JP2006298792A - 脂肪蓄積抑制剤及び飲食品 - Google Patents
脂肪蓄積抑制剤及び飲食品 Download PDFInfo
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- JP2006298792A JP2006298792A JP2005119858A JP2005119858A JP2006298792A JP 2006298792 A JP2006298792 A JP 2006298792A JP 2005119858 A JP2005119858 A JP 2005119858A JP 2005119858 A JP2005119858 A JP 2005119858A JP 2006298792 A JP2006298792 A JP 2006298792A
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- fat accumulation
- fat
- beverage
- tea
- active ingredient
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- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
- A23F3/18—Extraction of water soluble tea constituents
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
- C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
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Abstract
【解決手段】下記の化学式(1)で示され、緑茶又は包種茶を抽出して得られるメチル化カテキンを有効成分量含有した。
[R1,R2,R3,R4は、それぞれ独立に水素原子、メチル基のいずれかであり、X1,X2は、それぞれ独立に水素原子、ヒドロキシ基のどちらかである。]
【化1】
Description
村松敬一郎編 「茶の科学」朝倉書店(2000)
本発明に係る脂肪蓄積抑制剤は、所定の茶葉由来のメチル化カテキン成分を有効成分量含有する。ここで「メチル化カテキン」とは、化学式(1)で示されるものであり、メチル化されたカテキン及び精製の際の不可避成分をいう。本発明におけるメチル化カテキンは主として、エピガロカテキン−3−O−(3−O−メチル)ガレート(以下、EGCG3”Meという)、エピカテキン−3−O−(3−O−メチル)ガレート(以下、ECG3”Meという)、エピカテキン−3−O−(4−O−メチル)ガレート(以下、ECG4”Meという)、エピガロカテキン−3−O−(4−O−メチル)ガレート(以下、EGCG4”Meという)、ガロカテキン−3−O−(3−O−メチル)ガレート(以下、GCG3”Meという)、カテキン−3−O−(3−O−メチル)ガレート(以下、CG3”Meという)、カテキン−3−O−(4−O−メチル)ガレート(以下、CG4”Meという)、又は、ガロカテキン−3−O−(4−O−メチル)ガレート(以下、GCG4”Meという)及びこれらの異性化体を含むことが好ましい。
べにふうきは30倍量の純水を用いて、90℃で抽出を行って得た抽出液中のメチル化カテキン成分を、有機溶媒を用いた合成樹脂の吸脱着により精製した。この精製物1gとべにふうき粉末19g、乳糖60g、及びステアリン酸マグネシウム15gを均一に混合し、常法に従って錠剤、カプセル剤とした。
実施例1に記載の方法で得られた精製物200mgをカプセルに封入してカプセル剤とした。
実施例1に記載の方法で得られた精製物2gと、べにふうき茶葉粉末78gと澱粉及び乳糖をそれぞれ10g均一に混合し、常法に従って散剤とした。
実施例1に記載の方法で得られた精製物2gと、べにふうき茶葉粉末8gショ糖20g、水飴(75%固形分)60g、水9.5g、着色料0.45g及び香料0.05gを常法に従って飴とした。
実施例1に記載の方法で得られた精製物2gと、べにふうき茶葉粉末8g、薄力粉32g、全卵16g、バター16g、砂糖25g、水10.8gベーキングパウダー0.2gを常法に従ってクッキーとした。
べにふうきの茶葉は30倍量の純水を用いて、90℃で抽出を行って得た抽出液を、重曹などの水質調整剤及びビタミンCを添加混合した。殺菌し密封容器に窒素充填して試験飲料1とした。
メチル化カテキン成分は、佐野らの方法(J,Agr1c.Food.Chem.1999,47,1906−1910)に従って精製した。この方法は具体的には、有機溶媒で抽出して、HP−20のカラムにより精製する方法をいう。体重250gの雄性SDラットより精巣周囲の脂肪組織を採取し、常法に従って組織をコラゲナーゼとヒアルロニターゼで処理して細胞を分散させ、細胞浮遊液を調製した。また、遠心分離により浮遊した成熟脂肪細胞と、沈降した脂肪細胞前駆細胞を含む細胞群を分離回収し、前者をフラスコ中で、後者を96六ウェルの培養プレート中で(3万個/0.1mL培地/ウェル)3日間培養した。
4適齢の雄性ICR系マウスを8匹ずつ3群に分け、それぞれに精製飼料(AIN−93G)、及びやぶきた茶葉粉末を1%添加した精製飼料、べにふうき茶葉を0.5%添加した精製飼料を7週間自由摂取させた。飼育終了後、体重、精巣脂肪重量、肝臓中の中性脂肪濃度を試験群間で比較した。なお、べにふうき茶葉の飼料への添加量は、やぶきた茶葉と総カテキン量を合わせるため半量とした。その結果を表2に示す。
Claims (8)
