JP2003514770A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003514770A5 JP2003514770A5 JP2001522958A JP2001522958A JP2003514770A5 JP 2003514770 A5 JP2003514770 A5 JP 2003514770A5 JP 2001522958 A JP2001522958 A JP 2001522958A JP 2001522958 A JP2001522958 A JP 2001522958A JP 2003514770 A5 JP2003514770 A5 JP 2003514770A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- disease
- composition according
- compound
- glycero
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL131887 | 1999-09-14 | ||
| IL13188799A IL131887A0 (en) | 1999-09-14 | 1999-09-14 | Phospholipid prodrugs of anti-proliferative drugs |
| PCT/IL2000/000562 WO2001019320A2 (en) | 1999-09-14 | 2000-09-13 | Phospholipid prodrugs of anti-proliferative drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003514770A JP2003514770A (ja) | 2003-04-22 |
| JP2003514770A5 true JP2003514770A5 (OSRAM) | 2007-10-11 |
Family
ID=11073248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522958A Pending JP2003514770A (ja) | 1999-09-14 | 2000-09-13 | 抗増殖性医薬の燐脂質プロドラッグ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6774121B1 (OSRAM) |
| EP (1) | EP1218013A4 (OSRAM) |
| JP (1) | JP2003514770A (OSRAM) |
| AU (1) | AU781507B2 (OSRAM) |
| CA (1) | CA2382633A1 (OSRAM) |
| IL (2) | IL131887A0 (OSRAM) |
| NZ (1) | NZ517522A (OSRAM) |
| WO (1) | WO2001019320A2 (OSRAM) |
| ZA (1) | ZA200201081B (OSRAM) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7135584B2 (en) | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
| US5962437A (en) | 1994-08-29 | 1999-10-05 | Wake Forest University | Lipid analogs for treating viral infections |
| US7026469B2 (en) * | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
| US6670341B1 (en) | 1999-10-28 | 2003-12-30 | Wake Forest University Health Sciences | Compositions and methods for double-targeting virus infections and targeting cancer cells |
| US7309696B2 (en) | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
| RU2316349C2 (ru) | 2001-05-02 | 2008-02-10 | Пердью Рисерч Фаундейшн | Лечение и диагностика заболеваний, опосредованных макрофагами |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US7410956B2 (en) * | 2002-02-11 | 2008-08-12 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
| NZ535828A (en) | 2002-04-26 | 2007-10-26 | Gilead Sciences Inc | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such |
| EA200501676A1 (ru) | 2003-04-25 | 2006-04-28 | Джилид Сайэнс, Инк. | Фосфонатсодержащие ингибиторы киназы (варианты), способ их получения, фармацевтическая композиция, лекарственная форма на их основе и способ ингибирования киназы у млекопитающего (варианты) |
| DK1628685T3 (da) | 2003-04-25 | 2011-03-21 | Gilead Sciences Inc | Antivirale phosphonatanaloge |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| WO2004096287A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| DE602004017452D1 (de) | 2003-05-30 | 2008-12-11 | Purdue Research Foundation | Diagnoseverfahren für atherosklerose |
| US7427624B2 (en) | 2003-10-24 | 2008-09-23 | Gilead Sciences, Inc. | Purine nucleoside phosphorylase inhibitory phosphonate compounds |
| US7432273B2 (en) | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| CA2543142A1 (en) | 2003-10-24 | 2005-05-12 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds |
| CN1906196A (zh) | 2003-12-22 | 2007-01-31 | 吉里德科学公司 | 具有hiv和hcv抗病毒活性的4＇－取代的卡波韦－和阿巴卡韦－衍生物以及相关化合物 |
| AU2005330489B2 (en) | 2004-07-27 | 2011-08-25 | Gilead Sciences, Inc. | Nucleoside phosphonate conjugates as anti HIV agents |
| WO2007006041A2 (en) | 2005-07-05 | 2007-01-11 | Purdue Research Foundation | Imaging and therapeutic method using monocytes |
| DE102006019907A1 (de) * | 2006-04-28 | 2007-10-31 | Müller-Enoch, Dieter, Prof. Dr. | Verwendung von substituierten Glycerinderivaten zur Herstellung einer pharmazeutischen Zubereitung |
| EP2087337A4 (en) | 2006-11-03 | 2010-09-08 | Purdue Research Foundation | METHOD AND DEVICE FOR EX-VIVO FLOW CYTOMETRY |
| CA2677792C (en) | 2007-02-07 | 2015-04-14 | Purdue Research Foundation | Positron emission tomography imaging method |
| EP2164525A2 (en) | 2007-05-25 | 2010-03-24 | Purdue Research Foundation | Method of imaging localized infections |
| PE20110219A1 (es) | 2008-07-08 | 2011-03-31 | Gilead Sciences Inc | Sales del compuesto n-[(s)({[(2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofuran-2-il]oxi}metil)fenoxifosfinoil]-l-alaninato de etilo como inhibidores de vih |
| WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
| EP2563404B1 (en) * | 2010-04-30 | 2016-09-21 | Urogen Pharma Ltd. | Phospholipid drug analogs |
| US20120003298A1 (en) * | 2010-04-30 | 2012-01-05 | Alcide Barberis | Methods for inducing an immune response |
