JP2005538041A5 - - Google Patents
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- Publication number
- JP2005538041A5 JP2005538041A5 JP2003578426A JP2003578426A JP2005538041A5 JP 2005538041 A5 JP2005538041 A5 JP 2005538041A5 JP 2003578426 A JP2003578426 A JP 2003578426A JP 2003578426 A JP2003578426 A JP 2003578426A JP 2005538041 A5 JP2005538041 A5 JP 2005538041A5
- Authority
- JP
- Japan
- Prior art keywords
- sema4a
- protein
- mammalian
- cell
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004169 proteins and genes Human genes 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 210000001744 T-lymphocyte Anatomy 0.000 claims 10
- 102000037865 fusion proteins Human genes 0.000 claims 7
- 108020001507 fusion proteins Proteins 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 4
- 230000021633 leukocyte mediated immunity Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 101000650820 Homo sapiens Semaphorin-4A Proteins 0.000 claims 2
- 108050000099 Sema domains Proteins 0.000 claims 2
- 102000009203 Sema domains Human genes 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000043687 human SEMA4A Human genes 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010054979 Secondary immunodeficiency Diseases 0.000 claims 1
- 230000006044 T cell activation Effects 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 230000008827 biological function Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 108020001580 protein domains Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10213762A DE10213762A1 (de) | 2002-03-26 | 2002-03-26 | Neues costimulierendes Molekül und dessen Verwendung |
| PCT/EP2003/002785 WO2003080673A1 (en) | 2002-03-26 | 2003-03-18 | Costimulatory molecule and its use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005538041A JP2005538041A (ja) | 2005-12-15 |
| JP2005538041A5 true JP2005538041A5 (enExample) | 2006-05-11 |
Family
ID=27816004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003578426A Pending JP2005538041A (ja) | 2002-03-26 | 2003-03-18 | 共刺激分子及びその使用 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1490406A1 (enExample) |
| JP (1) | JP2005538041A (enExample) |
| AU (1) | AU2003219068A1 (enExample) |
| DE (1) | DE10213762A1 (enExample) |
| WO (1) | WO2003080673A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0414924A (pt) | 2003-10-03 | 2006-11-07 | Brigham & Womens Hospital | ligantes de tim-3 e seus métodos |
| TW200539890A (en) * | 2004-03-12 | 2005-12-16 | Brigham & Womens Hospital | Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function |
| DE202006007590U1 (de) | 2006-05-12 | 2006-12-14 | Osaka University | Verwendung einer Zusammensetzung, die Sema7A- und VLA-1-Interaktion inhibiert, zum Behandeln von Cytokin-vermittelten Erkrankungen |
| WO2008055889A1 (en) * | 2006-11-10 | 2008-05-15 | Osaka University | Compositions and methods of treating oncological, inflammatory and autoimmune diseases mediated by sema4a |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000055371A1 (en) * | 1999-03-18 | 2000-09-21 | Human Genome Sciences, Inc. | 27 human secreted proteins |
| US7033780B1 (en) * | 1999-06-14 | 2006-04-25 | Millennium Pharmaceuticals, Inc. | Nucleic acids corresponding to TANGO 294 a gene encoding a lipase—like protein |
| WO2002006339A2 (en) * | 2000-07-03 | 2002-01-24 | Curagen Corporation | Proteins and nucleic acids encoding same |
| EP1355935A2 (en) * | 2001-02-02 | 2003-10-29 | Incyte Genomics, Inc. | Secreted proteins |
-
2002
- 2002-03-26 DE DE10213762A patent/DE10213762A1/de not_active Withdrawn
-
2003
- 2003-03-18 JP JP2003578426A patent/JP2005538041A/ja active Pending
- 2003-03-18 WO PCT/EP2003/002785 patent/WO2003080673A1/en not_active Ceased
- 2003-03-18 EP EP03714841A patent/EP1490406A1/en not_active Withdrawn
- 2003-03-18 AU AU2003219068A patent/AU2003219068A1/en not_active Abandoned
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