biosciences Australia Pty Ltd | Phenyl amino pyrimidine bicyclic compounds and uses thereof |
| WO2014013014A1 (en) | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Jak inhibitors for activation of epidermal stem cell populations |
| WO2014031438A2 (en) * | 2012-08-20 | 2014-02-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
| EP2903970A4 (en) | 2012-10-08 | 2016-11-30 | Portola Pharm Inc | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS |
| RS58062B1 (sr) | 2014-04-02 | 2019-02-28 | Bristol Myers Squibb Co | Biaril inhibitori kinaze |
| TWI681954B (zh) | 2014-06-12 | 2020-01-11 | 美商西爾拉癌症醫學公司 | Ｎ-（氰基甲基）-４-（２-（４-𠰌啉基苯基胺基）嘧啶-４-基）苯甲醯胺 |
| CN112142655A (zh) * | 2015-10-01 | 2020-12-29 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
| CN108290843B (zh) | 2015-10-01 | 2021-08-24 | 百时美施贵宝公司 | 联芳基激酶抑制剂 |
| WO2018041989A1 (en) | 2016-09-02 | 2018-03-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating refractory celiac disease type 2 |
| JP2022526713A (ja) | 2019-03-21 | 2022-05-26 | オンクセオ | がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子 |
| JP2022527972A (ja) | 2019-04-02 | 2022-06-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前悪性病変を有する患者において癌を予測及び予防する方法 |
| WO2020212395A1 (en) | 2019-04-16 | 2020-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN113549018B (zh) * | 2020-04-24 | 2024-02-27 | 中国药科大学 | 蛋白激酶抑制剂及其衍生物，制备方法、药物组合物和应用 |
| CN115403516B (zh) * | 2021-08-03 | 2024-01-26 | 河南省儿童医院郑州儿童医院 | 含3,4,5-三取代基苯环的芳杂环化合物、药物组合物及其制备方法和应用 |
| CN115703760B (zh) * | 2021-08-11 | 2024-05-31 | 山东大学 | 2,4-二取代嘧啶类细胞周期蛋白依赖性激酶酶抑制剂及其制备方法和应用 |
| CN118891251A (zh) * | 2022-02-03 | 2024-11-01 | 奈可萨斯医药有限公司 | 芳基烃受体激动剂及其用途 |
| WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
| KR20250054814A (ko) * | 2022-09-05 | 2025-04-23 | 티와이케이 메디슨즈, 인코포레이티드 | Cdk4 키나아제 억제제로 사용되는 화합물 및 이의 용도 |
| CN117886801B (zh) * | 2024-03-14 | 2024-05-17 | 中国药科大学 | 吡啶酮嘧啶类cdk抑制剂及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| GB8412184D0 (en) * | 1984-05-12 | 1984-06-20 | Fisons Plc | Biologically active nitrogen heterocycles |
| EP0672035A1 (en) | 1993-10-01 | 1995-09-20 | Novartis AG | Pyrimidineamine derivatives and processes for the preparation thereof |
| JP2983636B2 (ja) | 1993-10-01 | 1999-11-29 | ノバルティス アクチェンゲゼルシャフト | 薬理学的に活性なピリジン誘導体及びその製造方法 |
| ATE325113T1 (de) | 1993-10-01 | 2006-06-15 | Novartis Pharma Gmbh | Pharmacologisch wirksame pyrimidinderivate und verfahren zu deren herstellung |
| GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| CN1312807A (zh) | 1998-06-19 | 2001-09-12 | 希龙公司 | 糖元合成酶激酶3的抑制剂 |
| GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| AU2001295026B2 (en) * | 2000-09-06 | 2008-04-03 | Novartis Vaccines And Diagnostics, Inc. | Inhibitors of glycogen synthase kinase 3 |
| ATE346064T1 (de) | 2000-09-15 | 2006-12-15 | Vertex Pharma | Pyrazolverbindungen als protein-kinasehemmer |
| US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| US7129242B2 (en) * | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| US6949544B2 (en) | 2001-03-29 | 2005-09-27 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases |
| GB0107901D0 (en) * | 2001-03-29 | 2001-05-23 | Cyclacel Ltd | Anti-cancer compounds |
| WO2003030909A1 (en) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| WO2004041789A1 (en) | 2002-11-01 | 2004-05-21 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of jak and other protein kinases |
-
2003
- 2003-11-05 JP JP2004550489A patent/JP2006508107A/ja active Pending
- 2003-11-05 EP EP03778111A patent/EP1560824A1/en not_active Withdrawn
- 2003-11-05 WO PCT/US2003/035188 patent/WO2004041810A1/en not_active Ceased
- 2003-11-05 AU AU2003286895A patent/AU2003286895A1/en not_active Abandoned
- 2003-11-05 US US10/702,113 patent/US7348335B2/en not_active Expired - Fee Related
- 2003-11-05 CA CA002507406A patent/CA2507406A1/en not_active Abandoned
-
2010
- 2010-06-18 JP JP2010139840A patent/JP2010195838A/ja active Pending
- 2010-11-19 AU AU2010246324A patent/AU2010246324B2/en not_active Ceased
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