JP2005538126A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005538126A5 JP2005538126A5 JP2004526887A JP2004526887A JP2005538126A5 JP 2005538126 A5 JP2005538126 A5 JP 2005538126A5 JP 2004526887 A JP2004526887 A JP 2004526887A JP 2004526887 A JP2004526887 A JP 2004526887A JP 2005538126 A5 JP2005538126 A5 JP 2005538126A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- acceptable salt
- represents hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 231100000886 tinnitus Toxicity 0.000 claims 4
- 206010001497 Agitation Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 210000003027 ear inner Anatomy 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- CZVXMPYMWAKWEV-UHFFFAOYSA-N CN(C)C1=C2C=CC=C(C2=CC=C1)S(=O)(=O)NC(C(N)C1=CC=CC=C1)C1=CC=CC=C1 Chemical compound CN(C)C1=C2C=CC=C(C2=CC=C1)S(=O)(=O)NC(C(N)C1=CC=CC=C1)C1=CC=CC=C1 CZVXMPYMWAKWEV-UHFFFAOYSA-N 0.000 description 1
- XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229930007927 cymene Natural products 0.000 description 1
- PONXTPCRRASWKW-KBPBESRZSA-N diphenylethylenediamine Chemical compound C1([C@H](N)[C@@H](N)C=2C=CC=CC=2)=CC=CC=C1 PONXTPCRRASWKW-KBPBESRZSA-N 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- CZVXMPYMWAKWEV-UIOOFZCWSA-N n-[(1s,2s)-2-amino-1,2-diphenylethyl]-5-(dimethylamino)naphthalene-1-sulfonamide Chemical compound C1([C@H](N)[C@@H](NS(=O)(=O)C2=C3C=CC=C(C3=CC=C2)N(C)C)C=2C=CC=CC=2)=CC=CC=C1 CZVXMPYMWAKWEV-UIOOFZCWSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0218244A GB0218244D0 (en) | 2002-08-06 | 2002-08-06 | Organic compounds |
| GB0218243A GB0218243D0 (en) | 2002-08-06 | 2002-08-06 | Organic compounds |
| PCT/EP2003/008669 WO2004014391A1 (en) | 2002-08-06 | 2003-08-05 | Use of carboxamides for the treatment of tinnitus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005538126A JP2005538126A (ja) | 2005-12-15 |
| JP2005538126A5 true JP2005538126A5 (enExample) | 2006-09-21 |
Family
ID=31716915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004526887A Pending JP2005538126A (ja) | 2002-08-06 | 2003-08-05 | 耳鳴の処置のためのカルボキサミドの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7465723B2 (enExample) |
| EP (1) | EP1528927A1 (enExample) |
| JP (1) | JP2005538126A (enExample) |
| CN (1) | CN1674909A (enExample) |
| AU (1) | AU2003266965A1 (enExample) |
| BR (1) | BR0313230A (enExample) |
| CA (1) | CA2494660A1 (enExample) |
| WO (1) | WO2004014391A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0303615D0 (en) * | 2003-02-17 | 2003-03-19 | Novartis Ag | Use of organic compounds |
| AR048318A1 (es) * | 2004-03-22 | 2006-04-19 | Novartis Ag | Formulaciones de matriz orales que comprenden licarbazepina |
| PT2380575E (pt) * | 2005-05-06 | 2015-06-17 | Bial Portela & Ca Sa | Acetato de eslicarbazepina e utilização |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| US9410427B2 (en) * | 2012-06-05 | 2016-08-09 | United Technologies Corporation | Compressor power and torque transmitting hub |
