JP2006502235A5 - - Google Patents
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- Publication number
- JP2006502235A5 JP2006502235A5 JP2004568899A JP2004568899A JP2006502235A5 JP 2006502235 A5 JP2006502235 A5 JP 2006502235A5 JP 2004568899 A JP2004568899 A JP 2004568899A JP 2004568899 A JP2004568899 A JP 2004568899A JP 2006502235 A5 JP2006502235 A5 JP 2006502235A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- amino
- heteroaryl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41212002P | 2002-09-18 | 2002-09-18 | |
| US47126503P | 2003-05-16 | 2003-05-16 | |
| US48458103P | 2003-07-02 | 2003-07-02 | |
| PCT/IB2003/003823 WO2004026863A1 (en) | 2002-09-18 | 2003-09-08 | Novel oxazole and thiazole compounds as transforming growth factor (tgf) inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006502235A JP2006502235A (ja) | 2006-01-19 |
| JP2006502235A5 true JP2006502235A5 (cg-RX-API-DMAC7.html) | 2006-09-28 |
| JP4518956B2 JP4518956B2 (ja) | 2010-08-04 |
Family
ID=32034216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004568899A Expired - Fee Related JP4518956B2 (ja) | 2002-09-18 | 2003-09-08 | トランスフォーミング成長因子（ｔｇｆ）阻害剤としての新規トリアゾールおよびオキサゾール化合物 |
Country Status (28)
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039241A1 (es) * | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| UA80295C2 (en) * | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
| CN1681805A (zh) * | 2002-09-18 | 2005-10-12 | 辉瑞产品公司 | 作为转化生长因子(tgf)抑制剂的新的咪唑类化合物 |
| AU2003259475A1 (en) * | 2002-09-18 | 2004-04-08 | Pfizer Products Inc. | Pyrazole derivatives as transforming growth factor (TGF) inhibitors |
| PA8595001A1 (es) | 2003-03-04 | 2004-09-28 | Pfizer Prod Inc | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf) |
| GB0313914D0 (en) * | 2003-06-16 | 2003-07-23 | Smithkline Beecham Corp | Compounds |
| MX2007001727A (es) * | 2004-08-13 | 2007-04-20 | Genentech Inc | Compuestos a base de 2-amido-tiazol que exhiben actividad inhibidora de enzima que utiliza atp y composiciones y usos de los mismos. |
| EP1798229A4 (en) * | 2004-09-07 | 2009-07-29 | Sankyo Co | SUBSTITUTED BIPHENYL DERIVATIVE |
| EP1799664A1 (en) | 2004-09-20 | 2007-06-27 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| EP1799667B1 (en) | 2004-09-20 | 2013-03-20 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| CA2580845A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| BRPI0515505A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e sua utilização como inibidores da estearoil-coa desaturase |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| WO2006101521A2 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| AU2006325706B2 (en) * | 2005-12-16 | 2012-03-29 | Novartis Ag | Control of intraocular pressure using ALK5 modulation agents |
| WO2008150827A1 (en) * | 2007-05-29 | 2008-12-11 | Smithkline Beecham Corporation | Naphthyridine, derivatives as p13 kinase inhibitors |
| WO2009111502A2 (en) | 2008-03-03 | 2009-09-11 | University Of Notre Dame Du Lac | Anti-cancer compounds, synthesis thereof, and methods of using same |
| US8865732B2 (en) | 2008-03-21 | 2014-10-21 | Novartis Ag | Heterocyclic compounds and uses thereof |