| EP2646056A1 (en) * | 2010-12-02 | 2013-10-09 | Ben Gurion University of the Negev Research and Development Authority | Conjugates of a phospholipid and a drug for the treatment of inflammatory bowel disease |
| US9499800B2 (en) | 2013-12-26 | 2016-11-22 | Regents Of The University Of Minnesota | Methods of making and using chemically self assembled-nanorings |
| WO2016081203A2 (en) * | 2014-11-17 | 2016-05-26 | Cellectar Biosciences, Inc. | Phospholipid ether analogs as cancer-targeting drug vehicles |
| ES2969496T3 (es) | 2017-08-01 | 2024-05-20 | Gilead Sciences Inc | Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2- il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales |
| WO2019200043A1 (en) * | 2018-04-11 | 2019-10-17 | New Mexico Tech University Research Park Coporation | Lipid prodrugs for use in drug delivery |
| WO2025202629A1 (en) | 2024-03-26 | 2025-10-02 | Coopervision International Limited | Contact lens loaded with a glycerophospholipid |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61152694A (ja) * | 1984-12-27 | 1986-07-11 | Toyama Chem Co Ltd | 新規な５−フルオロ−２′−デオキシウリジン−５′−ホスフエ−ト誘導体およびその塩 |
| US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| EP0237051B1 (en) | 1986-03-14 | 1991-05-02 | Fujisawa Pharmaceutical Co., Ltd. | Prodrug compounds, process for the preparation thereof and sustained release preparation comprising the same |
| JPS6383093A (ja) * | 1986-09-27 | 1988-04-13 | Toyo Jozo Co Ltd | ヌクレオシド−リン脂質複合体 |
| US5411947A (en) | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
| WO1991016920A1 (en) | 1990-05-07 | 1991-11-14 | Vical, Inc. | Lipid prodrugs of salicylate and nonsteroidal anti-inflammatory drugs |
| US5543389A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
| US5149794A (en) | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
| EP0594677A4 (en) | 1991-07-12 | 1997-09-17 | Vical Inc | Antiviral liponucleosides: treatment of hepatitis b |
| IL105244A (en) | 1993-03-31 | 2003-07-31 | Dpharm Ltd | Prodrugs with enhanced penetration into cells |
| US6413949B1 (en) | 1995-06-07 | 2002-07-02 | D-Pharm, Ltd. | Prodrugs with enhanced penetration into cells |
| US7517858B1 (en) * | 1995-06-07 | 2009-04-14 | The Regents Of The University Of California | Prodrugs of pharmaceuticals with improved bioavailability |
| JP2001500847A (ja) * | 1996-08-02 | 2001-01-23 | スミスクライン・ビーチャム・コーポレイション | 癌の検出および処置の新規方法 |
| US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| EP1057024A4 (en) * | 1998-02-23 | 2002-10-30 | Diadexus Inc | METHOD FOR USING PLA 2? AS A METASTASE MARKER AND ASU-SELECTED CARCINOMAS FOR DIAGNOSIS |
-
1999
- 1999-09-14 IL IL13188799A patent/IL131887A0/xx unknown
-
2000
- 2000-09-13 JP JP2001522958A patent/JP2003514770A/ja active Pending
- 2000-09-13 NZ NZ517522A patent/NZ517522A/en not_active IP Right Cessation
- 2000-09-13 AU AU73093/00A patent/AU781507B2/en not_active Ceased
- 2000-09-13 CA CA002382633A patent/CA2382633A1/en not_active Abandoned
- 2000-09-13 EP EP00960946A patent/EP1218013A4/en not_active Withdrawn
- 2000-09-13 US US10/088,160 patent/US6774121B1/en not_active Expired - Fee Related
- 2000-09-13 WO PCT/IL2000/000562 patent/WO2001019320A2/en not_active Ceased
-
2002
- 2002-02-07 ZA ZA200201081A patent/ZA200201081B/en unknown
- 2002-03-07 IL IL148554A patent/IL148554A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003514770A5 (OSRAM) | ||
| US10570123B2 (en) | Pharmacokinetically improved compounds | |
| CN102131812B (zh) | 吡咯并[2，3-d]嘧啶化合物 | |
| US6774121B1 (en) | Phospholipid prodrugs of anti-proliferative drugs | |
| EP1948242B9 (en) | Cytotoxic compounds | |
| US9255106B2 (en) | Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors | |
| US9096627B2 (en) | Hydroxamic acid derivatives | |
| TWI508725B (zh) | 脂肪酸富馬酸酯衍生物及其用途 | |
| JP2006523202A (ja) | 生体還元により活性化されるプロドラッグ | |
| US20120202793A1 (en) | Rho kinase inhibitors | |
| US20110092478A1 (en) | Diazabenzo[de] anthracen-3-one compounds and methods for inhibiting parp | |
| TWI736578B (zh) | 6-5元稠合唑環衍生物及其藥物組合物，以及作為藥物的應用 | |
| CN111971287B (zh) | 作为trk激酶抑制剂的大环化合物 | |
| EP1383742B1 (en) | Synthesis and methods of use of tetrahydroindolone analogues and derivatives | |
| CN113372366A (zh) | 一种吡咯并嘧啶类化合物的盐、其晶型及其应用 | |
| ES2914355T3 (es) | Inhibidores bicíclicos de la histona desacetilasa | |
| KR20190025545A (ko) | 특정 단백질 키나제 억제제 | |
| CN116472041A (zh) | 氘修饰的噻吩并吡啶酮化合物 | |
| CN105732733A (zh) | 基于葡萄糖的具有锁定功能的新型脑靶向前药 | |
| EP1480984B1 (en) | Condensed camptothecins as antitumor agents | |
| US11129899B1 (en) | Methotrexate derivatives and uses thereof | |
| CN107353286A (zh) | 新型咪唑并[1,2-b]哒嗪酰胺类Bcr-Abl激酶抑制剂及其制备方法和应用 | |
| CN116693505A (zh) | 一种靶向降解egfr蛋白的化合物及其制法和应用 | |
| WO2015096697A1 (zh) | 非环核苷磷酸酯类衍生物及其制备方法与在医学上的应用 | |
| CN101370813A (zh) | 用作抗癌药物的6-[(取代的)苯基]三唑并嘧啶类的二聚体和加合物 |