JP2006507277A - ２４時間有効な持続放出トラマドール製剤 - Google Patents

２４時間有効な持続放出トラマドール製剤 Download PDF

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Publication number
JP2006507277A
JP2006507277A JP2004545655A JP2004545655A JP2006507277A JP 2006507277 A JP2006507277 A JP 2006507277A JP 2004545655 A JP2004545655 A JP 2004545655A JP 2004545655 A JP2004545655 A JP 2004545655A JP 2006507277 A JP2006507277 A JP 2006507277A
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Prior art keywords
hours
composition
tramadol
administration
plasma concentration
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JP2004545655A
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English (en)
Japanese (ja)
Inventor
レナエルツ ビンセント
ローレ オウアジ‐ンジキ パトリシア
ベーコン ジョナサン
オウゼルールー ラシッド
ジェルヴェ ソニア
ラモウニ ミロード
スミス デーモン
Original Assignee
ラボファーマ インコーポレイテッド
ラボファーマ ヨーロッパ リミテッド
ラボファーマ（バルバドス）リミテッド
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32179487&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2006507277(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ラボファーマ インコーポレイテッド, ラボファーマ ヨーロッパ リミテッド, ラボファーマ（バルバドス）リミテッド filed Critical ラボファーマ インコーポレイテッド
Publication of JP2006507277A publication Critical patent/JP2006507277A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2004545655A 2002-10-25 2003-10-27 ２４時間有効な持続放出トラマドール製剤 Pending JP2006507277A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28102602A 2002-10-25 2002-10-25
US51037803P 2003-10-10 2003-10-10
PCT/CA2003/001638 WO2004037222A2 (fr) 2002-10-25 2003-10-27 Preparations de tramadol a liberation soutenue dotees d'une efficacite de 24 heures

Publications (1)

Publication Number Publication Date
JP2006507277A true JP2006507277A (ja) 2006-03-02

Family

ID=32179487

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004545655A Pending JP2006507277A (ja) 2002-10-25 2003-10-27 ２４時間有効な持続放出トラマドール製剤

Country Status (11)

Country Link
JP (1) JP2006507277A (fr)
KR (1) KR20050083816A (fr)
AR (1) AR045972A1 (fr)
AU (1) AU2003275855B2 (fr)
CA (1) CA2503155A1 (fr)
IL (1) IL168114A (fr)
NO (1) NO20052479D0 (fr)
PT (1) PT1594460E (fr)
RU (1) RU2328275C2 (fr)
UA (1) UA84277C2 (fr)
WO (1) WO2004037222A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009534429A (ja) * 2006-04-26 2009-09-24 アルファファーム ピーティーワイ リミテッド コーティングされていない分離したユニットおよび延長放出マトリクスを含む制御放出配合物
JP2019519488A (ja) * 2016-05-05 2019-07-11 アクエスティブ セラピューティクス インコーポレイテッド 透過性増強された医薬組成物

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
EP1905435A3 (fr) * 2003-03-11 2008-05-14 Euro-Celtique S.A. Régime de dosage de titrage pour tramadol à libération contrôlée
US7413749B2 (en) 2003-03-11 2008-08-19 Purdue Pharma L.P. Titration dosing regimen for controlled release tramadol
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
BRPI0511137A (pt) * 2004-05-14 2007-11-27 Janssen Pharmaceutica Nv compostos opióides de carboxamido
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
PL1931346T3 (pl) * 2005-09-09 2013-01-31 Angelini Labopharm Llc Kompozycja trazodonu do podawania raz na dobę
JP5774853B2 (ja) 2008-01-25 2015-09-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 医薬投薬形
TWI524904B (zh) 2008-05-09 2016-03-11 歌林達股份有限公司 製備醫藥用固體劑型，尤指錠劑之方法，及製備固體劑型，尤指錠劑之前驅物之方法
AU2009253739B2 (en) 2008-05-27 2014-02-06 Otolanum Ag Methods of treating mammals with eustachian tube dysfunctions
CA2741751C (fr) * 2008-10-27 2017-05-09 Alza Corporation Forme posologique orale d'acetaminophene/tramadol a liberation prolongee
CA2765971C (fr) 2009-07-22 2017-08-22 Gruenenthal Gmbh Forme galenique extrudee a chaud a liberation controlee
JP2012533586A (ja) 2009-07-22 2012-12-27 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 酸化安定化された不正使用防止剤形
ES2606227T3 (es) 2010-02-03 2017-03-23 Grünenthal GmbH Preparación de una composición farmacéutica en polvo mediante una extrusora
NZ608865A (en) 2010-09-02 2015-03-27 Gruenenthal Chemie Tamper resistant dosage form comprising an anionic polymer
AU2011297901B2 (en) 2010-09-02 2014-07-31 Grunenthal Gmbh Tamper resistant dosage form comprising inorganic salt
CN103841964A (zh) 2011-07-29 2014-06-04 格吕伦塔尔有限公司 提供药物立即释放的抗破碎片剂
PT2736497T (pt) 2011-07-29 2017-11-30 Gruenenthal Gmbh Comprimido resistente a adulteração proporcionando libertação imediata de fármaco
JP6117249B2 (ja) 2012-02-28 2017-04-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形
WO2013156453A1 (fr) 2012-04-18 2013-10-24 Grünenthal GmbH Forme pharmaceutique inviolable et résistante à la libération massive
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
MX371432B (es) 2013-05-29 2020-01-30 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido que contiene una o mas particulas.
CA2913209A1 (fr) 2013-05-29 2014-12-04 Grunenthal Gmbh Forme dosifiee inviolable a profil de liberation bimodale
MX368846B (es) 2013-07-12 2019-10-18 Gruenenthal Gmbh Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo.
EP3073994A1 (fr) 2013-11-26 2016-10-05 Grünenthal GmbH Préparation de composition pharmaceutique en poudre par cryo-broyage
EP3142646A1 (fr) 2014-05-12 2017-03-22 Grünenthal GmbH Formulation pour capsule à libération immédiate résistant aux manipulations illicites comprenant du tapentadol
EA201692388A1 (ru) 2014-05-26 2017-05-31 Грюненталь Гмбх Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
EA035434B1 (ru) 2015-04-24 2020-06-15 Грюненталь Гмбх Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями
EP3346991A1 (fr) 2015-09-10 2018-07-18 Grünenthal GmbH Protection contre un surdosage par voie orale à l'aide de formulations à libération immédiate dissuasives d'abus

