JP2006502086A5 - - Google Patents
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- Publication number
- JP2006502086A5 JP2006502086A5 JP2003559480A JP2003559480A JP2006502086A5 JP 2006502086 A5 JP2006502086 A5 JP 2006502086A5 JP 2003559480 A JP2003559480 A JP 2003559480A JP 2003559480 A JP2003559480 A JP 2003559480A JP 2006502086 A5 JP2006502086 A5 JP 2006502086A5
- Authority
- JP
- Japan
- Prior art keywords
- carbons
- amino acid
- branched
- hydrogen
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 125000000539 amino acid group Chemical group 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 239000008249 pharmaceutical aerosol Substances 0.000 claims description 5
- 239000003380 propellant Substances 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 150000001261 hydroxy acids Chemical class 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 239000012752 auxiliary agent Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical group C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims 1
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 108010077895 Sarcosine Proteins 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 239000008365 aqueous carrier Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical compound NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 claims 1
- 229940043230 sarcosine Drugs 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229960003080 taurine Drugs 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34278701P | 2001-12-21 | 2001-12-21 | |
| US60/342,787 | 2001-12-21 | ||
| PCT/US2002/041299 WO2003059317A2 (en) | 2001-12-21 | 2002-12-20 | Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006502086A JP2006502086A (ja) | 2006-01-19 |
| JP2006502086A5 true JP2006502086A5 (enExample) | 2006-03-02 |
| JP4959919B2 JP4959919B2 (ja) | 2012-06-27 |
Family
ID=23343270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003559480A Expired - Fee Related JP4959919B2 (ja) | 2001-12-21 | 2002-12-20 | 官能基を有するポリエチレングリコール賦形剤を用いた医薬用エアロゾル組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7718162B2 (enExample) |
| EP (1) | EP1458357B1 (enExample) |
| JP (1) | JP4959919B2 (enExample) |
| AT (1) | ATE424186T1 (enExample) |
| AU (1) | AU2002367032B8 (enExample) |
| CA (1) | CA2470520A1 (enExample) |
| DE (1) | DE60231428D1 (enExample) |
| WO (1) | WO2003059317A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1458357B1 (en) | 2001-12-21 | 2009-03-04 | 3M Innovative Properties Company | Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient |
| EP1458354A1 (en) * | 2001-12-21 | 2004-09-22 | 3M Innovative Properties Company | Medicinal aerosol formulations comprising ion pair complexes |
| CA2470498A1 (en) * | 2001-12-21 | 2003-07-24 | 3M Innovative Properties Company | Medicinal aerosol compositions with an amide and/or ester containing excipient compound |
| GB0614621D0 (en) | 2006-07-24 | 2006-08-30 | 3M Innovative Properties Co | Metered dose dispensers |
| GB0620700D0 (en) | 2006-10-19 | 2006-11-29 | 3M Innovative Properties Co | Metered dose valves and dispensers |
| NZ599344A (en) | 2009-09-25 | 2015-02-27 | Reddy’S Lab Ltd Dr | Formulations comprising triptan compounds |
| US11337962B2 (en) | 2009-09-25 | 2022-05-24 | Upsher-Smith Laboratories, Llc | Formulations comprising triptan compounds |
| US20120272951A1 (en) | 2009-12-16 | 2012-11-01 | 3M Innovative Properties Company | Formulations and methods for controlling mdi particle size delivery |
| GB201118188D0 (en) | 2011-10-21 | 2011-12-07 | 3M Innovative Properties Co | Manufacture of medicinal aerosol canisters |
| GB201210580D0 (en) | 2012-06-14 | 2012-08-01 | 3M Innovative Properties Co | Metered dose dispensing valve |
| GB201221063D0 (en) | 2012-11-23 | 2013-01-09 | 3M Innovative Properties Co | Metered dose dispensing valve |
| EP3649175A1 (en) | 2017-07-07 | 2020-05-13 | Basf Se | Alkoxylated esteramines and salts thereof |
