RU2340345C2 - Схема восполнения эстрогена - Google Patents

Схема восполнения эстрогена Download PDF

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Publication number
RU2340345C2
RU2340345C2 RU2005108977/15A RU2005108977A RU2340345C2 RU 2340345 C2 RU2340345 C2 RU 2340345C2 RU 2005108977/15 A RU2005108977/15 A RU 2005108977/15A RU 2005108977 A RU2005108977 A RU 2005108977A RU 2340345 C2 RU2340345 C2 RU 2340345C2
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RU
Russia
Prior art keywords
doses
estrogen
activity
phases
substance exhibiting
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RU2005108977/15A
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English (en)
Russian (ru)
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RU2005108977A (ru
Inventor
Роберт КАСПЕР (CA)
Роберт КАСПЕР
Гидеон КОПЕРНИК (IL)
Гидеон КОПЕРНИК
Зеев ШОХАМ (IL)
Зеев ШОХАМ
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Роберт КАСПЕР
Гидеон КОПЕРНИК
Зеев ШОХАМ
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Publication of RU2005108977A publication Critical patent/RU2005108977A/ru
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Publication of RU2340345C2 publication Critical patent/RU2340345C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2005108977/15A 2002-08-28 2003-08-28 Схема восполнения эстрогена RU2340345C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40633102P 2002-08-28 2002-08-28
US60/406,331 2002-08-28

Publications (2)

Publication Number Publication Date
RU2005108977A RU2005108977A (ru) 2005-10-10
RU2340345C2 true RU2340345C2 (ru) 2008-12-10

Family

ID=31978284

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005108977/15A RU2340345C2 (ru) 2002-08-28 2003-08-28 Схема восполнения эстрогена

Country Status (25)

Country Link
US (1) US8946198B2 (https=)
EP (1) EP1539184B1 (https=)
JP (1) JP2005538150A (https=)
KR (1) KR20050059092A (https=)
CN (1) CN1678324A (https=)
AT (1) ATE345804T1 (https=)
AU (1) AU2003264203A1 (https=)
BR (1) BR0313921A (https=)
CA (1) CA2495330A1 (https=)
CY (1) CY1106019T1 (https=)
DE (1) DE60309895T2 (https=)
DK (1) DK1539184T3 (https=)
ES (1) ES2277139T3 (https=)
HR (1) HRP20050291A2 (https=)
IL (1) IL166585A0 (https=)
MX (1) MXPA05002294A (https=)
NO (1) NO20051545L (https=)
NZ (1) NZ538342A (https=)
PL (1) PL374762A1 (https=)
PT (1) PT1539184E (https=)
RS (1) RS20050184A (https=)
RU (1) RU2340345C2 (https=)
UA (1) UA82851C2 (https=)
WO (1) WO2004019954A1 (https=)
ZA (1) ZA200501274B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022384B2 (en) 2011-07-28 2018-07-17 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US11590147B2 (en) 2015-06-22 2023-02-28 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods

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US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
US8633178B2 (en) 2011-11-23 2014-01-21 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
MX2016011801A (es) * 2014-03-12 2017-07-14 Warner Chilcott Co Llc Crema de estradiol de dosis baja.
EP3145489A1 (en) 2014-05-22 2017-03-29 TherapeuticsMD, Inc. Natural combination hormone replacement formulations and therapies
LT3310345T (lt) 2015-06-18 2021-06-25 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
CR20180042A (es) 2015-06-18 2018-05-03 Mithra Pharmaceuticals S A Unidad de dosificación orodispersable que contiene un componente estetrol.
DK3701944T3 (da) 2015-06-18 2022-03-14 Estetra Srl Oro-dispergerbar doseringsenhed indeholdende en estetrolkomponent
LT3310346T (lt) 2015-06-18 2021-06-10 Estetra Sprl Burnoje disperguojama tabletė, turinti estetrolio
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
KR102712911B1 (ko) 2016-08-05 2024-10-04 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
CN111989105B (zh) 2018-04-19 2024-07-19 埃斯特拉私人有限责任公司 化合物以及它们在缓解绝经相关症状中的用途
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物

Citations (3)

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RU98100451A (ru) * 1995-06-07 1999-11-27 Сигнус, Инк. Трансдермальный пластырь и способ введения 17-деацетилноргестимата отдельно или в сочетании с эстрогеном
WO2000059577A1 (en) * 1999-03-30 2000-10-12 Jencap Research Ltd. Low dose estrogen interrupted hormone replacement therapy
RU2165259C2 (ru) * 1995-04-08 2001-04-20 Шеринг Акциенгезелльшафт Фармацевтический комбинированный препарат для гормональной контрацепции

