JP2006316040A5 - - Google Patents
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- JP2006316040A5 JP2006316040A5 JP2005310518A JP2005310518A JP2006316040A5 JP 2006316040 A5 JP2006316040 A5 JP 2006316040A5 JP 2005310518 A JP2005310518 A JP 2005310518A JP 2005310518 A JP2005310518 A JP 2005310518A JP 2006316040 A5 JP2006316040 A5 JP 2006316040A5
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- Prior art keywords
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- antibody
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- chemotherapeutic agent
- her2
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- 239000000203 mixture Substances 0.000 claims 123
- 239000002246 antineoplastic agent Substances 0.000 claims 31
- 229940127089 cytotoxic agent Drugs 0.000 claims 31
- 229940022353 herceptin Drugs 0.000 claims 26
- 229960000575 trastuzumab Drugs 0.000 claims 24
- 238000000034 method Methods 0.000 claims 21
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 18
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 18
- 230000000683 nonmetastatic effect Effects 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 16
- 230000004083 survival effect Effects 0.000 claims 16
- 201000011510 cancer Diseases 0.000 claims 14
- 208000017891 HER2 positive breast carcinoma Diseases 0.000 claims 12
- 229930012538 Paclitaxel Natural products 0.000 claims 10
- 229960001592 paclitaxel Drugs 0.000 claims 10
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 10
- 206010061819 Disease recurrence Diseases 0.000 claims 9
- 238000002512 chemotherapy Methods 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 238000011470 radical surgery Methods 0.000 claims 7
- 238000009098 adjuvant therapy Methods 0.000 claims 6
- 210000001165 lymph node Anatomy 0.000 claims 5
- 238000001356 surgical procedure Methods 0.000 claims 5
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 4
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 4
- 229960004397 cyclophosphamide Drugs 0.000 claims 4
- 229960003668 docetaxel Drugs 0.000 claims 4
- 102000015694 estrogen receptors Human genes 0.000 claims 4
- 108010038795 estrogen receptors Proteins 0.000 claims 4
- 102000003998 progesterone receptors Human genes 0.000 claims 4
- 108090000468 progesterone receptors Proteins 0.000 claims 4
- 238000011498 curative surgery Methods 0.000 claims 3
- 230000000977 initiatory effect Effects 0.000 claims 3
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 2
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 2
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 claims 2
- 241000863480 Vinca Species 0.000 claims 2
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 2
- 229940046836 anti-estrogen Drugs 0.000 claims 2
- 230000001833 anti-estrogenic effect Effects 0.000 claims 2
- 238000009175 antibody therapy Methods 0.000 claims 2
- 239000003886 aromatase inhibitor Substances 0.000 claims 2
- 229960004117 capecitabine Drugs 0.000 claims 2
- 238000004590 computer program Methods 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- 239000000328 estrogen antagonist Substances 0.000 claims 2
- 229960005420 etoposide Drugs 0.000 claims 2
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- 229940046159 pegylated liposomal doxorubicin Drugs 0.000 claims 2
- 150000003058 platinum compounds Chemical class 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 229960001196 thiotepa Drugs 0.000 claims 2
- 230000035899 viability Effects 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000001755 vocal effect Effects 0.000 claims 1
Images
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68112505P | 2005-05-13 | 2005-05-13 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013092728A Division JP6133668B2 (ja) | 2005-05-13 | 2013-04-25 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2013109685A Division JP2013163694A (ja) | 2005-05-13 | 2013-05-24 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006316040A JP2006316040A (ja) | 2006-11-24 |
| JP2006316040A5 true JP2006316040A5 (https=) | 2008-12-04 |
Family
ID=37450489
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005310518A Pending JP2006316040A (ja) | 2005-05-13 | 2005-10-25 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2013092728A Expired - Lifetime JP6133668B2 (ja) | 2005-05-13 | 2013-04-25 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2013109685A Pending JP2013163694A (ja) | 2005-05-13 | 2013-05-24 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2015140158A Withdrawn JP2015187168A (ja) | 2005-05-13 | 2015-07-14 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2017088352A Pending JP2017132806A (ja) | 2005-05-13 | 2017-04-27 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2017088351A Withdrawn JP2017132805A (ja) | 2005-05-13 | 2017-04-27 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2018200936A Pending JP2019011374A (ja) | 2005-05-13 | 2018-10-25 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2020041610A Withdrawn JP2020094061A (ja) | 2005-05-13 | 2020-03-11 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2022075920A Pending JP2022093642A (ja) | 2005-05-13 | 2022-05-02 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013092728A Expired - Lifetime JP6133668B2 (ja) | 2005-05-13 | 2013-04-25 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2013109685A Pending JP2013163694A (ja) | 2005-05-13 | 2013-05-24 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2015140158A Withdrawn JP2015187168A (ja) | 2005-05-13 | 2015-07-14 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2017088352A Pending JP2017132806A (ja) | 2005-05-13 | 2017-04-27 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2017088351A Withdrawn JP2017132805A (ja) | 2005-05-13 | 2017-04-27 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2018200936A Pending JP2019011374A (ja) | 2005-05-13 | 2018-10-25 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2020041610A Withdrawn JP2020094061A (ja) | 2005-05-13 | 2020-03-11 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| JP2022075920A Pending JP2022093642A (ja) | 2005-05-13 | 2022-05-02 | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8591897B2 (https=) |
| JP (9) | JP2006316040A (https=) |
| AR (4) | AR054254A1 (https=) |
| BR (1) | BRPI0601736A (https=) |
| CA (2) | CA2790058C (https=) |
| MX (2) | MX344809B (https=) |
Families Citing this family (86)
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| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| KR20130056201A (ko) * | 2000-05-19 | 2013-05-29 | 제넨테크, 인크. | ＥｒｂＢ 길항제에 의한 암 치료요법에 대한 효과적인 반응의 가능성을 개선시키기 위한 유전자 검출 분석 |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| SV2006002143A (es) * | 2004-06-16 | 2006-01-26 | Genentech Inc | Uso de un anticuerpo para el tratamiento del cancer resistente al platino |
| KR20140032004A (ko) | 2004-07-22 | 2014-03-13 | 제넨테크, 인크. | Ｈｅｒ２ 항체 조성물 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| JP2008523073A (ja) * | 2004-12-07 | 2008-07-03 | ジェネンテック・インコーポレーテッド | Ｈｅｒ阻害剤を用いた治療のための患者の選択 |
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