CA2501942A1 - Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents - Google Patents
Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents Download PDFInfo
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- CA2501942A1 CA2501942A1 CA002501942A CA2501942A CA2501942A1 CA 2501942 A1 CA2501942 A1 CA 2501942A1 CA 002501942 A CA002501942 A CA 002501942A CA 2501942 A CA2501942 A CA 2501942A CA 2501942 A1 CA2501942 A1 CA 2501942A1
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- compound
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- cancer
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- dihydroartemisinin
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 229960004448 pentamidine Drugs 0.000 description 1
- 150000003058 platinum compounds Chemical class 0.000 description 1
- YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical class COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- 229930004725 sesquiterpene Natural products 0.000 description 1
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- 230000011664 signaling Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- ZISJLHQNEVGTIU-RFEYTNPVSA-M sodium 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoate Chemical compound [Na+].C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)CCC([O-])=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 ZISJLHQNEVGTIU-RFEYTNPVSA-M 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
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- 239000008117 stearic acid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/271,960 US6790863B2 (en) | 2002-10-15 | 2002-10-15 | Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents |
| US10/271,960 | 2002-10-15 | ||
| PCT/US2003/032049 WO2004034976A2 (en) | 2002-10-15 | 2003-10-09 | Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer nd anti-infective agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2501942A1 true CA2501942A1 (en) | 2004-04-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002501942A Abandoned CA2501942A1 (en) | 2002-10-15 | 2003-10-09 | Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6790863B2 (enExample) |
| EP (1) | EP1551389A4 (enExample) |
| JP (1) | JP2006504753A (enExample) |
| AU (1) | AU2003282543B2 (enExample) |
| CA (1) | CA2501942A1 (enExample) |
| MX (1) | MXPA05003920A (enExample) |
| WO (1) | WO2004034976A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6790863B2 (en) * | 2002-10-15 | 2004-09-14 | University Of Mississippi | Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents |
| CA2570961C (en) * | 2004-06-21 | 2015-09-01 | University Of Mississippi | Anticancer and antiprotozoal dihydroartemisinene and dihydroartemisitene dimers with desirable chemical functionalities |
| CN1311832C (zh) * | 2005-01-12 | 2007-04-25 | 四川科伦药业股份有限公司 | 溴代二氢青蒿素的医药用途 |
| FR2899586B1 (fr) * | 2006-04-11 | 2008-06-20 | Sanofi Aventis Sa | Dimeres de derives d'artemisinine, leur preparation et leur application en therapeutique |
| US7566465B2 (en) * | 2006-12-21 | 2009-07-28 | The United States Of America As Represented By The Secretary Of The Army | Artemisinins in the clinical and veterinary management of kinetoplastid infections |
| FR2934593B1 (fr) * | 2008-07-29 | 2010-09-10 | Pf Medicament | Derives dimeriques d'artemisinine et application en therapie anticancereuse |
| GB2489641B (en) | 2010-01-22 | 2018-02-21 | Council Scient Ind Res | A new series of artemisinin derivatives and process for preparation thereof |