- 前記メチル化カテキンは「べにふうき」、「べにふじ」、「べにほまれ」、「やえほ」、「するがわせ」、「ゆたかみどり」、「かなやみどり」、「おくむさし」、「青心大パン」、「青心烏龍」、「大葉烏龍」、「紅花」、「べにひかり」、「やまかい」、「やまみどり」、「からべに」、「香駿」、「そうふう」及び「おくみどり」、もしくはこれらの混合物の茶葉由来のものである請求項1に記載の脂肪蓄積抑制剤。
- 脂肪の蓄積を抑制するために有効であるために用いられる旨の表示、及び/又は脂肪蓄積抑制剤として有効成分量含有する旨の表示を付したものである請求項1又は2に記載の脂肪蓄積抑制剤。
- 請求項1から3いずれかに記載の脂肪蓄積抑制剤を、飲料100mlあたり2mgから100mg含有する飲料。
- 請求項1から3いずれかに記載の脂肪蓄積抑制剤を、100gあたり100mgから5000mg含有する食品。
- 請求項1から3いずれかに記載の脂肪蓄積抑制剤を、2mgから200mg含有する医薬品。
- 請求項1から3いずれかに記載の脂肪蓄積抑制剤を、飲料に有効成分量含有させることにより、この飲料に脂肪蓄積抑制作用を新たに付与する方法。
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JP2005119858A JP5261808B2 (ja) | 2005-04-18 | 2005-04-18 | 脂肪蓄積抑制剤、医薬品及び脂肪蓄積抑制作用を新たに付与する方法 |
US11/911,711 US20080319052A1 (en) | 2005-04-18 | 2006-04-13 | Lipopexia Inhibitor and Food or Beverage |
PCT/JP2006/307858 WO2006112366A1 (ja) | 2005-04-18 | 2006-04-13 | 脂肪蓄積抑制剤及び飲食品 |
US12/549,102 US20090312409A1 (en) | 2005-04-18 | 2009-08-27 | Lipopexia inhibitor and food or beverage |
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Cited By (3)
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JP2008178320A (ja) * | 2007-01-23 | 2008-08-07 | Asahi Soft Drinks Co Ltd | 容器入り茶飲料群の製造方法 |
JP2011004635A (ja) * | 2009-06-24 | 2011-01-13 | Asahi Soft Drinks Co Ltd | 茶エキスの製造方法、茶粉末の製造方法及び茶エキス又は茶粉末に含まれるカテキン中のメチル化カテキンの濃度を高める方法。 |
JP2012031101A (ja) * | 2010-07-30 | 2012-02-16 | Kurume Univ | 非アルコール性脂肪性肝炎の改善用組成物 |
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JP5128826B2 (ja) * | 2007-02-07 | 2013-01-23 | 独立行政法人農業・食品産業技術総合研究機構 | 新規なメチル化カテキン及びそれを含む組成 |
WO2010121203A1 (en) * | 2009-04-16 | 2010-10-21 | Ocean Spray Cranberries, Inc. | Phenolics extraction and use |
WO2011042958A1 (ja) * | 2009-10-06 | 2011-04-14 | 森永製菓株式会社 | ポリフェノール類化合物の吸収促進剤及びその利用 |
JP5965735B2 (ja) * | 2012-06-14 | 2016-08-10 | 森永製菓株式会社 | 水溶性向上剤、水溶性向上方法、及び、水溶液調製方法 |
CN104824245A (zh) * | 2015-05-14 | 2015-08-12 | 广西梧州茂圣茶业有限公司 | 具有预防和改善脂肪肝功效的六堡茶珍的制备工艺 |
KR102411895B1 (ko) * | 2020-06-09 | 2022-06-24 | 바이오스펙트럼 주식회사 | 수선화속 식물 추출물을 포함하는 비만 및/또는 대사성 질환의 예방 또는 치료용 조성물 |
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JP2008178320A (ja) * | 2007-01-23 | 2008-08-07 | Asahi Soft Drinks Co Ltd | 容器入り茶飲料群の製造方法 |
JP2011004635A (ja) * | 2009-06-24 | 2011-01-13 | Asahi Soft Drinks Co Ltd | 茶エキスの製造方法、茶粉末の製造方法及び茶エキス又は茶粉末に含まれるカテキン中のメチル化カテキンの濃度を高める方法。 |
JP2012031101A (ja) * | 2010-07-30 | 2012-02-16 | Kurume Univ | 非アルコール性脂肪性肝炎の改善用組成物 |
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US20090312409A1 (en) | 2009-12-17 |
WO2006112366A1 (ja) | 2006-10-26 |
JP5261808B2 (ja) | 2013-08-14 |
US20080319052A1 (en) | 2008-12-25 |
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