JP2005536464A5 - - Google Patents
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- Publication number
- JP2005536464A5 JP2005536464A5 JP2004503475A JP2004503475A JP2005536464A5 JP 2005536464 A5 JP2005536464 A5 JP 2005536464A5 JP 2004503475 A JP2004503475 A JP 2004503475A JP 2004503475 A JP2004503475 A JP 2004503475A JP 2005536464 A5 JP2005536464 A5 JP 2005536464A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- halogen
- different
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/139,817 US6703399B2 (en) | 2002-05-06 | 2002-05-06 | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
| PCT/US2003/012650 WO2003095461A1 (en) | 2002-05-06 | 2003-04-22 | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005536464A JP2005536464A (ja) | 2005-12-02 |
| JP2005536464A5 true JP2005536464A5 (https=) | 2006-06-01 |
Family
ID=29399359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004503475A Pending JP2005536464A (ja) | 2002-05-06 | 2003-04-22 | カンプトテシンのハロアルキルエステルおよびこれらの化合物を使用する癌治療方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6703399B2 (https=) |
| EP (1) | EP1501836A1 (https=) |
| JP (1) | JP2005536464A (https=) |
| AU (1) | AU2003231068A1 (https=) |
| CA (1) | CA2484816C (https=) |
| WO (1) | WO2003095461A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100723454B1 (ko) * | 2004-08-21 | 2007-05-30 | 페어차일드코리아반도체 주식회사 | 높은 열 방출 능력을 구비한 전력용 모듈 패키지 및 그제조방법 |
| US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
| US7517891B2 (en) * | 2005-10-27 | 2009-04-14 | Glyconix Corporation | Camptothecin derivatives and improved synthetic methods |
| CN101522686A (zh) * | 2006-08-11 | 2009-09-02 | 克里斯特斯斯特林癌症研究基金会 | 制备喜树碱酯的方法 |
| WO2008070009A2 (en) * | 2006-12-01 | 2008-06-12 | Alza Corporation | Treating solid tumors and monocytic leukemia using topoisomerase inhibitors in liposomes |
| US7572803B2 (en) * | 2007-10-25 | 2009-08-11 | The Christus Stehlin Foundation For Cancer Research | Hydrated crystalline esters of camptothecin |
| CN102649795B (zh) * | 2011-06-23 | 2014-08-06 | 东北林业大学 | 10-甲氧基喜树碱衍生物、制备方法和用途 |
| US20130121921A1 (en) | 2011-11-11 | 2013-05-16 | The Christus Stehlin Foundation For Cancer Research | Rodent Therapeutic Model And Methods |
| CN103864811A (zh) * | 2012-12-13 | 2014-06-18 | 天津科技大学 | 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用 |
| WO2025077773A1 (zh) * | 2023-10-10 | 2025-04-17 | 上海翊维康医药有限责任公司 | 新的i型拓扑异构酶抑制剂及其制备方法和用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399282A (en) | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| JPS5612393A (en) * | 1979-07-10 | 1981-02-06 | Yakult Honsha Co Ltd | Novel camptothecin derivative |
| US5552154A (en) | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US6080751A (en) | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5965566A (en) | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5646159A (en) | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| US5731316A (en) | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US6407118B1 (en) | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US6096336A (en) | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US5922877A (en) | 1997-08-05 | 1999-07-13 | The Stehlin Foundation For Cancer Research | Methods of preparing and purifying 9-nitro-20-camptothecin |
| US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6350756B1 (en) | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
| GB0119578D0 (en) | 2001-08-10 | 2001-10-03 | Pharmacia & Upjohn Spa | Fluoro linkers |
-
2002
- 2002-05-06 US US10/139,817 patent/US6703399B2/en not_active Expired - Lifetime
-
2003
- 2003-04-22 JP JP2004503475A patent/JP2005536464A/ja active Pending
- 2003-04-22 AU AU2003231068A patent/AU2003231068A1/en not_active Abandoned
- 2003-04-22 CA CA2484816A patent/CA2484816C/en not_active Expired - Fee Related
- 2003-04-22 WO PCT/US2003/012650 patent/WO2003095461A1/en not_active Ceased
- 2003-04-22 EP EP03724193A patent/EP1501836A1/en not_active Withdrawn
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