JP2005538150A - エストロゲン補充療法 - Google Patents

エストロゲン補充療法 Download PDF

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Publication number
JP2005538150A
JP2005538150A JP2004531341A JP2004531341A JP2005538150A JP 2005538150 A JP2005538150 A JP 2005538150A JP 2004531341 A JP2004531341 A JP 2004531341A JP 2004531341 A JP2004531341 A JP 2004531341A JP 2005538150 A JP2005538150 A JP 2005538150A
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Prior art keywords
estrogen
dose
unit dose
activity
daily unit
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JP2004531341A
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Japanese (ja)
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JP2005538150A5 (https=
Inventor
キャスパー，ロバート
コペルニク，ギデオン
ショハム，ゼーブ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004531341A 2002-08-28 2003-08-28 エストロゲン補充療法 Pending JP2005538150A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40633102P 2002-08-28 2002-08-28
PCT/CA2003/001325 WO2004019954A1 (en) 2002-08-28 2003-08-28 Estrogen replacement regimen

Publications (2)

Publication Number Publication Date
JP2005538150A true JP2005538150A (ja) 2005-12-15
JP2005538150A5 JP2005538150A5 (https=) 2006-10-12

Family

ID=31978284

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004531341A Pending JP2005538150A (ja) 2002-08-28 2003-08-28 エストロゲン補充療法

Country Status (25)

Country Link
US (1) US8946198B2 (https=)
EP (1) EP1539184B1 (https=)
JP (1) JP2005538150A (https=)
KR (1) KR20050059092A (https=)
CN (1) CN1678324A (https=)
AT (1) ATE345804T1 (https=)
AU (1) AU2003264203A1 (https=)
BR (1) BR0313921A (https=)
CA (1) CA2495330A1 (https=)
CY (1) CY1106019T1 (https=)
DE (1) DE60309895T2 (https=)
DK (1) DK1539184T3 (https=)
ES (1) ES2277139T3 (https=)
HR (1) HRP20050291A2 (https=)
IL (1) IL166585A0 (https=)
MX (1) MXPA05002294A (https=)
NO (1) NO20051545L (https=)
NZ (1) NZ538342A (https=)
PL (1) PL374762A1 (https=)
PT (1) PT1539184E (https=)
RS (1) RS20050184A (https=)
RU (1) RU2340345C2 (https=)
UA (1) UA82851C2 (https=)
WO (1) WO2004019954A1 (https=)
ZA (1) ZA200501274B (https=)

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US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CA2942345C (en) * 2014-03-12 2020-12-01 Warner Chilcott Company, Llc Low-dose estradiol cream
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
MD3310333T2 (ro) 2015-06-18 2020-06-30 Estetra Sprl Unitate de dozare orodispersabilă care conține un component estetrol
RS61777B1 (sr) 2015-06-18 2021-06-30 Estetra Sprl Oralno-disperzibilna tableta koja sadrži estetrol
HUE054589T2 (hu) 2015-06-18 2021-09-28 Estetra Sprl Szájban diszpergálódó esztetrol tartalmú tabletta
CN116077454A (zh) 2015-06-18 2023-05-09 埃斯特拉有限责任公司 含雌四醇组分的口腔分散剂量单位
CN107847506A (zh) 2015-06-22 2018-03-27 来普卡公司 含17‑羟基孕酮酯的口服组合物和相关方法
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
DK3781171T3 (da) 2018-04-19 2022-05-02 Estetra Srl Sammensætninger og deres anvendelser til lindring af menopause-associerede symptomer
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01132523A (ja) * 1987-09-24 1989-05-25 Jencap Res Ltd ホルモン製剤及び方法
JPH10513152A (ja) * 1994-12-19 1998-12-15 オーソ・フアーマシユーチカル・コーポレーシヨン 抗黄体ホルモンおよびプロゲスチンを含有する周期相ホルモン養生法
WO2002055086A2 (en) * 2001-01-11 2002-07-18 Schering Aktiengesellschaft Hormone replacement therapy method and its administration form

