JP2006315956A - 解熱鎮痛用固形製剤 - Google Patents
解熱鎮痛用固形製剤 Download PDFInfo
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- JP2006315956A JP2006315956A JP2005136804A JP2005136804A JP2006315956A JP 2006315956 A JP2006315956 A JP 2006315956A JP 2005136804 A JP2005136804 A JP 2005136804A JP 2005136804 A JP2005136804 A JP 2005136804A JP 2006315956 A JP2006315956 A JP 2006315956A
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- Prior art keywords
- ibuprofen
- average particle
- particle size
- ethenzamide
- dissolution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000007787 solid Substances 0.000 title claims abstract description 7
- 230000000202 analgesic effect Effects 0.000 title description 7
- 230000001754 anti-pyretic effect Effects 0.000 title description 4
- 239000002221 antipyretic Substances 0.000 title description 4
- 239000002245 particle Substances 0.000 claims abstract description 38
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229960001680 ibuprofen Drugs 0.000 claims abstract description 34
- SBNKFTQSBPKMBZ-UHFFFAOYSA-N ethenzamide Chemical compound CCOC1=CC=CC=C1C(N)=O SBNKFTQSBPKMBZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 abstract description 20
- 239000003814 drug Substances 0.000 abstract description 20
- 229960000514 ethenzamide Drugs 0.000 abstract description 10
- 239000003907 antipyretic analgesic agent Substances 0.000 abstract description 8
- 238000010828 elution Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 238000004090 dissolution Methods 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 239000000843 powder Substances 0.000 description 5
- 238000007922 dissolution test Methods 0.000 description 4
- 229940035676 analgesics Drugs 0.000 description 3
- 239000000730 antalgic agent Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- -1 fatty acid ester Chemical class 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940124579 cold medicine Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 238000012812 general test Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000007561 laser diffraction method Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000000790 scattering method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000011882 ultra-fine particle Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本発明は、イブプロフェンとエテンザミドを同時配合した製剤において、両薬剤の溶出性を向上させた製剤の提供を目的とする。
【解決手段】 平均粒子径5〜100μmのエテンザミドおよび平均粒子径15〜40μmのイブプロフェンを含有する固形製剤。
【選択図】 なし
Description
実施例1のイブプロフェン(平均粒子径23.1μm)を、より粒子径の小さいイブプロフェン(平均粒子径10.7μm)15.12gに替えて、実施例1と同様にして、比較用粉状製剤を得た。
実施例1のイブプロフェン(平均粒子径23.1μm)を、より粒子径の大きいイブプロフェン(平均粒子径50.2μm)15.12gに替えて、実施例1と同様にして、比較用粉状製剤を得た。
実施例1のエテンザミド(平均粒子径:20.2μm)を、より粒子径の小さいエテンザミド(平均粒子径:2.5μm)8.82gに替えて、実施例1と同様にして、比較用粉状製剤を得た。
実施例1のエテンザミド(平均粒子径:20.2μm)を、より粒子径の大きいエテンザミド(平均粒子径:172.2μm)8.82gに替えて、実施例1と同様にして、比較用粉状製剤を得た。
実施例1、比較例1、比較例2、比較例3および比較例4で得られた製剤を日本薬局方一般試験法溶出試験法第2法(パドル法)に準拠して試験を実施した。試験液は精製水を用い、パドル回転数を毎分50回転にて試験を行い溶出率(%)を求めた。イブプロフェンの溶出試験結果を表1および図1に、エテンザミドの溶出試験結果を表2および図2に示した。
Claims (2)
- 平均粒子径5〜100μmのエテンザミドおよび平均粒子径15〜40μmのイブプロフェンを含有する固形製剤。
- 平均粒子径5〜100μmのエテンザミドおよび平均粒子径15〜40μmのイブプロフェンを含有し、配合比としてイブプロフェン1質量部に対してエテンザミドが0.05〜10質量部である固形製剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005136804A JP4822095B2 (ja) | 2005-05-10 | 2005-05-10 | 解熱鎮痛用固形製剤 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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JP2005136804A JP4822095B2 (ja) | 2005-05-10 | 2005-05-10 | 解熱鎮痛用固形製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006315956A true JP2006315956A (ja) | 2006-11-24 |
JP4822095B2 JP4822095B2 (ja) | 2011-11-24 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005136804A Active JP4822095B2 (ja) | 2005-05-10 | 2005-05-10 | 解熱鎮痛用固形製剤 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP4822095B2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014141469A (ja) * | 2012-12-27 | 2014-08-07 | Taisho Pharmaceutical Co Ltd | レイヤリング粒子 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06329556A (ja) * | 1993-05-20 | 1994-11-29 | Japan Tobacco Inc | 粉体及び固形剤における配合不適防止方法 |
WO1997041832A1 (fr) * | 1996-05-02 | 1997-11-13 | Taisho Pharmaceutical Co., Ltd. | Suspension de medicament acide difficilement soluble dans l'eau |
JP2003277266A (ja) * | 2002-03-25 | 2003-10-02 | Lion Corp | 分配用混合粉体、及びそれを使用した錠剤またはカプセル |
-
2005
- 2005-05-10 JP JP2005136804A patent/JP4822095B2/ja active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06329556A (ja) * | 1993-05-20 | 1994-11-29 | Japan Tobacco Inc | 粉体及び固形剤における配合不適防止方法 |
WO1997041832A1 (fr) * | 1996-05-02 | 1997-11-13 | Taisho Pharmaceutical Co., Ltd. | Suspension de medicament acide difficilement soluble dans l'eau |
JP2003277266A (ja) * | 2002-03-25 | 2003-10-02 | Lion Corp | 分配用混合粉体、及びそれを使用した錠剤またはカプセル |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014141469A (ja) * | 2012-12-27 | 2014-08-07 | Taisho Pharmaceutical Co Ltd | レイヤリング粒子 |
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JP4822095B2 (ja) | 2011-11-24 |
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