JP2005538974A5 - - Google Patents
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- Publication number
- JP2005538974A5 JP2005538974A5 JP2004518667A JP2004518667A JP2005538974A5 JP 2005538974 A5 JP2005538974 A5 JP 2005538974A5 JP 2004518667 A JP2004518667 A JP 2004518667A JP 2004518667 A JP2004518667 A JP 2004518667A JP 2005538974 A5 JP2005538974 A5 JP 2005538974A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cyano
- hydrogen
- halogen
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 43
- 229910052739 hydrogen Inorganic materials 0.000 claims 40
- 239000001257 hydrogen Substances 0.000 claims 40
- 229910052736 halogen Chemical group 0.000 claims 39
- -1 4- (2-methoxyphenyl) piperazin-1-yl Chemical group 0.000 claims 38
- 150000002367 halogens Chemical group 0.000 claims 37
- 125000004093 cyano group Chemical group *C#N 0.000 claims 30
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 30
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 20
- 125000003342 alkenyl group Chemical group 0.000 claims 18
- 125000000304 alkynyl group Chemical group 0.000 claims 18
- 125000002252 acyl group Chemical group 0.000 claims 17
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 11
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 10
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 10
- 229910052801 chlorine Inorganic materials 0.000 claims 10
- 239000000460 chlorine Substances 0.000 claims 10
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 10
- 229910052731 fluorine Inorganic materials 0.000 claims 10
- 239000011737 fluorine Substances 0.000 claims 10
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 10
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 201000009457 movement disease Diseases 0.000 claims 8
- WTDRDQBEARUVNC-LURJTMIESA-N 3-hydroxy-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 6
- 206010061536 Parkinson's disease Diseases 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 5
- 229940079593 drugs Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 206010003591 Ataxia Diseases 0.000 claims 4
- 206010013663 Drug dependence Diseases 0.000 claims 4
- 230000003111 delayed Effects 0.000 claims 4
- 201000010874 syndrome Diseases 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 208000007848 Alcoholism Diseases 0.000 claims 2
- 206010057668 Cognitive disease Diseases 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 208000001365 Hyperprolactinemia Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 2
- 206010057852 Nicotine dependence Diseases 0.000 claims 2
- 208000004224 Opium Dependence Diseases 0.000 claims 2
- 206010037211 Psychomotor hyperactivity Diseases 0.000 claims 2
- 208000005793 Restless Legs Syndrome Diseases 0.000 claims 2
- 108060002205 adhS Proteins 0.000 claims 2
- 125000004432 carbon atoms Chemical group C* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 238000002651 drug therapy Methods 0.000 claims 2
- 230000035935 pregnancy Effects 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 201000001880 sexual dysfunction Diseases 0.000 claims 2
- 231100000872 sexual dysfunction Toxicity 0.000 claims 2
- 230000002269 spontaneous Effects 0.000 claims 2
- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002123 temporal effect Effects 0.000 claims 1
- 0 CC(C)(CC(C)(C)N(CC1)CCN1c1ccccc1)CNC(c1c(*)c(cccc2)c2[n]1)=O Chemical compound CC(C)(CC(C)(C)N(CC1)CCN1c1ccccc1)CNC(c1c(*)c(cccc2)c2[n]1)=O 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10230062 | 2002-07-04 | ||
DE10232020A DE10232020A1 (de) | 2002-07-04 | 2002-07-10 | Neurorezeptoraktive Heteroarencarboxamide |
PCT/EP2003/007060 WO2004004729A1 (de) | 2002-07-04 | 2003-07-02 | Heteroarencarboxamide zur verwendung als dopamin-d3 liganden zur behandlung von zns-erkrankungen |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005538974A JP2005538974A (ja) | 2005-12-22 |
JP2005538974A5 true JP2005538974A5 (US20070167479A1-20070719-C00034.png) | 2006-04-20 |
Family
ID=30116602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004518667A Pending JP2005538974A (ja) | 2002-07-04 | 2003-07-02 | 中枢神経系の病気を治療するドーパミン−d3リガンドとして使用するためのヘテロアレーンカルボキサミド |
Country Status (18)
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
KR20050096922A (ko) | 2002-12-20 | 2005-10-06 | 니코노범 에이비 | 물리적 및 화학적으로 안정된 니코틴 함유 입자물질 |