| US8920855B1 (en) | 2012-10-30 | 2014-12-30 | Setem Hemth, Inc | Methods of topically treating tinnitus and related disorders |
| CN103980270A (zh) * | 2014-05-19 | 2014-08-13 | 埃斯特维华义制药有限公司 | 一种（r）-3-奎宁醇的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5472714A (en) * | 1993-09-08 | 1995-12-05 | Ciba-Geigy Corporation | Double-layered oxcarbazepine tablets |
| PT101732B (pt) | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| IL125244A (en) * | 1998-07-07 | 2002-12-01 | Yissum Res Dev Co | Pharmaceutical compositions containing low-melting waxes |
| GB9925962D0 (en) * | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
-
2003
- 2003-08-05 EP EP03747877A patent/EP1528927A1/en not_active Withdrawn
- 2003-08-05 CN CNA03818835XA patent/CN1674909A/zh active Pending
- 2003-08-05 BR BR0313230-7A patent/BR0313230A/pt not_active IP Right Cessation
- 2003-08-05 JP JP2004526887A patent/JP2005538126A/ja active Pending
- 2003-08-05 AU AU2003266965A patent/AU2003266965A1/en not_active Abandoned
- 2003-08-05 WO PCT/EP2003/008669 patent/WO2004014391A1/en not_active Ceased
- 2003-08-05 CA CA002494660A patent/CA2494660A1/en not_active Abandoned
- 2003-08-05 US US10/523,291 patent/US7465723B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100369894C (zh) | 氧化氮合酶抑制剂磷酸盐 | |
| JP2014501245A (ja) | ケモカイン受容体調節因子としてのリン酸誘導体 | |
| CN111527077A (zh) | 通过添加o,o′-二取代酒石酸对映异构体进行外消旋烟碱的对映异构体分离 | |
| ES2387802T3 (es) | Procedimiento novedoso para la fabricación de bisulfato de (+)-(S)-clopidogrel forma I | |
| CN106660949B (zh) | N-[4-(1-氨基乙基)-苯基]-磺酰胺衍生物的手性拆分方法 | |
| JP2005538126A5 (enExample) | ||
| TWI725098B (zh) | 藉由使用極性非質子性溶劑掌性解析n-[4-(1-胺基乙基)-苯基]-磺醯胺衍生物之方法 | |
| JP2003522122A (ja) | 置換ピペリジン−４−オンの製造 | |
| CN103987687A (zh) | 使用不对称催化剂的双环化合物的光学拆分方法 | |
| HUT70534A (en) | 2-amino-4-quinoline-dihydropyridines, process for producing them and their use for producing pharmaceutical compositions | |
| KR20150063519A (ko) | Mogat-2 억제제로서 유용한 신규 벤질 술폰아미드 화합물 | |
| JP2009513537A (ja) | エナンチオマー的に純粋なミルタザピンの調製方法 | |
| JP4170990B2 (ja) | 光学的に活性であるセリン誘導体の製造方法 | |
| CN108003134A (zh) | 一种r-（+）-硫辛酸的制备方法 | |
| CN1455770A (zh) | (2－氮杂二环[2.2.1]庚烷－7－基)甲醇衍生物作为烟碱类乙酰胆碱受体激动剂 | |
| WO2000047572A1 (fr) | Derives de (1-phenacy-3-phenyl-3-piperidylethyl)piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant | |
| TWI741111B (zh) | N-[4-(1-氨乙基)-2,6-二氟苯基]-甲磺醯胺之鏡像異構物的消旋方法 | |
| CN102471326A (zh) | 硫杂苯并薁丙酸衍生物的制备方法 | |
| JPS59112949A (ja) | 新規なｌ−スレオ−アドレナリン酸 | |
| TWI743210B (zh) | 用於製造(r)-n-[4-(1-胺乙基)-2,6-二氟苯基]甲烷磺胺之方法 | |
| CN108329236A (zh) | 一种恩杂鲁胺中间体的制备方法 | |
| JPH0395138A (ja) | ３―メチルヘプタン酸の光学分割法 | |
| CN105143172B (zh) | 用于降脂酰胺制备的dcc介导的偶联 | |
| JP2004511467A5 (enExample) | ||
| CN107674039A (zh) | 一种可比西他中间体的制备方法 |