JP2006500437A5 - - Google Patents
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- Publication number
- JP2006500437A5 JP2006500437A5 JP2004537295A JP2004537295A JP2006500437A5 JP 2006500437 A5 JP2006500437 A5 JP 2006500437A5 JP 2004537295 A JP2004537295 A JP 2004537295A JP 2004537295 A JP2004537295 A JP 2004537295A JP 2006500437 A5 JP2006500437 A5 JP 2006500437A5
- Authority
- JP
- Japan
- Prior art keywords
- polyethyleneimine
- polyethyleneimine polymer
- linear
- halide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920002873 Polyethylenimine Polymers 0.000 claims 35
- 229920000642 polymer Polymers 0.000 claims 32
- 229940079593 drug Drugs 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 14
- 150000004820 halides Chemical class 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims 3
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 150000001266 acyl halides Chemical class 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 229930182912 cyclosporin Natural products 0.000 claims 2
- 229960005309 estradiol Drugs 0.000 claims 2
- 229930182833 estradiol Natural products 0.000 claims 2
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 2
- 229960005420 etoposide Drugs 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000000962 organic group Chemical group 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000003367 polycyclic group Chemical group 0.000 claims 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 2
- 229960005205 prednisolone Drugs 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 229960003604 testosterone Drugs 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000001350 alkyl halides Chemical class 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 150000008282 halocarbons Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910001507 metal halide Inorganic materials 0.000 claims 1
- 150000005309 metal halides Chemical class 0.000 claims 1
- 229910000000 metal hydroxide Inorganic materials 0.000 claims 1
- 150000004692 metal hydroxides Chemical class 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 235000009518 sodium iodide Nutrition 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0221942.6A GB0221942D0 (en) | 2002-09-20 | 2002-09-20 | Drug delivery |
| PCT/GB2003/004036 WO2004026941A1 (en) | 2002-09-20 | 2003-09-22 | Drug delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006500437A JP2006500437A (ja) | 2006-01-05 |
| JP2006500437A5 true JP2006500437A5 (https=) | 2006-11-02 |
Family
ID=9944516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004537295A Pending JP2006500437A (ja) | 2002-09-20 | 2003-09-22 | 薬物送達 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060148982A1 (https=) |
| EP (1) | EP1543063B1 (https=) |
| JP (1) | JP2006500437A (https=) |
| AT (1) | ATE426635T1 (https=) |
| AU (1) | AU2003267581A1 (https=) |
| CA (1) | CA2499681A1 (https=) |
| DE (1) | DE60326859D1 (https=) |
| DK (1) | DK1543063T3 (https=) |
| GB (1) | GB0221942D0 (https=) |
| SI (1) | SI1543063T1 (https=) |
| WO (1) | WO2004026941A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0422877D0 (en) * | 2004-10-14 | 2004-11-17 | Univ Glasgow | Bioactive polymers |
| US8057821B2 (en) * | 2004-11-03 | 2011-11-15 | Egen, Inc. | Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof |
| AU2006336311B2 (en) | 2006-01-19 | 2013-01-24 | Allexcel, Inc. | Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers |
| CA2636739A1 (en) * | 2006-01-27 | 2007-08-02 | Ciba Holding Inc. | Polymeric anti-microbial agents |
| US20090246155A1 (en) * | 2006-12-05 | 2009-10-01 | Landec Corporation | Compositions and methods for personal care |
| US8399007B2 (en) * | 2006-12-05 | 2013-03-19 | Landec Corporation | Method for formulating a controlled-release pharmaceutical formulation |
| US20100004124A1 (en) * | 2006-12-05 | 2010-01-07 | David Taft | Systems and methods for delivery of materials for agriculture and aquaculture |
| EP2500015A1 (en) * | 2006-12-05 | 2012-09-19 | Landec Corporation | Delivery of drugs |
| US20090263346A1 (en) * | 2006-12-05 | 2009-10-22 | David Taft | Systems and methods for delivery of drugs |
| EP2126020B1 (de) * | 2006-12-22 | 2011-11-23 | Basf Se | Hydrophob modifizierte polyalkylenimine als farbübertragungsinhibitoren |
| CA2691002C (en) * | 2007-07-19 | 2016-05-10 | Allexcel, Inc. | Self-assembling amphiphilic polymers as anticancer agents |
| US8114883B2 (en) * | 2007-12-04 | 2012-02-14 | Landec Corporation | Polymer formulations for delivery of bioactive materials |
| FR2928373B1 (fr) | 2008-03-05 | 2010-12-31 | Centre Nat Rech Scient | Polymere derive de la polyethylenimine lineaire pour le transfert de gene. |
