JP2006028123A - 乳剤性皮膚外用剤 - Google Patents
乳剤性皮膚外用剤 Download PDFInfo
- Publication number
- JP2006028123A JP2006028123A JP2004211906A JP2004211906A JP2006028123A JP 2006028123 A JP2006028123 A JP 2006028123A JP 2004211906 A JP2004211906 A JP 2004211906A JP 2004211906 A JP2004211906 A JP 2004211906A JP 2006028123 A JP2006028123 A JP 2006028123A
- Authority
- JP
- Japan
- Prior art keywords
- emulsion
- ester
- castor oil
- hydrogenated castor
- polyoxyethylene hydrogenated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000004359 castor oil Substances 0.000 claims abstract description 21
- 235000019438 castor oil Nutrition 0.000 claims abstract description 21
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 21
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Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
【課題手段】安定化剤として、クロタミトン、ポリオキシエチレン硬化ヒマシ油およびプロピレングリコールを組み合わせて添加する。
【選択図】なし
Description
したがって、保存安定性に優れたエステル系ステロイド、ジフェンヒドラミン類およびメントールを含む乳剤性皮膚外用剤は、クロタミトン、ポリオキシエチレン硬化ヒマシ油およびプロピレングリコールを組み合わせることによってエステル系ステロイドの安定化と製剤の分離安定性の両者を改善したものとすることができる。
有機酸としては、酢酸、酪酸、吉草酸、プロピオン酸等が挙げられる。本発明で用いられるエステル系ステロイドの具体例としては、吉草酸酢酸プレドニゾロン、酢酸メチルプレドニゾロン、酢酸ヒドロコルチゾン、酪酸ヒドロコルチゾン、プロピオン酸アルクロメタゾン、酪酸クロベタゾン、プロピオン酸デプロドン、プロピオン酸ベクロメタゾン、吉草酸デキサメタゾン、吉草酸べタメタゾン、酪酸プロピオン酸ヒドロコルチゾン、吉草酸
ジフルコルトロン、ジプロピオン酸デキサメタゾン、ジプロピオン酸ベタメタゾン、酢酸ジフロラゾン、プロピオン酸クロベタゾールが示されるが、好ましくは、吉草酸酢酸プレドニゾロンである。
エステル系ステロイドの配合量は、用いるステロイドによってその作用の強弱が異なることから、一概にはいえないが、皮膚外用剤中、0.01〜10w/w%程度配合でき、好ましくは、0.1〜0.2w/w%である。
〔実施例1〜25〕
乳剤性皮膚外用剤の調製法
油分、界面活性剤を加温(80℃)溶融した組成物に吉草酸酢酸プレドニゾロン、メントール、クロタミトン、その他の油溶性成分を溶解させた油性組成物を調製した。加温(83℃)した精製水に塩酸ジフェンヒドラミン以外の水溶性成分を添加し、溶解、又は分散して水性組成物を調製した。油性組成物と水性組成物を加温(80℃)状態で撹拌・混合し、乳化させ、撹拌しながら60℃まで徐冷して精製水の一部(溶剤)に塩酸ジフェンヒドラミンを溶解し、添加後、撹拌し、pHを4.5に調整し、更に撹拌しながら徐冷して室温とし、本発明の乳剤性皮膚外用剤を調製した。
上記の調製法を用いて調製された、実施例1〜25の乳剤性皮膚外用剤の組成を表1〜5に示した。
吉草酸酢酸プレドニゾロンの加水分解の原因を解明し、その防止策を検討するために、表1の比較例1〜3の組成を有する乳剤性皮膚外用剤を、上記の方法と同様に調製した。比較例1〜3と実施例1〜6の乳剤性皮膚外用剤ポリエチレン製容器に入れ、40℃、7
5%RHにおいて3ヶ月保存して、残存する吉草酸酢酸プレドニゾロン量(PVA残存率%)を、日本薬局方の一般試験法の液体クロトグラフ法に従って測定した。その結果を表1に示す。
上記の乳剤性皮膚外用剤の調製法に従い、実施例7のポリオキシエチレン硬化ヒマシ油60(5.0w/w%)を添加せず、代わりにポリオキシエチレンステアリルエーテル(3.0w/w%)を添加した比較例4および実施例7のプロピレングリコール(5.0w/w%)を添加せず、代わりに1,3−ブチレングリコール(5.0w/w%)を添加した比較例5を作成し、これをポリエチレン製容器に入れ、40℃、75%RHにおいて6ヶ月保存した。製剤の外観を観察した結果、比較例4および5は、水性成分が分離した状態にあった。
Claims (3)
- エステル系ステロイド、ジフェンヒドラミン類、メントール、クロタミトン、ポリオキシエチレン硬化ヒマシ油、プロピレングリコール、水、及び油分を含有することを特徴とするO/W型乳剤性皮膚外用剤。
- エステル系ステロイドが吉草酸酢酸プレドニゾロン、ジフェンヒドラミン類が塩酸ジフェンヒドラミンである請求項1記載のO/W型乳剤性皮膚外用剤。
- クロタミトン3〜7w/w%、ポリオキシエチレン硬化ヒマシ油1〜7.5w/w%、プロピレングリコール0.1〜10w/w%を含有する請求項1または2記載のO/W型乳剤性皮膚外用剤。
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