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US4826831A (en) * 1983-08-05 1989-05-02 Pre Jay Holdings Limited Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
EP0303306B1 (en) * 1987-08-08 1993-03-10 Akzo N.V. Contraceptive implant
US4900734A (en) * 1987-08-27 1990-02-13 Maxson Wayne S Novel pharmaceutical composition containing estradiol and progesterone for oral administration
US5108995A (en) * 1987-09-24 1992-04-28 Jencap Research Ltd. Hormone preparation and method
US5256421A (en) * 1987-09-24 1993-10-26 Jencap Research Ltd. Hormone preparation and method
US5422119A (en) * 1987-09-24 1995-06-06 Jencap Research Ltd. Transdermal hormone replacement therapy
US5276022A (en) * 1987-09-24 1994-01-04 Jencap Research Ltd. Hormone preparation and method
DE3888269T2 (de) * 1987-09-24 1994-07-07 Jencap Research Ltd Hormon-Zusammensetzung und -Anwendung.
US5382873A (en) * 1991-12-04 1995-01-17 U.S. Philips Corporation High-pressure discharge lamp with incandescing metal droplets
US5521166A (en) * 1994-12-19 1996-05-28 Ortho Pharmaceitical Corporation Antiprogestin cyclophasic hormonal regimen
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US6506390B2 (en) * 1996-06-25 2003-01-14 Akzo Nobel Progestogen-anti-progestogen regimens
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DE10100911A1 (de) * 2001-01-11 2002-08-01 Schering Ag Verfahren zur Hormonersatztherapie und dessen Darreichungsform

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
RU2165259C2 (ru) * 1995-04-08 2001-04-20 Шеринг Акциенгезелльшафт Фармацевтический комбинированный препарат для гормональной контрацепции
RU98100451A (ru) * 1995-06-07 1999-11-27 Сигнус, Инк. Трансдермальный пластырь и способ введения 17-деацетилноргестимата отдельно или в сочетании с эстрогеном
WO2000059577A1 (en) * 1999-03-30 2000-10-12 Jencap Research Ltd. Low dose estrogen interrupted hormone replacement therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
реферат базы данных PubMed: Rebar RW et al. Low-dose esterified estrogens (0.3 mg/day): long-term and shorm-term effects on menopausal symptoms and qualite of life in postmenopausal women. Climacteric. 2000 Sep; 3(3):176-82. {on line] PMID: 11910619 [найдено 28.06.2007]. *
ЭНЦИКЛОПЕДИЯ ЛЕКАРСТВ РЛС 2001, с.919 статья «фемостон» Р.Н.М. van de Weijer et al. Отношение женщин к возобновлению у них менструальных кровотечений в результате ЗГТ и приемлемость для них менструальноподобных реакций. Maturitas 30 1998 р.257-263 [найдено 28.06.2007] Найдено из Интернет: <URL: http://hghltd.yandex.com/yandbtm? url=http%3A%2F%2Fwww.climax.ru%2Fdoctors.... *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022384B2 (en) 2011-07-28 2018-07-17 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US11590147B2 (en) 2015-06-22 2023-02-28 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods

Also Published As

Publication number Publication date
AU2003264203A1 (en) 2004-03-19
MXPA05002294A (es) 2005-09-12
JP2005538150A (ja) 2005-12-15
NZ538342A (en) 2007-08-31
RS20050184A (sr) 2007-11-15
DE60309895D1 (de) 2007-01-04
ATE345804T1 (de) 2006-12-15
US8946198B2 (en) 2015-02-03
HRP20050291A2 (en) 2005-10-31
WO2004019954A1 (en) 2004-03-11
EP1539184B1 (en) 2006-11-22
DE60309895T2 (de) 2007-10-18
UA82851C2 (en) 2008-05-26
PT1539184E (pt) 2007-02-28
US20060089337A1 (en) 2006-04-27
ES2277139T3 (es) 2007-07-01
NO20051545L (no) 2005-03-23
RU2005108977A (ru) 2005-10-10
IL166585A0 (en) 2006-01-15
DK1539184T3 (da) 2007-03-19
CN1678324A (zh) 2005-10-05
CY1106019T1 (el) 2011-04-06
BR0313921A (pt) 2005-07-19
EP1539184A1 (en) 2005-06-15
CA2495330A1 (en) 2004-03-11
ZA200501274B (en) 2006-08-30
KR20050059092A (ko) 2005-06-17
PL374762A1 (en) 2005-10-31

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20090829