| AU2012203026B2 (en) * | 2008-03-21 | 2014-06-12 | Novartis Ag | Novel heterocyclic compounds and uses thereof |
| US8338604B2 (en) | 2008-06-20 | 2012-12-25 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| EP3089971B1 (en) | 2014-01-01 | 2020-07-29 | Medivation Technologies LLC | Compounds and methods of use |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| CN105585565B (zh) * | 2014-10-23 | 2019-10-01 | 中国医学科学院药物研究所 | 含2-苯胺基-4-噻唑基吡啶衍生物及其制法和药物组合物与用途 |
| CN106243012A (zh) * | 2016-08-02 | 2016-12-21 | 北方民族大学 | 新型吲哚类衍生物及其制备方法 |
| ES2974991T3 (es) | 2016-09-19 | 2024-07-02 | Novartis Ag | Combinaciones terapéuticas que comprenden un inhibidor de RAF y un inhibidor de ERK |
| KR102641827B1 (ko) | 2017-05-02 | 2024-03-04 | 노파르티스 아게 | 병용 요법 |
| KR102892521B1 (ko) * | 2017-06-14 | 2025-11-27 | 트레베나, 인코포레이티드. | S1p1 활성을 조정하기 위한 화합물 및 그를 사용하는 방법 |
| US12187703B2 (en) | 2019-05-13 | 2025-01-07 | Novartis Ag | Crystalline forms of N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2 (trifluoromethyl)isonicotinamide as Raf inhibitors for the treatment of cancer |
| CN112694477B (zh) * | 2019-10-22 | 2024-02-06 | 四川科伦博泰生物医药股份有限公司 | 吡唑并环类化合物，包含其的药物组合物，其制备方法及其用途 |
| CN114727977B (zh) | 2019-11-19 | 2025-12-30 | 特维娜有限公司 | 化合物和化合物s1p1调节剂的制备方法 |
| CN115466260B (zh) * | 2022-09-06 | 2023-10-13 | 延边大学 | 含氨基酸结构的咪唑和噻唑类衍生物及其制备方法和应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0149884B1 (en) | 1983-09-09 | 1992-12-16 | Takeda Chemical Industries, Ltd. | 5-pyridyl-1,3-thiazole derivatives, their production and use |
| GB9201692D0 (en) | 1992-01-27 | 1992-03-11 | Smithkline Beecham Intercredit | Compounds |
| WO1998052941A1 (en) | 1997-05-22 | 1998-11-26 | G.D. Searle And Co. | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS |
| CN1264376A (zh) | 1997-05-22 | 2000-08-23 | G·D·瑟尔公司 | 作为p38激酶抑制剂的3(5)－杂芳基取代的吡唑化合物 |
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| JPH11193281A (ja) | 1997-10-27 | 1999-07-21 | Takeda Chem Ind Ltd | アデノシンａ３受容体拮抗剤およびチアゾール化合物 |
| DE60001229T2 (de) * | 1999-04-09 | 2003-10-30 | Smithkline Beecham Corp., Philadelphia | Triarylimidazole |
| EP1205478A4 (en) | 1999-08-06 | 2004-06-30 | Takeda Chemical Industries Ltd | P38MAP KINASE INHIBITORS |
| CO5271680A1 (es) | 2000-02-21 | 2003-04-30 | Smithkline Beecham Corp | Compuestos |
| GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
| PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| GB0027987D0 (en) * | 2000-11-16 | 2001-01-03 | Smithkline Beecham Plc | Compounds |
| US20040039198A1 (en) | 2000-11-16 | 2004-02-26 | Bender Paul E. | Compounds |
| EP1354603A1 (en) | 2000-12-26 | 2003-10-22 | Takeda Chemical Industries, Ltd. | Concomitant drugs |
| GB0100762D0 (en) | 2001-01-11 | 2001-02-21 | Smithkline Beecham Plc | Novel use |
| GB0102668D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
| WO2002062787A1 (en) | 2001-02-02 | 2002-08-15 | Glaxo Group Limited | Pyrazoles as tgf inhibitors |
| JPWO2002062775A1 (ja) | 2001-02-02 | 2004-06-10 | 山之内製薬株式会社 | ２−アシルアミノチアゾール誘導体又はその塩 |
| GB0102672D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
| ES2237671T3 (es) | 2001-02-02 | 2005-08-01 | Smithkline Beecham Corporation | Derivados de pirazol contra la sobreexpresion de tgf. |
