JP2006504753A - 抗癌剤および抗感染症薬としてのジヒドロアルテミシニンおよびジヒドロアルテミシテンの二量体 - Google Patents

抗癌剤および抗感染症薬としてのジヒドロアルテミシニンおよびジヒドロアルテミシテンの二量体 Download PDF

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JP2006504753A
JP2006504753A JP2004544832A JP2004544832A JP2006504753A JP 2006504753 A JP2006504753 A JP 2006504753A JP 2004544832 A JP2004544832 A JP 2004544832A JP 2004544832 A JP2004544832 A JP 2004544832A JP 2006504753 A JP2006504753 A JP 2006504753A
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compound
compounds
dihydroartemisinin
activity
cancer
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JP2006504753A5 (enExample
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マームード エイ エルソーリー
サミアー エイ ロス
アーメッド エム ギャラル
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ユニヴァーシティー オブ ミシシッピ
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Publication of JP2006504753A publication Critical patent/JP2006504753A/ja
Publication of JP2006504753A5 publication Critical patent/JP2006504753A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2004544832A 2002-10-15 2003-10-09 抗癌剤および抗感染症薬としてのジヒドロアルテミシニンおよびジヒドロアルテミシテンの二量体 Pending JP2006504753A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/271,960 US6790863B2 (en) 2002-10-15 2002-10-15 Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents
PCT/US2003/032049 WO2004034976A2 (en) 2002-10-15 2003-10-09 Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer nd anti-infective agents

Publications (2)

Publication Number Publication Date
JP2006504753A true JP2006504753A (ja) 2006-02-09
JP2006504753A5 JP2006504753A5 (enExample) 2006-12-07

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ID=32069214

Family Applications (1)

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JP2004544832A Pending JP2006504753A (ja) 2002-10-15 2003-10-09 抗癌剤および抗感染症薬としてのジヒドロアルテミシニンおよびジヒドロアルテミシテンの二量体

Country Status (7)

Country Link
US (3) US6790863B2 (enExample)
EP (1) EP1551389A4 (enExample)
JP (1) JP2006504753A (enExample)
AU (1) AU2003282543B2 (enExample)
CA (1) CA2501942A1 (enExample)
MX (1) MXPA05003920A (enExample)
WO (1) WO2004034976A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009533398A (ja) * 2006-04-11 2009-09-17 サノフイ−アベンテイス アルテミシニン誘導体の二量体、この調製およびこの治療上の使用
JP2011529472A (ja) * 2008-07-29 2011-12-08 ピエール、ファーブル、メディカマン アーテミシニンの二量体誘導体および抗ガン療法における用途
JP2022522544A (ja) * 2019-02-26 2022-04-19 マフムード エイ エルソーリー リーシュマニア症の処置用に選択されたアーテミシニンダイマー

