JP2005536492A5 - - Google Patents
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- Publication number
- JP2005536492A5 JP2005536492A5 JP2004519862A JP2004519862A JP2005536492A5 JP 2005536492 A5 JP2005536492 A5 JP 2005536492A5 JP 2004519862 A JP2004519862 A JP 2004519862A JP 2004519862 A JP2004519862 A JP 2004519862A JP 2005536492 A5 JP2005536492 A5 JP 2005536492A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- hydrogen
- aryl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- -1 2-tetrahydropyranyl Chemical group 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 3
- 206010062207 Mycobacterial infection Diseases 0.000 claims 3
- 108010059993 Vancomycin Proteins 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 208000027531 mycobacterial infectious disease Diseases 0.000 claims 3
- 125000004193 piperazinyl group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229960003165 vancomycin Drugs 0.000 claims 3
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 3
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- WDZVMMIIHATAQV-UHFFFAOYSA-N C[n]1cnc(S(=O)=O)c1 Chemical compound C[n]1cnc(S(=O)=O)c1 WDZVMMIIHATAQV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/189,710 US7022667B2 (en) | 2002-07-03 | 2002-07-03 | O-derivatized nocathiacin derivatives |
| PCT/US2003/021012 WO2004004646A2 (en) | 2002-07-03 | 2003-07-02 | O-derivatized nocathiacin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536492A JP2005536492A (ja) | 2005-12-02 |
| JP2005536492A5 true JP2005536492A5 (enExample) | 2006-04-06 |
Family
ID=30114034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004519862A Withdrawn JP2005536492A (ja) | 2002-07-03 | 2003-07-02 | Ｏ−誘導型ノカチアシン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7022667B2 (enExample) |
| EP (1) | EP1531854A4 (enExample) |
| JP (1) | JP2005536492A (enExample) |
| CN (1) | CN1678340A (enExample) |
| AU (1) | AU2003247783A1 (enExample) |
| BR (1) | BR0312550A (enExample) |
| CA (1) | CA2491074A1 (enExample) |
| MX (1) | MXPA05000140A (enExample) |
| WO (1) | WO2004004646A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4036440B2 (ja) * | 2002-03-29 | 2008-01-23 | 東洋合成工業株式会社 | 新規な感光性化合物及び感光性樹脂並びに感光性組成物 |
| EP2010202B1 (en) * | 2006-04-18 | 2013-09-25 | Piramal Enterprises Limited | Antibacterial compounds |
| GB0609617D0 (en) * | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Process & intermediate |
| US20080242597A1 (en) * | 2006-10-20 | 2008-10-02 | Kun Liu | Antibiotic compounds |
| US20080132500A1 (en) * | 2006-10-20 | 2008-06-05 | Kun Liu | Antibiotic compounds |
| CN116829524A (zh) * | 2021-01-06 | 2023-09-29 | 中外制药株式会社 | 酸性官能团的烷基化方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ509306A (en) | 1998-07-16 | 2002-07-26 | Bristol Myers Squibb Co | Nocathiacin antibiotics |
| AU5806499A (en) | 1998-09-04 | 2000-03-27 | Bristol-Myers Squibb Company | Nocathiacin antibiotic derivatives prepared by microbial biotransformation |
| US6287827B1 (en) * | 1999-05-05 | 2001-09-11 | Bristol-Myers Squibb Company | Halo- or hydroxy-substituted nocathiacin antibiotics |
| US20020055465A1 (en) | 2000-08-14 | 2002-05-09 | Wenying Li | Nocathiacin antibiotics prepared by biotransformation or chemical methods |
| US20020065219A1 (en) | 2000-08-15 | 2002-05-30 | Naidu B. Narasimhulu | Water soluble thiazolyl peptide derivatives |
-
2002
- 2002-07-03 US US10/189,710 patent/US7022667B2/en not_active Expired - Lifetime
-
2003
- 2003-07-02 CN CNA038206323A patent/CN1678340A/zh active Pending
- 2003-07-02 WO PCT/US2003/021012 patent/WO2004004646A2/en not_active Ceased
- 2003-07-02 AU AU2003247783A patent/AU2003247783A1/en not_active Abandoned
- 2003-07-02 MX MXPA05000140A patent/MXPA05000140A/es unknown
- 2003-07-02 BR BR0312550-5A patent/BR0312550A/pt not_active Application Discontinuation
- 2003-07-02 JP JP2004519862A patent/JP2005536492A/ja not_active Withdrawn
- 2003-07-02 EP EP03763185A patent/EP1531854A4/en not_active Withdrawn
- 2003-07-02 CA CA002491074A patent/CA2491074A1/en not_active Abandoned
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