| GB0102673D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
| GB0102665D0 (en) * | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
| US20050080113A1 (en) | 2001-06-11 | 2005-04-14 | Shigenori Ohkawa | Medicinal compositions |
| AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| GB0217787D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | C ompounds |
| WO2004013135A1 (en) | 2002-07-31 | 2004-02-12 | Smithkline Beecham Corporation | 2-phenylpyridin-4-yl derivatives as alk5 inhibitors |
| KR20050057393A (ko) | 2002-09-18 | 2005-06-16 | 화이자 프로덕츠 인크. | 전환 성장 인자 (ｔｇｆ) 억제제로서 트리아졸 유도체 |
| HRP20050246A2 (en) | 2002-09-18 | 2005-10-31 | Pfizer Products Inc. | Novel isothiazole and isoxazole compounds as transforming growth factor (tgf) inhibitors |
| AU2003259475A1 (en) | 2002-09-18 | 2004-04-08 | Pfizer Products Inc. | Pyrazole derivatives as transforming growth factor (TGF) inhibitors |
| CN1681805A (zh) | 2002-09-18 | 2005-10-12 | 辉瑞产品公司 | 作为转化生长因子(tgf)抑制剂的新的咪唑类化合物 |
-
2003
- 2003-09-08 CA CA2499429A patent/CA2499429C/en not_active Expired - Fee Related
- 2003-09-08 HR HR20050250A patent/HRP20050250A2/xx not_active Application Discontinuation
- 2003-09-08 EA EA200500354A patent/EA200500354A1/ru unknown
- 2003-09-08 PL PL03375975A patent/PL375975A1/xx not_active Application Discontinuation
- 2003-09-08 KR KR1020057004611A patent/KR20050057415A/ko not_active Ceased
- 2003-09-08 EP EP03797426A patent/EP1542994B1/en not_active Expired - Lifetime
- 2003-09-08 JP JP2004568899A patent/JP4518956B2/ja not_active Expired - Fee Related
- 2003-09-08 ES ES03797426T patent/ES2323421T3/es not_active Expired - Lifetime
- 2003-09-08 AT AT03797426T patent/ATE430147T1/de not_active IP Right Cessation
- 2003-09-08 BR BR0314383-0A patent/BR0314383A/pt not_active IP Right Cessation
- 2003-09-08 OA OA1200500075A patent/OA12926A/en unknown
- 2003-09-08 AU AU2003256003A patent/AU2003256003A1/en not_active Abandoned
- 2003-09-08 DE DE60327443T patent/DE60327443D1/de not_active Expired - Lifetime
- 2003-09-08 AP AP2005003261A patent/AP2005003261A0/xx unknown
- 2003-09-08 CN CNA038222205A patent/CN1681810A/zh active Pending
- 2003-09-08 MX MXPA05002332A patent/MXPA05002332A/es active IP Right Grant
- 2003-09-08 WO PCT/IB2003/003823 patent/WO2004026863A1/en not_active Ceased
- 2003-09-15 PA PA20038582701A patent/PA8582701A1/es unknown
- 2003-09-15 UY UY27978A patent/UY27978A1/es not_active Application Discontinuation
- 2003-09-15 PE PE2003000939A patent/PE20040987A1/es not_active Application Discontinuation
- 2003-09-16 AR ARP030103357A patent/AR041273A1/es unknown
- 2003-09-17 US US10/667,187 patent/US7273936B2/en not_active Expired - Fee Related
- 2003-09-17 TW TW092125637A patent/TW200413362A/zh unknown
-
2005
- 2005-02-24 IS IS7711A patent/IS7711A/is unknown
- 2005-03-15 CR CR7743A patent/CR7743A/es not_active Application Discontinuation
- 2005-03-16 CO CO05024531A patent/CO5550473A2/es not_active Application Discontinuation
- 2005-03-18 MA MA28157A patent/MA27443A1/fr unknown
- 2005-04-15 NO NO20051838A patent/NO20051838L/no unknown
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