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826831A (en) * 1983-08-05 1989-05-02 Pre Jay Holdings Limited Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
ES2054784T3 (es) 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.
US4900734A (en) * 1987-08-27 1990-02-13 Maxson Wayne S Novel pharmaceutical composition containing estradiol and progesterone for oral administration
US5256421A (en) 1987-09-24 1993-10-26 Jencap Research Ltd. Hormone preparation and method
US5422119A (en) 1987-09-24 1995-06-06 Jencap Research Ltd. Transdermal hormone replacement therapy
US5276022A (en) 1987-09-24 1994-01-04 Jencap Research Ltd. Hormone preparation and method
US5108995A (en) 1987-09-24 1992-04-28 Jencap Research Ltd. Hormone preparation and method
US5382873A (en) 1991-12-04 1995-01-17 U.S. Philips Corporation High-pressure discharge lamp with incandescing metal droplets
DE19513662A1 (de) * 1995-04-08 1996-10-10 Schering Ag Pharmazeutisches Kombinationspräparat zur hormonalen Kontrazeption
CA2222133C (en) * 1995-06-07 2002-12-24 Cygnus, Inc. Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen
US6506390B2 (en) * 1996-06-25 2003-01-14 Akzo Nobel Progestogen-anti-progestogen regimens
CA2267743C (en) * 1999-03-30 2011-07-26 Robert F. Casper Low dose estrogen interrupted hormone replacement therapy
US6653298B2 (en) * 2000-01-14 2003-11-25 Sterix Limited Composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01132523A (ja) * 1987-09-24 1989-05-25 Jencap Res Ltd ホルモン製剤及び方法
JPH10513152A (ja) * 1994-12-19 1998-12-15 オーソ・フアーマシユーチカル・コーポレーシヨン 抗黄体ホルモンおよびプロゲスチンを含有する周期相ホルモン養生法
WO2002055086A2 (en) * 2001-01-11 2002-07-18 Schering Aktiengesellschaft Hormone replacement therapy method and its administration form

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
JPN5005005053, ＣＡＳＰＥＲ Ｒ Ｆ, ＡＭＥＲＩＣＡＮ ＪＯＵＲＮＡＬ ＯＦ ＯＢＳＴＥＴＲＩＣＳ ＆ ＧＹＮＥＣＯＬＯＧＹ, 199304, Ｖ１６８ Ｎ４, Ｐ１１８８−１１９６, US *
JPN6010016261, Ｗ Ｘ Ｗｕ ｅｔ ａｌ．, "Ｒｅｇｕｌａｔｉｏｎ ｏｆ ｔｈｅ ｅｓｔｒｏｇｅｎ ｒｅｃｅｐｔｏｒ ａｎｄ ｉｔｓ ｍｅｓｓｅｎｇｅｒ ｒｉｂｏｎｕｃｌｅｉｃ ａｃｉｄ ｉｎ ｔｈｅ ｏｖａｒｉｅｃｔｏｍｉｚｅｄ ｓｈｅｅｐ ｍ", Ｂｉｏｌｏｇｙ ｏｆ Ｒｅｐｒｏｄｕｃｔｉｏｎ, 19961001, Ｖｏｌ． ５５， Ｎｏ． ４, ｐｐ． ７６２−７６８ *
JPN6010016262, Ｃｌｅｗｅｌｌ ＷＨ ｅｔ ａｌ．, "Ｓｔｉｍｕｌｕｓ ｓｕｍｍａｔｉｏｎ ａｎｄ ｔａｃｈｙｐｈｙｌａｘｉｓ ｉｎ ｅｓｔｒｏｇｅｎ ｒｅｓｐｏｎｓｅ ｉｎ ｓｈｅｅｐ．", Ａｍｅｒｉｃａｎ Ｊｏｕｒｎａｌ ｏｆ Ｏｂｓｔｅｔｒｉｃｓ ａｎｄ Ｇｙｎｅｃｏｌｏｇｙ, 19801101, Ｖｏｌ． １３８， Ｎｏ． ５, ｐｐ． ４８５−４９３ *
JPN6010016263, Ｍｅｄｌｏｃｋ ＫＬ ｅｔ ａｌ．, "Ｅｓｔｒａｄｉｏｌ ｄｏｗｎ−ｒｅｇｕｌａｔｉｏｎ ｏｆ ｔｈｅ ｒａｔ ｕｔｅｒｉｎｅ ｅｓｔｒｏｇｅｎ ｒｅｃｅｐｔｏｒ．", Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｓｏｃｉｅｔｙ ｆｏｒ Ｅｘｐｅｒｉｍｅｎｔａｌ Ｂｉｏｌｏｇｙ ａｎｄ Ｍｅｄｉｃｉｎｅ, 199103, Ｖｏｌ． １９６， Ｎｏ． ３, ｐｐ． ２９３−３００ *
JPN6010016265, Ｍｅｄｌｏｃｋ ＫＬ ｅｔ ａｌ．, "Ｓｈｏｒｔ−ｔｅｒｍ ｅｆｆｅｃｔｓ ｏｆ ｐｈｙｓｉｏｌｏｇｉｃａｌ ａｎｄ ｐｈａｒｍａｃｏｌｏｇｉｃａｌ ｄｏｓｅｓ ｏｆ ｅｓｔｒａｄｉｏｌ ｏｎ ｅｓｔｒｏｇｅｎ ｒｅｃｅｐｔｏｒ ａｎｄ", Ｊｏｕｒｎａｌ ｏｆ Ｒｅｃｅｐｔｏｒ Ｒｅｓｅａｒｃｈ, 1991, Ｖｏｌ． １１， Ｎｏ． ５, ｐｐ． ７４３−７５６ *
JPN6010016266, Ｎ Ｈ Ｉｎｇ ｅｔ ａｌ．, "Ｅｓｔｒｏｇｅｎ ｅｎｈａｎｃｅｓ ｅｎｄｏｍｅｔｒｉａｌ ｅｓｔｒｏｇｅｎ ｒｅｃｅｐｔｏｒ ｇｅｎｅ ｅｘｐｒｅｓｓｉｏｎ ｂｙ ａ ｐｏｓｔｔｒａｎｓｃｒｉｐｔｉｏｎａｌ ｍｅｃｈａｎｉｓｍ ｉ", Ｂｉｏｌｏｇｙ ｏｆ Ｒｅｐｒｏｄｕｃｔｉｏｎ, 199603, Ｖｏｌ． ５４， Ｎｏ． ３, ｐｐ． ５９１−５９９ *
JPN6010016268, 大浜紘三 他, "更年期医療としてのホルモン補充療法 ホルモン補充療法で使用される薬剤の種類とその使い分け，投与法", Ｐｒｏｇｒｅｓｓ ｉｎ Ｍｅｄｉｃｉｎｅ, 199801, Ｖｏｌ． １８， Ｎｏ． １, ｐｐ． ２５−２８ *

Also Published As

Publication number Publication date
EP1539184A1 (en) 2005-06-15
RS20050184A (sr) 2007-11-15
CY1106019T1 (el) 2011-04-06
US20060089337A1 (en) 2006-04-27
DE60309895T2 (de) 2007-10-18
RU2005108977A (ru) 2005-10-10
BR0313921A (pt) 2005-07-19
UA82851C2 (en) 2008-05-26
HRP20050291A2 (en) 2005-10-31
MXPA05002294A (es) 2005-09-12
CA2495330A1 (en) 2004-03-11
NO20051545L (no) 2005-03-23
WO2004019954A1 (en) 2004-03-11
ES2277139T3 (es) 2007-07-01
AU2003264203A1 (en) 2004-03-19
DK1539184T3 (da) 2007-03-19
RU2340345C2 (ru) 2008-12-10
CN1678324A (zh) 2005-10-05
PT1539184E (pt) 2007-02-28
DE60309895D1 (de) 2007-01-04
ATE345804T1 (de) 2006-12-15
EP1539184B1 (en) 2006-11-22
KR20050059092A (ko) 2005-06-17
NZ538342A (en) 2007-08-31
US8946198B2 (en) 2015-02-03
ZA200501274B (en) 2006-08-30
PL374762A1 (en) 2005-10-31
IL166585A0 (en) 2006-01-15

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