| GB0903559D0 (en) | 2009-03-02 | 2009-04-08 | Univ London Pharmacy | Oral delivery of hydrophilic drugs to the brain |
| CN102427834A (zh) | 2009-04-28 | 2012-04-25 | 苏尔莫迪克斯公司 | 用于递送生物活性剂的装置和方法 |
| GB0915449D0 (en) | 2009-09-04 | 2009-10-07 | Univ Robert Gordon | Composition |
| EP2563843B1 (en) | 2010-04-28 | 2017-12-06 | University Of Georgia Research Foundation, Inc. | Photochemical cross-linkable polymers, methods of marking photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers |
| US8721936B2 (en) | 2011-04-21 | 2014-05-13 | University Of Georgia Research Foundation, Inc. | Devices and methods for forming non-spherical particles |
| US9861727B2 (en) | 2011-05-20 | 2018-01-09 | Surmodics, Inc. | Delivery of hydrophobic active agent particles |
| US10213529B2 (en) | 2011-05-20 | 2019-02-26 | Surmodics, Inc. | Delivery of coated hydrophobic active agent particles |
| WO2013012664A2 (en) | 2011-07-15 | 2013-01-24 | The University Of Georgia Research Foundation, Inc | Permanent attachment of agents to surfaces containing c-h functionality |
| US9439421B2 (en) | 2011-08-04 | 2016-09-13 | University Of Georgia Research Foundation, Inc. | Permanent attachment of ammonium and guanidine-based antimicrobials to surfaces containing -OH functionality |
| WO2013056007A2 (en) | 2011-10-14 | 2013-04-18 | University Of Georgia Research Foundation, Inc. | Photochemical cross-linkable polymers, methods of making photochemical cross-linkable plolymers, methods of using photochemical cross-linkable poloymers, and methods of making articles containing photochemical cross-linkable polymers |
| EP2914297B1 (en) * | 2012-11-05 | 2019-01-09 | SurModics, Inc. | Composition and method for delivery of hydrophobic active agents |
| US11246963B2 (en) | 2012-11-05 | 2022-02-15 | Surmodics, Inc. | Compositions and methods for delivery of hydrophobic active agents |
| US10898446B2 (en) | 2016-12-20 | 2021-01-26 | Surmodics, Inc. | Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces |
| US12226552B2 (en) | 2019-09-30 | 2025-02-18 | Surmodics, Inc. | Active agent depots formed in situ |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5879022A (ja) * | 1981-11-04 | 1983-05-12 | Bitamin Kenkyusho:Kk | 第四級窒素原子を含有する新規な金属架橋高分子化合物、その製法及び該高分子化合物を有効成分とする高脂血症治療剤 |
| US5338532A (en) * | 1986-08-18 | 1994-08-16 | The Dow Chemical Company | Starburst conjugates |
| US5681543A (en) * | 1988-02-29 | 1997-10-28 | Shering Aktiengesellschaft | Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI |
| JPH01236240A (ja) * | 1989-01-14 | 1989-09-21 | Miyoshi Oil & Fat Co Ltd | 新規な高分子化合物 |
| DE3901527A1 (de) * | 1989-01-20 | 1990-07-26 | Hoechst Ag | Alkylierte polyethyleniminderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel sowie pharmazeutische praeparate |
| JP3406970B2 (ja) * | 1993-12-27 | 2003-05-19 | ミヨシ油脂株式会社 | 両性界面活性剤 |
| JP3526661B2 (ja) * | 1995-06-23 | 2004-05-17 | ミヨシ油脂株式会社 | 抗菌剤、抗菌性樹脂及び抗菌性塗料 |
| EP0912493A1 (en) * | 1996-06-19 | 1999-05-06 | The Procter & Gamble Company | Process for removing malodors from modified polyamines |
| CA2321200A1 (en) * | 1998-02-27 | 1999-09-02 | Dnavec Research Inc. | Composition for transporting negatively charged substances |
| JP3523821B2 (ja) * | 2000-02-09 | 2004-04-26 | ナノキャリア株式会社 | 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物 |
| US6696038B1 (en) * | 2000-09-14 | 2004-02-24 | Expression Genetics, Inc. | Cationic lipopolymer as biocompatible gene delivery agent |
| CN1479632A (zh) * | 2000-10-09 | 2004-03-03 | 用于将核酸导入细胞的复合物 | |
| DE10065710A1 (de) * | 2000-12-29 | 2002-07-04 | Bayer Ag | Arzneimittel enthaltend ein Polyamin als Wirksubstanz |
| GB0221941D0 (en) * | 2002-09-20 | 2002-10-30 | Univ Strathclyde | Polysoaps |
-
2002
- 2002-09-20 GB GBGB0221942.6A patent/GB0221942D0/en not_active Ceased
-
2003
- 2003-09-22 JP JP2004537295A patent/JP2006500437A/ja active Pending
- 2003-09-22 US US10/528,602 patent/US20060148982A1/en not_active Abandoned
- 2003-09-22 AU AU2003267581A patent/AU2003267581A1/en not_active Abandoned
- 2003-09-22 EP EP03748273A patent/EP1543063B1/en not_active Expired - Lifetime
- 2003-09-22 CA CA002499681A patent/CA2499681A1/en not_active Abandoned
- 2003-09-22 DE DE60326859T patent/DE60326859D1/de not_active Expired - Lifetime
- 2003-09-22 SI SI200331599T patent/SI1543063T1/sl unknown
- 2003-09-22 AT AT03748273T patent/ATE426635T1/de not_active IP Right Cessation
- 2003-09-22 WO PCT/GB2003/004036 patent/WO2004026941A1/en not_active Ceased
- 2003-09-22 DK DK03748273T patent/DK1543063T3/da active
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