JP2006500409A - Ｎｏ供与ジクロフェナクのようなｎｏ供与化合物の製造方法 - Google Patents

Ｎｏ供与ジクロフェナクのようなｎｏ供与化合物の製造方法 Download PDF

Info

Publication number
JP2006500409A
JP2006500409A JP2004538109A JP2004538109A JP2006500409A JP 2006500409 A JP2006500409 A JP 2006500409A JP 2004538109 A JP2004538109 A JP 2004538109A JP 2004538109 A JP2004538109 A JP 2004538109A JP 2006500409 A JP2006500409 A JP 2006500409A
Authority
JP
Japan
Prior art keywords
compound
formula
group
solvent
iva
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2004538109A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006500409A5 (enExample
Inventor
アンデルソン，ヨハン
ベッリ，アルド
カンナタ，ヴィンセンゾ
ヘドベルグ，マルティン
パルムグレン，アンドレアス
シュルダイ，シグリド
ストーム，マリカ
ヴィラ，マルコ
Original Assignee
ニコックス エス エイ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0202801A external-priority patent/SE0202801D0/xx
Priority claimed from SE0301476A external-priority patent/SE0301476D0/xx
Application filed by ニコックス エス エイ filed Critical ニコックス エス エイ
Publication of JP2006500409A publication Critical patent/JP2006500409A/ja
Publication of JP2006500409A5 publication Critical patent/JP2006500409A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
    • C07C211/55—Diphenylamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2004538109A 2002-09-20 2003-09-18 Ｎｏ供与ジクロフェナクのようなｎｏ供与化合物の製造方法 Withdrawn JP2006500409A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0202801A SE0202801D0 (sv) 2002-09-20 2002-09-20 New crystal form
SE0301476A SE0301476D0 (sv) 2003-05-20 2003-05-20 Manufacturing process for no-donating compounds
PCT/SE2003/001465 WO2004026808A1 (en) 2002-09-20 2003-09-18 Manufacturing process for no-donating compounds such as no-donating diclofenac

Publications (2)

Publication Number Publication Date
JP2006500409A true JP2006500409A (ja) 2006-01-05
JP2006500409A5 JP2006500409A5 (enExample) 2006-11-02

Family

ID=32033036

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004538109A Withdrawn JP2006500409A (ja) 2002-09-20 2003-09-18 Ｎｏ供与ジクロフェナクのようなｎｏ供与化合物の製造方法

Country Status (13)

Country Link
US (2) US20060122402A1 (enExample)
EP (1) EP1558559A1 (enExample)
JP (1) JP2006500409A (enExample)
KR (1) KR20050057496A (enExample)
CN (1) CN1684940A (enExample)
AU (1) AU2003265035A1 (enExample)
BR (1) BR0314365A (enExample)
CA (1) CA2498943A1 (enExample)
MX (1) MXPA05003050A (enExample)
NZ (1) NZ538727A (enExample)
PL (1) PL375321A1 (enExample)
RU (1) RU2322434C2 (enExample)
WO (1) WO2004026808A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
JP2005539089A (ja) 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
US7632866B2 (en) 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
SE0301880D0 (sv) * 2003-06-25 2003-06-25 Astrazeneca Uk Ltd New drug delivery composition
WO2009037705A2 (en) * 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation
WO2009037707A2 (en) 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
CN116789631B (zh) * 2023-07-06 2024-05-31 陕西理工大学 一种酶协同光控一氧化氮供体、其制备及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1546478A (fr) * 1967-01-27 1968-11-22 Rhone Poulenc Sa Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation
DE3811118C1 (enExample) * 1988-03-31 1989-10-12 Merckle Gmbh, 7902 Blaubeuren, De
ES2073995B1 (es) * 1993-05-17 1996-03-01 Espanola Explosivos Procedimiento para la obtencion de nitratoalquil oxetanos.
JP3775796B2 (ja) * 1993-10-06 2006-05-17 ニコックス エス エイ 抗炎症活性及び／又は鎮痛活性を有する硝酸エステル類及びそれらの製造方法
RU2145595C1 (ru) * 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
EP1126838A4 (en) * 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
US6355666B1 (en) * 2000-06-23 2002-03-12 Medinox, Inc. Protected forms of pharmacologically active agents and uses therefor

Also Published As

Publication number Publication date
AU2003265035A1 (en) 2004-04-08
KR20050057496A (ko) 2005-06-16
CA2498943A1 (en) 2004-04-01
CN1684940A (zh) 2005-10-19
BR0314365A (pt) 2005-07-19
US20090170934A1 (en) 2009-07-02
WO2004026808A1 (en) 2004-04-01
RU2322434C2 (ru) 2008-04-20
PL375321A1 (en) 2005-11-28
NZ538727A (en) 2008-01-31
US20060122402A1 (en) 2006-06-08
RU2005107785A (ru) 2005-12-10
MXPA05003050A (es) 2005-05-27
EP1558559A1 (en) 2005-08-03

Similar Documents

Publication Publication Date Title
US20090096314A1 (en) Electric motor
CN101903324A (zh) 一种制备Remodulin中的活性成分曲前列素的改良方法
US20090170934A1 (en) Manufacturing process for no-donating compounds such as no-donating diclofenac
RU2742005C2 (ru) Способы получения 4-алкокси-3-(ацил или алкил)оксипиколинамидов
JP2001518459A (ja) 葉酸拮抗剤を作成するのに有用な方法及び中間体
KR102266680B1 (ko) 벨리노스테트의 다형태 및 이의 제조 방법
JP7036724B2 (ja) ピラゾール－アミド化合物の製造方法
JP2018518489A (ja) アプレミラスト及びその中間体の調製方法
CA3083672A1 (en) Process for the preparation of roxadustat and its intermediates
JP4528123B2 (ja) ナプロキセンのニトロオキシ誘導体の製造法
JP4771659B2 (ja) 新規な方法
JP2005510557A6 (ja) 新規な方法
JP2006500409A5 (enExample)
US20060142595A1 (en) Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCI
US7544809B2 (en) Method for the preparation of oxazoles by condensing aromatic aldehydes with α-ketoximes to form n-oxides and reacting same with activated acid derivatives
ZA200502224B (en) Manufacturing process for no-donating compounds such as no-donating diclofenac.
WO2021130163A1 (en) A process for the synthesis of melphalan
CN100378065C (zh) 2-氯甲基-6-甲基苯甲酸酯的合成
JPS59101437A (ja) フルオレン−９−カルボン酸の製法
JP2026505630A (ja) イソオキサゾリン誘導体を調製する方法
JPH0576473B2 (enExample)
TW202404470A (zh) 用於製備４－取代的２－㗁唑啶酮之方法
WO2024175691A1 (en) Process for the preparation of substituted chalcones
CN118359521A (zh) 一种硫醚或硫酯类化合物的制备方法
JPS6051460B2 (ja) 炭酸エステル類、その製造方法およびその用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060913

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060913

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20090831