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6790863B2 (en) * 2002-10-15 2004-09-14 University Of Mississippi Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents
CA2570961C (en) * 2004-06-21 2015-09-01 University Of Mississippi Anticancer and antiprotozoal dihydroartemisinene and dihydroartemisitene dimers with desirable chemical functionalities
CN1311832C (zh) * 2005-01-12 2007-04-25 四川科伦药业股份有限公司 溴代二氢青蒿素的医药用途
US7566465B2 (en) * 2006-12-21 2009-07-28 The United States Of America As Represented By The Secretary Of The Army Artemisinins in the clinical and veterinary management of kinetoplastid infections
CA2787722C (en) 2010-01-22 2018-08-21 Council Of Scientific & Industrial Research A series of artemisinin derivatives and process for preparation thereof
WO2012111025A2 (en) 2011-02-14 2012-08-23 Council Of Scientific & Industrial Research 1,2,3-triazole containing artemisinin compounds and process for preparation thereof
US9011892B2 (en) 2011-10-25 2015-04-21 U.S. Phytotherapy, Inc. Artemisinin with berberine compositions and methods of making
US9675582B2 (en) 2011-10-25 2017-06-13 U.S. Phytotherapy, Inc. Alternative ACT with natural botanical active GRAS ingredients for treatment and prevention of the Zika virus
US9358261B2 (en) 2011-10-25 2016-06-07 U.S. Phytotherapy, Inc. Additional artemisinin and berberine compositions and methods of making
US9487538B2 (en) 2013-01-22 2016-11-08 The Johns Hopkins University Two-carbon linked artemisinin-derived trioxane dimers
WO2015041722A1 (en) 2013-09-17 2015-03-26 Kryptonite Group, Ltd Enhanced artemisinin-based combination therapy for treating parasitic mediated disease
CN106928274B (zh) * 2017-02-28 2019-09-10 东南大学 一种双氢青蒿素二倍体衍生物、其药物组合物及应用
CN109467565B (zh) * 2018-08-16 2020-07-10 云白药征武科技(上海)有限公司 双氢青蒿素三聚体及其制备方法和应用
CN110305017B (zh) * 2019-08-09 2022-02-25 大理大学 降桉烷倍半萜类化合物及其药物组合物和制备方法与应用
CN110448551A (zh) * 2019-08-23 2019-11-15 西南大学 二氢青蒿素衍生物在制备抗血管生成药物中的应用
CN110354270B (zh) * 2019-08-30 2022-04-15 中国中医科学院中药研究所 一种青蒿琥酯聚乙二醇衍生物及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6287584A (ja) * 1985-10-07 1987-04-22 ペンウオルト・コ−ポレ−シヨン ビス（ジベンゾ〔ｂ，ｄ〕ピラニルオキシ）プロパン
WO1992022545A1 (en) * 1991-06-14 1992-12-23 Fidia S.P.A. New coumarin derivatives
US5677468A (en) * 1995-06-29 1997-10-14 Hauser, Inc. Artemisinin dimer compounds having anticancer activity
JP2001527043A (ja) * 1997-12-30 2001-12-25 ハウサー，インコーポレイティド 抗マラリア、抗増殖及び抗腫瘍活性を有する、ｃ−１０炭素原子−置換されているアルテミシニン様トリオキサン化合物類

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952603A (en) 1988-06-20 1990-08-28 Elferaly Farouk S Method for the isolation of artemisinin from Artemisia annua
US6790863B2 (en) * 2002-10-15 2004-09-14 University Of Mississippi Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6287584A (ja) * 1985-10-07 1987-04-22 ペンウオルト・コ−ポレ−シヨン ビス（ジベンゾ〔ｂ，ｄ〕ピラニルオキシ）プロパン
WO1992022545A1 (en) * 1991-06-14 1992-12-23 Fidia S.P.A. New coumarin derivatives
US5677468A (en) * 1995-06-29 1997-10-14 Hauser, Inc. Artemisinin dimer compounds having anticancer activity
US5856351A (en) * 1995-06-29 1999-01-05 Zheng; Qun Y. Artemisinin dimer compounds having anticancer activity
JP2001527043A (ja) * 1997-12-30 2001-12-25 ハウサー，インコーポレイティド 抗マラリア、抗増殖及び抗腫瘍活性を有する、ｃ−１０炭素原子−置換されているアルテミシニン様トリオキサン化合物類

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009533398A (ja) * 2006-04-11 2009-09-17 サノフイ−アベンテイス アルテミシニン誘導体の二量体、この調製およびこの治療上の使用
JP2011529472A (ja) * 2008-07-29 2011-12-08 ピエール、ファーブル、メディカマン アーテミシニンの二量体誘導体および抗ガン療法における用途
JP2022522544A (ja) * 2019-02-26 2022-04-19 マフムード エイ エルソーリー リーシュマニア症の処置用に選択されたアーテミシニンダイマー
JP7534726B2 (ja) 2019-02-26 2024-08-15 マフムード エイ エルソーリー リーシュマニア症の処置用に選択されたアーテミシニンダイマー

Also Published As

Publication number Publication date
US6790863B2 (en) 2004-09-14
EP1551389A4 (en) 2008-08-27
EP1551389A2 (en) 2005-07-13
MXPA05003920A (es) 2005-06-17
US7098242B2 (en) 2006-08-29
WO2004034976A2 (en) 2004-04-29
US20040266860A1 (en) 2004-12-30
WO2004034976A3 (en) 2004-08-12
US20040229938A1 (en) 2004-11-18
AU2003282543B2 (en) 2009-02-26
AU2003282543A1 (en) 2004-05-04
US20040072896A1 (en) 2004-04-15
CA2501942A1 (en) 2004-04-29

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