| CN117042803A (zh) * | 2021-12-02 | 2023-11-10 | 丽泽润有限公司 | 具有多功能应用的天然赋形剂及其制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1163028B (de) * | 1960-03-09 | 1964-02-13 | Hoechst Ag | Verfahren zur Polymerisation von Vinylchlorid |
| ATE71520T1 (de) * | 1986-03-10 | 1992-02-15 | Burghart Kurt | Pharmazeutische zubereitung sowie verfahren zur herstellung derselben. |
| JP2573275B2 (ja) * | 1986-03-10 | 1997-01-22 | ブルグハルト，クルト | 薬学的製剤及びその製造法 |
| US5225183A (en) * | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| US5342940A (en) * | 1989-05-27 | 1994-08-30 | Sumitomo Pharmaceuticals Company, Limited | Polyethylene glycol derivatives, process for preparing the same |
| JP2854974B2 (ja) * | 1990-06-29 | 1999-02-10 | フアイソンズ・ピーエルシー | 加圧エアロゾル組成物 |
| WO1994008599A1 (en) * | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
| ES2129117T3 (es) | 1992-12-09 | 1999-06-01 | Boehringer Ingelheim Pharma | Formulaciones en disolucion en forma de aerosol medicinales estabilizadas. |
| KR100321649B1 (ko) * | 1993-03-17 | 2002-07-22 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | 에스테르,아미드또는머캅토에스테르로부터유도된분산보조제를함유하는에어로졸제제 |
| DE69405719T2 (de) * | 1993-03-17 | 1998-01-15 | Minnesota Mining & Mfg | Aerosolzubereitung, enthaltend ein aus einem diol-disäure-derivat abgeleitetes dispergiermittel |
| US5492688A (en) * | 1993-04-28 | 1996-02-20 | The Center For Innovative Technology | Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent |
| JPH09506097A (ja) * | 1993-12-02 | 1997-06-17 | アボツト・ラボラトリーズ | 非ｃｆｃ噴射剤と共に用いるエアロゾル薬物調剤 |
| US5508023A (en) * | 1994-04-11 | 1996-04-16 | The Center For Innovative Technology | Pharmaceutically acceptable agents for solubilizing, wetting, emulsifying, or lubricating in metered dose inhaler formulations which use HFC-227 propellant |
| US6524557B1 (en) | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
| ZA9711732B (en) * | 1996-12-31 | 1998-12-28 | Quadrant Holdings Cambridge | Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery |
| US6126919A (en) * | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| US6218353B1 (en) * | 1997-08-27 | 2001-04-17 | Micell Technologies, Inc. | Solid particulate propellant systems and aerosol containers employing the same |
| US6136294C1 (en) * | 1998-09-22 | 2002-09-24 | Aeropharm Technology Inc | Amino acid stabilized medical aerosol formulation |
| BR9914799A (pt) * | 1998-10-27 | 2001-07-10 | Alcon Lab Inc | Sistema conservante para composições farmacêuticas administráveis topicamente contendo um sabão de ácido graxo/aminoácido |
| US6258857B1 (en) * | 1999-02-04 | 2001-07-10 | Kyowa Industrial Co., Ltd. | Internal liquid composition contained as internal liquid in a releasing container and releasing container product |
| GB0016876D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Novel formulation |
| JP2004509159A (ja) | 2000-09-22 | 2004-03-25 | グラクソ グループ リミテッド | 新規なアルカン酸誘導体 |
| KR20030097876A (ko) | 2001-05-21 | 2003-12-31 | 넥타르 테라퓨틱스 | 화학적으로 개질된 인슐린의 폐 투여 |
| GB0125127D0 (en) | 2001-10-19 | 2001-12-12 | Glaxo Group Ltd | Compounds |
| CA2470498A1 (en) * | 2001-12-21 | 2003-07-24 | 3M Innovative Properties Company | Medicinal aerosol compositions with an amide and/or ester containing excipient compound |
| EP1458357B1 (en) | 2001-12-21 | 2009-03-04 | 3M Innovative Properties Company | Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient |
-
2002
- 2002-12-20 EP EP02806511A patent/EP1458357B1/en not_active Expired - Lifetime
- 2002-12-20 CA CA002470520A patent/CA2470520A1/en not_active Abandoned
- 2002-12-20 AT AT02806511T patent/ATE424186T1/de not_active IP Right Cessation
- 2002-12-20 AU AU2002367032A patent/AU2002367032B8/en not_active Ceased
- 2002-12-20 US US10/327,200 patent/US7718162B2/en not_active Expired - Fee Related
- 2002-12-20 WO PCT/US2002/041299 patent/WO2003059317A2/en not_active Ceased
- 2002-12-20 DE DE60231428T patent/DE60231428D1/de not_active Expired - Lifetime
- 2002-12-20 JP JP2003559480A patent/JP4959919B2/ja not_active Expired - Fee Related
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