JP2005536549A5 - - Google Patents
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- Publication number
- JP2005536549A5 JP2005536549A5 JP2004530846A JP2004530846A JP2005536549A5 JP 2005536549 A5 JP2005536549 A5 JP 2005536549A5 JP 2004530846 A JP2004530846 A JP 2004530846A JP 2004530846 A JP2004530846 A JP 2004530846A JP 2005536549 A5 JP2005536549 A5 JP 2005536549A5
- Authority
- JP
- Japan
- Prior art keywords
- ethylideneamino
- fluorobenzyl
- biphenyl
- carboxylic acid
- hydroxyindan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 ethylideneamino Chemical group 0.000 claims 25
- NNJMFJSKMRYHSR-UHFFFAOYSA-N 4-phenylbenzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C1=CC=CC=C1 NNJMFJSKMRYHSR-UHFFFAOYSA-N 0.000 claims 24
- 150000001408 amides Chemical class 0.000 claims 24
- 238000011282 treatment Methods 0.000 claims 19
- 208000010877 cognitive disease Diseases 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 11
- 230000002265 prevention Effects 0.000 claims 9
- 208000028698 Cognitive impairment Diseases 0.000 claims 8
- 201000000980 schizophrenia Diseases 0.000 claims 8
- PTIASGVLWNOMTD-FIRIVFDPSA-N N-[(1R,2R)-6-[[N-[2-(4-fluorophenyl)ethyl]-C-methylcarbonimidoyl]amino]-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-phenylbenzamide Chemical compound FC1=CC=C(CCNC(C)=NC2=CC=C3C[C@H]([C@@H](C3=C2)NC(=O)C2=CC=C(C=C2)C2=CC=CC=C2)O)C=C1 PTIASGVLWNOMTD-FIRIVFDPSA-N 0.000 claims 7
- 238000000634 powder X-ray diffraction Methods 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 claims 4
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 4
- 208000027061 mild cognitive impairment Diseases 0.000 claims 4
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims 2
- PVOKVYGHPPFETE-RTBURBONSA-N N-[(2R,3R)-3-amino-2-hydroxy-2,3-dihydro-1H-inden-5-yl]-N'-[2-(4-fluorophenyl)ethyl]ethanimidamide Chemical compound C1([C@@H](N)[C@H](O)CC1=CC=1)=CC=1NC(C)=NCCC1=CC=C(F)C=C1 PVOKVYGHPPFETE-RTBURBONSA-N 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 1
- 201000000381 schizophrenia 1 Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40544302P | 2002-08-22 | 2002-08-22 | |
| PCT/US2003/023260 WO2004018411A1 (en) | 2002-08-22 | 2003-08-12 | Muscarinic agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005536549A JP2005536549A (ja) | 2005-12-02 |
| JP2005536549A5 true JP2005536549A5 (https=) | 2006-09-28 |
| JP4469280B2 JP4469280B2 (ja) | 2010-05-26 |
Family
ID=31946873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004530846A Expired - Fee Related JP4469280B2 (ja) | 2002-08-22 | 2003-08-12 | ムスカリン性アゴニスト |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7160922B2 (https=) |
| EP (1) | EP1534667B1 (https=) |
| JP (1) | JP4469280B2 (https=) |
| CN (1) | CN100554247C (https=) |
| AR (1) | AR040889A1 (https=) |
| AT (1) | ATE491683T1 (https=) |
| AU (1) | AU2003256791B2 (https=) |
| BR (1) | BR0313161A (https=) |
| CA (1) | CA2493958C (https=) |
| CY (1) | CY1111115T1 (https=) |
| DE (1) | DE60335380D1 (https=) |
| DK (1) | DK1534667T3 (https=) |
| ES (1) | ES2355213T3 (https=) |
| MX (1) | MXPA05002080A (https=) |
| PE (1) | PE20040894A1 (https=) |
| PT (1) | PT1534667E (https=) |
| SI (1) | SI1534667T1 (https=) |
| TW (1) | TW200410922A (https=) |
| WO (1) | WO2004018411A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2275095A3 (en) * | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| JP2013523679A (ja) | 2010-03-29 | 2013-06-17 | ビーエーエスエフ ソシエタス・ヨーロピア | 殺菌性イミノ誘導体 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA76492C2 (en) * | 2001-09-21 | 2006-08-15 | Lilly Co Eli | Muscarinic agonists, a pharmaceutical composition on their basis |
-
2003
- 2003-08-12 DE DE60335380T patent/DE60335380D1/de not_active Expired - Lifetime
- 2003-08-12 JP JP2004530846A patent/JP4469280B2/ja not_active Expired - Fee Related
- 2003-08-12 AU AU2003256791A patent/AU2003256791B2/en not_active Ceased
- 2003-08-12 CA CA2493958A patent/CA2493958C/en not_active Expired - Fee Related
- 2003-08-12 EP EP03792989A patent/EP1534667B1/en not_active Expired - Lifetime
- 2003-08-12 US US10/524,960 patent/US7160922B2/en not_active Expired - Fee Related
- 2003-08-12 BR BR0313161-0A patent/BR0313161A/pt not_active IP Right Cessation
- 2003-08-12 DK DK03792989.0T patent/DK1534667T3/da active
- 2003-08-12 CN CNB038192500A patent/CN100554247C/zh not_active Expired - Fee Related
- 2003-08-12 PT PT03792989T patent/PT1534667E/pt unknown
- 2003-08-12 SI SI200331933T patent/SI1534667T1/sl unknown
- 2003-08-12 WO PCT/US2003/023260 patent/WO2004018411A1/en not_active Ceased
- 2003-08-12 AT AT03792989T patent/ATE491683T1/de active
- 2003-08-12 MX MXPA05002080A patent/MXPA05002080A/es active IP Right Grant
- 2003-08-12 ES ES03792989T patent/ES2355213T3/es not_active Expired - Lifetime
- 2003-08-20 TW TW092122893A patent/TW200410922A/zh unknown
- 2003-08-20 AR AR20030103011A patent/AR040889A1/es unknown
- 2003-08-21 PE PE2003000851A patent/PE20040894A1/es not_active Application Discontinuation
-
2011
- 2011-01-19 CY CY20111100057T patent/CY1111115T1/el unknown
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