JP2006504659A - ミリアポロンの全合成 - Google Patents

ミリアポロンの全合成 Download PDF

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Publication number
JP2006504659A
JP2006504659A JP2004523987A JP2004523987A JP2006504659A JP 2006504659 A JP2006504659 A JP 2006504659A JP 2004523987 A JP2004523987 A JP 2004523987A JP 2004523987 A JP2004523987 A JP 2004523987A JP 2006504659 A JP2006504659 A JP 2006504659A
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JP
Japan
Prior art keywords
compound
formula
substituted
mmol
unsubstituted
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JP2004523987A
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English (en)
Japanese (ja)
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JP2006504659A5 (de
Inventor
マルタ・ペレス・アルバレス
カルロス・デル・ポゾ・ロサーダ
アンドレス・フランセシュ・ソリョーゾ
カルメン・クエバス・マルシャンテ
Original Assignee
ファーマ・マール・エス・アー・ウー
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Application filed by ファーマ・マール・エス・アー・ウー filed Critical ファーマ・マール・エス・アー・ウー
Publication of JP2006504659A publication Critical patent/JP2006504659A/ja
Publication of JP2006504659A5 publication Critical patent/JP2006504659A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
JP2004523987A 2002-07-30 2003-07-30 ミリアポロンの全合成 Pending JP2006504659A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0217638.6A GB0217638D0 (en) 2002-07-30 2002-07-30 Total synthesis of myriaporones
PCT/GB2003/003327 WO2004011458A1 (en) 2002-07-30 2003-07-30 Total synthesis of myriaporones

Publications (2)

Publication Number Publication Date
JP2006504659A true JP2006504659A (ja) 2006-02-09
JP2006504659A5 JP2006504659A5 (de) 2006-09-14

Family

ID=9941374

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004523987A Pending JP2006504659A (ja) 2002-07-30 2003-07-30 ミリアポロンの全合成

Country Status (20)

Country Link
US (1) US7521478B2 (de)
EP (1) EP1532139B1 (de)
JP (1) JP2006504659A (de)
KR (1) KR20050053599A (de)
CN (1) CN100390167C (de)
AT (1) ATE364603T1 (de)
AU (1) AU2003248984A1 (de)
CA (1) CA2494532A1 (de)
DE (1) DE60314426T2 (de)
DK (1) DK1532139T3 (de)
ES (1) ES2289337T3 (de)
GB (1) GB0217638D0 (de)
IL (1) IL166484A0 (de)
MX (1) MXPA05001176A (de)
NO (1) NO20051037L (de)
NZ (1) NZ537678A (de)
PT (1) PT1532139E (de)
RU (1) RU2328492C2 (de)
SI (1) SI1532139T1 (de)
WO (1) WO2004011458A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514708A (en) * 1994-02-18 1996-05-07 Pharmamar, S.A. Cytotoxic metabolites from Myriapora truncata

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514708A (en) * 1994-02-18 1996-05-07 Pharmamar, S.A. Cytotoxic metabolites from Myriapora truncata