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753361A (ja) * 1993-05-10 1995-02-28 Euro Celtique Sa 放出が調整された調合物、経口投与形態及びその製造方法
JP2000510487A (ja) * 1997-07-02 2000-08-15 ユーロ―セルティーク，エス．エイ． 安定化された徐放性トラマドール製剤
JP2001278813A (ja) * 2000-03-29 2001-10-10 Basf Ag 遅延された作用物質の放出および高い機械的安定性を有する経口投与形、前記投与形の医薬品および該投与形の使用
WO2002002084A1 (fr) * 2000-06-29 2002-01-10 Vincent Lenaerts Amidon reticule a forte teneur en amylose pouvant etre utilise dans des preparations pharmaceutique a liberation prolongee et procedes de fabrication associes
WO2002066026A2 (fr) * 2001-02-21 2002-08-29 Grünenthal GmbH Medicament a base de tramadol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19530575A1 (de) * 1995-08-19 1997-02-20 Gruenenthal Gmbh Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753361A (ja) * 1993-05-10 1995-02-28 Euro Celtique Sa 放出が調整された調合物、経口投与形態及びその製造方法
JP2000510487A (ja) * 1997-07-02 2000-08-15 ユーロ―セルティーク，エス．エイ． 安定化された徐放性トラマドール製剤
JP2001278813A (ja) * 2000-03-29 2001-10-10 Basf Ag 遅延された作用物質の放出および高い機械的安定性を有する経口投与形、前記投与形の医薬品および該投与形の使用
WO2002002084A1 (fr) * 2000-06-29 2002-01-10 Vincent Lenaerts Amidon reticule a forte teneur en amylose pouvant etre utilise dans des preparations pharmaceutique a liberation prolongee et procedes de fabrication associes
WO2002066026A2 (fr) * 2001-02-21 2002-08-29 Grünenthal GmbH Medicament a base de tramadol

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009534429A (ja) * 2006-04-26 2009-09-24 アルファファーム ピーティーワイ リミテッド コーティングされていない分離したユニットおよび延長放出マトリクスを含む制御放出配合物
JP2019519488A (ja) * 2016-05-05 2019-07-11 アクエスティブ セラピューティクス インコーポレイテッド 透過性増強された医薬組成物

Also Published As

Publication number Publication date
AU2003275855B2 (en) 2009-04-23
RU2328275C2 (ru) 2008-07-10
AR045972A1 (es) 2005-11-23
UA84277C2 (ru) 2008-10-10
IL168114A (en) 2011-05-31
WO2004037222A2 (fr) 2004-05-06
NO20052479L (no) 2005-05-23
KR20050083816A (ko) 2005-08-26
PT1594460E (pt) 2008-06-27
CA2503155A1 (fr) 2004-05-06
WO2004037222A3 (fr) 2005-09-22
RU2005115855A (ru) 2006-01-20
AU2003275855A1 (en) 2004-05-13
NO20052479D0 (no) 2005-05-23

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