JP2005538150A - エストロゲン補充療法 - Google Patents

エストロゲン補充療法 Download PDF

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Publication number
JP2005538150A
JP2005538150A JP2004531341A JP2004531341A JP2005538150A JP 2005538150 A JP2005538150 A JP 2005538150A JP 2004531341 A JP2004531341 A JP 2004531341A JP 2004531341 A JP2004531341 A JP 2004531341A JP 2005538150 A JP2005538150 A JP 2005538150A
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Prior art keywords
estrogen
dose
unit dose
activity
daily unit
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Japanese (ja)
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JP2005538150A5 (https=
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キャスパー，ロバート
コペルニク，ギデオン
ショハム，ゼーブ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004531341A 2002-08-28 2003-08-28 エストロゲン補充療法 Pending JP2005538150A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40633102P 2002-08-28 2002-08-28
PCT/CA2003/001325 WO2004019954A1 (en) 2002-08-28 2003-08-28 Estrogen replacement regimen

Publications (2)

Publication Number Publication Date
JP2005538150A true JP2005538150A (ja) 2005-12-15
JP2005538150A5 JP2005538150A5 (https=) 2006-10-12

Family

ID=31978284

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004531341A Pending JP2005538150A (ja) 2002-08-28 2003-08-28 エストロゲン補充療法

Country Status (25)

Country Link
US (1) US8946198B2 (https=)
EP (1) EP1539184B1 (https=)
JP (1) JP2005538150A (https=)
KR (1) KR20050059092A (https=)
CN (1) CN1678324A (https=)
AT (1) ATE345804T1 (https=)
AU (1) AU2003264203A1 (https=)
BR (1) BR0313921A (https=)
CA (1) CA2495330A1 (https=)
CY (1) CY1106019T1 (https=)
DE (1) DE60309895T2 (https=)
DK (1) DK1539184T3 (https=)
ES (1) ES2277139T3 (https=)
HR (1) HRP20050291A2 (https=)
IL (1) IL166585A0 (https=)
MX (1) MXPA05002294A (https=)
NO (1) NO20051545L (https=)
NZ (1) NZ538342A (https=)
PL (1) PL374762A1 (https=)
PT (1) PT1539184E (https=)
RS (1) RS20050184A (https=)
RU (1) RU2340345C2 (https=)
UA (1) UA82851C2 (https=)
WO (1) WO2004019954A1 (https=)
ZA (1) ZA200501274B (https=)

Families Citing this family (30)

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US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US8633178B2 (en) 2011-11-23 2014-01-21 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
MX2016011801A (es) * 2014-03-12 2017-07-14 Warner Chilcott Co Llc Crema de estradiol de dosis baja.
EP3145489A1 (en) 2014-05-22 2017-03-29 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
LT3310345T (lt) 2015-06-18 2021-06-25 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
CR20180042A (es) 2015-06-18 2018-05-03 Mithra Pharmaceuticals S A Unidad de dosificación orodispersable que contiene un componente estetrol.
DK3701944T3 (da) 2015-06-18 2022-03-14 Estetra Srl Oro-dispergerbar doseringsenhed indeholdende en estetrolkomponent
LT3310346T (lt) 2015-06-18 2021-06-10 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
AU2016284459B2 (en) 2015-06-22 2021-12-23 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
KR102712911B1 (ko) 2016-08-05 2024-10-04 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
CN111989105B (zh) 2018-04-19 2024-07-19 埃斯特拉私人有限责任公司 化合物以及它们在缓解绝经相关症状中的用途
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01132523A (ja) * 1987-09-24 1989-05-25 Jencap Res Ltd ホルモン製剤及び方法
JPH10513152A (ja) * 1994-12-19 1998-12-15 オーソ・フアーマシユーチカル・コーポレーシヨン 抗黄体ホルモンおよびプロゲスチンを含有する周期相ホルモン養生法
WO2002055086A2 (en) * 2001-01-11 2002-07-18 Schering Aktiengesellschaft Hormone replacement therapy method and its administration form