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6010001821, ＲＯＵＳＨ，Ｗ．Ｒ． ｅｔ ａｌ, "Ｓｔｕｄｉｅｓ ｏｎ ｔｈｅ Ｓｙｎｔｈｅｓｉｓ ｏｆ Ｔｅｄａｎｏｌｉｄｅ： Ｓｙｎｔｈｅｓｉｓ ｏｆ ｔｈｅ Ｃ（５）−Ｃ（２１） Ｓｅｇｍｅｎｔ ｖｉａ ａ Ｈｉｇｈｌｙ Ｓｔｅｒｅｏｓｅｌｅｃ", Ｏｒｇａｎｉｃ Ｌｅｔｔｅｒｓ, 1999, Ｖｏｌ．１， Ｎｏ．１, ｐ．９５−９８ *
JPN6010001824, ＬＯＨ，Ｔ． ｅｔ ａｌ, "Ｓｙｎｔｈｅｔｉｃ ｓｔｕｄｉｅｓ ｔｏｗａｒｄｓ ｔｈｅ ｔｏｔａｌ ｓｙｎｔｈｅｓｉｓ ｏｆ ｔｅｄａｎｏｌｉｄｅ： ｆｏｒｍａｔｉｏｎ ｏｆ ｔｈｅ Ｃ（１３）−Ｃ（２３） ｆｒａｇｍｅｎｔ", Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ, 2001, Ｖｏｌ．４２， Ｎｏ．１８, ｐ．３２２３−３２２６ *
JPN6010001827, ＲＯＵＳＨ，Ｗ．Ｒ． ｅｔ ａｌ, "Ａｎ ＮＭＲ Ｍｅｔｈｏｄ ｆｏｒ Ａｓｓｉｇｎｉｎｇ Ｒｅｌａｔｉｖｅ Ｓｔｅｒｅｏｃｈｅｍｉｓｔｒｙ ｔｏ β−Ｈｙｄｒｏｘｙ Ｋｅｔｏｎｅｓ Ｄｅｒｉｖｉｎｇ ｆｒｏｍ Ａｌｄｏｌ Ｒｅａｃｔ", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ, 20020521, Ｖｏｌ．６７， Ｎｏ．１２, ｐ．４２８４−４２８９ *
JPN6010001830, ＴＡＹＬＯＲ，Ｒ．Ｅ． ｅｔ ａｌ, "Ａ ｄｉｖｅｒｇｅｎｔ ａｐｐｒｏａｃｈ ｔｏ ｔｈｅ ｍｙｒｉａｐｏｒｏｎｅｓ ａｎｄ ｔｅｄａｎｏｌｉｄｅ： ｅｎａｎｔｉｏｓｅｌｅｃｔｉｖｅ ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｔｈｅ ｃｏｍｍｏｎ", Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ, 1998, Ｖｏｌ．３９， Ｎｏ．５１, ｐ．９３６１−９３６４ *
JPN6010001832, ＺＨＥＮＧ，Ｂ． ｅｔ ａｌ, "Ｆａｃｉｌｅ ｃｈｅｌａｔｉｏｎ−ｃｏｎｔｒｏｌｌｅｄ ｒｅｄｕｃｔｉｖｅ ｏｐｅｎｉｎｇ ｏｆ ｍｅｔｈｏｘｙｂｅｎｚｙｌｉｄｅｎｅ ａｃｅｔａｌｓ ｗｉｔｈ Ｂｕ３ＳｎＨ ａｎｄ ＭｇＢｒ２． Ｒ", Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ, 2000, Ｖｏｌ．４１， Ｎｏ．３３, ｐ．６４４１−６４４５ *
JPN6010001835, ＺＨＥＮＧ，Ｂ． ｅｔ ａｌ, "Ｓｔｕｄｉｅｓ ｏｎ ｔｈｅ ｓｙｎｔｈｅｓｉｓ ｏｆ ｍｙｒｉａｐｏｒｏｎｅｓ： ｓｔｅｒｅｏｓｅｌｅｃｔｉｖｅ ｓｙｎｔｈｅｓｉｓ ｏｆ ｔｈｅ Ｃ５−Ｃ１３ ｆｒａｇｍｅｎｔ ｓｔａｒｔｉｎｇ", Ｃｈｅｍｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ, 2000, Ｖｏｌ．４８， Ｎｏ．１１, ｐ．１７６１−１７６５ *

Also Published As

Publication number Publication date
IL166484A0 (en) 2006-01-15
US20060084819A1 (en) 2006-04-20
CN1684956A (zh) 2005-10-19
KR20050053599A (ko) 2005-06-08
NZ537678A (en) 2006-11-30
CN100390167C (zh) 2008-05-28
GB0217638D0 (en) 2002-09-11
RU2005105329A (ru) 2005-08-27
DK1532139T3 (da) 2007-10-15
US20080103320A2 (en) 2008-05-01
RU2328492C2 (ru) 2008-07-10
US20080269511A2 (en) 2008-10-30
ATE364603T1 (de) 2007-07-15
PT1532139E (pt) 2007-09-20
EP1532139A1 (de) 2005-05-25
CA2494532A1 (en) 2004-02-05
EP1532139B1 (de) 2007-06-13
DE60314426T2 (de) 2008-02-14
ES2289337T3 (es) 2008-02-01
DE60314426D1 (de) 2007-07-26
US7521478B2 (en) 2009-04-21
MXPA05001176A (es) 2005-09-12
SI1532139T1 (sl) 2007-10-31
WO2004011458A1 (en) 2004-02-05
NO20051037L (no) 2005-04-13
AU2003248984A1 (en) 2004-02-16

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