DE102004037445A1 (de) * | 2004-08-02 | 2006-03-16 | Schwarz Pharma Ag | Carboxamide des Indolizins und seiner Aza- und Diazaderivate |
DE102004054634A1 (de) * | 2004-11-12 | 2006-05-18 | Schwarz Pharma Ag | Azaindolcarboxamide |
DE102004063797A1 (de) * | 2004-12-30 | 2006-07-13 | Schwarz Pharma Ag | Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide |
US20090238761A1 (en) * | 2005-01-03 | 2009-09-24 | Universita Degli Studi Di Siena | Novel Aryl Piperazine Derivatives With Medical Utility |
AU2007224584A1 (en) | 2006-03-16 | 2007-09-20 | Niconovum Ab | Improved snuff composition |
FR2903986A1 (fr) * | 2006-07-21 | 2008-01-25 | Pierre Fabre Medicament Sa | Nouveaux derives chromenes ou thiochromenes carboxamides, leur procede de preparation et leurs applications en therapeutique |
US8748608B2 (en) * | 2007-06-15 | 2014-06-10 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | 4-phenylpiperazine derivatives with functionalized linkers as dopamine D3 receptor selective ligands and methods of use |
JP5701213B2 (ja) | 2008-10-10 | 2015-04-15 | インスティチュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー.エル.エー.チャイナ | 新規なドーパミンd3受容体リガンド、その調製及び使用 |
US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
FR2949465B1 (fr) * | 2009-09-01 | 2011-08-12 | Pf Medicament | Derives chromones, leur procede de preparation et leurs applications therapeutiques |
US11299476B2 (en) | 2016-03-14 | 2022-04-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof |
US11337971B2 (en) | 2018-09-11 | 2022-05-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dopamine D3 receptor selective antagonists/partial agonists and uses thereof |
CN114409621B (zh) * | 2022-02-09 | 2023-09-08 | 江苏省原子医学研究所 | 一种靶向多巴胺d3受体的诊疗药物及其应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3646047A (en) * | 1970-02-02 | 1972-02-29 | American Cyanamid Co | Certain benzo(b)thiophene-2-carboxamide derivatives |
US3646048A (en) * | 1970-02-02 | 1972-02-29 | American Cyanamid Co | N-(tert-aminoalkyl)-2-indenecarboxamides |
NL8005133A (nl) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
US5106849A (en) * | 1988-05-24 | 1992-04-21 | American Home Products Corporation | Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders |
CA1340113C (en) * | 1988-05-24 | 1998-11-03 | Magid A. Abou-Gharbia | Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity |
ES2027898A6 (es) * | 1991-01-24 | 1992-06-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de la 2-metoxifenilpiperacina. |
SE9201138D0 (sv) * | 1992-04-09 | 1992-04-09 | Astra Ab | Novel phthalimidoalkylpiperazines |
DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
CZ315098A3 (cs) * | 1996-04-05 | 1999-04-14 | Société De Conseils De Recherches Et D'applications Scientifiques (S. C. R. A. S.) | Antagonisté alfa1-adrenergických receptorů |
HUP0103987A3 (en) * | 2001-09-28 | 2004-11-29 | Richter Gedeon Vegyeszet | Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates |
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2003
- 2003-07-02 EP EP03762588A patent/EP1519726B1/de not_active Expired - Lifetime
- 2003-07-02 CA CA002489396A patent/CA2489396A1/en not_active Abandoned
- 2003-07-02 DK DK03762588T patent/DK1519726T3/da active
- 2003-07-02 JP JP2004518667A patent/JP2005538974A/ja active Pending
- 2003-07-02 WO PCT/EP2003/007060 patent/WO2004004729A1/de active IP Right Grant
- 2003-07-02 RU RU2004139041/04A patent/RU2320656C2/ru not_active IP Right Cessation
- 2003-07-02 MX MXPA05000033A patent/MXPA05000033A/es not_active Application Discontinuation
- 2003-07-02 KR KR1020047021525A patent/KR20050075281A/ko not_active Application Discontinuation
- 2003-07-02 DE DE50306588T patent/DE50306588D1/de not_active Expired - Fee Related
- 2003-07-02 CN CN03815742XA patent/CN1665503A/zh active Pending
- 2003-07-02 US US10/519,487 patent/US20050197343A1/en not_active Abandoned
- 2003-07-02 AU AU2003246356A patent/AU2003246356A1/en not_active Abandoned
- 2003-07-02 ES ES03762588T patent/ES2280799T3/es not_active Expired - Lifetime
- 2003-07-02 PL PL03374612A patent/PL374612A1/xx unknown
- 2003-07-02 AT AT03762588T patent/ATE354367T1/de not_active IP Right Cessation
-
2004
- 2004-12-02 IL IL16567704A patent/IL165677A0/xx unknown
-
2005
- 2005-01-25 NO NO20050386A patent/NO20050386L/no not_active Application Discontinuation
- 2005-08-10 HK HK05106891A patent/HK1074579A1/xx not_active IP Right Cessation