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826831A (en) * 1983-08-05 1989-05-02 Pre Jay Holdings Limited Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
EP0303306B1 (en) * 1987-08-08 1993-03-10 Akzo N.V. Contraceptive implant
US4900734A (en) * 1987-08-27 1990-02-13 Maxson Wayne S Novel pharmaceutical composition containing estradiol and progesterone for oral administration
US5108995A (en) * 1987-09-24 1992-04-28 Jencap Research Ltd. Hormone preparation and method
US5256421A (en) * 1987-09-24 1993-10-26 Jencap Research Ltd. Hormone preparation and method
US5422119A (en) * 1987-09-24 1995-06-06 Jencap Research Ltd. Transdermal hormone replacement therapy
US5276022A (en) * 1987-09-24 1994-01-04 Jencap Research Ltd. Hormone preparation and method
US5382873A (en) * 1991-12-04 1995-01-17 U.S. Philips Corporation High-pressure discharge lamp with incandescing metal droplets
DE19513662A1 (de) * 1995-04-08 1996-10-10 Schering Ag Pharmazeutisches Kombinationspräparat zur hormonalen Kontrazeption
CN1188189C (zh) * 1995-06-07 2005-02-09 奥瑟－麦内尔制药公司 基质层含有17－脱乙酰基诺孕酯的经皮贴片及基质的用途
US6506390B2 (en) * 1996-06-25 2003-01-14 Akzo Nobel Progestogen-anti-progestogen regimens
CA2267743C (en) * 1999-03-30 2011-07-26 Robert F. Casper Low dose estrogen interrupted hormone replacement therapy
US6653298B2 (en) * 2000-01-14 2003-11-25 Sterix Limited Composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01132523A (ja) * 1987-09-24 1989-05-25 Jencap Res Ltd ホルモン製剤及び方法
JPH10513152A (ja) * 1994-12-19 1998-12-15 オーソ・フアーマシユーチカル・コーポレーシヨン 抗黄体ホルモンおよびプロゲスチンを含有する周期相ホルモン養生法
WO2002055086A2 (en) * 2001-01-11 2002-07-18 Schering Aktiengesellschaft Hormone replacement therapy method and its administration form