| US9006467B2 (en) | 2011-02-14 | 2015-04-14 | Councel of Scientific & Industrial Research | 1,2,3-triazole containing artemisinin compounds and process for preparation thereof |
| US9675582B2 (en) | 2011-10-25 | 2017-06-13 | U.S. Phytotherapy, Inc. | Alternative ACT with natural botanical active GRAS ingredients for treatment and prevention of the Zika virus |
| EP2770985A4 (en) | 2011-10-25 | 2015-01-21 | U S Phytotherapy Inc | ARTEMISININE AND BERBERINE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF |
| US9358261B2 (en) | 2011-10-25 | 2016-06-07 | U.S. Phytotherapy, Inc. | Additional artemisinin and berberine compositions and methods of making |
| US9487538B2 (en) | 2013-01-22 | 2016-11-08 | The Johns Hopkins University | Two-carbon linked artemisinin-derived trioxane dimers |
| WO2015041723A1 (en) | 2013-09-17 | 2015-03-26 | Kryptonite Group, Ltd | Artemisinin-based combination therapy for treating viral mediated disease |
| CN106928274B (zh) * | 2017-02-28 | 2019-09-10 | 东南大学 | 一种双氢青蒿素二倍体衍生物、其药物组合物及应用 |
| CN109467565B (zh) * | 2018-08-16 | 2020-07-10 | 云白药征武科技(上海)有限公司 | 双氢青蒿素三聚体及其制备方法和应用 |
| JP7534726B2 (ja) * | 2019-02-26 | 2024-08-15 | マフムード エイ エルソーリー | リーシュマニア症の処置用に選択されたアーテミシニンダイマー |
| CN110305017B (zh) * | 2019-08-09 | 2022-02-25 | 大理大学 | 降桉烷倍半萜类化合物及其药物组合物和制备方法与应用 |
| CN110448551A (zh) * | 2019-08-23 | 2019-11-15 | 西南大学 | 二氢青蒿素衍生物在制备抗血管生成药物中的应用 |
| CN110354270B (zh) * | 2019-08-30 | 2022-04-15 | 中国中医科学院中药研究所 | 一种青蒿琥酯聚乙二醇衍生物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647674A (en) * | 1985-10-07 | 1987-03-03 | Pennwalt Corporation | Bis-(dibenzo[b,d]pyranyloxy) propanes |
| US4952603A (en) | 1988-06-20 | 1990-08-28 | Elferaly Farouk S | Method for the isolation of artemisinin from Artemisia annua |
| IT1247476B (it) * | 1991-06-14 | 1994-12-17 | Fidia Spa | Derivati della cumarina. |
| US5677468A (en) * | 1995-06-29 | 1997-10-14 | Hauser, Inc. | Artemisinin dimer compounds having anticancer activity |
| US6160004A (en) * | 1997-12-30 | 2000-12-12 | Hauser, Inc. | C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities |
| US6790863B2 (en) * | 2002-10-15 | 2004-09-14 | University Of Mississippi | Dihydroartemisinin and dihydroartemisitene dimers as anti-cancer and anti-infective agents |
-
2002
- 2002-10-15 US US10/271,960 patent/US6790863B2/en not_active Expired - Lifetime
-
2003
- 2003-10-09 EP EP03774733A patent/EP1551389A4/en not_active Withdrawn
- 2003-10-09 JP JP2004544832A patent/JP2006504753A/ja active Pending
- 2003-10-09 WO PCT/US2003/032049 patent/WO2004034976A2/en not_active Ceased
- 2003-10-09 CA CA002501942A patent/CA2501942A1/en not_active Abandoned
- 2003-10-09 MX MXPA05003920A patent/MXPA05003920A/es active IP Right Grant
- 2003-10-09 AU AU2003282543A patent/AU2003282543B2/en not_active Ceased
-
2004
- 2004-06-21 US US10/872,616 patent/US20040229938A1/en not_active Abandoned
- 2004-07-21 US US10/896,192 patent/US7098242B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1551389A4 (en) | 2008-08-27 |
| MXPA05003920A (es) | 2005-06-17 |
| JP2006504753A (ja) | 2006-02-09 |
| AU2003282543B2 (en) | 2009-02-26 |
| US20040229938A1 (en) | 2004-11-18 |
| AU2003282543A1 (en) | 2004-05-04 |
| WO2004034976A2 (en) | 2004-04-29 |
| US20040072896A1 (en) | 2004-04-15 |
| WO2004034976A3 (en) | 2004-08-12 |
| US7098242B2 (en) | 2006-08-29 |
| US6790863B2 (en) | 2004-09-14 |
| US20040266860A1 (en) | 2004-12-30 |
| EP1551389A2 (en) | 2005-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |