JP2006117704A5 - - Google Patents

Info

Publication number

JP2006117704A5

JP2006117704A5 JP2006025034A JP2006025034A JP2006117704A5 JP 2006117704 A5 JP2006117704 A5 JP 2006117704A5 JP 2006025034 A JP2006025034 A JP 2006025034A JP 2006025034 A JP2006025034 A JP 2006025034A JP 2006117704 A5 JP2006117704 A5 JP 2006117704A5

Authority

JP

Japan

Prior art keywords

pge1

freeze

maltose

weight

product according

Prior art date

2006-02-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000047 product Substances 0.000 claims 27
• GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 claims 23
• 229960000711 alprostadil Drugs 0.000 claims 23
• GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 claims 23
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 13
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 13
• 229920000858 Cyclodextrin Polymers 0.000 claims 10
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 10
• 238000000354 decomposition reaction Methods 0.000 claims 9
• 238000003860 storage Methods 0.000 claims 8
• 238000004519 manufacturing process Methods 0.000 claims 7
• 150000001875 compounds Chemical class 0.000 claims 5
• 239000007857 degradation product Substances 0.000 claims 5
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
• 238000009472 formulation Methods 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 239000007864 aqueous solution Substances 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 238000004811 liquid chromatography Methods 0.000 claims 2
• 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims 1
• 208000031104 Arterial Occlusive disease Diseases 0.000 claims 1
• 208000002330 Congenital Heart Defects Diseases 0.000 claims 1
• 208000031481 Pathologic Constriction Diseases 0.000 claims 1
• HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims 1
• 229940043377 alpha-cyclodextrin Drugs 0.000 claims 1
• 208000021328 arterial occlusion Diseases 0.000 claims 1
• 230000017531 blood circulation Effects 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 208000028831 congenital heart disease Diseases 0.000 claims 1
• 230000001419 dependent effect Effects 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 239000002552 dosage form Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 230000008014 freezing Effects 0.000 claims 1
• 238000007710 freezing Methods 0.000 claims 1
• 210000005259 peripheral blood Anatomy 0.000 claims 1
• 239000011886 peripheral blood Substances 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• 208000037804 stenosis Diseases 0.000 claims 1
• 230000036262 stenosis Effects 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
• NZYDCCAWWIOPFI-SGOYRCKQSA-N CCCCC/C=C/C=C/[C@H]([C@@H](CCCCCCC(O)=O)C(C1)=O)[C@@H]1O Chemical compound CCCCC/C=C/C=C/[C@H]([C@@H](CCCCCCC(O)=O)C(C1)=O)[C@@H]1O NZYDCCAWWIOPFI-SGOYRCKQSA-N 0.000 description 1