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
JPN5005005053, ＣＡＳＰＥＲ Ｒ Ｆ, ＡＭＥＲＩＣＡＮ ＪＯＵＲＮＡＬ ＯＦ ＯＢＳＴＥＴＲＩＣＳ ＆ ＧＹＮＥＣＯＬＯＧＹ, 199304, Ｖ１６８ Ｎ４, Ｐ１１８８−１１９６, US *
JPN6010016261, Ｗ Ｘ Ｗｕ ｅｔ ａｌ．, "Ｒｅｇｕｌａｔｉｏｎ ｏｆ ｔｈｅ ｅｓｔｒｏｇｅｎ ｒｅｃｅｐｔｏｒ ａｎｄ ｉｔｓ ｍｅｓｓｅｎｇｅｒ ｒｉｂｏｎｕｃｌｅｉｃ ａｃｉｄ ｉｎ ｔｈｅ ｏｖａｒｉｅｃｔｏｍｉｚｅｄ ｓｈｅｅｐ ｍ", Ｂｉｏｌｏｇｙ ｏｆ Ｒｅｐｒｏｄｕｃｔｉｏｎ, 19961001, Ｖｏｌ． ５５， Ｎｏ． ４, ｐｐ． ７６２−７６８ *
JPN6010016262, Ｃｌｅｗｅｌｌ ＷＨ ｅｔ ａｌ．, "Ｓｔｉｍｕｌｕｓ ｓｕｍｍａｔｉｏｎ ａｎｄ ｔａｃｈｙｐｈｙｌａｘｉｓ ｉｎ ｅｓｔｒｏｇｅｎ ｒｅｓｐｏｎｓｅ ｉｎ ｓｈｅｅｐ．", Ａｍｅｒｉｃａｎ Ｊｏｕｒｎａｌ ｏｆ Ｏｂｓｔｅｔｒｉｃｓ ａｎｄ Ｇｙｎｅｃｏｌｏｇｙ, 19801101, Ｖｏｌ． １３８， Ｎｏ． ５, ｐｐ． ４８５−４９３ *
JPN6010016263, Ｍｅｄｌｏｃｋ ＫＬ ｅｔ ａｌ．, "Ｅｓｔｒａｄｉｏｌ ｄｏｗｎ−ｒｅｇｕｌａｔｉｏｎ ｏｆ ｔｈｅ ｒａｔ ｕｔｅｒｉｎｅ ｅｓｔｒｏｇｅｎ ｒｅｃｅｐｔｏｒ．", Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｓｏｃｉｅｔｙ ｆｏｒ Ｅｘｐｅｒｉｍｅｎｔａｌ Ｂｉｏｌｏｇｙ ａｎｄ Ｍｅｄｉｃｉｎｅ, 199103, Ｖｏｌ． １９６， Ｎｏ． ３, ｐｐ． ２９３−３００ *
JPN6010016265, Ｍｅｄｌｏｃｋ ＫＬ ｅｔ ａｌ．, "Ｓｈｏｒｔ−ｔｅｒｍ ｅｆｆｅｃｔｓ ｏｆ ｐｈｙｓｉｏｌｏｇｉｃａｌ ａｎｄ ｐｈａｒｍａｃｏｌｏｇｉｃａｌ ｄｏｓｅｓ ｏｆ ｅｓｔｒａｄｉｏｌ ｏｎ ｅｓｔｒｏｇｅｎ ｒｅｃｅｐｔｏｒ ａｎｄ", Ｊｏｕｒｎａｌ ｏｆ Ｒｅｃｅｐｔｏｒ Ｒｅｓｅａｒｃｈ, 1991, Ｖｏｌ． １１， Ｎｏ． ５, ｐｐ． ７４３−７５６ *
JPN6010016266, Ｎ Ｈ Ｉｎｇ ｅｔ ａｌ．, "Ｅｓｔｒｏｇｅｎ ｅｎｈａｎｃｅｓ ｅｎｄｏｍｅｔｒｉａｌ ｅｓｔｒｏｇｅｎ ｒｅｃｅｐｔｏｒ ｇｅｎｅ ｅｘｐｒｅｓｓｉｏｎ ｂｙ ａ ｐｏｓｔｔｒａｎｓｃｒｉｐｔｉｏｎａｌ ｍｅｃｈａｎｉｓｍ ｉ", Ｂｉｏｌｏｇｙ ｏｆ Ｒｅｐｒｏｄｕｃｔｉｏｎ, 199603, Ｖｏｌ． ５４， Ｎｏ． ３, ｐｐ． ５９１−５９９ *
JPN6010016268, 大浜紘三 他, "更年期医療としてのホルモン補充療法 ホルモン補充療法で使用される薬剤の種類とその使い分け，投与法", Ｐｒｏｇｒｅｓｓ ｉｎ Ｍｅｄｉｃｉｎｅ, 199801, Ｖｏｌ． １８， Ｎｏ． １, ｐｐ． ２５−２８ *

Also Published As

Publication number Publication date
AU2003264203A1 (en) 2004-03-19
MXPA05002294A (es) 2005-09-12
NZ538342A (en) 2007-08-31
RS20050184A (sr) 2007-11-15
DE60309895D1 (de) 2007-01-04
ATE345804T1 (de) 2006-12-15
US8946198B2 (en) 2015-02-03
HRP20050291A2 (en) 2005-10-31
WO2004019954A1 (en) 2004-03-11
EP1539184B1 (en) 2006-11-22
DE60309895T2 (de) 2007-10-18
UA82851C2 (en) 2008-05-26
PT1539184E (pt) 2007-02-28
RU2340345C2 (ru) 2008-12-10
US20060089337A1 (en) 2006-04-27
ES2277139T3 (es) 2007-07-01
NO20051545L (no) 2005-03-23
RU2005108977A (ru) 2005-10-10
IL166585A0 (en) 2006-01-15
DK1539184T3 (da) 2007-03-19
CN1678324A (zh) 2005-10-05
CY1106019T1 (el) 2011-04-06
BR0313921A (pt) 2005-07-19
EP1539184A1 (en) 2005-06-15
CA2495330A1 (en) 2004-03-11
ZA200501274B (en) 2006-08-30
KR20050059092A (ko) 2005-06-17
PL374762A1 (en) 2005-10-31

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