CA2470520A1 - Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient - Google Patents

Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient Download PDF

Info

Publication number
CA2470520A1
CA2470520A1 CA002470520A CA2470520A CA2470520A1 CA 2470520 A1 CA2470520 A1 CA 2470520A1 CA 002470520 A CA002470520 A CA 002470520A CA 2470520 A CA2470520 A CA 2470520A CA 2470520 A1 CA2470520 A1 CA 2470520A1
Authority
CA
Canada
Prior art keywords
medicinal
drug
composition
excipient
aerosol composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002470520A
Other languages
English (en)
French (fr)
Inventor
James S. Stefely
Daniel C. Duan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2470520A1 publication Critical patent/CA2470520A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002470520A 2001-12-21 2002-12-20 Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient Abandoned CA2470520A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34278701P 2001-12-21 2001-12-21
US60/342,787 2001-12-21
PCT/US2002/041299 WO2003059317A2 (en) 2001-12-21 2002-12-20 Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient

Publications (1)

Publication Number Publication Date
CA2470520A1 true CA2470520A1 (en) 2003-07-24

Family

ID=23343270

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002470520A Abandoned CA2470520A1 (en) 2001-12-21 2002-12-20 Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient

Country Status (8)

Country Link
US (1) US7718162B2 (enExample)
EP (1) EP1458357B1 (enExample)
JP (1) JP4959919B2 (enExample)
AT (1) ATE424186T1 (enExample)
AU (1) AU2002367032B8 (enExample)
CA (1) CA2470520A1 (enExample)
DE (1) DE60231428D1 (enExample)
WO (1) WO2003059317A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1458357B1 (en) 2001-12-21 2009-03-04 3M Innovative Properties Company Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient
EP1458354A1 (en) * 2001-12-21 2004-09-22 3M Innovative Properties Company Medicinal aerosol formulations comprising ion pair complexes
CA2470498A1 (en) * 2001-12-21 2003-07-24 3M Innovative Properties Company Medicinal aerosol compositions with an amide and/or ester containing excipient compound
GB0614621D0 (en) 2006-07-24 2006-08-30 3M Innovative Properties Co Metered dose dispensers
GB0620700D0 (en) 2006-10-19 2006-11-29 3M Innovative Properties Co Metered dose valves and dispensers
NZ599344A (en) 2009-09-25 2015-02-27 Reddy’S Lab Ltd Dr Formulations comprising triptan compounds
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
US20120272951A1 (en) 2009-12-16 2012-11-01 3M Innovative Properties Company Formulations and methods for controlling mdi particle size delivery
GB201118188D0 (en) 2011-10-21 2011-12-07 3M Innovative Properties Co Manufacture of medicinal aerosol canisters
GB201210580D0 (en) 2012-06-14 2012-08-01 3M Innovative Properties Co Metered dose dispensing valve
GB201221063D0 (en) 2012-11-23 2013-01-09 3M Innovative Properties Co Metered dose dispensing valve
EP3649175A1 (en) 2017-07-07 2020-05-13 Basf Se Alkoxylated esteramines and salts thereof
CN117042803A (zh) * 2021-12-02 2023-11-10 丽泽润有限公司 具有多功能应用的天然赋形剂及其制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1163028B (de) * 1960-03-09 1964-02-13 Hoechst Ag Verfahren zur Polymerisation von Vinylchlorid
ATE71520T1 (de) * 1986-03-10 1992-02-15 Burghart Kurt Pharmazeutische zubereitung sowie verfahren zur herstellung derselben.
JP2573275B2 (ja) * 1986-03-10 1997-01-22 ブルグハルト，クルト 薬学的製剤及びその製造法
US5225183A (en) * 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
US5342940A (en) * 1989-05-27 1994-08-30 Sumitomo Pharmaceuticals Company, Limited Polyethylene glycol derivatives, process for preparing the same
JP2854974B2 (ja) * 1990-06-29 1999-02-10 フアイソンズ・ピーエルシー 加圧エアロゾル組成物
WO1994008599A1 (en) * 1992-10-14 1994-04-28 The Regents Of The University Of Colorado Ion-pairing of drugs for improved efficacy and delivery
ES2129117T3 (es) 1992-12-09 1999-06-01 Boehringer Ingelheim Pharma Formulaciones en disolucion en forma de aerosol medicinales estabilizadas.
KR100321649B1 (ko) * 1993-03-17 2002-07-22 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 에스테르,아미드또는머캅토에스테르로부터유도된분산보조제를함유하는에어로졸제제
DE69405719T2 (de) * 1993-03-17 1998-01-15 Minnesota Mining & Mfg Aerosolzubereitung, enthaltend ein aus einem diol-disäure-derivat abgeleitetes dispergiermittel
US5492688A (en) * 1993-04-28 1996-02-20 The Center For Innovative Technology Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent
JPH09506097A (ja) * 1993-12-02 1997-06-17 アボツト・ラボラトリーズ 非ｃｆｃ噴射剤と共に用いるエアロゾル薬物調剤
US5508023A (en) * 1994-04-11 1996-04-16 The Center For Innovative Technology Pharmaceutically acceptable agents for solubilizing, wetting, emulsifying, or lubricating in metered dose inhaler formulations which use HFC-227 propellant
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
ZA9711732B (en) * 1996-12-31 1998-12-28 Quadrant Holdings Cambridge Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery
US6126919A (en) * 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US6218353B1 (en) * 1997-08-27 2001-04-17 Micell Technologies, Inc. Solid particulate propellant systems and aerosol containers employing the same
US6136294C1 (en) * 1998-09-22 2002-09-24 Aeropharm Technology Inc Amino acid stabilized medical aerosol formulation
BR9914799A (pt) * 1998-10-27 2001-07-10 Alcon Lab Inc Sistema conservante para composições farmacêuticas administráveis topicamente contendo um sabão de ácido graxo/aminoácido
US6258857B1 (en) * 1999-02-04 2001-07-10 Kyowa Industrial Co., Ltd. Internal liquid composition contained as internal liquid in a releasing container and releasing container product
GB0016876D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Novel formulation
JP2004509159A (ja) 2000-09-22 2004-03-25 グラクソ　グループ　リミテッド 新規なアルカン酸誘導体
KR20030097876A (ko) 2001-05-21 2003-12-31 넥타르 테라퓨틱스 화학적으로 개질된 인슐린의 폐 투여
GB0125127D0 (en) 2001-10-19 2001-12-12 Glaxo Group Ltd Compounds
CA2470498A1 (en) * 2001-12-21 2003-07-24 3M Innovative Properties Company Medicinal aerosol compositions with an amide and/or ester containing excipient compound
EP1458357B1 (en) 2001-12-21 2009-03-04 3M Innovative Properties Company Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient

Also Published As

Publication number Publication date
WO2003059317A2 (en) 2003-07-24
AU2002367032A1 (en) 2003-07-30
EP1458357A2 (en) 2004-09-22
ATE424186T1 (de) 2009-03-15
DE60231428D1 (de) 2009-04-16
WO2003059317A3 (en) 2003-11-20
JP4959919B2 (ja) 2012-06-27
AU2002367032B2 (en) 2008-09-25
US7718162B2 (en) 2010-05-18
JP2006502086A (ja) 2006-01-19
EP1458357B1 (en) 2009-03-04
AU2002367032B8 (en) 2008-10-23
US20030152521A1 (en) 2003-08-14

Similar Documents

Publication Publication Date Title
CA2344816C (en) Medicinal aerosol formulation
AU2002367032B2 (en) Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient
MXPA02007229A (es) Un metodo para administrar una formulacion medicinal en aerosol.
WO2001060420A1 (en) A medicinal aerosol formulation
NZ511923A (en) Pharmaceutical aerosol composition containing HFA 227 and HFA 134a
US7186402B2 (en) Medicinal aerosol compositions with an amide and/or ester containing excipient compound
US20030147814A1 (en) Medicinal aerosol formulations comprising ion pair complexes
AU2001224727B2 (en) A method of treating a systemic disease
AU2001224727A1 (en) A method of treating a systemic disease
AU783120B2 (en) A medicinal aerosol formulation
ES2317306T3 (es) Procedimiento para la preparacion de formulaciones en aerosol en suspension, en el que las particulas se forman por precipitacion dentro de un frasco de aerosol.
HK1097777B (en) Medicinal aerosol formulation
US20040042966A1 (en) Method of treating a systemic disease
HK1079425A1 (zh) 福莫特罗超细制剂

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued